MX368149B - Derivados de imidazo [4, 5-c] piridina y pirrolo [2,3-c] piridina como inhibidores ssao. - Google Patents

Derivados de imidazo [4, 5-c] piridina y pirrolo [2,3-c] piridina como inhibidores ssao.

Info

Publication number
MX368149B
MX368149B MX2015012010A MX2015012010A MX368149B MX 368149 B MX368149 B MX 368149B MX 2015012010 A MX2015012010 A MX 2015012010A MX 2015012010 A MX2015012010 A MX 2015012010A MX 368149 B MX368149 B MX 368149B
Authority
MX
Mexico
Prior art keywords
pyridine
pyrrolo
imidazo
ssao inhibitors
derivatives
Prior art date
Application number
MX2015012010A
Other languages
English (en)
Other versions
MX2015012010A (es
Inventor
Evans David
Espensen Max
Patient Lee
Simpson Iain
Savory Edward
Original Assignee
Proximagen Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proximagen Llc filed Critical Proximagen Llc
Publication of MX2015012010A publication Critical patent/MX2015012010A/es
Publication of MX368149B publication Critical patent/MX368149B/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Los compuestos de fórmula (I) son inhibidores de la acividad de la Amino Oxidasa Sensible a Semicarbazida (SSAO) útiles en el tratamiento de inflamación, una enfermedad inflamatoria, un trastorno inmune o autoinmune, o inhibición del crecimiento del tumor.
MX2015012010A 2013-03-13 2014-03-13 Derivados de imidazo [4, 5-c] piridina y pirrolo [2,3-c] piridina como inhibidores ssao. MX368149B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1304526.5A GB201304526D0 (en) 2013-03-13 2013-03-13 New compounds
PCT/GB2014/050765 WO2014140592A1 (en) 2013-03-13 2014-03-13 Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as ssao inhibitors

Publications (2)

Publication Number Publication Date
MX2015012010A MX2015012010A (es) 2016-04-07
MX368149B true MX368149B (es) 2019-09-20

Family

ID=48189848

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012010A MX368149B (es) 2013-03-13 2014-03-13 Derivados de imidazo [4, 5-c] piridina y pirrolo [2,3-c] piridina como inhibidores ssao.

Country Status (22)

Country Link
US (9) US9428498B2 (es)
EP (1) EP2970260B1 (es)
JP (2) JP6334577B2 (es)
KR (1) KR102187811B1 (es)
CN (1) CN105189494B (es)
AU (1) AU2014229763B2 (es)
BR (1) BR112015022011B1 (es)
CA (1) CA2902121C (es)
DK (1) DK2970260T3 (es)
EA (1) EA034066B1 (es)
ES (1) ES2727977T3 (es)
GB (1) GB201304526D0 (es)
HK (1) HK1214249A1 (es)
HU (1) HUE043456T2 (es)
MX (1) MX368149B (es)
NZ (1) NZ711229A (es)
PL (1) PL2970260T3 (es)
PT (1) PT2970260T (es)
SG (2) SG11201507182TA (es)
TR (1) TR201907590T4 (es)
WO (1) WO2014140592A1 (es)
ZA (1) ZA201506182B (es)

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GB201507048D0 (en) 2015-04-24 2015-06-10 Proximagen Ltd Treatment of pain
AU2016366635A1 (en) 2015-12-07 2018-06-21 Benevolentai Cambridge Limited VAP-1 inhibitors for treating pain
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
US20230190728A1 (en) * 2020-03-26 2023-06-22 Proximagen, Llc New therapeutic uses of compounds

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US9428498B2 (en) 2016-08-30
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