MX380758B - Compuesto que tiene actividad inhibitoria de idh mutante, método de preparación y usos del mismo. - Google Patents

Compuesto que tiene actividad inhibitoria de idh mutante, método de preparación y usos del mismo.

Info

Publication number
MX380758B
MX380758B MX2018011592A MX2018011592A MX380758B MX 380758 B MX380758 B MX 380758B MX 2018011592 A MX2018011592 A MX 2018011592A MX 2018011592 A MX2018011592 A MX 2018011592A MX 380758 B MX380758 B MX 380758B
Authority
MX
Mexico
Prior art keywords
compound
preparation
inhibitory activity
hdi
mutant
Prior art date
Application number
MX2018011592A
Other languages
English (en)
Other versions
MX2018011592A (es
Inventor
Feifei Liu
Huixin Wan
Jian Ding
Jianhua Cao
Lei Jiang
Meiyu Geng
Min Huang
Qiangang Zheng
Shuai Tang
Xianlei Fu
Xiaojing Lan
Original Assignee
Shanghai Haihe Pharmaceutical Co Ltd
Shanghai Inst Materia Medica Cas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Haihe Pharmaceutical Co Ltd, Shanghai Inst Materia Medica Cas filed Critical Shanghai Haihe Pharmaceutical Co Ltd
Publication of MX2018011592A publication Critical patent/MX2018011592A/es
Publication of MX380758B publication Critical patent/MX380758B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Una proteína tolerante a herbicidas SUM1, su gen de codificación y un uso de la misma, en donde la proteína tolerante a herbicidas comprende: (a) una proteína que tiene una secuencia de aminoácidos tal como se muestra en SEC ID NO: 1; o (b) una proteína que se deriva de (a) sustituir y/o eliminar y/o agregar uno o más aminoácidos en la secuencia de aminoácidos de (a), y tiene la actividad de tifensulfuron hidrolasa. La proteína tolerante a herbicidas SUM1 puede mostrar una mayor tolerancia a una pluralidad de los herbicidas de sulfonilurea, puede tolerar una concentración de campo de cuatro veces y por ende tiene una amplia perspectiva de aplicación en las plantas.
MX2018011592A 2016-03-22 2017-03-21 Compuesto que tiene actividad inhibitoria de idh mutante, método de preparación y usos del mismo. MX380758B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610165095.1A CN107216312B (zh) 2016-03-22 2016-03-22 一种具有突变型idh抑制活性的化合物、其制备方法及用途
PCT/CN2017/077467 WO2017162133A1 (zh) 2016-03-22 2017-03-21 一种具有突变型idh抑制活性的化合物、其制备方法及用途

Publications (2)

Publication Number Publication Date
MX2018011592A MX2018011592A (es) 2019-06-24
MX380758B true MX380758B (es) 2025-03-12

Family

ID=59899244

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011592A MX380758B (es) 2016-03-22 2017-03-21 Compuesto que tiene actividad inhibitoria de idh mutante, método de preparación y usos del mismo.

Country Status (11)

Country Link
US (1) US10682352B2 (es)
EP (1) EP3434674B1 (es)
JP (1) JP6718553B2 (es)
KR (1) KR102245434B1 (es)
CN (1) CN107216312B (es)
AU (1) AU2017239295B2 (es)
CA (1) CA3018602C (es)
EA (1) EA037974B1 (es)
ES (1) ES2870910T3 (es)
MX (1) MX380758B (es)
WO (1) WO2017162133A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110407855A (zh) * 2018-04-26 2019-11-05 上海嗣新生物科技有限公司 2-氨基嘧啶啶衍生物及其制备方法和用途
GB201814151D0 (en) * 2018-08-31 2018-10-17 Ucl Business Plc Compounds
CN111825666B (zh) * 2019-04-23 2024-03-08 上海仕谱生物科技有限公司 二聚或多聚体形式的突变型idh抑制剂
US12521395B2 (en) * 2019-11-08 2026-01-13 Nerviano Medical Sciences S.R.L. Gem-disubstituted heterocyclic compounds and their use as IDH inhibitors
CN112375069B (zh) * 2020-11-20 2022-09-13 湖北民族大学 一种4-脲基嘧啶类化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012005299A1 (ja) * 2010-07-07 2013-09-05 日本新薬株式会社 Ｒｏｓチロシンキナーゼ阻害剤
JPWO2012020786A1 (ja) * 2010-08-11 2013-10-28 日本新薬株式会社 医薬組成物
WO2012020787A1 (ja) * 2010-08-11 2012-02-16 日本新薬株式会社 悪性リンパ腫治療剤
EP2771337B1 (en) * 2011-09-27 2017-08-02 Novartis AG 3-(pyrimidin-4-yl)-oxazolidin-2-ones as inhibitors of mutant idh
WO2014141104A1 (en) * 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
BR112015022483A2 (pt) 2013-03-14 2017-07-18 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
WO2014147586A1 (en) * 2013-03-22 2014-09-25 Novartis Ag 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
MX372986B (es) * 2014-09-19 2020-03-31 Forma Therapeutics Inc Composiciones de pirimidin quinolinona como inhibidores de isocitrato deshidrogenasa mutante (mt-idh)

Also Published As

Publication number Publication date
ES2870910T3 (es) 2021-10-28
EP3434674A1 (en) 2019-01-30
EA201892098A1 (ru) 2019-07-31
CN107216312A (zh) 2017-09-29
US20190111056A1 (en) 2019-04-18
EP3434674B1 (en) 2021-02-24
CA3018602A1 (en) 2017-09-28
WO2017162133A1 (zh) 2017-09-28
US10682352B2 (en) 2020-06-16
CN107216312B (zh) 2023-08-01
KR102245434B1 (ko) 2021-04-29
KR20180132721A (ko) 2018-12-12
AU2017239295B2 (en) 2020-01-02
JP6718553B2 (ja) 2020-07-08
CA3018602C (en) 2021-06-22
JP2019510819A (ja) 2019-04-18
EA037974B1 (ru) 2021-06-18
AU2017239295A1 (en) 2018-10-18
MX2018011592A (es) 2019-06-24
EP3434674A4 (en) 2019-11-27

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