MX9200569A - Derivados de 5-heteroil indol. - Google Patents
Derivados de 5-heteroil indol.Info
- Publication number
- MX9200569A MX9200569A MX9200569A MX9200569A MX9200569A MX 9200569 A MX9200569 A MX 9200569A MX 9200569 A MX9200569 A MX 9200569A MX 9200569 A MX9200569 A MX 9200569A MX 9200569 A MX9200569 A MX 9200569A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- heteroil
- indol
- derivatives
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65471291A | 1991-02-12 | 1991-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9200569A true MX9200569A (es) | 1992-08-01 |
Family
ID=24625959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9200569A MX9200569A (es) | 1991-02-12 | 1992-02-10 | Derivados de 5-heteroil indol. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0571471B1 (enExample) |
| JP (1) | JPH07121942B2 (enExample) |
| KR (1) | KR930703305A (enExample) |
| AT (1) | ATE135005T1 (enExample) |
| AU (1) | AU655456B2 (enExample) |
| CA (1) | CA2101521A1 (enExample) |
| CZ (1) | CZ165693A3 (enExample) |
| DE (1) | DE69208868T2 (enExample) |
| DK (1) | DK0571471T3 (enExample) |
| ES (1) | ES2084347T3 (enExample) |
| FI (1) | FI933551L (enExample) |
| GR (1) | GR3019778T3 (enExample) |
| HU (1) | HUT65766A (enExample) |
| IE (1) | IE920442A1 (enExample) |
| IL (1) | IL100888A0 (enExample) |
| MX (1) | MX9200569A (enExample) |
| MY (1) | MY131298A (enExample) |
| NO (1) | NO932859L (enExample) |
| NZ (1) | NZ241584A (enExample) |
| PT (1) | PT100114A (enExample) |
| TW (1) | TW263508B (enExample) |
| WO (1) | WO1992013856A1 (enExample) |
| YU (1) | YU13792A (enExample) |
| ZA (1) | ZA92969B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW288010B (enExample) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| PL172405B1 (en) * | 1992-04-07 | 1997-09-30 | Pfizer | Derivatives of indole |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| CA2190501A1 (en) * | 1994-05-19 | 1995-11-30 | Jose Luis Castro Pineiro | Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists |
| AU2621995A (en) * | 1994-06-01 | 1995-12-21 | Zeneca Limited | Indole derivatives as prodrugs of 5-ht1-like receptor agonists |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| GB9501865D0 (en) * | 1995-01-31 | 1995-03-22 | Merck Sharp & Dohme | Therapeutic agents |
| CZ288897A3 (cs) * | 1995-03-20 | 1998-02-18 | Eli Lilly And Company | V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje |
| AU7261196A (en) * | 1995-10-10 | 1997-04-30 | Eli Lilly And Company | N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| FR2763243A1 (fr) * | 1997-05-14 | 1998-11-20 | Pf Medicament | Utilisation d'amines indoliques comme medicaments antithrombotiques |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| EP1068198B1 (en) | 1998-03-09 | 2003-05-28 | H.Lundbeck A/S | 5-heteroaryl substituted indoles |
| AU4831899A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | 5-HT1F agonists |
| MXPA01010655A (es) * | 1999-04-21 | 2002-11-04 | Allelix Biopharma | Compuestos de piperidin-indol que tienen afinidad por 5-ht6. |
| WO2001034146A1 (en) * | 1999-11-08 | 2001-05-17 | Smithkline Beecham Corporation | Novel anti-infectives |
| BR0114552A (pt) * | 2000-10-20 | 2003-07-01 | Biovitrum Ab | N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia |
| DE10121217A1 (de) | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| WO2003099206A2 (en) | 2002-05-21 | 2003-12-04 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
| CA2509982C (en) * | 2002-11-28 | 2011-11-08 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| SI1883451T1 (sl) | 2005-04-13 | 2011-04-29 | Neuraxon Inc | Substituirane indolne spojine z NOS inhibitorno aktivnostjo |
| UA97348C2 (en) * | 2005-07-29 | 2012-02-10 | 4Сц Аг | HETEROCYCLIC NF-kB INHIBITORS |
| CA2637531A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| AR060451A1 (es) | 2006-04-13 | 2008-06-18 | Neuraxon Inc | Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos |
| WO2008021851A2 (en) * | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists for opioid receptors |
| TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| US8673909B2 (en) | 2007-11-16 | 2014-03-18 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
| EP2638014B1 (en) | 2010-11-08 | 2017-01-04 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases |
| AU2013259624B2 (en) | 2012-05-08 | 2017-10-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| JP6236068B2 (ja) | 2012-05-08 | 2017-11-22 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγ活性を阻害し疾患を治療するためのテトラヒドロナフチリジンおよび関連二環式化合物 |
| US9783511B2 (en) | 2013-12-20 | 2017-10-10 | Lycera Corporation | Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| US9809561B2 (en) | 2013-12-20 | 2017-11-07 | Merck Sharp & Dohme Corp. | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| MX2016010998A (es) | 2014-02-27 | 2017-03-31 | Lycera Corp | Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados. |
| US10189777B2 (en) | 2014-05-05 | 2019-01-29 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease |
| JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
| JP2018510135A (ja) | 2015-02-11 | 2018-04-12 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用 |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| CA2987289A1 (en) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease |
| KR20180070697A (ko) | 2015-10-27 | 2018-06-26 | 머크 샤프 앤드 돔 코포레이션 | Ror감마t 저해제로서의 치환된 인다졸 화합물 및 이의 용도 |
| WO2017075178A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| DE3678805D1 (de) * | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
| GB8600398D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| EG19650A (en) * | 1990-06-07 | 1995-09-30 | Wellcome Found | Derivatives of indol and their use for treatment of megraine |
-
1992
- 1992-01-28 TW TW081100627A patent/TW263508B/zh active
- 1992-02-03 KR KR1019930702398A patent/KR930703305A/ko not_active Ceased
- 1992-02-03 CZ CS931656A patent/CZ165693A3/cs unknown
- 1992-02-03 WO PCT/US1992/000556 patent/WO1992013856A1/en not_active Ceased
- 1992-02-03 AT AT92904837T patent/ATE135005T1/de not_active IP Right Cessation
- 1992-02-03 JP JP4505422A patent/JPH07121942B2/ja not_active Expired - Lifetime
- 1992-02-03 EP EP92904837A patent/EP0571471B1/en not_active Expired - Lifetime
- 1992-02-03 HU HU9302328A patent/HUT65766A/hu unknown
- 1992-02-03 DK DK92904837.9T patent/DK0571471T3/da active
- 1992-02-03 DE DE69208868T patent/DE69208868T2/de not_active Expired - Fee Related
- 1992-02-03 ES ES92904837T patent/ES2084347T3/es not_active Expired - Lifetime
- 1992-02-03 AU AU12637/92A patent/AU655456B2/en not_active Ceased
- 1992-02-03 CA CA002101521A patent/CA2101521A1/en not_active Abandoned
- 1992-02-03 FI FI933551A patent/FI933551L/fi not_active Application Discontinuation
- 1992-02-06 IL IL100888A patent/IL100888A0/xx unknown
- 1992-02-10 PT PT100114A patent/PT100114A/pt not_active Application Discontinuation
- 1992-02-10 MX MX9200569A patent/MX9200569A/es unknown
- 1992-02-11 YU YU13792A patent/YU13792A/sh unknown
- 1992-02-11 MY MYPI92000204A patent/MY131298A/en unknown
- 1992-02-11 NZ NZ241584A patent/NZ241584A/en unknown
- 1992-02-11 ZA ZA92969A patent/ZA92969B/xx unknown
- 1992-02-11 IE IE044292A patent/IE920442A1/en not_active Application Discontinuation
-
1993
- 1993-08-11 NO NO93932859A patent/NO932859L/no unknown
-
1996
- 1996-04-29 GR GR960401158T patent/GR3019778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0571471T3 (da) | 1996-04-01 |
| HUT65766A (en) | 1994-07-28 |
| EP0571471A1 (en) | 1993-12-01 |
| ZA92969B (en) | 1993-08-11 |
| ES2084347T3 (es) | 1996-05-01 |
| NZ241584A (en) | 1994-12-22 |
| JPH06500122A (ja) | 1994-01-06 |
| ATE135005T1 (de) | 1996-03-15 |
| WO1992013856A1 (en) | 1992-08-20 |
| FI933551A7 (fi) | 1993-08-11 |
| FI933551A0 (fi) | 1993-08-11 |
| AU655456B2 (en) | 1994-12-22 |
| EP0571471B1 (en) | 1996-03-06 |
| CZ165693A3 (en) | 1994-05-18 |
| MY131298A (en) | 2007-08-30 |
| NO932859D0 (no) | 1993-08-11 |
| PT100114A (pt) | 1993-05-31 |
| NO932859L (no) | 1993-08-11 |
| IE920442A1 (en) | 1992-08-12 |
| TW263508B (enExample) | 1995-11-21 |
| FI933551L (fi) | 1993-08-11 |
| DE69208868D1 (de) | 1996-04-11 |
| IL100888A0 (en) | 1992-11-15 |
| AU1263792A (en) | 1992-09-07 |
| KR930703305A (ko) | 1993-11-29 |
| JPH07121942B2 (ja) | 1995-12-25 |
| GR3019778T3 (en) | 1996-07-31 |
| CA2101521A1 (en) | 1992-08-13 |
| HU9302328D0 (en) | 1993-10-28 |
| YU13792A (sh) | 1994-11-15 |
| DE69208868T2 (de) | 1996-10-17 |
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