AU2016258188B2 - Histone deacetylase inhibitors and compositions and methods of use thereof - Google Patents

Histone deacetylase inhibitors and compositions and methods of use thereof Download PDF

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Publication number
AU2016258188B2
AU2016258188B2 AU2016258188A AU2016258188A AU2016258188B2 AU 2016258188 B2 AU2016258188 B2 AU 2016258188B2 AU 2016258188 A AU2016258188 A AU 2016258188A AU 2016258188 A AU2016258188 A AU 2016258188A AU 2016258188 B2 AU2016258188 B2 AU 2016258188B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound
mixture
azabicyclo
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AU2016258188A
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English (en)
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AU2016258188A1 (en
Inventor
Perla Breccia
Celia Dominguez
Alan F. HAUGHAN
Rebecca E. Jarvis
Christopher A. LUCKHURST
Michel C. Maillard
Elizabeth A. Saville-Stones
Andrew J. STOTT
Amanda VAN DE POËL
Michael Wall
Grant Wishart
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CHDI Foundation Inc
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CHDI Foundation Inc
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Publication of AU2016258188A1 publication Critical patent/AU2016258188A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AU2016258188A 2015-05-07 2016-05-06 Histone deacetylase inhibitors and compositions and methods of use thereof Active AU2016258188B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562158363P 2015-05-07 2015-05-07
US62/158,363 2015-05-07
PCT/US2016/031335 WO2016179554A1 (en) 2015-05-07 2016-05-06 Histone deacetylase inhibitors and compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2016258188A1 AU2016258188A1 (en) 2017-11-23
AU2016258188B2 true AU2016258188B2 (en) 2021-08-26

Family

ID=57218014

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016258188A Active AU2016258188B2 (en) 2015-05-07 2016-05-06 Histone deacetylase inhibitors and compositions and methods of use thereof

Country Status (11)

Country Link
US (2) US10053434B2 (enExample)
EP (1) EP3291810B1 (enExample)
JP (1) JP6805172B2 (enExample)
KR (1) KR20180002729A (enExample)
CN (1) CN107735088B (enExample)
AU (1) AU2016258188B2 (enExample)
CA (1) CA2984618C (enExample)
EA (1) EA036965B1 (enExample)
IL (1) IL255448B2 (enExample)
MX (1) MX378983B (enExample)
WO (1) WO2016179554A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180002729A (ko) * 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
CA2984621C (en) 2015-05-07 2023-09-26 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
EP3487843A1 (en) * 2016-07-22 2019-05-29 Syngenta Participations AG Microbiocidal oxadiazole derivatives
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CN109627207A (zh) * 2018-12-17 2019-04-16 天津药明康德新药开发有限公司 一种3-(二氟甲氧基)哌啶盐酸盐的制备方法
WO2022174193A1 (en) * 2021-02-15 2022-08-18 The Research Foundation For The State University Of New York Radiolabeled compositions and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013008162A1 (en) * 2011-07-08 2013-01-17 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2590811C (en) 2004-12-10 2013-07-30 Barbara Attenni Heterocycle derivatives as histone deacetylase (hdac) inhibitors
US8901156B2 (en) 2010-01-13 2014-12-02 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013009810A1 (en) 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009830A1 (en) 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
HRP20170928T1 (hr) 2011-08-30 2017-09-22 Chdi Foundation, Inc. Inhibitori kinurenin-3-monooksigenaze, farmaceutski pripravci, i postupci za njihovu upotrebu
WO2013066833A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods to inhibit histone deacetylase (hdac) enzymes
WO2013066835A2 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
AU2012345557A1 (en) * 2011-11-28 2014-06-26 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
SG11201406311UA (en) * 2012-04-05 2014-11-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CA2984621C (en) 2015-05-07 2023-09-26 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
KR20180002729A (ko) * 2015-05-07 2018-01-08 씨에이치디아이 파운데이션, 인코포레이티드 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법
HUE061174T2 (hu) 2015-07-27 2023-05-28 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazol-szulfonamid-származék vegyületek mint hiszton-deacetiláz-6 inhibitorok, és az ilyen vegyületeket tartalmazó gyógyszerkészímény
BR112017027798B1 (pt) 2015-07-27 2023-12-19 Chong Kun Dang Pharmaceutical Corp Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos
CN108137518B (zh) 2015-08-04 2021-08-31 株式会社钟根堂 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑衍生物化合物及包含其的药物组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006408A1 (en) * 2011-07-01 2013-01-10 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013008162A1 (en) * 2011-07-08 2013-01-17 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease

Also Published As

Publication number Publication date
MX378983B (es) 2025-03-10
JP6805172B2 (ja) 2020-12-23
EP3291810A4 (en) 2018-11-07
US10053434B2 (en) 2018-08-21
IL255448B1 (en) 2023-03-01
KR20180002729A (ko) 2018-01-08
EP3291810A1 (en) 2018-03-14
CA2984618C (en) 2024-01-09
EA201792247A1 (ru) 2018-06-29
CN107735088A (zh) 2018-02-23
MX2017014300A (es) 2018-08-09
IL255448B2 (en) 2023-07-01
EA036965B1 (ru) 2021-01-20
WO2016179554A1 (en) 2016-11-10
BR112017023711A2 (pt) 2018-07-17
HK1252487A1 (en) 2019-05-24
CA2984618A1 (en) 2016-11-10
JP2018515489A (ja) 2018-06-14
CN107735088B (zh) 2021-11-02
AU2016258188A1 (en) 2017-11-23
US20160326124A1 (en) 2016-11-10
EP3291810B1 (en) 2022-08-10
IL255448A0 (en) 2017-12-31
US20190202795A1 (en) 2019-07-04

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