MX392757B - Composiciones de ácido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y método de uso de las mismas. - Google Patents

Composiciones de ácido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y método de uso de las mismas.

Info

Publication number
MX392757B
MX392757B MX2017013102A MX2017013102A MX392757B MX 392757 B MX392757 B MX 392757B MX 2017013102 A MX2017013102 A MX 2017013102A MX 2017013102 A MX2017013102 A MX 2017013102A MX 392757 B MX392757 B MX 392757B
Authority
MX
Mexico
Prior art keywords
angptl3
compositions
ribonucleic acid
angiopoetin
rnai
Prior art date
Application number
MX2017013102A
Other languages
English (en)
Spanish (es)
Other versions
MX2017013102A (es
Inventor
Gregory Hinkle
James Butler
Kevin Fitzgerald
Martin Maier
Stephanie Williams
William Querbes
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2017013102A publication Critical patent/MX2017013102A/es
Publication of MX392757B publication Critical patent/MX392757B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
MX2017013102A 2015-04-13 2016-04-13 Composiciones de ácido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y método de uso de las mismas. MX392757B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562146604P 2015-04-13 2015-04-13
US201562261361P 2015-12-01 2015-12-01
PCT/US2016/027271 WO2016168286A1 (en) 2015-04-13 2016-04-13 Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2017013102A MX2017013102A (es) 2018-02-23
MX392757B true MX392757B (es) 2025-03-24

Family

ID=55806850

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017013102A MX392757B (es) 2015-04-13 2016-04-13 Composiciones de ácido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y método de uso de las mismas.
MX2022006507A MX2022006507A (es) 2015-04-13 2017-10-11 Composiciones de acido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y metodo de uso de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022006507A MX2022006507A (es) 2015-04-13 2017-10-11 Composiciones de acido ribonucleico de interferencia (arni) de angiopoyetina-tipo 3 (angptl3) y metodo de uso de las mismas.

Country Status (13)

Country Link
US (4) US10570393B2 (enExample)
EP (1) EP3283631A1 (enExample)
JP (3) JP6975641B2 (enExample)
KR (2) KR20250005546A (enExample)
CN (2) CN107743522B (enExample)
AU (2) AU2016247922B2 (enExample)
BR (1) BR112017021053A2 (enExample)
CA (1) CA2982450A1 (enExample)
EA (1) EA201792263A1 (enExample)
IL (2) IL254786B (enExample)
MX (2) MX392757B (enExample)
TW (3) TWI862799B (enExample)
WO (1) WO2016168286A1 (enExample)

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JP6975641B2 (ja) 2015-04-13 2021-12-01 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法
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WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
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CN113227376B (zh) 2019-05-22 2024-04-09 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
KR20220112290A (ko) * 2019-12-09 2022-08-10 엠피리코 인크. 안지오포이에틴 유사 4(angptl4) 관련 질환의 치료를 위한 올리고뉴클레오타이드
GB2627637B (en) 2020-03-04 2024-11-20 Verve Therapeutics Inc A method for reducing the risk of coronary disease
EP4133074A1 (en) * 2020-04-07 2023-02-15 uniQure IP B.V. Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof
CN115516092B (zh) * 2020-09-30 2025-05-16 亿腾医药（苏州）有限公司 血管生成素样3(ANGPTL3)的siRNA及其用途
WO2022079222A1 (en) * 2020-10-16 2022-04-21 Sanofi Novel rna compositions and methods for inhibiting angptl3
CN114685585B (zh) * 2020-12-31 2024-06-04 苏州瑞博生物技术股份有限公司 核苷酸序列、双链寡核苷酸、药物组合物与缀合物及制备方法和用途
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JP2024511473A (ja) * 2021-03-24 2024-03-13 アタランタ セラピューティクス，インコーポレーテッド パターン化化学修飾を有する二本鎖ｓｉｒｎａ
JP2024535852A (ja) * 2021-09-17 2024-10-02 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＡＮＧＰＴＬ４をサイレンシングするためのｉＲＮＡ組成物および方法
TW202521697A (zh) * 2021-09-23 2025-06-01 大陸商上海舶望製藥有限公司 用於抑制血管生成素樣3（angptl3）蛋白表達的組合物和方法
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CN119585431A (zh) * 2022-08-08 2025-03-07 大睿生物医药科技(上海)有限公司 调控ANGPTL3基因活性的siRNA分子
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