MX360785B - Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor. - Google Patents

Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor.

Info

Publication number
MX360785B
MX360785B MX2016015761A MX2016015761A MX360785B MX 360785 B MX360785 B MX 360785B MX 2016015761 A MX2016015761 A MX 2016015761A MX 2016015761 A MX2016015761 A MX 2016015761A MX 360785 B MX360785 B MX 360785B
Authority
MX
Mexico
Prior art keywords
oxa
compounds
activity against
amide derivatives
against pain
Prior art date
Application number
MX2016015761A
Other languages
English (en)
Other versions
MX2016015761A (es
Inventor
Virgili-Bernado Marina
ALONSO-XALMA Mónica
ALEGRET-MOLINA Carlos
Almansa-Rosales Carmen
Merce-Vidal Ramón
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2016015761A publication Critical patent/MX2016015761A/es
Publication of MX360785B publication Critical patent/MX360785B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se refiere a compuestos con actividad farmacológica dual contra tanto el receptor sigma (s) como el receptor opioide µ. y más particularmente a compuestos de diazaespiroundecano que presentan esta actividad farmacológica, a procesos para preparar tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor. (ver Fórmula) en donde (ver Fórmula) Y es n es 1 o 2; q es 1, 2, 3, 4, 5 o 6; X es un enlace, -C(O)O-, -C(O)NR8-, -C(O) -, -O- o - C(R4R4')- ; R1 es C(O)R5 o S(O)2R5.
MX2016015761A 2014-06-02 2015-06-02 Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor. MX360785B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382208 2014-06-02
PCT/EP2015/001114 WO2015185208A1 (en) 2014-06-02 2015-06-02 Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain

Publications (2)

Publication Number Publication Date
MX2016015761A MX2016015761A (es) 2017-04-10
MX360785B true MX360785B (es) 2018-11-16

Family

ID=50972617

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015761A MX360785B (es) 2014-06-02 2015-06-02 Derivados de amina de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor.

Country Status (11)

Country Link
US (1) US10065971B2 (es)
EP (1) EP3149005B1 (es)
JP (1) JP6516773B2 (es)
CN (1) CN106459083B (es)
AR (1) AR100713A1 (es)
CA (1) CA2949572A1 (es)
ES (1) ES2678770T3 (es)
MX (1) MX360785B (es)
PT (1) PT3149005T (es)
TW (1) TW201615642A (es)
WO (1) WO2015185208A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
MX2017006513A (es) * 2014-11-21 2018-04-11 Esteve Labor Dr Compuestos de tipo 1,9-diazaespiroundecano con actividad multimodal contra el dolor.
PT3365346T (pt) 2015-10-23 2020-03-05 Esteve Pharmaceuticals Sa Compostos de oxa-diazaspiro tendo atividade contra a dor
US10183918B2 (en) * 2015-10-23 2019-01-22 Laboratorios Del Dr. Esteve S.A. Oxa-azaspiro compounds having activity against pain
TN2018000122A1 (en) 2015-11-16 2019-10-04 Esteve Labor Dr Oxadiazaspiro compounds for the treatment of drug abuse and addiction
AR113770A1 (es) 2017-10-17 2020-06-10 Esteve Pharmaceuticals Sa Sales de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaspiro[5.5]undecan-3-ona
EP3858813A4 (en) * 2018-09-27 2022-06-22 Shenzhen Chipscreen Biosciences Co., Ltd. QUINOLONE DERIVATIVE WITH INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY
TW202309006A (zh) * 2021-04-30 2023-03-01 西班牙商塔拉森斯調節公司 作為ｓｉｇｍａ配體的新穎吡啶磺醯胺衍生物、其製備方法及用途，以及包含該吡啶－磺醯胺衍生物的醫藥組成物
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353900A (en) 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
JP5217438B2 (ja) 2005-11-18 2013-06-19 小野薬品工業株式会社 塩基性基を含有する化合物およびその用途
EP1982714A1 (en) * 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) * 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
WO2009098448A1 (en) * 2008-02-06 2009-08-13 Astrazeneca Ab Compounds
AU2012229187B2 (en) 2011-03-14 2016-11-10 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
GB201107985D0 (en) * 2011-05-13 2011-06-29 Astrazeneca Ab Process
WO2013115294A1 (ja) * 2012-01-31 2013-08-08 東レ株式会社 ジアザスピロウレア誘導体及びその医薬用途
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物

Also Published As

Publication number Publication date
ES2678770T3 (es) 2018-08-17
JP2017516817A (ja) 2017-06-22
US10065971B2 (en) 2018-09-04
JP6516773B2 (ja) 2019-05-22
US20170197984A1 (en) 2017-07-13
EP3149005B1 (en) 2018-04-18
CN106459083A (zh) 2017-02-22
TW201615642A (zh) 2016-05-01
WO2015185208A1 (en) 2015-12-10
CA2949572A1 (en) 2015-12-10
MX2016015761A (es) 2017-04-10
AR100713A1 (es) 2016-10-26
PT3149005T (pt) 2018-07-24
CN106459083B (zh) 2019-10-01
EP3149005A1 (en) 2017-04-05

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