MX9203295A - Fusiones de peptido y proteina a moleculas de tioredoxina y similares a tioredoxina. - Google Patents

Fusiones de peptido y proteina a moleculas de tioredoxina y similares a tioredoxina.

Info

Publication number
MX9203295A
MX9203295A MX9203295A MX9203295A MX9203295A MX 9203295 A MX9203295 A MX 9203295A MX 9203295 A MX9203295 A MX 9203295A MX 9203295 A MX9203295 A MX 9203295A MX 9203295 A MX9203295 A MX 9203295A
Authority
MX
Mexico
Prior art keywords
molecule
protein
thioredoxin
thoredoxin
peptide
Prior art date
Application number
MX9203295A
Other languages
English (en)
Inventor
John Mccoy
Edward R Lavallie
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of MX9203295A publication Critical patent/MX9203295A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MX9203295A 1991-02-06 1992-02-06 Fusiones de peptido y proteina a moleculas de tioredoxina y similares a tioredoxina. MX9203295A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65253191A 1991-02-06 1991-02-06
US07/745,382 US5270181A (en) 1991-02-06 1991-08-14 Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
PCT/US1992/000944 WO1992013955A1 (en) 1991-02-06 1992-02-06 Peptide and protein fusions to thioredoxin and thioredoxin-like molecules

Publications (1)

Publication Number Publication Date
MX9203295A true MX9203295A (es) 1992-07-01

Family

ID=27096313

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9203295A MX9203295A (es) 1991-02-06 1992-02-06 Fusiones de peptido y proteina a moleculas de tioredoxina y similares a tioredoxina.

Country Status (9)

Country Link
US (1) US5270181A (es)
EP (3) EP0574506B1 (es)
JP (1) JP2513978B2 (es)
AT (2) ATE237692T1 (es)
AU (1) AU663489B2 (es)
CA (1) CA2093643C (es)
DE (2) DE69233008T2 (es)
MX (1) MX9203295A (es)
WO (1) WO1992013955A1 (es)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646016A (en) * 1991-02-06 1997-07-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
WO1993006116A1 (en) 1991-09-20 1993-04-01 Syntex-Synergen Neuroscience Joint Venture Glial derived neurotrophic factor
NZ251820A (en) * 1992-03-30 1996-07-26 Immunex Corp Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide
EP0566410A3 (en) 1992-04-17 1994-08-24 Sankyo Co Derivatives of adipogenesis inhibitory factor, their preparation and their use
JP3149185B2 (ja) * 1993-01-15 2001-03-26 ジェネティックス・インスティテュート・インコーポレイテッド エンテロキナーゼのクローニングおよび使用方法
US6746859B1 (en) * 1993-01-15 2004-06-08 Genetics Institute, Llc Cloning of enterokinase and method of use
US5563046A (en) * 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US5914254A (en) * 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
US6270757B1 (en) 1994-04-21 2001-08-07 Genetics Institute, Inc. Formulations for IL-11
US5635182A (en) * 1994-06-16 1997-06-03 Genetics Institute, Inc. Method of detecting ligand interactions
DE69532127T2 (de) * 1994-07-20 2004-08-26 Genetics Institute, Inc., Cambridge Interaktions-fullensysteme zum nachweis von protein-interaktionen
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
US5582821A (en) * 1994-07-22 1996-12-10 Genetics Institute, Inc. Methods for treating bleeding disorders
US5639635A (en) * 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US6274547B1 (en) 1996-06-14 2001-08-14 Genetics Institute, Inc. Methods comprising the use of human interleukin-11 receptor proteins
AU717928B2 (en) 1994-12-22 2000-04-06 Genetics Institute, Llc Human interleukin-11 receptor
US5935822A (en) * 1995-03-21 1999-08-10 The Regents Of The University Of Colorado Product and process for membrane and soluble polypeptide segregation
US6344343B1 (en) 1995-03-21 2002-02-05 The Regents Of The University Of Colorado Product and process for membrane and soluble polypeptide segregation
DE69637659D1 (de) * 1995-05-15 2008-10-09 Abbott Lab Verankerte expression heterologer proteine
US6352972B1 (en) 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US6126933A (en) * 1995-06-27 2000-10-03 Genetics Institute Methods of treating inflammatory bowel diseases by administering IL-11
US6887461B1 (en) 1998-10-26 2005-05-03 Genetics Institute, Llc Method of using IL-11 for treating mucositis
US6540993B1 (en) * 1995-06-27 2003-04-01 Wyeth Method of treating inflammatory bowel disease using a topical formulation of IL-11
JP3092904B2 (ja) * 1995-10-13 2000-09-25 株式会社エイチ・エス・ピー研究所 細菌により可溶性蛋白質を生産する方法
AU707191B2 (en) 1995-12-28 1999-07-08 Fujirebio Inc. Fused DNA sequence, fused protein expressed from said fused DNA sequence and method for expressing said protein
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
AU2922397A (en) * 1996-04-30 1997-11-19 Schering Corporation Expression of soluble heterologous proteins in bacteria utilizing a thioredoxin/protein expression vector
US7655436B1 (en) 1996-04-30 2010-02-02 Schering Corporation Expression of soluble heterologous proteins in bacteria utilizing a thioredoxin/protein expression vector
US7901910B2 (en) 1996-05-14 2011-03-08 Gregory Thomas Maine Embedded expression of insoluble heterologous proteins
US5858724A (en) * 1996-07-16 1999-01-12 Pel-Freez Recombinant rabbit tissue factor
US6815174B1 (en) * 1996-11-28 2004-11-09 Edgardo Poskus Thioredoxin-glutamate decarboxylase 65 fusion protein
US5831049A (en) * 1997-01-03 1998-11-03 Incyte Pharmaceuticals, Inc. Human thioredoxin
EP1911841B1 (en) * 1997-01-08 2015-06-03 Life Technologies Corporation Methods for production of proteins
ATE397061T1 (de) * 1997-01-08 2008-06-15 Invitrogen Corp Verfahren zur herstellung von proteinen
GB9703406D0 (en) 1997-02-19 1997-04-09 Chiron Spa Expression of heterologous proteins
US6852508B1 (en) 1997-02-28 2005-02-08 Genetics Institute, Llc Chemokine with amino-terminal modifications
US6100387A (en) * 1997-02-28 2000-08-08 Genetics Institute, Inc. Chimeric polypeptides containing chemokine domains
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
US5989868A (en) 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
WO1999015560A1 (en) * 1997-09-26 1999-04-01 Sloan-Kettering Institute For Cancer Research Soluble polypeptide having a delta-serrate-lag2 domain of delta homologue and uses thereof
PL340433A1 (en) 1997-11-10 2001-02-12 Gen Hospital Corp Detection systems for detecting and recording protein-specific actions and functional interactions
US6077689A (en) * 1997-12-24 2000-06-20 Amgen Inc. Enhanced solubility of recombinant proteins
KR100269671B1 (ko) * 1998-03-21 2000-10-16 박호군 면역 검출법을 이용한 hiv의 감염 억제 활성 물질의 검색방법 및 그에 사용되는 변이단백질
US6733991B1 (en) 1998-05-08 2004-05-11 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses therefor
US6746852B1 (en) 1998-05-08 2004-06-08 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses thereof
CA2237915A1 (en) 1998-05-19 1999-11-19 Stephen Shaughnessy Osteoporosis treatment
WO1999064835A2 (en) * 1998-06-10 1999-12-16 Tatton William G Screening method for dehydrogenase oligomerisation modulators
BR9914519A (pt) 1998-10-13 2001-07-03 Univ Georgia Res Found Peptìdios bioativos estabilizados e métodos de identificação, sìntese e uso
US20030190740A1 (en) 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
US6387664B1 (en) * 1999-02-26 2002-05-14 Secretary Of Agency Of Industrial Science And Technology Sparc fusion protein and method for producing the same
US6953777B2 (en) * 1999-03-11 2005-10-11 Genetics Indtitute LLC Use of interleukin-11 to prevent immune-mediated cytotoxicity
EP1096948A4 (en) 1999-04-15 2004-04-07 Inst Genetics Llc USE OF INTERLEUKIN-11 FOR TREATING GASTROINTESTINAL DISEASES
HUP0301349A3 (en) * 1999-07-15 2005-12-28 Genetics Inst Llc Cambridge Formulations for il-11
AU2001257012A1 (en) * 2000-04-14 2001-10-30 Genencor International, Inc. Methods for selective targeting
US7129326B2 (en) * 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
KR20020003917A (ko) * 2000-06-26 2002-01-16 복성해 꼬리 단백질과 인간 인터루킨-16의 융합 단백질, 이 융합단백질을 코딩하는 유전자, 이 유전자를 포함하는 발현벡터, 이 벡터로 형질전환된 대장균 및 이 대장균을이용한 인간 인터루킨-16의 생산 방법
AU2001272491A1 (en) * 2000-06-26 2002-01-08 Smithkline Beecham Biologicals (S.A.) Triple fusion proteins comprising ubiquitin fused between thioredoxin and a polypeptide of interest
US6632638B1 (en) 2000-11-17 2003-10-14 Amgen, Inc. Enhanced solubility of recombinant proteins using Uracil DNA glycosylase inhibitor
CA2439263C (en) 2001-03-02 2012-10-23 Frank Becker Three hybrid assay system
US20020128190A1 (en) * 2001-03-09 2002-09-12 Leslie Lobel Expression of properly folded and soluble extracellular domain of a gonadotropin receptor
JP4838957B2 (ja) * 2001-05-02 2011-12-14 独立行政法人理化学研究所 無細胞タンパク質合成系を用いたタンパク質の製造方法
US20040143104A1 (en) * 2001-08-08 2004-07-22 Wadsworth Samuel C. Methods of treating diabetes and other blood sugar disorders
WO2003014318A2 (en) * 2001-08-08 2003-02-20 Genzyme Corporation Methods for treating diabetes and other blood sugar disorders
WO2003049693A2 (en) * 2001-12-06 2003-06-19 Wyeth Method and composition for inducing weight loss
US7572886B2 (en) * 2001-12-18 2009-08-11 Centre National De La Recherche Scientifique Death associated proteins, and THAP1 and PAR4 pathways in apoptosis control
US7858297B2 (en) * 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
US6982080B2 (en) * 2002-03-15 2006-01-03 Wyeth Hydroxyethyl starch—containing polypeptide compositions
JP4359707B2 (ja) 2002-05-22 2009-11-04 独立行政法人理化学研究所 チオレドキシン融合タンパク質発現ベクターを用いた無細胞タンパク質合成系によるタンパク質の製造方法
EP2586440A2 (en) 2002-06-24 2013-05-01 Paratek Pharmaceuticals, Inc. Methods for preventing and treating microbial infections by modulating transcription factors
MXPA05002899A (es) * 2002-09-16 2005-05-27 Wyeth Corp Formulaciones de liberacion controlada para administracion oral de un agente terapeutico polipeptido y sus metodos de uso.
EP2581383A1 (en) 2002-11-25 2013-04-17 Genencor International, Inc. Skin or hair binding peptides
JP4441170B2 (ja) * 2002-11-28 2010-03-31 独立行政法人理化学研究所 Ｓ１２リボソームタンパク質に変異を有する大腸菌細胞抽出液及びそれを用いる無細胞系によるタンパク質の製造方法
KR20050114268A (ko) * 2003-03-31 2005-12-05 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 티오리독신 변이체
US20050107318A1 (en) * 2003-11-17 2005-05-19 Samuel Wadsworth Methods of treating diabetes and other blood sugar disorders
CA2576247C (en) 2004-08-26 2016-08-30 The University Of Western Ontario Pharmaceutical compositions comprising inhibitors of iron transport, and method of identifying iron transport inhibitors, in staphylococcus aureus
JP4868731B2 (ja) 2004-11-17 2012-02-01 独立行政法人理化学研究所 哺乳動物培養細胞由来の無細胞タンパク質合成システム
JP4590249B2 (ja) * 2004-11-17 2010-12-01 独立行政法人理化学研究所 糖タンパク質合成用の無細胞タンパク質合成システム
JP4787488B2 (ja) * 2004-11-19 2011-10-05 独立行政法人理化学研究所 直鎖状鋳型ｄｎａを用いた無細胞タンパク質合成方法及びそのための細胞抽出液
KR100699279B1 (ko) 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
JP5161796B2 (ja) * 2006-02-24 2013-03-13 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 抗アミロイド免疫原性組成物、方法、および使用
EP1854455B1 (en) 2006-05-10 2009-10-07 Biocompatibles UK Limited Spherical microcapsules comprising GLP-1 peptides, their production and use
WO2008042495A2 (en) 2006-07-21 2008-04-10 Life Technologies Corporation Sharply resolving labeled protein molecular weight standards
AU2007291448B2 (en) * 2006-08-31 2014-02-20 Nexigen Gmbh Methods for detecting protein-peptide interactions
JP5191390B2 (ja) * 2006-10-11 2013-05-08 オリエンタル酵母工業株式会社 可溶型ｒａｎｋｌとエピトープタグの融合タンパク質を含む試薬
EP2213747B1 (en) * 2007-11-05 2021-06-30 Riken Method for producing membrane protein
US20100029499A1 (en) * 2008-04-25 2010-02-04 Merck Patent Gmbh Artificial Protein Scaffolds
KR20140001257A (ko) 2008-05-13 2014-01-06 유니버시티 오브 캔사스 금속 추출 펩타이드(ｍａｐ) 태그 및 관련된 방법
EP2145898A1 (en) 2008-07-15 2010-01-20 CHIESI FARMACEUTICI S.p.A. Anti-amyloid immunogenic compositions, methods and uses
EP2163243A1 (en) 2008-09-12 2010-03-17 Biocompatibles UK Limited Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof
FR2940292B1 (fr) * 2008-12-23 2013-05-10 Isp Investments Inc Peptides derives d'hmg-coa reductase et composition cosmetique et/ou pharmaceutique les contenant
PT104331A (pt) * 2009-01-13 2010-07-13 Escola Superior Agrária De Coi Protenas de fus†o, processo para a sua preparaã†o e sua utilizaã†o em sistemas de express†o de protenas recombinantes
KR101016766B1 (ko) * 2009-01-15 2011-02-25 한국과학기술연구원 티오레독신이 융합된 단백질 발현용 플라스미드 및 이를 이용한 목적 단백질의 생산방법
US20100209931A1 (en) * 2009-02-13 2010-08-19 Yolanda Sanchez Compositions for Identifying Novel Compositions for the Treatment of Disease and Methods of Using Same
EP2251028A1 (en) 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
CA2783968A1 (en) 2009-12-10 2011-06-16 Escola Superior Agraria De Coimbra Immunogens, process for preparation and use in systems of polyclonal antibodies production
WO2011151721A1 (en) 2010-06-04 2011-12-08 Lupin Limited Process for production of fusion proteins using truncated e. coli thioredoxin
WO2011151716A1 (en) * 2010-06-04 2011-12-08 Lupin Limited Process for the purification of recombinant human il-11
EP2585107B1 (en) 2010-06-25 2018-10-24 Vaccibody AS Homodimeric protein constructs
WO2012034704A1 (en) 2010-09-15 2012-03-22 Biocompatibles Uk Ltd. Treatment of vascular diseases using encapsulated cells encoding and secreting glp-1, or a fragment or variant thereof
EP2675899A4 (en) 2011-02-16 2014-09-10 Glycosyn LLC BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA
CN104066841B (zh) 2012-01-23 2018-01-02 旭硝子株式会社 表达载体和蛋白质的制造方法
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
AR094276A1 (es) * 2012-12-21 2015-07-22 Alkem Laboratories Ltd Marcadores de fusion y sistema de vector de expresion para la expresion de hormona paratiroides humana (rhpth)
JP7095990B2 (ja) 2014-09-18 2022-07-05 シーダーズ－サイナイ メディカル センター 線維症を治療するための組成物及び方法
CN107708718B (zh) 2015-04-22 2022-01-11 西达-赛奈医疗中心 用于治疗2型糖尿病的肠内递送的苦味寡肽
WO2017022696A1 (ja) 2015-07-31 2017-02-09 国立研究開発法人理化学研究所 膜タンパク質の製造方法およびその利用
KR101962067B1 (ko) * 2018-04-23 2019-03-25 한림대학교 산학협력단 Txnl1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
CN108912221A (zh) * 2018-07-31 2018-11-30 成都英普博集生物科技有限公司 用于生产重组融合蛋白的辅助蛋白、编码基因、重组融合蛋白、重组表达载体及制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769326A (en) * 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4745069A (en) * 1982-05-25 1988-05-17 Eli Lilly And Company Cloning vectors for expression of exogenous protein
FR2565163B1 (fr) * 1984-05-30 1989-04-07 Patterson Cy Nv Clavier a touches de commande manuelle combinees avec un systeme d'affichage
GB8518753D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Microbiological products
US4801536A (en) * 1985-10-11 1989-01-31 Genetics Institute, Inc. Method for producing heterologous proteins
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
GB8625435D0 (en) * 1986-10-23 1986-11-26 Erba Farmitalia Human apolipoprotein ai
JPS6438099A (en) * 1987-04-07 1989-02-08 Agency Ind Science Techn Fused protein or dihydrofolate reductase and bradykinin
US5011772A (en) * 1988-02-05 1991-04-30 Public Health Research Institute Of The City Of N.Y. High yield protein production system
FR2649616B1 (fr) 1989-07-13 1991-10-18 C3P Seringue et aiguille d'injection a usage unique
EP0425821B1 (en) * 1989-09-29 1994-08-10 Ajinomoto Co., Inc. The use of human ADF (=Adult T-cell leukemia-derived factor) for producing a medicament
EP0596969A1 (en) * 1991-07-29 1994-05-18 British Bio-Technology Limited Igf-ii analogues
GB9120221D0 (en) * 1991-09-23 1991-11-06 Smithkline Beecham Biolog Novel compounds

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JP2513978B2 (ja) 1996-07-10
DE69233779D1 (de) 2010-03-18
US5270181A (en) 1993-12-14
EP1231217B1 (en) 2010-01-27
WO1992013955A1 (en) 1992-08-20
EP1231275A3 (en) 2004-01-21
ATE237692T1 (de) 2003-05-15
CA2093643C (en) 2001-10-30
ATE456661T1 (de) 2010-02-15
AU1467192A (en) 1992-09-07
CA2093643A1 (en) 1992-08-07
EP1231275A2 (en) 2002-08-14
EP0574506B1 (en) 2003-04-16
DE69233008D1 (de) 2003-05-22
EP0574506A1 (en) 1993-12-22
JPH05507209A (ja) 1993-10-21
AU663489B2 (en) 1995-10-12
DE69233008T2 (de) 2004-01-22
EP1231217A3 (en) 2004-01-21

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