MX383770B - Moduladores heteroaromáticos del receptor huérfano relacionado con retinoide gamma. - Google Patents
Moduladores heteroaromáticos del receptor huérfano relacionado con retinoide gamma.Info
- Publication number
- MX383770B MX383770B MX2019000361A MX2019000361A MX383770B MX 383770 B MX383770 B MX 383770B MX 2019000361 A MX2019000361 A MX 2019000361A MX 2019000361 A MX2019000361 A MX 2019000361A MX 383770 B MX383770 B MX 383770B
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- alkyl
- cycloalkyl
- membered
- retinoid
- Prior art date
Links
- 102100023421 Nuclear receptor ROR-gamma Human genes 0.000 title 1
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16020268 | 2016-07-13 | ||
| PCT/EP2017/067390 WO2018011201A1 (en) | 2016-07-13 | 2017-07-11 | Heteroaromatic modulators of the retinoid-related orphan receptor gamma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019000361A MX2019000361A (es) | 2019-05-23 |
| MX383770B true MX383770B (es) | 2025-03-14 |
Family
ID=56511303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000361A MX383770B (es) | 2016-07-13 | 2017-07-11 | Moduladores heteroaromáticos del receptor huérfano relacionado con retinoide gamma. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10662181B2 (https=) |
| EP (1) | EP3484880B1 (https=) |
| JP (1) | JP7016344B2 (https=) |
| KR (1) | KR102490140B1 (https=) |
| CN (1) | CN109476653B (https=) |
| AU (1) | AU2017294969B2 (https=) |
| BR (1) | BR112019000486A2 (https=) |
| CA (1) | CA3030370A1 (https=) |
| DK (1) | DK3484880T3 (https=) |
| ES (1) | ES2834009T3 (https=) |
| IL (1) | IL264141B (https=) |
| MX (1) | MX383770B (https=) |
| MY (1) | MY196990A (https=) |
| PL (1) | PL3484880T3 (https=) |
| PT (1) | PT3484880T (https=) |
| RU (1) | RU2771280C2 (https=) |
| SA (1) | SA519400868B1 (https=) |
| SG (1) | SG11201811107WA (https=) |
| UA (1) | UA123330C2 (https=) |
| WO (1) | WO2018011201A1 (https=) |
| ZA (1) | ZA201808436B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109476653B (zh) * | 2016-07-13 | 2022-04-22 | 利奥制药有限公司 | 类视黄醇相关孤儿受体γ的杂芳族调节剂 |
| CN111825654A (zh) * | 2019-04-19 | 2020-10-27 | 北京酷瓴生物技术有限公司 | 苯甲烯哌啶衍生物及其制备方法、中间体和用途 |
| CN112898292A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS244821B2 (en) * | 1983-06-16 | 1986-08-14 | Boehringer Ingelheim Ltd | Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas |
| WO2004073612A2 (en) | 2003-02-13 | 2004-09-02 | Merck & Co. Inc. | Estrogen receptor modulators |
| FR2879381B1 (fr) | 2004-12-15 | 2008-12-26 | Thales Sa | Systeme de distribution quantique de cle de cryptage a variables continues |
| AU2006231929B2 (en) * | 2005-04-04 | 2012-09-06 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
| EP2511275A1 (en) | 2011-04-12 | 2012-10-17 | Bioprojet | Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists |
| WO2014086894A1 (en) * | 2012-12-06 | 2014-06-12 | Glaxo Group Limited | Modulators of the retinoid-related orphan receptor gamma (ror-gamma) for use in the treatment of autoimmune and inflammatory diseases |
| CN105705492B (zh) * | 2013-11-05 | 2019-11-05 | 豪夫迈·罗氏有限公司 | 作为rorc调节剂用于治疗自身免疫性疾病的5,6,7,8-四氢-5,8-亚甲基噌啉衍生物 |
| WO2015180613A1 (en) | 2014-05-28 | 2015-12-03 | Glaxosmithkline Intellectual Property Development Limited | Novel compounds |
| AU2015267909B2 (en) | 2014-05-28 | 2018-03-22 | Glaxosmithkline Intellectual Property Development Limited | Novel compounds |
| JP6522665B2 (ja) | 2014-05-28 | 2019-05-29 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 新規化合物 |
| CN109476653B (zh) * | 2016-07-13 | 2022-04-22 | 利奥制药有限公司 | 类视黄醇相关孤儿受体γ的杂芳族调节剂 |
-
2017
- 2017-07-11 CN CN201780043425.2A patent/CN109476653B/zh not_active Expired - Fee Related
- 2017-07-11 PT PT177372844T patent/PT3484880T/pt unknown
- 2017-07-11 EP EP17737284.4A patent/EP3484880B1/en active Active
- 2017-07-11 UA UAA201901406A patent/UA123330C2/uk unknown
- 2017-07-11 JP JP2019501569A patent/JP7016344B2/ja not_active Expired - Fee Related
- 2017-07-11 MX MX2019000361A patent/MX383770B/es unknown
- 2017-07-11 WO PCT/EP2017/067390 patent/WO2018011201A1/en not_active Ceased
- 2017-07-11 CA CA3030370A patent/CA3030370A1/en active Pending
- 2017-07-11 AU AU2017294969A patent/AU2017294969B2/en not_active Ceased
- 2017-07-11 SG SG11201811107WA patent/SG11201811107WA/en unknown
- 2017-07-11 BR BR112019000486-6A patent/BR112019000486A2/pt active Search and Examination
- 2017-07-11 PL PL17737284T patent/PL3484880T3/pl unknown
- 2017-07-11 US US16/317,655 patent/US10662181B2/en active Active
- 2017-07-11 KR KR1020197003804A patent/KR102490140B1/ko active Active
- 2017-07-11 MY MYPI2018002824A patent/MY196990A/en unknown
- 2017-07-11 ES ES17737284T patent/ES2834009T3/es active Active
- 2017-07-11 RU RU2019103883A patent/RU2771280C2/ru active
- 2017-07-11 DK DK17737284.4T patent/DK3484880T3/da active
-
2018
- 2018-12-13 ZA ZA2018/08436A patent/ZA201808436B/en unknown
-
2019
- 2019-01-08 IL IL264141A patent/IL264141B/en unknown
- 2019-01-13 SA SA519400868A patent/SA519400868B1/ar unknown
-
2020
- 2020-05-15 US US16/874,961 patent/US10934282B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20250289A1 (ar) | صور بلورية جديدة | |
| EA201591703A1 (ru) | Замещенные 2-азабициклы и их применение в качестве модуляторов рецепторов орексина | |
| CY1120635T1 (el) | Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης | |
| PH12015502192A1 (en) | Novel compounds | |
| EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
| EA201690473A1 (ru) | Комбинированный состав двух противовирусных соединений | |
| EA201591429A1 (ru) | 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена | |
| TR201900050T4 (tr) | Kaynaştırılmış heterosiklik bileşik ve bunun haşere kontrol uygulaması. | |
| EA201890522A1 (ru) | Способ получения противогрибковых соединений | |
| MX377277B (es) | Derivados de fenoximetilo. | |
| AR085324A1 (es) | Composiciones de moleculas pesticidas y proceso de aplicacion de dichas composiciones para controlar acaros, insectos y otras plagas | |
| EA201600317A1 (ru) | Гербицидные соединения | |
| JO3509B1 (ar) | معدلات p2x7 | |
| EA201600344A1 (ru) | Гербицидные соединения | |
| CO2018007136A2 (es) | Derivados de heterocicleno como agentes de control de plagas | |
| MX2021011971A (es) | Proceso para preparar cicloserinas sustituidas. | |
| EA201490213A1 (ru) | Бензофурановые соединения для лечения инфекций вирусом гепатита с | |
| NZ742952A (en) | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | |
| AR097253A1 (es) | Derivado de pirazolilpirazol sustituido y el uso del mismo como herbicida | |
| MX2020006016A (es) | Polimorfos. | |
| MX383770B (es) | Moduladores heteroaromáticos del receptor huérfano relacionado con retinoide gamma. | |
| JOP20200030B1 (ar) | مركب خماسي الحلقة | |
| EA201500605A1 (ru) | Новые производные замещенного 1,4-дитиина и их применение в качестве фунгицидов | |
| SA520412408B1 (ar) | عملية تحضير مركبات ثنائي أريل أوكسي بنزو ديازول غير متجانسة مزدوجة الاستبدال | |
| EA202190989A1 (ru) | Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений |