MX392140B - Composiciones y uso de las mismas para tratar la enfermedad celiaca. - Google Patents

Composiciones y uso de las mismas para tratar la enfermedad celiaca.

Info

Publication number
MX392140B
MX392140B MX2017015786A MX2017015786A MX392140B MX 392140 B MX392140 B MX 392140B MX 2017015786 A MX2017015786 A MX 2017015786A MX 2017015786 A MX2017015786 A MX 2017015786A MX 392140 B MX392140 B MX 392140B
Authority
MX
Mexico
Prior art keywords
seq
compositions
celiac disease
residue
amino acid
Prior art date
Application number
MX2017015786A
Other languages
English (en)
Other versions
MX2017015786A (es
Inventor
Christine Elaine Tinberg
Clancey Wolf
David Baker
Ingrid Swanson Pultz
Justin Bloomfield Siegel
Lance Stewart
Original Assignee
Univ Washington
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Univ California filed Critical Univ Washington
Publication of MX2017015786A publication Critical patent/MX2017015786A/es
Publication of MX392140B publication Critical patent/MX392140B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a los polipéptidos y métodos para su uso, se divulgan teniendo la secuencia de aminoácido por lo menos 75% idéntica a la secuencia de aminoácido de la SEQ ID NO:1, se proporcionan, en donde (a) el polipéptido degrada un PFQPQLPY (SEQ ID NO: 140) péptido y/o un PFPQPQQPF (SEQ ID NO: 68) a pH 4; (b) residuo 467 es Ser, residuo 267 es Glu y residuo 271 es Asp; y (c) el polipéptido comprende un cambio del aminoácido de la SEQ ID NO: 1 en uno o más residuos seleccionado del grupo que consistente en 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174 y 456.
MX2017015786A 2015-06-08 2016-06-08 Composiciones y uso de las mismas para tratar la enfermedad celiaca. MX392140B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562172557P 2015-06-08 2015-06-08
PCT/US2016/036356 WO2016200880A1 (en) 2015-06-08 2016-06-08 Compositions and methods for treating celiac sprue disease

Publications (2)

Publication Number Publication Date
MX2017015786A MX2017015786A (es) 2018-12-11
MX392140B true MX392140B (es) 2025-03-21

Family

ID=56194586

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017015786A MX392140B (es) 2015-06-08 2016-06-08 Composiciones y uso de las mismas para tratar la enfermedad celiaca.
MX2022005483A MX2022005483A (es) 2015-06-08 2017-12-05 Composiciones y uso de las mismas para tratar la enfermedad celiaca.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022005483A MX2022005483A (es) 2015-06-08 2017-12-05 Composiciones y uso de las mismas para tratar la enfermedad celiaca.

Country Status (26)

Country Link
US (4) US10793846B2 (es)
EP (1) EP3302518A1 (es)
JP (3) JP7325030B2 (es)
KR (2) KR20240152328A (es)
CN (1) CN107873053A (es)
AU (2) AU2016276436C1 (es)
BR (1) BR112017026142A2 (es)
CA (1) CA2988651A1 (es)
CL (2) CL2017003097A1 (es)
CO (1) CO2017013720A2 (es)
CR (1) CR20170567A (es)
DO (1) DOP2017000286A (es)
EA (1) EA037603B1 (es)
EC (1) ECSP17080844A (es)
HK (1) HK1245129A1 (es)
IL (3) IL317483A (es)
MX (2) MX392140B (es)
MY (1) MY189160A (es)
NZ (1) NZ737500A (es)
PE (1) PE20180509A1 (es)
PH (1) PH12017502213A1 (es)
SA (1) SA517390479B1 (es)
SG (1) SG10201911867YA (es)
TN (1) TN2017000520A1 (es)
WO (1) WO2016200880A1 (es)
ZA (1) ZA202302340B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3033100B1 (en) 2013-08-14 2018-10-03 University Of Washington Through Its Center For Commercialization Compositions for treating celiac sprue disease
CN107873053A (zh) * 2015-06-08 2018-04-03 华盛顿大学 治疗乳糜泻疾病的组合物和方法
JP7202893B2 (ja) 2016-06-12 2023-01-12 武田薬品工業株式会社 炎症性腸疾患を治療する方法
CN110325636A (zh) * 2016-12-22 2019-10-11 Ew营养有限责任公司 稳定的蛋白酶变体
JP2023548083A (ja) * 2020-10-30 2023-11-15 ユニヴァーシティ オブ ワシントン セリアックスプルー病を治療するための組成物及び方法
JP7268910B2 (ja) * 2021-09-16 2023-05-08 株式会社ユニバーサルエンターテインメント 遊技機
JP7268911B2 (ja) * 2021-09-16 2023-05-08 株式会社ユニバーサルエンターテインメント 遊技機
WO2024233959A1 (en) * 2023-05-11 2024-11-14 Digestiva, Inc. Wine dehazing methods and compositions
WO2025068987A1 (en) 2023-09-28 2025-04-03 Takeda Pharmaceutical Company Limited A method of producing a kumamolisin-as polypeptide

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Publication number Priority date Publication date Assignee Title
FR2688229B1 (fr) 1992-03-09 1995-06-23 Ulice Soc Procede de synthese enzymatique d'esters alkyliques de peptides, produits ainsi obtenus et utilisation desdits produits.
JP2002078489A (ja) * 2000-09-04 2002-03-19 Daiwa Kasei Kk セリン残基が活性発現に関与する新規酸性プロテアーゼ
US7320788B2 (en) 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
EP2364718B1 (en) 2002-02-14 2016-07-06 The Board of Trustees of the Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7462688B2 (en) 2002-05-14 2008-12-09 The Board Of Trustees Of The Leland Stanford Junior University Peptides for diagnostic and therapeutic methods for celiac sprue
CA2487247A1 (en) 2002-05-14 2003-11-27 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
US7202216B2 (en) 2002-05-14 2007-04-10 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
US7265093B2 (en) 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
AU2003294473A1 (en) 2002-11-20 2004-06-15 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic method for celiac sprue
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
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US7534426B2 (en) 2004-04-26 2009-05-19 The Board Of Trustees Of The Leland Stanford Junior University Glutenase enzyme assays
US7628985B2 (en) 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
EP1600141B1 (en) 2004-05-24 2013-04-17 3M Deutschland GmbH Collagenolytic active enzyme containing compositions for the treatment of dental caries
EP1726643A1 (en) 2005-05-27 2006-11-29 Direvo Biotech AG Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances
CA2733514C (en) 2008-08-21 2017-10-24 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
HU0900199D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis of gluten-induced autoimmune diseases
CN102858795A (zh) * 2010-02-02 2013-01-02 天野酶制品美国有限公司 蛋白酶针对谷蛋白不耐受的用途
JP6342802B2 (ja) 2011-08-10 2018-06-13 ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗａｓｈｉｎｇｔｏｎ Ｔｈｒｏｕｇｈ Ｉｔｓ Ｃｅｎｔｅｒ Ｆｏｒ Ｃｏｍｍｅｒｃｉａｌｉｚａｔｉｏｎ セリアックスプルー病を治療するための組成物および方法
EP2788018B1 (en) 2011-12-06 2016-06-29 Fondazione Istituto Insubrico di Ricerca per la Vita New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus
EP3033100B1 (en) 2013-08-14 2018-10-03 University Of Washington Through Its Center For Commercialization Compositions for treating celiac sprue disease
KR102288722B1 (ko) * 2013-08-30 2021-08-12 모멘티브 퍼포먼스 머티리얼즈 인크. 아미노산을 갖는 수분 경화성 화합물
CN107873053A (zh) * 2015-06-08 2018-04-03 华盛顿大学 治疗乳糜泻疾病的组合物和方法

Also Published As

Publication number Publication date
BR112017026142A2 (pt) 2018-08-14
MX2017015786A (es) 2018-12-11
ZA202302340B (en) 2024-10-30
TN2017000520A1 (en) 2019-04-12
AU2016276436C1 (en) 2024-09-12
WO2016200880A1 (en) 2016-12-15
CA2988651A1 (en) 2016-12-15
US20230130764A1 (en) 2023-04-27
SG10201911867YA (en) 2020-01-30
US20200109387A1 (en) 2020-04-09
KR102702879B1 (ko) 2024-09-04
JP7429907B2 (ja) 2024-02-09
MX2022005483A (es) 2022-06-02
NZ737500A (en) 2025-02-28
PH12017502213A1 (en) 2018-06-11
US10988748B2 (en) 2021-04-27
EA037603B1 (ru) 2021-04-20
KR20240152328A (ko) 2024-10-21
AU2016276436A1 (en) 2017-12-07
IL256103A (en) 2018-02-28
CR20170567A (es) 2018-06-14
HK1245129A1 (zh) 2018-08-24
JP2024041995A (ja) 2024-03-27
US20210171928A1 (en) 2021-06-10
CN107873053A (zh) 2018-04-03
MY189160A (en) 2022-01-29
DOP2017000286A (es) 2018-03-30
US20180142226A1 (en) 2018-05-24
SA517390479B1 (ar) 2022-11-10
EA201792362A1 (ru) 2018-05-31
IL288768A (en) 2022-02-01
JP7325030B2 (ja) 2023-08-14
IL256103B (en) 2022-01-01
PE20180509A1 (es) 2018-03-09
KR20180023903A (ko) 2018-03-07
EA201792362A8 (ru) 2018-12-28
CL2023000752A1 (es) 2024-04-12
JP2021151250A (ja) 2021-09-30
EP3302518A1 (en) 2018-04-11
CO2017013720A2 (es) 2018-04-10
JP2018517409A (ja) 2018-07-05
US10793846B2 (en) 2020-10-06
IL317483A (en) 2025-02-01
ECSP17080844A (es) 2018-03-31
AU2022241520A1 (en) 2022-10-27
AU2016276436B2 (en) 2022-07-07
US11485961B2 (en) 2022-11-01
CL2017003097A1 (es) 2018-06-29

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