MX378404B - Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri. - Google Patents

Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri.

Info

Publication number
MX378404B
MX378404B MX2019007595A MX2019007595A MX378404B MX 378404 B MX378404 B MX 378404B MX 2019007595 A MX2019007595 A MX 2019007595A MX 2019007595 A MX2019007595 A MX 2019007595A MX 378404 B MX378404 B MX 378404B
Authority
MX
Mexico
Prior art keywords
tetraazabicyclo
imaging agents
compounds suitable
chelate compounds
mri imaging
Prior art date
Application number
MX2019007595A
Other languages
English (en)
Other versions
MX2019007595A (es
Inventor
Andreas Richard Meijer
Brian Christopher Bales
Michael James Rishel
Mikkel Jacob Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of MX2019007595A publication Critical patent/MX2019007595A/es
Publication of MX378404B publication Critical patent/MX378404B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención proporciona compuestos de la fórmula (I) que representa un poli-aza-macrociclo con brazos laterales de ácido carboxílico que forman complejo con manganeso como el metal del núcleo. Los complejos son adecuados para usarse como agentes de contraste en la toma de imágenes de resonancia magnética (MRI).
MX2019007595A 2016-12-21 2017-12-21 Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri. MX378404B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437082P 2016-12-21 2016-12-21
PCT/EP2017/084148 WO2018115314A1 (en) 2016-12-21 2017-12-21 Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents

Publications (2)

Publication Number Publication Date
MX2019007595A MX2019007595A (es) 2019-09-09
MX378404B true MX378404B (es) 2025-03-10

Family

ID=60857088

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007595A MX378404B (es) 2016-12-21 2017-12-21 Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri.

Country Status (17)

Country Link
US (1) US10730897B2 (es)
EP (1) EP3558394B1 (es)
JP (1) JP7258753B2 (es)
KR (1) KR102550339B1 (es)
CN (1) CN110290815A (es)
AU (1) AU2017382953B2 (es)
BR (1) BR112019012757A2 (es)
CA (1) CA3048104A1 (es)
DK (1) DK3558394T3 (es)
ES (1) ES2813077T3 (es)
HU (1) HUE050402T2 (es)
LT (1) LT3558394T (es)
MX (1) MX378404B (es)
PL (1) PL3558394T3 (es)
RU (1) RU2769699C2 (es)
WO (1) WO2018115314A1 (es)
ZA (1) ZA201904006B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
EP3728168B1 (en) * 2017-12-20 2022-03-30 General Electric Company Anionic chelate compounds
EP4611824A1 (en) * 2022-10-31 2025-09-10 Yale University Transition metal complexes for mri applications and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE68908185T2 (de) 1988-09-27 1993-11-25 Nycomed Salutar Inc Chelat-zusammensetzung.
ZA929576B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
CN1993357B (zh) 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
NO331773B1 (no) * 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
DK2988756T4 (da) * 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds

Also Published As

Publication number Publication date
JP7258753B2 (ja) 2023-04-17
EP3558394B1 (en) 2020-06-03
PL3558394T3 (pl) 2020-11-16
DK3558394T3 (da) 2020-08-24
LT3558394T (lt) 2020-09-10
ES2813077T3 (es) 2021-03-22
AU2017382953B2 (en) 2021-10-21
RU2019118365A (ru) 2021-01-22
ZA201904006B (en) 2022-04-28
HUE050402T2 (hu) 2020-12-28
AU2017382953A2 (en) 2019-09-12
EP3558394A1 (en) 2019-10-30
NZ754888A (en) 2025-05-02
KR102550339B1 (ko) 2023-07-04
US20200062791A1 (en) 2020-02-27
CA3048104A1 (en) 2018-06-28
WO2018115314A1 (en) 2018-06-28
RU2769699C2 (ru) 2022-04-05
BR112019012757A2 (pt) 2019-11-26
MX2019007595A (es) 2019-09-09
AU2017382953A1 (en) 2019-07-04
RU2019118365A3 (es) 2021-03-09
KR20190098193A (ko) 2019-08-21
US10730897B2 (en) 2020-08-04
CN110290815A (zh) 2019-09-27
JP2020503310A (ja) 2020-01-30

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