EA201590028A1 - Ингибиторы гистондеацетилазы и их композиции и способы их применения - Google Patents

Ингибиторы гистондеацетилазы и их композиции и способы их применения

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Publication number
EA201590028A1
EA201590028A1 EA201590028A EA201590028A EA201590028A1 EA 201590028 A1 EA201590028 A1 EA 201590028A1 EA 201590028 A EA201590028 A EA 201590028A EA 201590028 A EA201590028 A EA 201590028A EA 201590028 A1 EA201590028 A1 EA 201590028A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
compositions
methods
histondeacetylase
hdac
Prior art date
Application number
EA201590028A
Other languages
English (en)
Inventor
Селия Домингез
Кристофер А. Лакхерст
Роланд В. Бурли
Эндрю Дж. Стотт
Перла Бречча
Original Assignee
Схди Фаундейшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Схди Фаундейшн, Инк. filed Critical Схди Фаундейшн, Инк.
Publication of EA201590028A1 publication Critical patent/EA201590028A1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Предусмотрены ингибиторы гистондеацетилазы (HDAC) формулы I, их композиции и способы их применения.
EA201590028A 2012-07-16 2013-07-16 Ингибиторы гистондеацетилазы и их композиции и способы их применения EA201590028A1 (ru)

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TW201245115A (en) 2011-01-24 2012-11-16 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
US9562021B2 (en) 2013-03-14 2017-02-07 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP2968207A4 (en) 2013-03-14 2016-09-28 Chdi Foundation Inc HISTON DEACETYLASE INHIBITORS AND COMPOSITIONS
WO2014159224A1 (en) 2013-03-14 2014-10-02 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
WO2015187542A1 (en) 2014-06-02 2015-12-10 Chdi Foundation Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
KR102078528B1 (ko) 2018-04-18 2020-02-19 성균관대학교산학협력단 신규한 hdac6 억제제를 이용한 치매 또는 인지장애 예방 또는 치료용 약학적 조성물

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US7125871B2 (en) 2000-05-31 2006-10-24 Eli Lilly And Company Excitatory amino acid receptor modulators
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ATE506354T1 (de) * 2003-01-06 2011-05-15 Lilly Co Eli Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
GB0316889D0 (en) 2003-07-18 2003-08-20 Univ London Pharmaceutical agents
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ES2384182T3 (es) 2005-11-01 2012-07-02 Sumitomo Chemical Company, Limited Proceso para la producción de 6,6-dimetil-3-oxabiciclo[3,1,0]hexan-2-ona
US8518979B2 (en) 2007-02-21 2013-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Alpha-halo- and alpha-alkyl-cyclopropylcarboxy compounds and uses thereof
US9096565B2 (en) * 2007-04-09 2015-08-04 Methylgene Inc. Inhibitors of histone deacetylase
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases

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TW201408628A (zh) 2014-03-01
AU2013290417A1 (en) 2015-02-05
MX2015000719A (es) 2015-04-10
CA2878651A1 (en) 2014-01-23
JP2015528009A (ja) 2015-09-24
US20170042892A1 (en) 2017-02-16
PH12015500069A1 (en) 2015-03-16
SG11201500205RA (en) 2015-02-27
US9855267B2 (en) 2018-01-02
WO2014014900A8 (en) 2014-03-27
EP2871955A1 (en) 2015-05-20
KR20150036046A (ko) 2015-04-07
AR091773A1 (es) 2015-02-25
BR112015001135A2 (pt) 2017-06-27
IL236686A0 (en) 2015-02-26
US20150203468A1 (en) 2015-07-23
WO2014014900A1 (en) 2014-01-23

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