PL427190A1 - Fosfoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac, sposób ich wytwarzania oraz ich zastosowanie - Google Patents
Fosfoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac, sposób ich wytwarzania oraz ich zastosowanieInfo
- Publication number
- PL427190A1 PL427190A1 PL427190A PL42719018A PL427190A1 PL 427190 A1 PL427190 A1 PL 427190A1 PL 427190 A PL427190 A PL 427190A PL 42719018 A PL42719018 A PL 42719018A PL 427190 A1 PL427190 A1 PL 427190A1
- Authority
- PL
- Poland
- Prior art keywords
- application
- analogs
- phosphoorganic
- producing
- peptide derivatives
- Prior art date
Links
- 101710156605 Diablo homolog, mitochondrial Proteins 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Przedmiotem zgłoszenia są fosforoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac o wzorze ogólnym 1. Zgłoszenie dotyczy również sposobu ich wytwarzania oraz zastosowania jako środków przeciwnowotworowych.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL427190A PL233276B1 (pl) | 2018-09-27 | 2018-09-27 | Fosforoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac, sposób ich wytwarzania oraz ich zastosowanie |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL427190A PL233276B1 (pl) | 2018-09-27 | 2018-09-27 | Fosforoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac, sposób ich wytwarzania oraz ich zastosowanie |
Publications (2)
Publication Number | Publication Date |
---|---|
PL427190A1 true PL427190A1 (pl) | 2019-04-23 |
PL233276B1 PL233276B1 (pl) | 2019-09-30 |
Family
ID=66167901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL427190A PL233276B1 (pl) | 2018-09-27 | 2018-09-27 | Fosforoorganiczne pochodne peptydowe będące analogami N-końcowej sekwencji białka Smac, sposób ich wytwarzania oraz ich zastosowanie |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL233276B1 (pl) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016402A2 (en) * | 2000-08-23 | 2002-02-28 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
US20020177557A1 (en) * | 2000-09-29 | 2002-11-28 | Yigong Shi | Compositions and method for regulating apoptosis |
-
2018
- 2018-09-27 PL PL427190A patent/PL233276B1/pl unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016402A2 (en) * | 2000-08-23 | 2002-02-28 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
US20020177557A1 (en) * | 2000-09-29 | 2002-11-28 | Yigong Shi | Compositions and method for regulating apoptosis |
Non-Patent Citations (3)
Title |
---|
E. MASTRANGELO ET AL., THE ACTIVATOR OF APOPTOSIS SMAC-DIABLO ACTS AS A TETRAMER IN SOLUTION, 3 February 2015 (2015-02-03) * |
K. WELSH ET AL., CHARACTERIZATION OF POTENT SMAC MIMETICS THAT SENSITIZE CANCER CELLS TO TNF FAMILY-INDUCED APOPTOSIS, 12 September 2016 (2016-09-12) * |
T.L.F. DE SOUZA, CONFORMATIONAL SELECTION, DYNAMIC RESTRICTION AND THE HYDROPHOBIC EFFECT COUPLED TO STABILIZATION OF THE BIR3 DOMAIN OF THE HUMAN X-LINKED INHIBITOR OF APOPTOSIS PROTEIN BY THE TETRAPEPTIDE AVPI, 2010 * |
Also Published As
Publication number | Publication date |
---|---|
PL233276B1 (pl) | 2019-09-30 |
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