MX378983B - Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos. - Google Patents
Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos.Info
- Publication number
- MX378983B MX378983B MX2017014300A MX2017014300A MX378983B MX 378983 B MX378983 B MX 378983B MX 2017014300 A MX2017014300 A MX 2017014300A MX 2017014300 A MX2017014300 A MX 2017014300A MX 378983 B MX378983 B MX 378983B
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- histone deacetylase
- deacetylase inhibitors
- inhibitors
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158363P | 2015-05-07 | 2015-05-07 | |
| PCT/US2016/031335 WO2016179554A1 (en) | 2015-05-07 | 2016-05-06 | Histone deacetylase inhibitors and compositions and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017014300A MX2017014300A (es) | 2018-08-09 |
| MX378983B true MX378983B (es) | 2025-03-10 |
Family
ID=57218014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017014300A MX378983B (es) | 2015-05-07 | 2016-05-06 | Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10053434B2 (enExample) |
| EP (1) | EP3291810B1 (enExample) |
| JP (1) | JP6805172B2 (enExample) |
| KR (1) | KR20180002729A (enExample) |
| CN (1) | CN107735088B (enExample) |
| AU (1) | AU2016258188B2 (enExample) |
| CA (1) | CA2984618C (enExample) |
| EA (1) | EA036965B1 (enExample) |
| IL (1) | IL255448B2 (enExample) |
| MX (1) | MX378983B (enExample) |
| WO (1) | WO2016179554A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180002729A (ko) * | 2015-05-07 | 2018-01-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 |
| CA2984621C (en) | 2015-05-07 | 2023-09-26 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| EP3487843A1 (en) * | 2016-07-22 | 2019-05-29 | Syngenta Participations AG | Microbiocidal oxadiazole derivatives |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| CN109627207A (zh) * | 2018-12-17 | 2019-04-16 | 天津药明康德新药开发有限公司 | 一种3-(二氟甲氧基)哌啶盐酸盐的制备方法 |
| WO2022174193A1 (en) * | 2021-02-15 | 2022-08-18 | The Research Foundation For The State University Of New York | Radiolabeled compositions and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2590811C (en) | 2004-12-10 | 2013-07-30 | Barbara Attenni | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| US8901156B2 (en) | 2010-01-13 | 2014-12-02 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| WO2013006408A1 (en) * | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| JP6047563B2 (ja) * | 2011-07-08 | 2016-12-21 | ノバルティス アーゲー | 新規トリフルオロメチル−オキサジアゾール誘導体および疾患の治療におけるその使用 |
| WO2013009810A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| WO2013009830A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| HRP20170928T1 (hr) | 2011-08-30 | 2017-09-22 | Chdi Foundation, Inc. | Inhibitori kinurenin-3-monooksigenaze, farmaceutski pripravci, i postupci za njihovu upotrebu |
| WO2013066833A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| AU2012345557A1 (en) * | 2011-11-28 | 2014-06-26 | Novartis Ag | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| SG11201406311UA (en) * | 2012-04-05 | 2014-11-27 | Chdi Foundation Inc | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| CA2984621C (en) | 2015-05-07 | 2023-09-26 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| KR20180002729A (ko) * | 2015-05-07 | 2018-01-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 |
| HUE061174T2 (hu) | 2015-07-27 | 2023-05-28 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazol-szulfonamid-származék vegyületek mint hiszton-deacetiláz-6 inhibitorok, és az ilyen vegyületeket tartalmazó gyógyszerkészímény |
| BR112017027798B1 (pt) | 2015-07-27 | 2023-12-19 | Chong Kun Dang Pharmaceutical Corp | Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos |
| CN108137518B (zh) | 2015-08-04 | 2021-08-31 | 株式会社钟根堂 | 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑衍生物化合物及包含其的药物组合物 |
-
2016
- 2016-05-06 KR KR1020177034461A patent/KR20180002729A/ko not_active Withdrawn
- 2016-05-06 AU AU2016258188A patent/AU2016258188B2/en active Active
- 2016-05-06 JP JP2017557324A patent/JP6805172B2/ja active Active
- 2016-05-06 EA EA201792247A patent/EA036965B1/ru not_active IP Right Cessation
- 2016-05-06 US US15/148,907 patent/US10053434B2/en active Active
- 2016-05-06 CA CA2984618A patent/CA2984618C/en active Active
- 2016-05-06 WO PCT/US2016/031335 patent/WO2016179554A1/en not_active Ceased
- 2016-05-06 EP EP16790203.0A patent/EP3291810B1/en active Active
- 2016-05-06 CN CN201680040061.8A patent/CN107735088B/zh active Active
- 2016-05-06 MX MX2017014300A patent/MX378983B/es unknown
-
2017
- 2017-11-06 IL IL255448A patent/IL255448B2/en unknown
-
2018
- 2018-07-26 US US16/046,254 patent/US20190202795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6805172B2 (ja) | 2020-12-23 |
| EP3291810A4 (en) | 2018-11-07 |
| US10053434B2 (en) | 2018-08-21 |
| IL255448B1 (en) | 2023-03-01 |
| KR20180002729A (ko) | 2018-01-08 |
| EP3291810A1 (en) | 2018-03-14 |
| CA2984618C (en) | 2024-01-09 |
| EA201792247A1 (ru) | 2018-06-29 |
| CN107735088A (zh) | 2018-02-23 |
| MX2017014300A (es) | 2018-08-09 |
| AU2016258188B2 (en) | 2021-08-26 |
| IL255448B2 (en) | 2023-07-01 |
| EA036965B1 (ru) | 2021-01-20 |
| WO2016179554A1 (en) | 2016-11-10 |
| BR112017023711A2 (pt) | 2018-07-17 |
| HK1252487A1 (en) | 2019-05-24 |
| CA2984618A1 (en) | 2016-11-10 |
| JP2018515489A (ja) | 2018-06-14 |
| CN107735088B (zh) | 2021-11-02 |
| AU2016258188A1 (en) | 2017-11-23 |
| US20160326124A1 (en) | 2016-11-10 |
| EP3291810B1 (en) | 2022-08-10 |
| IL255448A0 (en) | 2017-12-31 |
| US20190202795A1 (en) | 2019-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX379817B (es) | Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos. | |
| CO2018005381A2 (es) | Inhibidores éster de acc y usos de los mismos | |
| CL2017000576A1 (es) | Inhibidores de mk2 y sus usos | |
| CO2018004124A2 (es) | Compuestos heterocíclicos | |
| CO2017002532A2 (es) | Indazoles sustituidos con bencilo como inhibidores de bub1 | |
| DK3442973T3 (da) | Hidtil ukendte forbindelser som autotaxinhæmmere og farmaceutiske sammensætninger omfattende samme | |
| PL3510033T3 (pl) | Związki i kompozycje jako inhibitory endosomalnych receptorów toll- podobnych | |
| CU20180001A7 (es) | Derivados de oxopiridina sustituidos y procesos para su preparación | |
| EA201890749A1 (ru) | ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ | |
| MX2019012434A (es) | Agentes inductores de apoptosis. | |
| HUE057041T2 (hu) | Hiszton deacetiláz hetero-halogén gátlói | |
| MX2016015565A (es) | Ciertos inhibidores de la proteina quinasa. | |
| CR20180072A (es) | Nuevos compuestos biciclicos como inhibidores de atx | |
| MX378983B (es) | Inhibidores de histona deacetilasa y composiciones y metodos para el uso de los mismos. | |
| CL2017001923A1 (es) | Derivados de 9h-pirrolo-dipiridina | |
| MX2017013875A (es) | Ciertos inhibidores de la proteína quinasa. | |
| CL2016003074A1 (es) | Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer. | |
| HK1220407A1 (zh) | 组蛋白去乙酰酶抑制剂，其组合物及其使用方法 | |
| EP3624804A4 (en) | HISTONE DEACETYLASE INHIBITORS (HDAC) | |
| DK3653620T3 (da) | Nye heteroarylamid-derivater som selektive inhibitorer af histondeacetylaser 1 og 2 (HDAC1-2) | |
| DOP2018000066A (es) | Compuestos útiles para inhibir ror-gamma-t | |
| EA201590028A1 (ru) | Ингибиторы гистондеацетилазы и их композиции и способы их применения | |
| HK1220406A1 (zh) | 组蛋白去乙酰酶抑制剂及组合物 | |
| EP3820859C0 (en) | HISTONE DEACETYLASE INHIBITORS | |
| DK3362450T3 (da) | N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose |