MX394040B - Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io. - Google Patents

Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io.

Info

Publication number
MX394040B
MX394040B MX2019010990A MX2019010990A MX394040B MX 394040 B MX394040 B MX 394040B MX 2019010990 A MX2019010990 A MX 2019010990A MX 2019010990 A MX2019010990 A MX 2019010990A MX 394040 B MX394040 B MX 394040B
Authority
MX
Mexico
Prior art keywords
phenothiazin
dimethylamino
bis
chloride
bromide
Prior art date
Application number
MX2019010990A
Other languages
English (en)
Other versions
MX2019010990A (es
Inventor
Daniela Benadiková
Erik Juhás
Juraj Cech
Vendel Smahovský
Vladimir Oremus
Original Assignee
Mikrochem Spol S R O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mikrochem Spol S R O filed Critical Mikrochem Spol S R O
Publication of MX2019010990A publication Critical patent/MX2019010990A/es
Publication of MX394040B publication Critical patent/MX394040B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a: un procedimiento para preparar bromuro o cloruro de 3,7-bis-(dimetilamino)-fenotiazin-5-io; un método para convertir el bromuro de 3,7-bis-(dimetilamino)-fenotiazin-5-io en cloruro de 3,7-bis-(dimetilamino)-fenotiazin-5-io; y la purificación del cloruro de 7-bis-(dimetilamino)-fenotiazin-5-io por cristalización a partir de una solución acuosa de ácido clorhídrico, lo que conduce a un cloruro de 3,7-bis-(dimetilamino)-fenotiazin-5-io farmacéuticamente aceptable (cloruro de metiltioninio, azul de metileno, MTC) de fórmula I a continuación. (ver Fórmula) Cloruro de 3,7-bis(dimetilamino)-fenotiazin-5-io Fórmula I.
MX2019010990A 2017-03-15 2018-03-15 Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io. MX394040B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471651P 2017-03-15 2017-03-15
EP17161172.6A EP3375777A1 (en) 2017-03-15 2017-03-15 Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
PCT/EP2018/056465 WO2018167185A1 (en) 2017-03-15 2018-03-15 Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide

Publications (2)

Publication Number Publication Date
MX2019010990A MX2019010990A (es) 2020-02-05
MX394040B true MX394040B (es) 2025-03-24

Family

ID=58358411

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019010990A MX394040B (es) 2017-03-15 2018-03-15 Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io.
MX2022007148A MX2022007148A (es) 2017-03-15 2019-09-13 Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022007148A MX2022007148A (es) 2017-03-15 2019-09-13 Metodo para la preparacion de cloruro o bromuro 3,7-bis-(dimetilamino)-fenotiazin-5-io.

Country Status (10)

Country Link
US (2) US11059797B2 (es)
EP (2) EP3375777A1 (es)
JP (1) JP7149971B2 (es)
KR (1) KR102615440B1 (es)
CN (1) CN110418784B (es)
CA (1) CA3053223A1 (es)
MX (2) MX394040B (es)
RU (1) RU2762826C2 (es)
WO (1) WO2018167185A1 (es)
ZA (1) ZA201905350B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021171235A1 (en) 2020-02-28 2021-09-02 Dishman Carbogen Amcis Ltd A process for the preparation of methylene blue
CN114507193B (zh) * 2022-04-19 2022-06-24 英科隆生物技术（杭州）有限公司 电子媒介体天青c的提纯方法
WO2023202464A1 (zh) * 2022-04-19 2023-10-26 英科隆生物技术（杭州）有限公司 一种电子媒介体的提纯方法
CN116947783A (zh) * 2022-04-19 2023-10-27 英科隆生物技术（杭州）有限公司 一种电子媒介体的提纯方法
EP4342451A1 (en) 2022-09-22 2024-03-27 Galenicum Health SLU Pharmaceutical compositions and manufacturing methods thereof
US20240115579A1 (en) 2022-09-22 2024-04-11 Galenicum Health S.L.U. Pharmaceutical compositions and manufacturing methods thereof
CN117777052B (zh) * 2023-12-26 2025-09-19 郑州海阔光电材料有限公司 一种吩噻嗪的制备方法
CN118359560B (zh) * 2024-06-18 2024-09-24 珠海前列药业有限公司 一种亚甲蓝的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1886C (de) 1877-12-15 1877-12-15 Basf Ag Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
US3641016A (en) * 1968-02-16 1972-02-08 Egyt Gyogyszervegyeszeti Gyar Thionine derivatives
GB9024775D0 (en) * 1990-11-14 1991-01-02 Axis Research Chemical compounds
US7176308B2 (en) 2002-06-17 2007-02-13 Verification Technologies, Inc. Processes for preparing novel methylene blue derivative
JP5186212B2 (ja) 2004-09-23 2013-04-17 ウィスタ ラボラトリーズ リミテッド メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法
US7101997B2 (en) * 2004-10-07 2006-09-05 Honeywell International Inc. Method for producing phenothiazinium compounds
AU2007274057B2 (en) 2006-07-11 2012-12-13 TauRx Therapeutics Management Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
PL2430007T3 (pl) 2009-05-12 2014-07-31 Wista Lab Ltd Sposoby chemicznej syntezy związków diaminofenotiazyniowych z zastosowaniem nadsiarczanowych środków utleniających
TWI629267B (zh) 2013-08-15 2018-07-11 益友製藥私人有限公司 二胺基吩噻鎓化合物之純化方法
GB201512678D0 (en) 2015-07-20 2015-08-26 Wista Lab Ltd Methods of chemical synthesis

Also Published As

Publication number Publication date
MX2022007148A (es) 2022-07-19
US11680052B2 (en) 2023-06-20
EP3596056A1 (en) 2020-01-22
US20200010436A1 (en) 2020-01-09
RU2019130882A3 (es) 2021-05-31
KR102615440B1 (ko) 2023-12-19
CA3053223A1 (en) 2018-09-20
RU2019130882A (ru) 2021-04-15
MX2019010990A (es) 2020-02-05
JP7149971B2 (ja) 2022-10-07
KR20190128672A (ko) 2019-11-18
BR112019018947A2 (pt) 2020-04-22
CN110418784A (zh) 2019-11-05
WO2018167185A1 (en) 2018-09-20
RU2762826C2 (ru) 2021-12-23
ZA201905350B (en) 2022-11-30
US20210292288A1 (en) 2021-09-23
JP2020510090A (ja) 2020-04-02
EP3375777A1 (en) 2018-09-19
US11059797B2 (en) 2021-07-13
CN110418784B (zh) 2023-06-09

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