MX382313B - Derivados del sobetiroma. - Google Patents

Derivados del sobetiroma.

Info

Publication number
MX382313B
MX382313B MX2018014114A MX2018014114A MX382313B MX 382313 B MX382313 B MX 382313B MX 2018014114 A MX2018014114 A MX 2018014114A MX 2018014114 A MX2018014114 A MX 2018014114A MX 382313 B MX382313 B MX 382313B
Authority
MX
Mexico
Prior art keywords
sobetirome
pharmaceutical compositions
sobetiroma
derivatives
compounds
Prior art date
Application number
MX2018014114A
Other languages
English (en)
Spanish (es)
Other versions
MX2018014114A (es
Inventor
Andrew Placzek
James Matthew Meinig
Jordan Devereaux
Skylar Ferrara
Tania Banerji
Tapasree Banerji
Thomas Scanlan
Original Assignee
Univ Oregon Health & Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon Health & Science filed Critical Univ Oregon Health & Science
Publication of MX2018014114A publication Critical patent/MX2018014114A/es
Publication of MX382313B publication Critical patent/MX382313B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • C07C39/07—Alkylated phenols containing only methyl groups, e.g. cresols, xylenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
MX2018014114A 2016-05-18 2017-05-18 Derivados del sobetiroma. MX382313B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338178P 2016-05-18 2016-05-18
PCT/US2017/033388 WO2017201320A1 (en) 2016-05-18 2017-05-18 Derivatives of sobetirome

Publications (2)

Publication Number Publication Date
MX2018014114A MX2018014114A (es) 2019-07-10
MX382313B true MX382313B (es) 2025-03-13

Family

ID=60326251

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014114A MX382313B (es) 2016-05-18 2017-05-18 Derivados del sobetiroma.

Country Status (21)

Country Link
US (3) US10544075B2 (OSRAM)
EP (2) EP3936497A1 (OSRAM)
JP (2) JP6982004B2 (OSRAM)
KR (1) KR102331596B1 (OSRAM)
CN (2) CN109475121B (OSRAM)
AU (1) AU2017267734B2 (OSRAM)
CA (1) CA3024680A1 (OSRAM)
CY (1) CY1124704T1 (OSRAM)
DK (1) DK3457851T3 (OSRAM)
ES (1) ES2888915T3 (OSRAM)
HR (1) HRP20211429T1 (OSRAM)
HU (1) HUE056357T2 (OSRAM)
IL (1) IL263050B (OSRAM)
LT (1) LT3457851T (OSRAM)
MX (1) MX382313B (OSRAM)
PL (1) PL3457851T3 (OSRAM)
PT (1) PT3457851T (OSRAM)
RS (1) RS62408B1 (OSRAM)
SI (1) SI3457851T1 (OSRAM)
SM (1) SMT202100551T1 (OSRAM)
WO (1) WO2017201320A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20180021A1 (es) 2015-02-20 2018-01-09 Univ Oregon Health & Science Derivados de sobetiroma
CN110200978B (zh) * 2016-04-22 2023-10-31 维京治疗股份有限公司 甲状腺β-激动剂的应用
WO2017185087A1 (en) 2016-04-22 2017-10-26 Viking Therapeutics Use of thyroid beta-agonists
CN109475121B (zh) * 2016-05-18 2021-06-25 俄勒冈健康科学大学 苏比替罗衍生物
IL276592B2 (en) * 2018-02-14 2023-11-01 Univ Oregon Health & Science History of Subtirum
JP2022513449A (ja) * 2018-12-12 2022-02-08 オートバーン セラピューティクス，インク． 新規な甲状腺模倣物
WO2020180624A1 (en) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Novel thyromimetics
EP4065098A4 (en) * 2019-11-29 2023-12-27 Autobahn Therapeutics, Inc. NOVEL THYROMIMETICS
JP2023530708A (ja) * 2020-06-17 2023-07-19 オートバーン セラピューティクス，インク． 甲状腺様作用剤
WO2021257834A1 (en) * 2020-06-17 2021-12-23 Autobahn Therapeutics, Inc. Thyromimetics
EP4333844A4 (en) * 2021-05-06 2025-03-19 Autobahn Therapeutics, Inc. Fatty acid amide hydroase (FAAH)-cleavable prodrugs of thyromimetics and combination with peripherally restricted FAAH inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CA1236641A (en) 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US5883294A (en) 1997-06-18 1999-03-16 The Regeants Of The University Of California Selective thyroid hormone analogs
GB9713739D0 (en) * 1997-06-27 1997-09-03 Karobio Ab Thyroid receptor ligands
ATE293595T1 (de) * 1998-06-30 2005-05-15 Univ California Thyroidhormon-analoga und verfahren zu ihrer herstellung
WO2000073292A1 (en) * 1999-06-01 2000-12-07 The University Of Texas Southwestern Medical Center Biaryl compounds
AU2001230929B2 (en) * 2000-02-17 2004-09-23 Bristol-Myers Squibb Co. Aniline-derived ligands for the thyroid receptor
JP2004514718A (ja) 2000-11-02 2004-05-20 アストラゼネカ　アクチボラグ 抗癌剤としての置換キノリン類
CA2606499C (en) * 2005-05-26 2017-06-13 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
JP5847533B2 (ja) * 2010-10-19 2016-01-27 田辺三菱製薬株式会社 新規甲状腺ホルモンβ受容体作動薬
JP2016517883A (ja) 2013-05-03 2016-06-20 オレゴン ヘルス アンド サイエンス ユニバーシティー Ｘ連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用
PE20180021A1 (es) * 2015-02-20 2018-01-09 Univ Oregon Health & Science Derivados de sobetiroma
WO2017015360A1 (en) 2015-07-20 2017-01-26 Oregon Health & Science University Quinolone-3-diarylethers
CN109475121B (zh) 2016-05-18 2021-06-25 俄勒冈健康科学大学 苏比替罗衍生物
WO2018208707A1 (en) 2017-05-08 2018-11-15 Neurovia, Inc. Methods and compositions for treating demyelinating diseases

Also Published As

Publication number Publication date
US20190210950A1 (en) 2019-07-11
SI3457851T1 (sl) 2022-04-29
MX2018014114A (es) 2019-07-10
KR20190006012A (ko) 2019-01-16
IL263050A (en) 2018-12-31
KR102331596B1 (ko) 2021-11-25
HRP20211429T1 (hr) 2021-12-10
SMT202100551T1 (it) 2022-01-10
US10544075B2 (en) 2020-01-28
RU2018142863A (ru) 2020-06-18
LT3457851T (lt) 2021-10-11
AU2017267734B2 (en) 2021-09-09
CN113277958A (zh) 2021-08-20
AU2017267734A1 (en) 2018-12-20
PL3457851T3 (pl) 2022-03-14
US10870616B2 (en) 2020-12-22
ES2888915T3 (es) 2022-01-10
EP3457851A4 (en) 2020-02-26
EP3936497A1 (en) 2022-01-12
US20240425437A1 (en) 2024-12-26
RU2018142863A3 (OSRAM) 2020-07-13
RS62408B1 (sr) 2021-10-29
JP2019516739A (ja) 2019-06-20
JP6982004B2 (ja) 2021-12-17
BR112018073679A2 (pt) 2019-02-26
CA3024680A1 (en) 2017-11-23
EP3457851B1 (en) 2021-06-23
US20200325092A1 (en) 2020-10-15
NZ748895A (en) 2024-12-20
EP3457851A1 (en) 2019-03-27
JP2022033788A (ja) 2022-03-02
CN109475121B (zh) 2021-06-25
HUE056357T2 (hu) 2022-02-28
CN109475121A (zh) 2019-03-15
DK3457851T3 (da) 2021-09-20
CY1124704T1 (el) 2022-07-22
PT3457851T (pt) 2021-09-28
WO2017201320A1 (en) 2017-11-23
IL263050B (en) 2021-09-30

Similar Documents

Publication Publication Date Title
MX382313B (es) Derivados del sobetiroma.
CL2019001744A1 (es) Derivados de benzoxazol como inmunomoduladores.
CL2018001685A1 (es) Compuestos heterociclicos como inmuno moduladores.
MX389513B (es) Compuestos heterocíclicos como inmunomoduladores.
EA201890185A1 (ru) Способы лечения опосредованных гепсидином нарушений
EA201891910A1 (ru) Гетероарильные ингибиторы pad4
ECSP16083602A (es) Derivados de quinolina como inhibidores smo
EA201691940A1 (ru) Новые соединения
MX372914B (es) Derivado de piperidina y metodo de preparacion y uso farmaceutico del mismo.
EA201692177A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
MX380777B (es) Compuestos y composiciones como agonistas del receptor tipo toll 7.
MX388170B (es) Polimorfos de selinexor
MX389724B (es) Compuestos de fenil-2-hidroxi-acetilamino-2-metil-fenilo
EA201990400A1 (ru) Соединения и композиции и их применение
CR20200214A (es) ALCOHOLES TERCIARIOS COMO INHIBIDORES DE PI3K-y
EA201891347A1 (ru) Аза-бензимидазольные ингибиторы pad4
PL410665A1 (pl) Inhibitory arginazy oraz ich zastosowania terapeutyczne
EA201791259A1 (ru) Производные пиперидина в качестве ингибиторов hdac1/2
MX2017001103A (es) Derivados de indolizina que son aplicables a enfermedades neurodegenerativas.
MX376700B (es) Compuestos heterociclicos fusionados como moduladores s1p.
MX2016012784A (es) Composiciones farmaceuticas solidas que comprenden derivados de biopterina y usos de tales composiciones.
MX394123B (es) Compuestos amidas, composiciones farmacéuticas de estos y métodos para utilizarlos
MX2017001603A (es) Derivados de piperazina como moduladores de los receptores x del higado.
MX383975B (es) Derivado de anillo fusionado como inhibidor del receptor a2a
MX2018001592A (es) Composiciones y metodos para el tratamiento y la prevencion de trastornos neurodegenerativos.