AR098427A1 - Procesos para la preparación de compuestos pirimidinilciclopentano - Google Patents
Procesos para la preparación de compuestos pirimidinilciclopentanoInfo
- Publication number
- AR098427A1 AR098427A1 ARP140104291A ARP140104291A AR098427A1 AR 098427 A1 AR098427 A1 AR 098427A1 AR P140104291 A ARP140104291 A AR P140104291A AR P140104291 A ARP140104291 A AR P140104291A AR 098427 A1 AR098427 A1 AR 098427A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- metal ion
- list
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Además se reivindican procesos para producir intermediarios y compuestos de fórmula (1) cuando R¹ es hidrógeno. Reivindicación 1: Un proceso para la preparación de un compuesto de la fórmula (1) o las sales de los mismos, que comprende la reacción del acoplamiento de un compuesto de la fórmula (2) con un compuesto de la fórmula (3) caracterizado porque R¹ es un grupo protector de amino seleccionado del listado de bencilo, benciloxicarbonilo (carbobenciloxi, CBZ), 9-fluorenilmetiloxicarbonilo (Fmoc), p-metoxibenciloxicarbonilo, p-nitrobenciloxicarbonilo, terc-butoxicarbonilo (BOC) y trifluoroacetilo; R² es un grupo protector de amino seleccionado del listado de bencilo, benciloxicarbonilo (carbobenciloxi, CBZ), 9-fluorenilmetiloxicarbonilo (Fmoc), p-metoxibenciloxicarbonilo, p-nitrobenciloxicarbonilo, terc-butoxicarbonilo (BOC) y trifluoroacetilo; M es un ión de metal seleccionado del listado de ión de metal alcalino, ión de metal alcalinotérreo y ión de metal de transición. Reivindicación 82: Un compuesto de la fórmula (2) caracterizado porque R¹ y M son lo definido en las reivindicaciones 1 a 5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13193030 | 2013-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098427A1 true AR098427A1 (es) | 2016-05-26 |
Family
ID=49582648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104291A AR098427A1 (es) | 2013-11-15 | 2014-11-14 | Procesos para la preparación de compuestos pirimidinilciclopentano |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9862689B2 (es) |
| EP (3) | EP3068770B1 (es) |
| JP (4) | JP6374503B2 (es) |
| KR (2) | KR102493603B1 (es) |
| CN (3) | CN110590606B (es) |
| AR (1) | AR098427A1 (es) |
| AU (4) | AU2014348570B2 (es) |
| CA (2) | CA3207199A1 (es) |
| ES (2) | ES2957314T3 (es) |
| HK (1) | HK1223102A1 (es) |
| HR (2) | HRP20231100T1 (es) |
| HU (1) | HUE063095T2 (es) |
| IL (3) | IL245636B (es) |
| MX (3) | MX2020009462A (es) |
| MY (2) | MY174153A (es) |
| NZ (1) | NZ720805A (es) |
| PL (2) | PL3656764T3 (es) |
| RU (2) | RU2019130505A (es) |
| SG (1) | SG10201901578UA (es) |
| SI (1) | SI3068770T1 (es) |
| WO (1) | WO2015073739A1 (es) |
| ZA (2) | ZA201603434B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110590606B (zh) * | 2013-11-15 | 2023-02-17 | 豪夫迈·罗氏有限公司 | 用于制备嘧啶基环戊烷化合物的方法 |
| JP6676043B2 (ja) | 2014-09-26 | 2020-04-08 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | （シクロペンチル［ｄ］ピリミジン−４−イル）ピペラジン化合物を調製する方法 |
| JP6875501B2 (ja) | 2016-08-10 | 2021-05-26 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ａｋｔプロテインキナーゼ阻害剤を含む薬学的組成物 |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| MX2007014494A (es) * | 2005-05-24 | 2008-02-11 | Hoffmann La Roche | Preparaciones de (s)-4-fluorometil-dihidro-furan-2-ona. |
| CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
| UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| CA2656618C (en) * | 2006-07-06 | 2014-08-26 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| CN101932564B (zh) * | 2008-01-09 | 2012-12-26 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类 |
| MX2010007546A (es) * | 2008-01-09 | 2010-09-30 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa. |
| AR070176A1 (es) * | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| HUE026181T2 (en) | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽 |
| US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
| MX2012011887A (es) | 2010-04-16 | 2012-11-30 | Genentech Inc | Foxo 3a como biomarcador predictivo para la eficacia del inhibidor de la via de quinasa pi3k/akt. |
| CN103635192B (zh) * | 2011-04-01 | 2017-07-04 | 基因泰克公司 | Akt抑制剂化合物和化疗剂的组合以及使用方法 |
| BR112014028589B1 (pt) | 2012-05-17 | 2022-08-23 | Genentech, Inc. | Ciclopentilpirimidina hidroxilada, seu processo de fabricação e seus intermediários |
| RU2642311C2 (ru) * | 2012-05-17 | 2018-01-24 | Дженентек, Инк. | Способ получения гидроксилированных циклопентапиримидиновых соединений и их солей |
| BR112014028570A2 (pt) | 2012-05-17 | 2018-04-24 | Array Biopharma Inc | processo para fabricação de compostos de ciclopentilpirimidina hidroxilada. |
| KR102125588B1 (ko) * | 2012-05-17 | 2020-06-22 | 제넨테크, 인크. | 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법 |
| SG11201407625WA (en) | 2012-05-17 | 2014-12-30 | Genentech Inc | Process for making amino acid compounds |
| CN110590606B (zh) | 2013-11-15 | 2023-02-17 | 豪夫迈·罗氏有限公司 | 用于制备嘧啶基环戊烷化合物的方法 |
| JP6676043B2 (ja) | 2014-09-26 | 2020-04-08 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | （シクロペンチル［ｄ］ピリミジン−４−イル）ピペラジン化合物を調製する方法 |
-
2014
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active IP Right Grant
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 RU RU2019130505A patent/RU2019130505A/ru unknown
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en active Application Filing
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 CN CN202110168758.6A patent/CN112898210A/zh active Pending
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 MX MX2020009462A patent/MX2020009462A/es unknown
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 KR KR1020227034215A patent/KR20220139440A/ko active IP Right Grant
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es unknown
-
2016
- 2016-05-13 MX MX2019006959A patent/MX2019006959A/es active IP Right Grant
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
- 2016-09-30 HK HK16111431.6A patent/HK1223102A1/zh unknown
-
2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
-
2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
- 2019-12-30 HR HRP20192340TT patent/HRP20192340T1/hr unknown
-
2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
-
2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
-
2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124170T1 (el) | Ενωσεις 1-κυανο-πυρρολιδινης ως αναστολεις usp30 | |
| PH12016501007A1 (en) | Substituted benzamides and methods of use thereof | |
| MX2019010531A (es) | Compuesto peptidico. | |
| MX2015010775A (es) | Benzoxazoles sustituidos y metodos para usarlos. | |
| CL2017002452A1 (es) | Nuevos compuestos bicíclicos | |
| EA030199B9 (ru) | Терапевтически активные соединения и способы их применения | |
| MX2021014531A (es) | Compuestos de aminopurina sustituida, composiciones del mismo, y metodos de tratamiento con los mismos. | |
| AR098427A1 (es) | Procesos para la preparación de compuestos pirimidinilciclopentano | |
| PH12017501539A1 (en) | Disacetoxytubulysin h and analogs thereof | |
| MX2018008095A (es) | Compuestos heterociclicos triciclicos condensados como inhibidores de integrasa del vih. | |
| PH12018502473A1 (en) | Pegylated carfilzomib compounds | |
| EA201692548A1 (ru) | Минеральные аминокислотные комплексы активных веществ | |
| MX2015017156A (es) | Inhibidores de bace. | |
| CL2021000421A1 (es) | Nuevo derivado de amina heterocíclico y composición farmacéutica que lo comprende. | |
| SV2018005702A (es) | Compuestos de 1,3,4-tiadiazol y su uso en el tratamiento del cancer | |
| EA201690924A1 (ru) | Фторфенилпиразольные соединения | |
| MX366678B (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| DOP2019000021A (es) | Derivado de triazolopirazinona útil como un inhibidor de pde1 humana | |
| PH12018500668A1 (en) | Therapeutic compounds and methods of use thereof | |
| EA201690966A1 (ru) | Новое соединение для лечения тяжелой гипогликемии | |
| RU2013119051A (ru) | Тетрапептид и средство, обладающее церебропротекторной и антиамнестической активностями | |
| MX2018015871A (es) | Cenicriviroc purificado e intermedios purificados para fabricar cenicriviroc. | |
| EA201400269A1 (ru) | Способ синтеза соединений 7,8-диметокси -1,3-дигидро-2h-3-бензазепин-2-она и применение в синтезе ивабрадина | |
| PE20211448A1 (es) | Procesos e intermedios para preparar un medicamento | |
| UA123797U (uk) | Похідні бензиліденаніліну як інгібітори тирозинази |