KR20180002729A - 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 - Google Patents

히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 Download PDF

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Publication number
KR20180002729A
KR20180002729A KR1020177034461A KR20177034461A KR20180002729A KR 20180002729 A KR20180002729 A KR 20180002729A KR 1020177034461 A KR1020177034461 A KR 1020177034461A KR 20177034461 A KR20177034461 A KR 20177034461A KR 20180002729 A KR20180002729 A KR 20180002729A
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KR
South Korea
Prior art keywords
alkyl
pharmaceutically acceptable
compound
acceptable salt
oxadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020177034461A
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English (en)
Korean (ko)
Inventor
셀리아 도밍게즈
마이클 씨. 메일라드
알란 에프. 호간
데 포엘 아만다 반
앤드류 제이. 스토트
크리스토퍼 에이. 루커스트
엘리자베스 에이. 새빌-스톤즈
그랜트 위샤르트
마이클 월
페를라 브레시아
레베카 이. 쟈비스
Original Assignee
씨에이치디아이 파운데이션, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 씨에이치디아이 파운데이션, 인코포레이티드 filed Critical 씨에이치디아이 파운데이션, 인코포레이티드
Publication of KR20180002729A publication Critical patent/KR20180002729A/ko
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020177034461A 2015-05-07 2016-05-06 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 Withdrawn KR20180002729A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562158363P 2015-05-07 2015-05-07
US62/158,363 2015-05-07
PCT/US2016/031335 WO2016179554A1 (en) 2015-05-07 2016-05-06 Histone deacetylase inhibitors and compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
KR20180002729A true KR20180002729A (ko) 2018-01-08

Family

ID=57218014

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177034461A Withdrawn KR20180002729A (ko) 2015-05-07 2016-05-06 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법

Country Status (11)

Country Link
US (2) US10053434B2 (enExample)
EP (1) EP3291810B1 (enExample)
JP (1) JP6805172B2 (enExample)
KR (1) KR20180002729A (enExample)
CN (1) CN107735088B (enExample)
AU (1) AU2016258188B2 (enExample)
CA (1) CA2984618C (enExample)
EA (1) EA036965B1 (enExample)
IL (1) IL255448B2 (enExample)
MX (1) MX378983B (enExample)
WO (1) WO2016179554A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3291809B1 (en) 2015-05-07 2021-08-25 CHDI Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
US10053434B2 (en) * 2015-05-07 2018-08-21 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
WO2018015447A1 (en) * 2016-07-22 2018-01-25 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CN109627207A (zh) * 2018-12-17 2019-04-16 天津药明康德新药开发有限公司 一种3-(二氟甲氧基)哌啶盐酸盐的制备方法
WO2022174193A1 (en) * 2021-02-15 2022-08-18 The Research Foundation For The State University Of New York Radiolabeled compositions and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1828171B1 (en) 2004-12-10 2014-03-12 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Heterocycle derivatives as histone deacetylase (hdac) inhibitors
KR101781663B1 (ko) 2010-01-13 2017-09-25 템페로 파마슈티칼즈, 인크. 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
US9056843B2 (en) 2011-07-08 2015-06-16 Novartis Ag Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009810A1 (en) 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
WO2013066835A2 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
WO2013066833A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods to inhibit histone deacetylase (hdac) enzymes
ES2606630T3 (es) 2011-11-28 2017-03-24 Novartis Ag Derivados de trifluorometil-oxadiazol novedosos y su uso en el tratamiento de enfermedad
US9822058B2 (en) * 2012-04-05 2017-11-21 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US10053434B2 (en) * 2015-05-07 2018-08-21 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP3291809B1 (en) 2015-05-07 2021-08-25 CHDI Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
MX376585B (es) 2015-07-27 2025-03-07 Chong Kun Dang Pharmaceutical Corp Compuestos derivados de sulfamida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos.
ES2935932T3 (es) 2015-07-27 2023-03-13 Chong Kun Dang Pharmaceutical Corp Compuestos de derivados de 1,3,4-oxadiazolsulfonamida como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos
AU2016303891B2 (en) 2015-08-04 2019-08-01 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
JP6805172B2 (ja) 2020-12-23
EP3291810A4 (en) 2018-11-07
WO2016179554A1 (en) 2016-11-10
JP2018515489A (ja) 2018-06-14
AU2016258188A1 (en) 2017-11-23
IL255448A0 (en) 2017-12-31
BR112017023711A2 (pt) 2018-07-17
AU2016258188B2 (en) 2021-08-26
US10053434B2 (en) 2018-08-21
CN107735088A (zh) 2018-02-23
MX378983B (es) 2025-03-10
CA2984618C (en) 2024-01-09
EP3291810B1 (en) 2022-08-10
CN107735088B (zh) 2021-11-02
MX2017014300A (es) 2018-08-09
IL255448B2 (en) 2023-07-01
EP3291810A1 (en) 2018-03-14
HK1252487A1 (en) 2019-05-24
CA2984618A1 (en) 2016-11-10
EA036965B1 (ru) 2021-01-20
EA201792247A1 (ru) 2018-06-29
US20190202795A1 (en) 2019-07-04
IL255448B1 (en) 2023-03-01
US20160326124A1 (en) 2016-11-10

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Date Code Title Description
PA0105 International application

Patent event date: 20171128

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination