MX389867B - Compuestos de pirazol como moduladores de fshr y usos de los mismos. - Google Patents
Compuestos de pirazol como moduladores de fshr y usos de los mismos.Info
- Publication number
- MX389867B MX389867B MX2017000182A MX2017000182A MX389867B MX 389867 B MX389867 B MX 389867B MX 2017000182 A MX2017000182 A MX 2017000182A MX 2017000182 A MX2017000182 A MX 2017000182A MX 389867 B MX389867 B MX 389867B
- Authority
- MX
- Mexico
- Prior art keywords
- fshr
- modulators
- pyrazole compounds
- compounds
- compositions
- Prior art date
Links
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 title 1
- 101000862396 Homo sapiens Follicle-stimulating hormone receptor Proteins 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 108010060374 FSH Receptors Proteins 0.000 abstract 2
- 102000018343 Follicle stimulating hormone receptors Human genes 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/080519 WO2015196335A1 (en) | 2014-06-23 | 2014-06-23 | Pyrazole compounds as modulators of fshr and uses thereof |
| PCT/CN2014/094459 WO2015196759A1 (en) | 2014-06-23 | 2014-12-22 | Pyrazole compounds as modulators of fshr and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017000182A MX2017000182A (es) | 2017-06-30 |
| MX389867B true MX389867B (es) | 2025-03-20 |
Family
ID=54936412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017000182A MX389867B (es) | 2014-06-23 | 2014-12-22 | Compuestos de pirazol como moduladores de fshr y usos de los mismos. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10208055B2 (en:Method) |
| EP (1) | EP3157929B1 (en:Method) |
| JP (3) | JP6557331B2 (en:Method) |
| KR (1) | KR102416279B1 (en:Method) |
| CN (1) | CN106573937B (en:Method) |
| AU (3) | AU2014398875B2 (en:Method) |
| CA (1) | CA2955415A1 (en:Method) |
| DK (1) | DK3157929T3 (en:Method) |
| ES (1) | ES2972131T3 (en:Method) |
| MX (1) | MX389867B (en:Method) |
| RU (1) | RU2752173C2 (en:Method) |
| WO (2) | WO2015196335A1 (en:Method) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| EP4335512A3 (en) * | 2017-12-22 | 2024-06-12 | HiberCell, Inc. | Chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| HUE062273T2 (hu) | 2018-05-03 | 2023-10-28 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Benzimidazolszármazékok mint a retinsavreceptor rokon árvareceptor-gamma (RORy) modulátorai és gyógyszerészeti felhasználásaik |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| WO2022007924A1 (zh) * | 2020-07-09 | 2022-01-13 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| EP4190789A1 (en) | 2020-07-29 | 2023-06-07 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Oxa-azaspiro derivative, and preparation method therefor and pharmaceutical use thereof |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| WO2024044778A2 (en) * | 2022-08-26 | 2024-02-29 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
| JP2025535050A (ja) * | 2022-10-05 | 2025-10-22 | ラディオネティクス オンコロジー，インク． | 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用 |
| WO2024184461A2 (en) | 2023-03-08 | 2024-09-12 | Ferring B.V. | Small molecule fsh receptor modulators |
| WO2024263803A2 (en) * | 2023-06-21 | 2024-12-26 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| CA2425889A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| ATE363473T1 (de) * | 2001-09-19 | 2007-06-15 | Pharmacia Corp | Substituierte pyrazoloverbindungen zur behandlung von entzündungen |
| PL377848A1 (pl) * | 2003-02-07 | 2006-02-20 | Daiichi Pharmaceutical Co., Ltd. | Pochodne pirazoli |
| MX2007014085A (es) * | 2005-05-12 | 2008-02-07 | Wyeth Corp | Pirrolobenzodiazepinas y derivados de carboxamida heterociclica como antagonistas de receptor de hormona estimulante del foliculo. |
| WO2008035356A2 (en) * | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| IT1393930B1 (it) * | 2009-02-25 | 2012-05-17 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| IT1394400B1 (it) | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | （二氫）咪唑並異〔５，１－ａ〕喹啉類 |
| EA201290305A1 (ru) * | 2009-11-13 | 2012-12-28 | Мерк Сероно С.А. | Производные трициклического пиразоламина |
| CA2837524C (en) | 2011-07-01 | 2019-08-20 | Merck Patent Gmbh | Dihydropyrazoles |
| JP6162694B2 (ja) | 2011-07-18 | 2017-07-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ベンズアミド類 |
| CN104080784B (zh) | 2012-01-10 | 2017-07-18 | 默克专利有限公司 | 用作卵泡刺激素调节剂的苯甲酰胺衍生物 |
| CN104114544A (zh) | 2012-02-08 | 2014-10-22 | 默克专利有限公司 | 用作卵泡刺激素受体激动剂的氘化噻唑烷酮类似物 |
| EP3013823B1 (en) | 2013-06-24 | 2017-11-01 | Merck Patent GmbH | Imidazole compounds as modulators of fshr and uses thereof |
| JP6625973B2 (ja) * | 2013-06-24 | 2019-12-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｓｈｒの調節剤としてのピラゾール化合物及びその使用 |
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
-
2014
- 2014-06-23 WO PCT/CN2014/080519 patent/WO2015196335A1/en not_active Ceased
- 2014-12-22 JP JP2017519756A patent/JP6557331B2/ja not_active Expired - Fee Related
- 2014-12-22 CN CN201480081442.1A patent/CN106573937B/zh not_active Expired - Fee Related
- 2014-12-22 AU AU2014398875A patent/AU2014398875B2/en not_active Ceased
- 2014-12-22 CA CA2955415A patent/CA2955415A1/en active Pending
- 2014-12-22 RU RU2017101829A patent/RU2752173C2/ru active
- 2014-12-22 DK DK14896199.8T patent/DK3157929T3/da active
- 2014-12-22 US US15/321,249 patent/US10208055B2/en active Active
- 2014-12-22 EP EP14896199.8A patent/EP3157929B1/en active Active
- 2014-12-22 KR KR1020177001959A patent/KR102416279B1/ko not_active Expired - Fee Related
- 2014-12-22 ES ES14896199T patent/ES2972131T3/es active Active
- 2014-12-22 WO PCT/CN2014/094459 patent/WO2015196759A1/en not_active Ceased
- 2014-12-22 MX MX2017000182A patent/MX389867B/es unknown
-
2018
- 2018-12-21 US US16/229,119 patent/US10941152B2/en not_active Expired - Fee Related
-
2019
- 2019-07-11 JP JP2019129171A patent/JP2019196375A/ja active Pending
-
2020
- 2020-02-20 AU AU2020201240A patent/AU2020201240A1/en not_active Abandoned
- 2020-11-18 JP JP2020191715A patent/JP2021038245A/ja active Pending
-
2021
- 2021-01-05 US US17/141,621 patent/US20220402929A1/en not_active Abandoned
- 2021-07-09 AU AU2021204814A patent/AU2021204814B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015196335A1 (en) | 2015-12-30 |
| US10208055B2 (en) | 2019-02-19 |
| EP3157929B1 (en) | 2023-12-13 |
| US10941152B2 (en) | 2021-03-09 |
| CN106573937A (zh) | 2017-04-19 |
| AU2014398875B2 (en) | 2019-11-21 |
| US20190135823A1 (en) | 2019-05-09 |
| CN106573937B (zh) | 2022-02-11 |
| MX2017000182A (es) | 2017-06-30 |
| AU2020201240A1 (en) | 2020-03-12 |
| EP3157929A4 (en) | 2018-03-07 |
| KR102416279B1 (ko) | 2022-07-01 |
| AU2021204814A1 (en) | 2021-08-05 |
| RU2752173C2 (ru) | 2021-07-23 |
| WO2015196759A1 (en) | 2015-12-30 |
| ES2972131T3 (es) | 2024-06-11 |
| JP6557331B2 (ja) | 2019-08-07 |
| US20170253605A1 (en) | 2017-09-07 |
| AU2021204814B2 (en) | 2023-07-20 |
| RU2017101829A3 (en:Method) | 2018-08-30 |
| JP2019196375A (ja) | 2019-11-14 |
| JP2021038245A (ja) | 2021-03-11 |
| EP3157929A1 (en) | 2017-04-26 |
| KR20170033314A (ko) | 2017-03-24 |
| JP2017524733A (ja) | 2017-08-31 |
| US20220402929A1 (en) | 2022-12-22 |
| DK3157929T3 (da) | 2024-02-05 |
| AU2014398875A1 (en) | 2017-02-02 |
| CA2955415A1 (en) | 2015-12-30 |
| RU2017101829A (ru) | 2018-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2017000182A (es) | Compuestos de pirazol como moduladores de fshr y usos de los mismos. | |
| CY1124595T1 (el) | Ρυθμιση δραστικοτητας συμπληρωματος | |
| CL2017001289A1 (es) | Compuestos bicíclicos fusionados, sus composiciones y su uso para el tratamiento de enfermedades relacionadas con la modulación del receptor x farnesoide (fxr). | |
| MX387228B (es) | Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculo y sus usos. | |
| ECSP17016797A (es) | Indazoles sustituidos con benzilo como inhibidores de bub1 | |
| NI201700129A (es) | Azabenzimidazoles y su uso como moduladores del receptor ampa. | |
| CL2018001478A1 (es) | Agonistas del receptor de apelina y métodos de uso | |
| PY1411052A (es) | Compuestos heterocíclicos y usos de los mismos | |
| UY35485A (es) | Compuestos heterocíclicos y usos de los mismos | |
| BR112016021687A2 (pt) | Comunicação através de nós de rede dedicados | |
| CL2015002125A1 (es) | Moduladores de receptores nmda de espiro-lactama y sus usos. | |
| DK3236943T3 (da) | Sammensætninger til ileo-jejunal lægemiddeladministration | |
| ECSP15043696A (es) | Compuestos de heteroarilo y sus usos | |
| MX374558B (es) | Compuestos de heteroarilo y sus usos. | |
| NI201500119A (es) | Compuestos de heteroarilo y sus usos | |
| MX2016015565A (es) | Ciertos inhibidores de la proteina quinasa. | |
| PH12015501998B1 (en) | Heterocyclic compounds and their uses | |
| AR101905A1 (es) | Compuestos bicíclicos | |
| ECSP17031525A (es) | Composiciones novedosas, usos y métodos para hacerlas | |
| MX2017013874A (es) | Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa. | |
| DK3325487T3 (da) | Formulering til bløde, anticholinerge analoger | |
| MX2015012416A (es) | Compuestos heterociclicos y sus usos. | |
| EA201790650A1 (ru) | Лекарственная форма и способы применения абиратерона ацетата | |
| DK3265459T3 (da) | Amidforbindelser som 5-ht4-receptoragonister | |
| DK3213752T3 (da) | Sammensætning til behandling af cancerstamceller |