US5646016A
(en)
*
|
1991-02-06 |
1997-07-08 |
Genetics Institute, Inc. |
Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
|
MX9205293A
(es)
|
1991-09-20 |
1993-05-01 |
Syntex Sinergen Neuroscience J |
Factores neurotrofico derivado del glial
|
NZ251820A
(en)
*
|
1992-03-30 |
1996-07-26 |
Immunex Corp |
Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide
|
IL105406A
(en)
|
1992-04-17 |
2000-01-31 |
Sankyo Co |
Derivatives of adipogenesis inhibitory factor processes for the preparation thereof and pharmaceutical compositions containing the same
|
US6746859B1
(en)
*
|
1993-01-15 |
2004-06-08 |
Genetics Institute, Llc |
Cloning of enterokinase and method of use
|
CA2153254C
(en)
*
|
1993-01-15 |
2002-05-21 |
Edward R. Lavallie |
Cloning of enterokinase and method of use
|
US5914254A
(en)
*
|
1993-08-02 |
1999-06-22 |
Celtrix Pharmaceuticals, Inc. |
Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
|
US5563046A
(en)
*
|
1993-08-02 |
1996-10-08 |
Celtrix Pharmaceuticals, Inc. |
Fusion polypeptides and proteins
|
US6270757B1
(en)
|
1994-04-21 |
2001-08-07 |
Genetics Institute, Inc. |
Formulations for IL-11
|
US5635182A
(en)
*
|
1994-06-16 |
1997-06-03 |
Genetics Institute, Inc. |
Method of detecting ligand interactions
|
EP1405911A1
(en)
*
|
1994-07-20 |
2004-04-07 |
The General Hospital Corporation |
Interaction trap systems for detecting protein interactions
|
US6399296B1
(en)
*
|
1994-07-20 |
2002-06-04 |
The General Hospital Corporation |
Interaction trap systems for detecting protein interactions
|
US5582821A
(en)
*
|
1994-07-22 |
1996-12-10 |
Genetics Institute, Inc. |
Methods for treating bleeding disorders
|
US5639635A
(en)
*
|
1994-11-03 |
1997-06-17 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US5789199A
(en)
*
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US6274547B1
(en)
*
|
1996-06-14 |
2001-08-14 |
Genetics Institute, Inc. |
Methods comprising the use of human interleukin-11 receptor proteins
|
DE69535274T2
(de)
|
1994-12-22 |
2007-06-06 |
Genetics Institute, LLC, Cambridge |
Verwendung eines menschlichen interleukin-11 rezeptors
|
US6344343B1
(en)
|
1995-03-21 |
2002-02-05 |
The Regents Of The University Of Colorado |
Product and process for membrane and soluble polypeptide segregation
|
US5935822A
(en)
*
|
1995-03-21 |
1999-08-10 |
The Regents Of The University Of Colorado |
Product and process for membrane and soluble polypeptide segregation
|
EP0826060B1
(en)
*
|
1995-05-15 |
2008-08-27 |
Abbott Laboratories |
Embedded expression of heterologous proteins
|
US6352972B1
(en)
|
1995-06-06 |
2002-03-05 |
Marcel E. Nimni |
Bone morphogenetic proteins and their use in bone growth
|
US6887461B1
(en)
*
|
1998-10-26 |
2005-05-03 |
Genetics Institute, Llc |
Method of using IL-11 for treating mucositis
|
US6540993B1
(en)
*
|
1995-06-27 |
2003-04-01 |
Wyeth |
Method of treating inflammatory bowel disease using a topical formulation of IL-11
|
US6126933A
(en)
*
|
1995-06-27 |
2000-10-03 |
Genetics Institute |
Methods of treating inflammatory bowel diseases by administering IL-11
|
JP3092904B2
(ja)
*
|
1995-10-13 |
2000-09-25 |
株式会社エイチ・エス・ピー研究所 |
細菌により可溶性蛋白質を生産する方法
|
AU707191B2
(en)
|
1995-12-28 |
1999-07-08 |
Fujirebio Inc. |
Fused DNA sequence, fused protein expressed from said fused DNA sequence and method for expressing said protein
|
AU2660397A
(en)
*
|
1996-04-05 |
1997-10-29 |
Board Of Regents, The University Of Texas System |
Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
|
WO1997041207A2
(en)
*
|
1996-04-30 |
1997-11-06 |
Schering Corporation |
Expression of soluble heterologous proteins in bacteria utilizing a thioredoxin/protein expression vector
|
US7655436B1
(en)
|
1996-04-30 |
2010-02-02 |
Schering Corporation |
Expression of soluble heterologous proteins in bacteria utilizing a thioredoxin/protein expression vector
|
US7901910B2
(en)
|
1996-05-14 |
2011-03-08 |
Gregory Thomas Maine |
Embedded expression of insoluble heterologous proteins
|
US5858724A
(en)
*
|
1996-07-16 |
1999-01-12 |
Pel-Freez |
Recombinant rabbit tissue factor
|
US6815174B1
(en)
*
|
1996-11-28 |
2004-11-09 |
Edgardo Poskus |
Thioredoxin-glutamate decarboxylase 65 fusion protein
|
US5831049A
(en)
*
|
1997-01-03 |
1998-11-03 |
Incyte Pharmaceuticals, Inc. |
Human thioredoxin
|
EP1911841B1
(en)
*
|
1997-01-08 |
2015-06-03 |
Life Technologies Corporation |
Methods for production of proteins
|
EP0963435B1
(en)
*
|
1997-01-08 |
2008-05-28 |
Invitrogen Corporation |
Methods for production of proteins
|
GB9703406D0
(en)
*
|
1997-02-19 |
1997-04-09 |
Chiron Spa |
Expression of heterologous proteins
|
US6852508B1
(en)
|
1997-02-28 |
2005-02-08 |
Genetics Institute, Llc |
Chemokine with amino-terminal modifications
|
US6100387A
(en)
*
|
1997-02-28 |
2000-08-08 |
Genetics Institute, Inc. |
Chimeric polypeptides containing chemokine domains
|
US6083715A
(en)
*
|
1997-06-09 |
2000-07-04 |
Board Of Regents, The University Of Texas System |
Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
|
US5989868A
(en)
*
|
1997-09-12 |
1999-11-23 |
The Board Of Regents Of The University Of Oklahoma |
Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
|
WO1999015560A1
(en)
*
|
1997-09-26 |
1999-04-01 |
Sloan-Kettering Institute For Cancer Research |
Soluble polypeptide having a delta-serrate-lag2 domain of delta homologue and uses thereof
|
EP1042351A4
(en)
|
1997-11-10 |
2003-06-25 |
Gen Hospital Corp |
DETECTION SYSTEMS FOR RECORDING INTERACTIONS BETWEEN PROTEINS AND FUNCTIONAL RELATIONSHIPS
|
US6077689A
(en)
*
|
1997-12-24 |
2000-06-20 |
Amgen Inc. |
Enhanced solubility of recombinant proteins
|
KR100269671B1
(ko)
*
|
1998-03-21 |
2000-10-16 |
박호군 |
면역 검출법을 이용한 hiv의 감염 억제 활성 물질의 검색방법 및 그에 사용되는 변이단백질
|
US6746852B1
(en)
|
1998-05-08 |
2004-06-08 |
Osi Pharmaceuticals, Inc. |
AGS proteins and nucleic acid molecules and uses thereof
|
US6733991B1
(en)
|
1998-05-08 |
2004-05-11 |
Osi Pharmaceuticals, Inc. |
AGS proteins and nucleic acid molecules and uses therefor
|
CA2237915A1
(en)
|
1998-05-19 |
1999-11-19 |
Stephen Shaughnessy |
Osteoporosis treatment
|
WO1999064835A2
(en)
*
|
1998-06-10 |
1999-12-16 |
Tatton William G |
Screening method for dehydrogenase oligomerisation modulators
|
US20030190740A1
(en)
|
1998-10-13 |
2003-10-09 |
The University Of Georgia Research Foundation, Inc |
Stabilized bioactive peptides and methods of identification, synthesis, and use
|
BR9914519A
(pt)
*
|
1998-10-13 |
2001-07-03 |
Univ Georgia Res Found |
Peptìdios bioativos estabilizados e métodos de identificação, sìntese e uso
|
US6387664B1
(en)
*
|
1999-02-26 |
2002-05-14 |
Secretary Of Agency Of Industrial Science And Technology |
Sparc fusion protein and method for producing the same
|
US6953777B2
(en)
*
|
1999-03-11 |
2005-10-11 |
Genetics Indtitute LLC |
Use of interleukin-11 to prevent immune-mediated cytotoxicity
|
WO2001007076A1
(en)
*
|
1999-04-15 |
2001-02-01 |
Genetics Institute, Inc. |
Use of interleukin-11 to treat gastrointestinal disorders
|
IL147599A0
(en)
*
|
1999-07-15 |
2002-08-14 |
Genetics Inst |
Formulations for il-11
|
DE60141088D1
(de)
*
|
2000-04-14 |
2010-03-04 |
Genencor Int |
Verfahren zur selektiven zielen
|
US7129326B2
(en)
*
|
2000-04-14 |
2006-10-31 |
Genencor International, Inc. |
Methods for selective targeting
|
KR20020003917A
(ko)
*
|
2000-06-26 |
2002-01-16 |
복성해 |
꼬리 단백질과 인간 인터루킨-16의 융합 단백질, 이 융합단백질을 코딩하는 유전자, 이 유전자를 포함하는 발현벡터, 이 벡터로 형질전환된 대장균 및 이 대장균을이용한 인간 인터루킨-16의 생산 방법
|
JP2004501648A
(ja)
*
|
2000-06-26 |
2004-01-22 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
チオレドキシンおよび目的のポリペプチドの間に融合するユビキチンを含む三重融合タンパク質
|
US6632638B1
(en)
|
2000-11-17 |
2003-10-14 |
Amgen, Inc. |
Enhanced solubility of recombinant proteins using Uracil DNA glycosylase inhibitor
|
US20030165873A1
(en)
|
2001-03-02 |
2003-09-04 |
Come Jon H. |
Three hybrid assay system
|
US20020128190A1
(en)
*
|
2001-03-09 |
2002-09-12 |
Leslie Lobel |
Expression of properly folded and soluble extracellular domain of a gonadotropin receptor
|
JP4838957B2
(ja)
*
|
2001-05-02 |
2011-12-14 |
独立行政法人理化学研究所 |
無細胞タンパク質合成系を用いたタンパク質の製造方法
|
US20040143104A1
(en)
*
|
2001-08-08 |
2004-07-22 |
Wadsworth Samuel C. |
Methods of treating diabetes and other blood sugar disorders
|
EP1572885A2
(en)
*
|
2001-08-08 |
2005-09-14 |
Genzyme Corporation |
Methods for treating diabetes and other blood sugar disorders
|
AU2002362088A1
(en)
*
|
2001-12-06 |
2003-06-23 |
Catholic University |
Method and composition for inducing weight loss
|
ATE451387T1
(de)
*
|
2001-12-18 |
2009-12-15 |
Endocube Sas |
Neue mit dem zelltod assoziierte proteine aus der thap familie und par4 verwandte signalwege, die bei der kontrolle von apoptosis involviert sind
|
US7858297B2
(en)
*
|
2001-12-18 |
2010-12-28 |
Centre National De La Recherche Scientifique Cnrs |
Chemokine-binding protein and methods of use
|
US7081446B2
(en)
*
|
2002-01-31 |
2006-07-25 |
The Trustees Of Columbia University In The City Of New York |
Long-acting follicle stimulating hormone analogues and uses thereof
|
US6982080B2
(en)
*
|
2002-03-15 |
2006-01-03 |
Wyeth |
Hydroxyethyl starch—containing polypeptide compositions
|
EP1507003B1
(en)
*
|
2002-05-22 |
2011-09-21 |
Riken |
Process for producing protein in cell-free protein synthesis system using thioredoxin fused protein expression vector
|
EP2586440A2
(en)
|
2002-06-24 |
2013-05-01 |
Paratek Pharmaceuticals, Inc. |
Methods for preventing and treating microbial infections by modulating transcription factors
|
MXPA05002899A
(es)
*
|
2002-09-16 |
2005-05-27 |
Wyeth Corp |
Formulaciones de liberacion controlada para administracion oral de un agente terapeutico polipeptido y sus metodos de uso.
|
CN102584951A
(zh)
|
2002-11-25 |
2012-07-18 |
金克克国际有限公司 |
皮肤或毛发结合肽
|
JP4441170B2
(ja)
*
|
2002-11-28 |
2010-03-31 |
独立行政法人理化学研究所 |
S12リボソームタンパク質に変異を有する大腸菌細胞抽出液及びそれを用いる無細胞系によるタンパク質の製造方法
|
KR20050114268A
(ko)
*
|
2003-03-31 |
2005-12-05 |
내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 |
티오리독신 변이체
|
US20050107318A1
(en)
*
|
2003-11-17 |
2005-05-19 |
Samuel Wadsworth |
Methods of treating diabetes and other blood sugar disorders
|
DK1784220T3
(en)
|
2004-08-26 |
2018-03-19 |
Univ Western Ontario |
BACTERIAL OBJECTIVES TO ACHIEVE IRON
|
JP4868731B2
(ja)
|
2004-11-17 |
2012-02-01 |
独立行政法人理化学研究所 |
哺乳動物培養細胞由来の無細胞タンパク質合成システム
|
JP4590249B2
(ja)
*
|
2004-11-17 |
2010-12-01 |
独立行政法人理化学研究所 |
糖タンパク質合成用の無細胞タンパク質合成システム
|
JP4787488B2
(ja)
*
|
2004-11-19 |
2011-10-05 |
独立行政法人理化学研究所 |
直鎖状鋳型dnaを用いた無細胞タンパク質合成方法及びそのための細胞抽出液
|
KR100699279B1
(ko)
|
2005-04-28 |
2007-03-23 |
학교법인 포항공과대학교 |
당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
|
MX2008010633A
(es)
*
|
2006-02-24 |
2008-09-25 |
Chiesi Farma Spa |
Composiciones inmunogenicas anti-amiloides, metodos y usos.
|
ATE444741T1
(de)
|
2006-05-10 |
2009-10-15 |
Biocompatibles Uk Ltd |
Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung
|
JP2009544974A
(ja)
|
2006-07-21 |
2009-12-17 |
ライフ テクノロジーズ コーポレーション |
鮮明に分解する標識タンパク質分子量標準
|
US9243243B2
(en)
*
|
2006-08-31 |
2016-01-26 |
Nexigen Gmbh |
Means and methods for detecting protein-peptide interactions
|
AU2007305855A1
(en)
*
|
2006-10-11 |
2008-04-17 |
Oriental Yeast Co., Ltd. |
Agent containing fused protein of soluble RANKL with epitope tag
|
US8226976B2
(en)
*
|
2007-11-05 |
2012-07-24 |
Riken |
Method of using cell-free protein synthesis to produce a membrane protein
|
JP2011519276A
(ja)
*
|
2008-04-25 |
2011-07-07 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
人工タンパク質スキャフォールド
|
JP5265762B2
(ja)
|
2008-05-13 |
2013-08-14 |
ユニバーシティ・オブ・カンザス |
金属抽出ペプチド(map)タグおよび関連する方法
|
EP2145898A1
(en)
|
2008-07-15 |
2010-01-20 |
CHIESI FARMACEUTICI S.p.A. |
Anti-amyloid immunogenic compositions, methods and uses
|
EP2163243A1
(en)
|
2008-09-12 |
2010-03-17 |
Biocompatibles UK Limited |
Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof
|
FR2940292B1
(fr)
*
|
2008-12-23 |
2013-05-10 |
Isp Investments Inc |
Peptides derives d'hmg-coa reductase et composition cosmetique et/ou pharmaceutique les contenant
|
PT104331A
(pt)
*
|
2009-01-13 |
2010-07-13 |
Escola Superior Agrária De Coi |
Protenas de fuso, processo para a sua preparaão e sua utilizaão em sistemas de expresso de protenas recombinantes
|
KR101016766B1
(ko)
*
|
2009-01-15 |
2011-02-25 |
한국과학기술연구원 |
티오레독신이 융합된 단백질 발현용 플라스미드 및 이를 이용한 목적 단백질의 생산방법
|
US20100209931A1
(en)
*
|
2009-02-13 |
2010-08-19 |
Yolanda Sanchez |
Compositions for Identifying Novel Compositions for the Treatment of Disease and Methods of Using Same
|
EP2251028A1
(en)
|
2009-05-12 |
2010-11-17 |
Biocompatibles Uk Ltd. |
Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
|
AU2009356279A1
(en)
|
2009-12-10 |
2012-07-26 |
Escola Superior Agraria De Coimbra |
Mmunogens, process for preparation and use in systems of polyclonal antibodies production
|
WO2011151721A1
(en)
|
2010-06-04 |
2011-12-08 |
Lupin Limited |
Process for production of fusion proteins using truncated e. coli thioredoxin
|
WO2011151716A1
(en)
*
|
2010-06-04 |
2011-12-08 |
Lupin Limited |
Process for the purification of recombinant human il-11
|
CA2803058C
(en)
*
|
2010-06-25 |
2022-07-05 |
Vaccibody As |
Homodimeric protein constructs
|
US20140004201A1
(en)
|
2010-09-15 |
2014-01-02 |
Biocompatibles Uk Ltd. |
Treatment of Vascular Diseases Using Encapsulated Cells Encoding and Secreting GLP-1, or a Fragment or Variant Thereof
|
CA2827313C
(en)
|
2011-02-16 |
2023-08-22 |
Glycosyn LLC |
Biosynthesis of human milk oligosaccharides in engineered bacteria
|
CN104066841B
(zh)
|
2012-01-23 |
2018-01-02 |
旭硝子株式会社 |
表达载体和蛋白质的制造方法
|
US9187735B2
(en)
|
2012-06-01 |
2015-11-17 |
University Of Kansas |
Metal abstraction peptide with superoxide dismutase activity
|
AR094276A1
(es)
*
|
2012-12-21 |
2015-07-22 |
Alkem Laboratories Ltd |
Marcadores de fusion y sistema de vector de expresion para la expresion de hormona paratiroides humana (rhpth)
|
WO2016044707A1
(en)
|
2014-09-18 |
2016-03-24 |
Cedars-Sinai Medical Center |
Compositions and methods for treating fibrosis
|
CN107708718B
(zh)
|
2015-04-22 |
2022-01-11 |
西达-赛奈医疗中心 |
用于治疗2型糖尿病的肠内递送的苦味寡肽
|
JP6722951B2
(ja)
|
2015-07-31 |
2020-07-15 |
国立研究開発法人理化学研究所 |
膜タンパク質の製造方法およびその利用
|
JP2019505512A
(ja)
|
2016-01-08 |
2019-02-28 |
バッシボディ アクスイェ セルスカプ |
治療用抗癌ネオエピトープワクチン
|
KR101962067B1
(ko)
*
|
2018-04-23 |
2019-03-25 |
한림대학교 산학협력단 |
Txnl1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
|
CN108912221A
(zh)
*
|
2018-07-31 |
2018-11-30 |
成都英普博集生物科技有限公司 |
用于生产重组融合蛋白的辅助蛋白、编码基因、重组融合蛋白、重组表达载体及制备方法
|