MX381844B - Dsba y dsbc ultrapurificado y métodos para elaborarlos y utilizarlos - Google Patents
Dsba y dsbc ultrapurificado y métodos para elaborarlos y utilizarlosInfo
- Publication number
- MX381844B MX381844B MX2017011189A MX2017011189A MX381844B MX 381844 B MX381844 B MX 381844B MX 2017011189 A MX2017011189 A MX 2017011189A MX 2017011189 A MX2017011189 A MX 2017011189A MX 381844 B MX381844 B MX 381844B
- Authority
- MX
- Mexico
- Prior art keywords
- dsbc
- dsba
- methods
- ultrapurified
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
- C12Y108/04—Oxidoreductases acting on sulfur groups as donors (1.8) with a disulfide as acceptor (1.8.4)
- C12Y108/04002—Protein-disulfide reductase (glutathione) (1.8.4.2), i.e. BdbC or BdbD
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/04—Intramolecular oxidoreductases (5.3) transposing S-S bonds (5.3.4)
- C12Y503/04001—Protein disulfide-isomerase (5.3.4.1), i.e. disufide bond-forming enzyme
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90212—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/99—Isomerases (5.)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562129701P | 2015-03-06 | 2015-03-06 | |
| PCT/US2016/021059 WO2016144824A1 (en) | 2015-03-06 | 2016-03-04 | Ultrapurified dsba and dsbc and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017011189A MX2017011189A (es) | 2018-01-23 |
| MX381844B true MX381844B (es) | 2025-03-13 |
Family
ID=55637452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017011189A MX381844B (es) | 2015-03-06 | 2016-03-04 | Dsba y dsbc ultrapurificado y métodos para elaborarlos y utilizarlos |
| MX2021000153A MX387454B (es) | 2015-03-06 | 2016-03-04 | DsbA Y DsbC ULTRAPURIFICADO Y MÉTODOS PARA ELABORARLOS Y UTILIZARLOS. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021000153A MX387454B (es) | 2015-03-06 | 2016-03-04 | DsbA Y DsbC ULTRAPURIFICADO Y MÉTODOS PARA ELABORARLOS Y UTILIZARLOS. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10073098B2 (enExample) |
| EP (2) | EP3636749B1 (enExample) |
| JP (2) | JP6865689B2 (enExample) |
| KR (1) | KR20170122216A (enExample) |
| CN (1) | CN107531749A (enExample) |
| AR (1) | AR103852A1 (enExample) |
| AU (1) | AU2016230018A1 (enExample) |
| CA (1) | CA2978256A1 (enExample) |
| ES (1) | ES2761726T3 (enExample) |
| HK (1) | HK1247936A1 (enExample) |
| HR (1) | HRP20192217T1 (enExample) |
| IL (1) | IL254166A0 (enExample) |
| MX (2) | MX381844B (enExample) |
| PL (1) | PL3265557T3 (enExample) |
| SG (2) | SG10202005917SA (enExample) |
| SI (1) | SI3265557T1 (enExample) |
| WO (1) | WO2016144824A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| SG10202005917SA (en) | 2015-03-06 | 2020-07-29 | Genentech Inc | Ultrapurified dsba and dsbc and methods of making and using the same |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| SG11202003907WA (en) | 2017-12-14 | 2020-05-28 | Flodesign Sonics Inc | Acoustic transducer drive and controller |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CA3174665A1 (en) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
| CN115028691B (zh) * | 2022-06-29 | 2024-09-10 | 青岛硕景生物科技有限公司 | 一种检测试纸用的独立质控系统、杂交瘤细胞株、质控线用包被单克隆抗体及其应用 |
| CN119874933A (zh) * | 2024-11-20 | 2025-04-25 | 金宇保灵生物药品有限公司 | 一种基于大肠杆菌的纳米抗体融合表达体系及其制备方法 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3645090A (en) | 1969-06-19 | 1972-02-29 | Citizen Watch Co Ltd | Day-date quick-adjuster for calender timepiece |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| CA2116774C (en) | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| WO1993016185A2 (en) | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Biosynthetic binding protein for cancer marker |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| GB9325718D0 (en) * | 1993-12-16 | 1994-02-16 | Ars Holding 89 Nv | Sensor device for sandwich assay |
| US5789199A (en) * | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5639635A (en) | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| AU2660397A (en) | 1996-04-05 | 1997-10-29 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| JP2000083670A (ja) * | 1998-09-09 | 2000-03-28 | Hsp Kenkyusho:Kk | ＤｓｂＡ／ＤｓｂＢ／ＤｓｂＣ／ＤｓｂＤ発現プラスミド |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| EP1161440A1 (en) * | 1999-03-17 | 2001-12-12 | Medical Research Council | Method for refolding molecules of polypeptides containing ig domains |
| US6872563B1 (en) * | 1999-10-05 | 2005-03-29 | President And Fellows Of Harvard College | Compositions and methods for production of disulfide bond containing proteins in host cells |
| AU2001247616B2 (en) | 2000-04-11 | 2007-06-14 | Genentech, Inc. | Multivalent antibodies and uses therefor |
| AU2002245142B2 (en) | 2000-12-14 | 2007-07-05 | Genentech, Inc. | Prokaryotically produced antibodies and uses thereof |
| ES2376454T3 (es) | 2000-12-22 | 2012-03-14 | Grad, Carole, Legal Representative Of Howard, Kaplan | Librer�?as de expresión en fago de fragmentos vh humanos. |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| AU2004309347B2 (en) | 2003-12-19 | 2010-03-04 | Genentech, Inc. | Monovalent antibody fragments useful as therapeutics |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| CN100475965C (zh) | 2005-07-22 | 2009-04-08 | 上海高科联合生物技术研发有限公司 | 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法 |
| WO2007147901A1 (en) | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
| DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
| JP5361738B2 (ja) * | 2007-01-22 | 2013-12-04 | ジェネンテック， インコーポレイテッド | 多価電解質沈殿物及びタンパク質の精製 |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| SI2496601T1 (sl) * | 2009-11-05 | 2017-09-29 | F. Hoffmann-La Roche Ag | Tehnike in sestavek za sekrecijo heterolognih polipeptidov |
| AU2010201410B2 (en) * | 2010-03-30 | 2015-04-30 | Pelican Technology Holdings, Inc. | High level expression of recombinant CRM197 |
| GB201012519D0 (en) | 2010-07-26 | 2010-09-08 | Ucl Business Plc | Method and system for anomaly detection in data sets |
| GB201012599D0 (en) * | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| EP3527274B1 (en) * | 2011-11-02 | 2025-12-24 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
| AU2014253785B2 (en) * | 2013-04-19 | 2018-07-19 | Sutro Biopharma, Inc. | Expression of biologically active proteins in a bacterial cell-free synthesis system using cell extracts with elevated levels of exogenous chaperones |
| RU2016107435A (ru) * | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты |
| SG10202005917SA (en) | 2015-03-06 | 2020-07-29 | Genentech Inc | Ultrapurified dsba and dsbc and methods of making and using the same |
-
2016
- 2016-03-04 SG SG10202005917SA patent/SG10202005917SA/en unknown
- 2016-03-04 EP EP19195777.8A patent/EP3636749B1/en active Active
- 2016-03-04 CA CA2978256A patent/CA2978256A1/en not_active Abandoned
- 2016-03-04 HK HK18107289.5A patent/HK1247936A1/zh unknown
- 2016-03-04 KR KR1020177026459A patent/KR20170122216A/ko not_active Ceased
- 2016-03-04 HR HRP20192217TT patent/HRP20192217T1/hr unknown
- 2016-03-04 MX MX2017011189A patent/MX381844B/es unknown
- 2016-03-04 PL PL16712126T patent/PL3265557T3/pl unknown
- 2016-03-04 SI SI201630544T patent/SI3265557T1/sl unknown
- 2016-03-04 AR ARP160100573A patent/AR103852A1/es not_active Application Discontinuation
- 2016-03-04 SG SG11201707186YA patent/SG11201707186YA/en unknown
- 2016-03-04 EP EP16712126.8A patent/EP3265557B1/en active Active
- 2016-03-04 AU AU2016230018A patent/AU2016230018A1/en not_active Abandoned
- 2016-03-04 WO PCT/US2016/021059 patent/WO2016144824A1/en not_active Ceased
- 2016-03-04 MX MX2021000153A patent/MX387454B/es unknown
- 2016-03-04 US US15/061,943 patent/US10073098B2/en active Active
- 2016-03-04 ES ES16712126T patent/ES2761726T3/es active Active
- 2016-03-04 JP JP2017546779A patent/JP6865689B2/ja active Active
- 2016-03-04 CN CN201680026013.3A patent/CN107531749A/zh active Pending
-
2017
- 2017-08-27 IL IL254166A patent/IL254166A0/en unknown
-
2018
- 2018-07-24 US US16/044,360 patent/US10690671B2/en active Active
-
2021
- 2021-01-07 JP JP2021001186A patent/JP7191132B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2761726T3 (es) | 2020-05-20 |
| AR103852A1 (es) | 2017-06-07 |
| US10073098B2 (en) | 2018-09-11 |
| SG11201707186YA (en) | 2017-10-30 |
| EP3636749A1 (en) | 2020-04-15 |
| EP3265557A1 (en) | 2018-01-10 |
| US20190056399A1 (en) | 2019-02-21 |
| HRP20192217T1 (hr) | 2020-02-21 |
| AU2016230018A1 (en) | 2017-09-21 |
| CN107531749A (zh) | 2018-01-02 |
| KR20170122216A (ko) | 2017-11-03 |
| MX2017011189A (es) | 2018-01-23 |
| HK1247936A1 (zh) | 2018-10-05 |
| JP6865689B2 (ja) | 2021-04-28 |
| IL254166A0 (en) | 2017-10-31 |
| MX387454B (es) | 2025-03-18 |
| EP3636749B1 (en) | 2022-04-27 |
| PL3265557T3 (pl) | 2020-03-31 |
| SG10202005917SA (en) | 2020-07-29 |
| CA2978256A1 (en) | 2016-09-15 |
| SI3265557T1 (sl) | 2020-02-28 |
| JP7191132B2 (ja) | 2022-12-16 |
| US20160370369A1 (en) | 2016-12-22 |
| EP3265557B1 (en) | 2019-10-16 |
| MX2021000153A (es) | 2021-10-28 |
| JP2021078502A (ja) | 2021-05-27 |
| WO2016144824A1 (en) | 2016-09-15 |
| US10690671B2 (en) | 2020-06-23 |
| JP2018516229A (ja) | 2018-06-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021000153A (es) | Dsba y dsbc ultrapurificado y métodos para elaborarlos y utilizarlos. | |
| CO2018011804A2 (es) | Receptores quiméricos de flt3 y métodos de uso de los mismos | |
| BR112019012343A2 (pt) | anticorpos il-11ra | |
| EA201990293A1 (ru) | Мультиспецифичные антитела против cd40 и cd137 | |
| MX2016009965A (es) | Produccion de alta titulacion de vectores virales adenoasociados. | |
| BR112017007636A2 (pt) | métodos para a preparação de ribosídeos | |
| TR2021016542A2 (tr) | Plazma bazlı filmler ve bunları üretme ve kullanma usulleri. | |
| EA201890493A1 (ru) | РЕПРЕССОРЫ Htt И ИХ ПРИМЕНЕНИЕ | |
| MX390940B (es) | Medio de cultivo celular complementado con taurina y metodos de uso. | |
| TWD170353S (zh) | 項鍊 | |
| BR112017003414A2 (pt) | composições compreendendo caseína e métodos para produzir as mesmas | |
| EA201791305A1 (ru) | Конденсированные пиримидины для лечения вич | |
| MX380263B (es) | Procesos para producir brivaracetam. | |
| EA201790505A1 (ru) | Соединение, нацеленое на ил-23а и фно-альфа, и его применение | |
| MX2023006415A (es) | Anticuerpos, usos y metodos. | |
| WO2016033437A3 (en) | Polyethers, polyamines, polythioethers, and methods for making same | |
| BR112016017584A2 (pt) | Composições de nanotribologia e métodos relacionados incluindo nanofolhas moleculares | |
| MX384727B (es) | Procesos para preparar oligómeros | |
| PH12016501689B1 (en) | Tatk-cdkl5 fusion proteins, compositions, formulations, and use thereof | |
| ZA201803476B (en) | Anti-cd22 antibody-maytansine conjugates and methods of use thereof | |
| MX2021007143A (es) | Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido. | |
| EA201791491A1 (ru) | Способы выделения тромбоцитов | |
| MX384182B (es) | Microorganismo recombinante para la produccion mejorada de quimicos finos. | |
| CO2018010286A2 (es) | Método para la purificación de proteínas | |
| UA117779C2 (uk) | Піразини як модулятори gpr6 |