MX9400113A - Novedosos derivados de acido piridona carboxilico. - Google Patents
Novedosos derivados de acido piridona carboxilico.Info
- Publication number
- MX9400113A MX9400113A MX9400113A MX9400113A MX9400113A MX 9400113 A MX9400113 A MX 9400113A MX 9400113 A MX9400113 A MX 9400113A MX 9400113 A MX9400113 A MX 9400113A MX 9400113 A MX9400113 A MX 9400113A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- lower alkyl
- hydrogen atom
- carboxylic acid
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Se proporcionan novedosos derivados de ácido piridona carboxílico y sus sales farmacéuticamente aceptables y sus ésteres fisiológicamente hidrolizables, que se representan por la formula (ver formula 1) en donde R1 es un alquilo inferior, un alquilo inferior substituido con halógeno, un alquenlo inferior, un ciclo alquilo o grupo fenilo substituido o no substituido; R2 es un átomo de hidrógeno, o un grupo alquilo inferior o un grupo amino; A es un átomo de nitrógeno o el grupo C-X en donde X es un hidrógeno o un átomo de halógeno, o un grupo alcoxi; y Z es un grupo que tiene la formula (ver formula 2) en donde n es 1 o 2; R3 y R4 cada uno representa un átomo de hidrógeno o un grupo alquilo inferior, con la condición de que si n es 2, uno de R3 y R4 es un átomo de hidrógeno; R5 y R6 cada uno representa un átomo de hidrógeno, un grupo hidroxi, alcoxi inferior o amino, que está sin substituir o substituido por un grupo alquilo inferior, con la condición de que uno de R5 y R6 es un átomo de hidrógeno, y R7 es un átomo de hidrógeno o un grupo alquilo inferior. Los compuestos de la presente invención muestran un espectro potente y amplio de actividades antibacterianas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR920026696 | 1992-12-30 | ||
KR930011125 | 1993-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9400113A true MX9400113A (es) | 1994-07-29 |
Family
ID=26629459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9400113A MX9400113A (es) | 1992-12-30 | 1994-01-03 | Novedosos derivados de acido piridona carboxilico. |
Country Status (14)
Country | Link |
---|---|
US (2) | US5527910A (es) |
EP (1) | EP0677050B1 (es) |
JP (1) | JP2948660B2 (es) |
CN (1) | CN1042632C (es) |
AT (1) | ATE204272T1 (es) |
AU (2) | AU689089B2 (es) |
CA (2) | CA2152817C (es) |
DE (1) | DE69330612D1 (es) |
HU (1) | HU219581B (es) |
MX (1) | MX9400113A (es) |
NO (2) | NO307883B1 (es) |
RU (1) | RU2161154C2 (es) |
WO (1) | WO1994015933A1 (es) |
YU (1) | YU83993A (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0664288A1 (en) * | 1992-10-09 | 1995-07-26 | Chugai Seiyaku Kabushiki Kaisha | Fluoroquinoline derivative |
US5527910A (en) * | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
US5990106A (en) * | 1994-02-04 | 1999-11-23 | Dainippon Pharmaceutical Co., Ltd. | Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof |
CN1090185C (zh) * | 1995-02-02 | 2002-09-04 | 大日本制药株式会社 | 有双环氨基取代的吡啶酮羧酸衍生物,其酯及盐,以及可用作其中间体的双环类胺 |
US6218563B1 (en) | 1998-12-03 | 2001-04-17 | Monsanto Company | Cyanophosphonamides and method for preparation |
EP2275141A1 (en) | 1999-03-17 | 2011-01-19 | Daiichi Pharmaceutical Co., Ltd. | Tastemasked pharmaceutical compositions |
US7334538B1 (en) * | 2004-07-27 | 2008-02-26 | Aquascience Research Group, Inc. | Topical medicants for aquatic animals |
WO2008045673A2 (en) * | 2006-10-06 | 2008-04-17 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, processes for its preparation and its use as antibacterial agents |
US7632944B2 (en) * | 2007-01-24 | 2009-12-15 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
US8252783B2 (en) | 2007-01-24 | 2012-08-28 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
WO2010131054A1 (en) | 2009-05-15 | 2010-11-18 | Bradford Pharma Limited | Redox drug derivatives |
CA2829939C (en) | 2011-03-15 | 2020-10-13 | Trius Therapeutics, Inc. | Tricyclic gyrase inhibitors |
PL2796460T3 (pl) * | 2011-12-21 | 2018-12-31 | Jiangsu Hengrui Medicine Co. Ltd. | Sześcioczłonowa pirolowa heteroarylowa pochodna pierścieniowa, sposób jej otrzymywania i zastosowania medyczne |
CN105189505B (zh) | 2012-09-12 | 2019-03-22 | 默克夏普&多梅有限公司 | 用作抗菌剂的三环促旋酶抑制剂 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3252972A (en) * | 1959-11-10 | 1966-05-24 | Ciba Geigy Corp | (n, n-bicycloalkylene-imino)-lower alkyl-guanidines |
US3246027A (en) * | 1961-03-22 | 1966-04-12 | Du Pont | Process for converting cis-1, 2-dicyanocy-clobutane to trans-1, 2-dicyanocyclobutane |
US3246006A (en) * | 1963-08-07 | 1966-04-12 | Du Pont | 2-(3-azabicyclo [3.2.0] hept-3-ylthio) benothiazole |
NL6504082A (es) * | 1965-03-31 | 1966-10-03 | ||
US3639390A (en) * | 1966-12-30 | 1972-02-01 | Ciba Ltd | Azabicycloalkane derivatives |
US3875154A (en) * | 1972-09-15 | 1975-04-01 | Univ Ca | Certain 5-thia-1-azabicyclo{8 4.2.0{9 octenes |
EP0022288A3 (en) * | 1979-07-06 | 1981-07-01 | Shell Internationale Researchmaatschappij B.V. | Method of sterilizing male anthers in plants, compositions and compounds suitable for use in such a method, and method of producing f1 hybrid seed |
JPS5649382A (en) * | 1979-09-28 | 1981-05-02 | Dainippon Pharmaceut Co Ltd | 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt |
US4382937A (en) * | 1981-02-27 | 1983-05-10 | Dainippon Pharmaceutical Co., Ltd. | Naphthyridine derivatives and their use as anti-bacterials |
US4431661A (en) * | 1981-08-20 | 1984-02-14 | American Cyanamid Company | 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor |
US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
IL77846A (en) * | 1985-03-25 | 1989-08-15 | Warner Lambert Co | Process for the preparation of 7-amino-quinolin-4-oxy-3-carboxylic acid derivatives |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
US4962108A (en) * | 1987-07-31 | 1990-10-09 | Warner-Lambert Company | Antibacterial quinoline compounds |
JPH0676400B2 (ja) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
WO1990002123A1 (en) * | 1988-08-23 | 1990-03-08 | Pfizer Inc. | Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters |
US5147873A (en) * | 1988-08-23 | 1992-09-15 | Pfizer Inc. | Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters |
CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
US5286723A (en) * | 1988-08-31 | 1994-02-15 | Daiichi Seiyaku Co., Ltd. | Spiro compound |
WO1991002526A1 (en) * | 1989-08-16 | 1991-03-07 | Pfizer Inc. | Azabicyclo quinolone carboxylic acids |
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
CA2030217A1 (en) * | 1989-11-21 | 1991-05-22 | Jun Imose | Pyridone-carboxylic acid derivatives useful as veterinary medicines |
CA2076982A1 (en) * | 1990-12-27 | 1992-06-28 | Akira Okura | Pyridonecarboxylic acid derivatives |
DE4120646A1 (de) * | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
EP0549857A1 (en) * | 1991-12-31 | 1993-07-07 | Korea Research Institute Of Chemical Technology | Antibacterial quinolone carboxylic acid derivatives |
DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
US5527910A (en) * | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
-
1993
- 1993-12-03 US US08/160,821 patent/US5527910A/en not_active Expired - Fee Related
- 1993-12-29 WO PCT/KR1993/000123 patent/WO1994015933A1/en active IP Right Grant
- 1993-12-29 EP EP94903116A patent/EP0677050B1/en not_active Expired - Lifetime
- 1993-12-29 CA CA002152817A patent/CA2152817C/en not_active Expired - Fee Related
- 1993-12-29 CA CA002226406A patent/CA2226406C/en not_active Expired - Fee Related
- 1993-12-29 AT AT94903116T patent/ATE204272T1/de not_active IP Right Cessation
- 1993-12-29 JP JP6515880A patent/JP2948660B2/ja not_active Expired - Lifetime
- 1993-12-29 HU HU9501727A patent/HU219581B/hu not_active IP Right Cessation
- 1993-12-29 DE DE69330612T patent/DE69330612D1/de not_active Expired - Lifetime
- 1993-12-29 RU RU95115237/04A patent/RU2161154C2/ru active
- 1993-12-29 AU AU57181/94A patent/AU689089B2/en not_active Ceased
- 1993-12-30 YU YU83993A patent/YU83993A/sh unknown
- 1993-12-30 CN CN93115335A patent/CN1042632C/zh not_active Expired - Fee Related
-
1994
- 1994-01-03 MX MX9400113A patent/MX9400113A/es not_active IP Right Cessation
-
1995
- 1995-06-29 NO NO952610A patent/NO307883B1/no not_active IP Right Cessation
-
1996
- 1996-01-26 US US08/592,171 patent/US5688965A/en not_active Expired - Fee Related
-
1997
- 1997-09-24 AU AU39220/97A patent/AU704969B2/en not_active Ceased
-
1999
- 1999-11-17 NO NO995638A patent/NO309087B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO995638D0 (no) | 1999-11-17 |
CN1098103A (zh) | 1995-02-01 |
AU704969B2 (en) | 1999-05-13 |
NO952610L (no) | 1995-08-29 |
NO309087B1 (no) | 2000-12-11 |
CA2226406A1 (en) | 1994-07-21 |
HUT72434A (en) | 1996-04-29 |
AU689089B2 (en) | 1998-03-26 |
CA2152817A1 (en) | 1994-07-21 |
ATE204272T1 (de) | 2001-09-15 |
NO952610D0 (no) | 1995-06-29 |
AU3922097A (en) | 1997-12-18 |
CA2226406C (en) | 2001-08-14 |
EP0677050B1 (en) | 2001-08-16 |
DE69330612D1 (de) | 2001-09-20 |
US5527910A (en) | 1996-06-18 |
HU219581B (hu) | 2001-05-28 |
US5688965A (en) | 1997-11-18 |
CN1042632C (zh) | 1999-03-24 |
JPH08505384A (ja) | 1996-06-11 |
NO307883B1 (no) | 2000-06-13 |
RU2161154C2 (ru) | 2000-12-27 |
YU83993A (sh) | 1996-10-09 |
AU5718194A (en) | 1994-08-15 |
HU9501727D0 (en) | 1995-08-28 |
NO995638L (no) | 1999-11-17 |
EP0677050A1 (en) | 1995-10-18 |
RU95115237A (ru) | 1997-06-10 |
JP2948660B2 (ja) | 1999-09-13 |
WO1994015933A1 (en) | 1994-07-21 |
CA2152817C (en) | 1998-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |