MX363536B - Gel transdermico de progestina/estradiol. - Google Patents
Gel transdermico de progestina/estradiol.Info
- Publication number
- MX363536B MX363536B MX2012006755A MX2012006755A MX363536B MX 363536 B MX363536 B MX 363536B MX 2012006755 A MX2012006755 A MX 2012006755A MX 2012006755 A MX2012006755 A MX 2012006755A MX 363536 B MX363536 B MX 363536B
- Authority
- MX
- Mexico
- Prior art keywords
- nestorone
- estradiol
- women
- transdermal gel
- estradiol transdermal
- Prior art date
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title abstract 2
- 229960005309 estradiol Drugs 0.000 title abstract 2
- 229930182833 estradiol Natural products 0.000 title abstract 2
- CKFBRGLGTWAVLG-GOMYTPFNSA-N elcometrine Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC(=C)[C@](OC(=O)C)(C(C)=O)[C@@]1(C)CC2 CKFBRGLGTWAVLG-GOMYTPFNSA-N 0.000 title 1
- 229950007611 elcometrine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 230000007407 health benefit Effects 0.000 abstract 1
- 238000001794 hormone therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28751409P | 2009-12-17 | 2009-12-17 | |
| PCT/US2010/060941 WO2011084668A1 (en) | 2009-12-17 | 2010-12-17 | Nestorone®/estradiol transdermal gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2012006755A MX2012006755A (es) | 2012-11-23 |
| MX363536B true MX363536B (es) | 2019-03-27 |
Family
ID=43640394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012006755A MX363536B (es) | 2009-12-17 | 2010-12-17 | Gel transdermico de progestina/estradiol. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9682087B2 (enExample) |
| EP (1) | EP2512486B1 (enExample) |
| JP (1) | JP6082249B2 (enExample) |
| KR (2) | KR101928321B1 (enExample) |
| CN (1) | CN102753180A (enExample) |
| AU (1) | AU2010339867B2 (enExample) |
| BR (1) | BR112012014059B1 (enExample) |
| CA (1) | CA2782075C (enExample) |
| ES (1) | ES2641613T3 (enExample) |
| IN (1) | IN2012DN04867A (enExample) |
| MX (1) | MX363536B (enExample) |
| NZ (1) | NZ600907A (enExample) |
| WO (1) | WO2011084668A1 (enExample) |
| ZA (1) | ZA201204267B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| CN102657661A (zh) * | 2012-04-15 | 2012-09-12 | 温州医学院 | Nestorone在制备治疗阿尔茨海默病的药物用途 |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| KR20170040209A (ko) | 2014-07-29 | 2017-04-12 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 경피 크림 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| RU2648470C2 (ru) * | 2016-03-03 | 2018-03-26 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральский государственный медицинский университет Министерства здравоохранения Российской Федерации" (ГБОУ ВПО УГМУ Минздрава России) | Способ оптимизации лечения женщин кардиотропной терапией и заместительной гормональной терапией при эстрогенодефиците с артериальной гипертензией в позднем репродуктивном периоде |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| EP4313318A4 (en) * | 2021-03-30 | 2025-03-26 | Viatris Inc. | LOW-DOSE ESTROGEN TRANSDERMAL SYSTEMS AND METHODS OF PRODUCTION AND USE THEREOF |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2180690T3 (es) | 1990-06-01 | 2003-02-16 | Population Council Inc | Preparacion de composiciones que comprenden st1435 para aplicacion topica. |
| US5198223A (en) | 1990-10-29 | 1993-03-30 | Alza Corporation | Transdermal formulations, methods and devices |
| US5122382A (en) * | 1990-10-29 | 1992-06-16 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
| JPH04342531A (ja) | 1991-05-21 | 1992-11-30 | Sekisui Chem Co Ltd | 経皮吸収製剤 |
| US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| BR112012009306A2 (pt) | 2009-10-19 | 2016-06-07 | Population Coucil Inc | método para regeneração de mielina em um paciente |
-
2010
- 2010-12-17 ES ES10799204.2T patent/ES2641613T3/es active Active
- 2010-12-17 JP JP2012544866A patent/JP6082249B2/ja not_active Expired - Fee Related
- 2010-12-17 CA CA2782075A patent/CA2782075C/en active Active
- 2010-12-17 US US13/515,552 patent/US9682087B2/en not_active Expired - Fee Related
- 2010-12-17 MX MX2012006755A patent/MX363536B/es unknown
- 2010-12-17 IN IN4867DEN2012 patent/IN2012DN04867A/en unknown
- 2010-12-17 WO PCT/US2010/060941 patent/WO2011084668A1/en not_active Ceased
- 2010-12-17 EP EP10799204.2A patent/EP2512486B1/en not_active Not-in-force
- 2010-12-17 KR KR1020187019976A patent/KR101928321B1/ko not_active Expired - Fee Related
- 2010-12-17 KR KR1020127018352A patent/KR20120107492A/ko not_active Ceased
- 2010-12-17 AU AU2010339867A patent/AU2010339867B2/en not_active Ceased
- 2010-12-17 NZ NZ600907A patent/NZ600907A/xx not_active IP Right Cessation
- 2010-12-17 BR BR112012014059-0A patent/BR112012014059B1/pt not_active IP Right Cessation
- 2010-12-17 CN CN201080063837.0A patent/CN102753180A/zh active Pending
-
2012
- 2012-06-11 ZA ZA2012/04267A patent/ZA201204267B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2641613T3 (es) | 2017-11-10 |
| WO2011084668A1 (en) | 2011-07-14 |
| CA2782075A1 (en) | 2011-07-14 |
| EP2512486A1 (en) | 2012-10-24 |
| EP2512486B1 (en) | 2017-06-28 |
| US20130045953A1 (en) | 2013-02-21 |
| IN2012DN04867A (enExample) | 2015-09-25 |
| KR20120107492A (ko) | 2012-10-02 |
| JP6082249B2 (ja) | 2017-02-15 |
| BR112012014059A8 (pt) | 2017-12-26 |
| AU2010339867B2 (en) | 2014-07-24 |
| JP2013514984A (ja) | 2013-05-02 |
| CN102753180A (zh) | 2012-10-24 |
| AU2010339867A1 (en) | 2012-07-19 |
| BR112012014059A2 (pt) | 2016-07-05 |
| BR112012014059B1 (pt) | 2020-03-10 |
| ZA201204267B (en) | 2013-01-31 |
| KR20180084149A (ko) | 2018-07-24 |
| KR101928321B1 (ko) | 2018-12-12 |
| NZ600907A (en) | 2013-11-29 |
| MX2012006755A (es) | 2012-11-23 |
| US9682087B2 (en) | 2017-06-20 |
| CA2782075C (en) | 2015-06-30 |
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