MX374852B - Procesos para la preparacion de compuestos de pirimidinilciclopentano - Google Patents
Procesos para la preparacion de compuestos de pirimidinilciclopentanoInfo
- Publication number
- MX374852B MX374852B MX2019006959A MX2019006959A MX374852B MX 374852 B MX374852 B MX 374852B MX 2019006959 A MX2019006959 A MX 2019006959A MX 2019006959 A MX2019006959 A MX 2019006959A MX 374852 B MX374852 B MX 374852B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- sup
- flexible substrate
- wearable
- useful
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- KHXLVDUXFUNEQQ-UHFFFAOYSA-N 2-cyclopentylpyrimidine Chemical class C1CCCC1C1=NC=CC=N1 KHXLVDUXFUNEQQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000758 substrate Substances 0.000 abstract 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso para la preparación de un compuesto de fórmula (I), donde R1 es como se define en la presente, que es útil como un intermediario en la preparación de los compuestos farmacéuticos activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13193030 | 2013-11-15 | ||
| PCT/US2014/065567 WO2015073739A1 (en) | 2013-11-15 | 2014-11-13 | Processes for the preparation of pyrimidinylcyclopentane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006959A MX2019006959A (es) | 2019-08-01 |
| MX374852B true MX374852B (es) | 2025-03-06 |
Family
ID=49582648
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9862689B2 (es) |
| EP (3) | EP3068770B1 (es) |
| JP (4) | JP6374503B2 (es) |
| KR (2) | KR102698200B1 (es) |
| CN (3) | CN105899492B (es) |
| AR (1) | AR098427A1 (es) |
| AU (5) | AU2014348570B2 (es) |
| CA (2) | CA2930870C (es) |
| ES (2) | ES2765511T3 (es) |
| HR (2) | HRP20231100T1 (es) |
| HU (1) | HUE063095T2 (es) |
| IL (3) | IL245636B (es) |
| MX (3) | MX367620B (es) |
| MY (2) | MY174153A (es) |
| NZ (1) | NZ720805A (es) |
| PL (2) | PL3068770T3 (es) |
| RU (1) | RU2702355C1 (es) |
| SG (1) | SG10201901578UA (es) |
| SI (1) | SI3068770T1 (es) |
| WO (1) | WO2015073739A1 (es) |
| ZA (2) | ZA201603434B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2930870C (en) | 2013-11-15 | 2023-09-19 | F. Hoffmann-La Roche Ag | Processes for the preparation of pyrimidinylcyclopentane compounds |
| KR102513869B1 (ko) | 2014-09-26 | 2023-03-23 | 에프. 호프만-라 로슈 아게 | (시클로펜틸[d]피리미딘-4-일)피페라진 화합물의 제조 방법 |
| KR102766096B1 (ko) | 2016-08-10 | 2025-02-12 | 에프. 호프만-라 로슈 아게 | Akt 단백질 키나아제 저해제를 포함하는 약학 조성물 |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| KR100927910B1 (ko) * | 2005-05-24 | 2009-11-19 | 에프. 호프만-라 로슈 아게 | (ｓ)-4-플루오로메틸-다이하이드로-퓨란-2-온의 제조 |
| CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
| KR101527232B1 (ko) * | 2006-07-06 | 2015-06-09 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 억제제로서의 시클로펜타〔ｄ〕피리미딘 |
| UA95641C2 (xx) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US7977078B2 (en) | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
| KR101624753B1 (ko) * | 2008-01-09 | 2016-05-26 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄 |
| KR101624752B1 (ko) * | 2008-01-09 | 2016-05-26 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄 |
| AR070176A1 (es) * | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽 |
| US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
| JP2013528787A (ja) * | 2010-04-16 | 2013-07-11 | ジェネンテック， インコーポレイテッド | Ｐｉ３ｋ／ａｋｔキナーゼ経路インヒビターの効果の予測バイオマーカーとしてのｆｏｘ０３ａ |
| KR20140025434A (ko) * | 2011-04-01 | 2014-03-04 | 제넨테크, 인크. | Akt 억제제 화합물 및 화학요법제의 조합물, 및 사용 방법 |
| MY169029A (en) * | 2012-05-17 | 2019-02-04 | Genentech Inc | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| PL2861583T3 (pl) | 2012-05-17 | 2016-12-30 | Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny | |
| MA37751B1 (fr) * | 2012-05-17 | 2018-08-31 | Genentech Inc | Procédé de préparation de composés d'acides aminés |
| BR112014028589B1 (pt) * | 2012-05-17 | 2022-08-23 | Genentech, Inc. | Ciclopentilpirimidina hidroxilada, seu processo de fabricação e seus intermediários |
| KR20200074252A (ko) * | 2012-05-17 | 2020-06-24 | 제넨테크, 인크. | 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법 |
| CA2930870C (en) | 2013-11-15 | 2023-09-19 | F. Hoffmann-La Roche Ag | Processes for the preparation of pyrimidinylcyclopentane compounds |
| KR102513869B1 (ko) | 2014-09-26 | 2023-03-23 | 에프. 호프만-라 로슈 아게 | (시클로펜틸[d]피리미딘-4-일)피페라진 화합물의 제조 방법 |
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2014
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 KR KR1020227034215A patent/KR102698200B1/ko active Active
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-13 MX MX2019006959A patent/MX374852B/es active IP Right Grant
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 MX MX2020009462A patent/MX385726B/es unknown
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en not_active Ceased
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 HR HRP20192340TT patent/HRP20192340T1/hr unknown
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active Active
- 2014-11-13 CN CN202110168758.6A patent/CN112898210B/zh active Active
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es not_active Application Discontinuation
-
2016
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
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2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
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2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
-
2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
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2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
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2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en not_active Abandoned
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2024
- 2024-08-16 AU AU2024205845A patent/AU2024205845A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |