MX360684B - Silicato de zirconio microporoso para el tratamiento de la hipercalemia. - Google Patents
Silicato de zirconio microporoso para el tratamiento de la hipercalemia.Info
- Publication number
- MX360684B MX360684B MX2015005104A MX2015005104A MX360684B MX 360684 B MX360684 B MX 360684B MX 2015005104 A MX2015005104 A MX 2015005104A MX 2015005104 A MX2015005104 A MX 2015005104A MX 360684 B MX360684 B MX 360684B
- Authority
- MX
- Mexico
- Prior art keywords
- zirconium silicate
- microporous zirconium
- compositions
- hyperkalemia
- treating hyperkalemia
- Prior art date
Links
- 208000002682 Hyperkalemia Diseases 0.000 title abstract 2
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/006—Baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/02—Processes using inorganic exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/14—Base exchange silicates, e.g. zeolites
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/20—Silicates
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/025—Silicon compounds without C-silicon linkages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00058—Temperature measurement
- B01J2219/00063—Temperature measurement of the reactants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00094—Jackets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00761—Details of the reactor
- B01J2219/00763—Baffles
- B01J2219/00765—Baffles attached to the reactor wall
- B01J2219/00768—Baffles attached to the reactor wall vertical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Geology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Combustion & Propulsion (AREA)
Abstract
La presente invención hace referencia a composiciones de silicato de zirconio microporoso novedosas que se formulan para eliminar toxinas, por ejemplo, iones potasio, del tracto gastrointestinal en una tasa elevada sin provocar efectos colaterales no deseados. Las formulaciones preferidas se diseñan para evitar el aumento del pH de la orina de los pacientes y/o evitar el ingreso posible de partículas en el torrente sanguíneo del paciente. También se describe un método para preparar cristales de ZS-9 de alta pureza que presentan un nivel mejorado de capacidad de intercambio de potasio. Las partículas son particularmente útiles en el tratamiento terapéutico de hipercalemia.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261716956P | 2012-10-22 | 2012-10-22 | |
US201361800182P | 2013-03-15 | 2013-03-15 | |
PCT/US2013/066207 WO2014066407A1 (en) | 2012-10-22 | 2013-10-22 | Microporous zirconium silicate for treating hyperkalemia |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015005104A MX2015005104A (es) | 2015-07-17 |
MX360684B true MX360684B (es) | 2018-11-13 |
Family
ID=50485556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005104A MX360684B (es) | 2012-10-22 | 2013-10-22 | Silicato de zirconio microporoso para el tratamiento de la hipercalemia. |
Country Status (16)
Country | Link |
---|---|
US (2) | US8877255B2 (es) |
EP (1) | EP2882444A4 (es) |
JP (1) | JP6423795B2 (es) |
KR (1) | KR102184602B1 (es) |
CN (1) | CN104797263B (es) |
AR (1) | AR093106A1 (es) |
AU (2) | AU2013334776B2 (es) |
BR (1) | BR112015008962B1 (es) |
CA (1) | CA2891053C (es) |
CL (1) | CL2015001014A1 (es) |
HK (1) | HK1211494A1 (es) |
IL (1) | IL237905A (es) |
MX (1) | MX360684B (es) |
PH (1) | PH12015500849A1 (es) |
WO (1) | WO2014066407A1 (es) |
ZA (1) | ZA201502186B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192737B2 (en) | 2002-03-29 | 2007-03-20 | Xoma Technology Ltd. | Methods and materials for increasing expression of recombinant polypeptides |
PL2673237T3 (pl) | 2011-02-11 | 2019-04-30 | Zs Pharma Inc | Zastosowanie krzemianu cyrkonu do leczenia hiperkaliemii |
US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
JP2015529640A (ja) | 2012-07-11 | 2015-10-08 | ズィーエス・ファーマ,インコーポレーテッド | 高カルシウム血症患者における高カリウム血症の治療のための微多孔性ケイ酸ジルコニウム、および高カリウム血症の治療のための改善されたカルシウム含有組成物 |
US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
WO2014066407A1 (en) | 2012-10-22 | 2014-05-01 | ZS Pharma, Inc. | Microporous zirconium silicate for treating hyperkalemia |
PT2981272T (pt) * | 2013-04-05 | 2023-05-03 | Zs Pharma Inc | Silicato de zircónio microporoso e diuréticos para a redução de potássio e tratamento de doença renal crónica e/ou cardíaca crónica |
US20160038538A1 (en) * | 2013-11-08 | 2016-02-11 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
KR102332954B1 (ko) * | 2013-11-08 | 2021-11-29 | 제트에스 파마, 인코포레이티드 | 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄 |
US9592253B1 (en) * | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
CA3132563A1 (en) | 2019-03-13 | 2020-09-17 | Astrazeneca Ab | Potassium-binding agents for use in hemodialysis patients |
US11577014B2 (en) | 2019-07-09 | 2023-02-14 | Uop Llc | Process for removing strontium ions from bodily fluids using metallate ion exchange compositions |
US11964266B2 (en) | 2019-07-09 | 2024-04-23 | Uop Llc | Process for removing cobalt, lead, cadmium and chromium ions from bodily fluids using metallate ion exchange compositions |
US11484875B2 (en) | 2019-07-09 | 2022-11-01 | Uop Llc | Process for removing mercury ions from bodily fluids using titanium metallate ion exchange compositions |
US12036528B2 (en) | 2020-09-30 | 2024-07-16 | Uop Llc | Process for removing lead ions from boldily fluids using metallate ion exchange compositions |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3329480A (en) | 1963-10-18 | 1967-07-04 | Union Oil Co | Crystalline zircono-silicate zeolites |
US3947279A (en) | 1971-12-23 | 1976-03-30 | Owens-Illinois, Inc. | Thermally crystallizable glasses possessing precision controlled crystallization and flow properties and process of producing same |
US4581141A (en) | 1978-02-27 | 1986-04-08 | Purdue Research Foundation | Dialysis material and method for removing uremic substances |
FR2444005A1 (fr) | 1978-12-15 | 1980-07-11 | Ugine Kuhlmann | Procede industriel de fabrication en semi-continu de zeolithe a |
US4943545A (en) | 1987-06-08 | 1990-07-24 | Mobil Oil Corporation | Activation of zeolites |
US5032556A (en) | 1989-02-21 | 1991-07-16 | Tosoh Corporation | Preparation method for zircon powder |
US5015453A (en) | 1989-04-28 | 1991-05-14 | W. R. Grace & Co.-Conn. | Crystalline group IVA metal-containing molecular sieve compositions |
JP3265344B2 (ja) | 1990-03-16 | 2002-03-11 | 東ソー株式会社 | ジルコン粉末の合成法 |
US5338527A (en) | 1992-08-20 | 1994-08-16 | Uop | Zirconium silicate composition, method of preparation and uses thereof |
US5624652A (en) | 1992-10-28 | 1997-04-29 | Crosfield Limited | Silicas |
US5518707A (en) | 1994-10-24 | 1996-05-21 | Uop | Metallo germanates |
GB9601398D0 (en) | 1996-01-24 | 1996-03-27 | Piper Edwina M | Composition |
IT1283284B1 (it) | 1996-03-21 | 1998-04-16 | Eniricerche Spa | Zeolite ers-10 e procedimento per la sua preparazione |
FR2750893B1 (fr) | 1996-07-12 | 1998-10-30 | Elf Aquitaine | Procede de synthese de zeolithe avec agitation homogene du milieu, dispositif et application |
CA2214495C (en) | 1996-09-25 | 2002-02-05 | Daniel L. Woodard | Hydrated zirconium silicate composition for purification of nucleic acids |
US5891417A (en) | 1997-04-08 | 1999-04-06 | Uop Llc | Zirconium silicate and zirconium germanate molecular sieves and process using the same |
US5888472A (en) | 1997-04-08 | 1999-03-30 | Uop Llc | Zirconium silicate molecular sieves and process using the same |
CA2268888A1 (en) | 1997-05-12 | 1998-11-19 | Itsuki Uehara | Separator for battery and alkali secondary battery using the same |
US6007790A (en) | 1998-08-13 | 1999-12-28 | Uop Llc | Family of microporous indium silicate compositions |
EP1038580B1 (en) | 1999-03-26 | 2005-05-25 | Uop Llc | Ammonium ion adsorption process using zirconium silicate and zirconium germanate molecular sieves |
US6332985B1 (en) | 1999-03-29 | 2001-12-25 | Uop Llc | Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions |
US6099737A (en) | 1999-03-29 | 2000-08-08 | Uop Llc | Process for removing toxins from blood using zirconium metallate or titanium metallate compositions |
US7041274B2 (en) | 1999-10-22 | 2006-05-09 | Intevep, S.A. | Aluminosilicate compositions, preparation and use |
US20020061521A1 (en) | 2000-01-31 | 2002-05-23 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
US6379641B1 (en) | 2000-05-01 | 2002-04-30 | Uop Llc | Microporous rare earth silicates and method of producing same |
US6596254B1 (en) | 2000-06-12 | 2003-07-22 | Sandia Corporation | Niobate-based octahedral molecular sieves |
JP2004502508A (ja) * | 2000-07-12 | 2004-01-29 | ユーオーピー エルエルシー | ジルコニウム又はチタニウム微孔性組成物を用いた体液からの毒素の除去方法 |
AU2002242103A1 (en) | 2001-02-06 | 2002-08-19 | Ash Medical Systems, Inc. | Monovalent-selective cation exchangers as oral sorbent therapy |
US6579460B1 (en) | 2001-03-13 | 2003-06-17 | Uop Llc | Process and composition for removing toxins from bodily fluids |
US6814871B1 (en) | 2001-07-13 | 2004-11-09 | Uop Llc | Process for removing pollutants from aqueous streams |
US6689335B1 (en) | 2002-12-19 | 2004-02-10 | Eastman Kodak Company | Silver ion sequester and release agent |
US6984403B2 (en) | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
CN1894029B (zh) | 2003-12-15 | 2011-05-11 | 旭化成化学株式会社 | 多孔成形物及其生产方法 |
US7854924B2 (en) | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
US8192758B2 (en) | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
US8282960B2 (en) | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
US7556799B2 (en) | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
KR101153035B1 (ko) | 2004-03-30 | 2012-06-11 | 리립사, 인크. | 이온 결합 조성물 |
WO2006071532A1 (en) | 2004-12-28 | 2006-07-06 | Renal Solutions, Inc. | Method of synthesizing zirconium phosphate particles |
WO2006134915A1 (ja) | 2005-06-14 | 2006-12-21 | Asahi Kasei Chemicals Corporation | 水処理装置及び水処理方法 |
KR20080059265A (ko) | 2005-09-30 | 2008-06-26 | 일립사, 인코포레이티드 | 포유동물의 위장관으로부터 칼륨 이온을 선택적으로제거하기 위한 방법 및 조성물 |
CA2624112A1 (en) | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
US8367112B2 (en) | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
WO2007127390A2 (en) | 2006-04-28 | 2007-11-08 | Biolife, L.L.C. | Materials and methods for wound treatment |
WO2008070072A2 (en) | 2006-12-01 | 2008-06-12 | Mutual Pharmaceutical Company, Inc. | Carvedilol forms, compositions, and methods of preparation thereof |
EP2079660B1 (en) | 2007-01-03 | 2017-01-11 | Insilico Co., Ltd. | Coordination polymer crystal with porous metal-organic frameworks and preperation method thereof |
ES2304890B1 (es) | 2007-04-03 | 2009-10-30 | Universidad De Zaragoza | Procedimiento de obtencion de esferas de titanosilicato. |
DE202009018701U1 (de) | 2008-02-26 | 2012-11-21 | Corning Incorporated | Läutermittel für Silikatgläser |
US20100104527A1 (en) | 2008-08-22 | 2010-04-29 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
EP2440210A4 (en) | 2009-06-12 | 2014-01-29 | Meritage Pharma Inc | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES |
US8865121B2 (en) | 2009-06-18 | 2014-10-21 | Basf Se | Organotemplate-free synthetic process for the production of a zeolitic material |
US20120070468A1 (en) | 2010-09-16 | 2012-03-22 | Uop Llc | Removal of toxins from gastrointestinal fluids |
PL2673237T3 (pl) | 2011-02-11 | 2019-04-30 | Zs Pharma Inc | Zastosowanie krzemianu cyrkonu do leczenia hiperkaliemii |
JP5982469B2 (ja) | 2011-04-08 | 2016-08-31 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | アシル化触媒の製造方法 |
US10092688B2 (en) | 2011-05-13 | 2018-10-09 | Laura Jean Robinson | Medicament kit and method of use |
US9527751B2 (en) | 2011-11-11 | 2016-12-27 | Basf Se | Organotemplate-free synthetic process for the production of a zeolitic material of the CHA-type structure |
JP2015510484A (ja) | 2012-02-06 | 2015-04-09 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 有機鋳型を用いない合成からの鉄及び銅含有ゼオライトベータ、及びそのNOxの選択的触媒還元における使用方法 |
US9475041B2 (en) | 2012-04-24 | 2016-10-25 | Basf Se | Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds |
WO2014066407A1 (en) | 2012-10-22 | 2014-05-01 | ZS Pharma, Inc. | Microporous zirconium silicate for treating hyperkalemia |
-
2013
- 2013-10-22 WO PCT/US2013/066207 patent/WO2014066407A1/en active Application Filing
- 2013-10-22 BR BR112015008962-3A patent/BR112015008962B1/pt active IP Right Grant
- 2013-10-22 US US14/060,279 patent/US8877255B2/en active Active
- 2013-10-22 EP EP13849651.8A patent/EP2882444A4/en active Pending
- 2013-10-22 CA CA2891053A patent/CA2891053C/en active Active
- 2013-10-22 AU AU2013334776A patent/AU2013334776B2/en active Active
- 2013-10-22 JP JP2015538141A patent/JP6423795B2/ja active Active
- 2013-10-22 MX MX2015005104A patent/MX360684B/es active IP Right Grant
- 2013-10-22 CN CN201380055238.8A patent/CN104797263B/zh active Active
- 2013-10-22 KR KR1020157012682A patent/KR102184602B1/ko active IP Right Grant
- 2013-10-23 AR ARP130103842A patent/AR093106A1/es not_active Application Discontinuation
-
2015
- 2015-02-20 US US14/628,017 patent/US9913860B2/en active Active
- 2015-03-23 IL IL237905A patent/IL237905A/en active IP Right Grant
- 2015-03-30 ZA ZA2015/02186A patent/ZA201502186B/en unknown
- 2015-04-17 PH PH12015500849A patent/PH12015500849A1/en unknown
- 2015-04-21 CL CL2015001014A patent/CL2015001014A1/es unknown
- 2015-12-17 HK HK15112476.1A patent/HK1211494A1/xx unknown
-
2017
- 2017-10-24 AU AU2017251722A patent/AU2017251722A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2882444A1 (en) | 2015-06-17 |
KR20150074053A (ko) | 2015-07-01 |
AU2017251722A1 (en) | 2017-11-09 |
CN104797263A (zh) | 2015-07-22 |
KR102184602B1 (ko) | 2020-11-30 |
CL2015001014A1 (es) | 2015-08-28 |
JP6423795B2 (ja) | 2018-11-14 |
CA2891053C (en) | 2020-12-01 |
AU2013334776B2 (en) | 2017-08-31 |
MX2015005104A (es) | 2015-07-17 |
CN104797263B (zh) | 2018-02-09 |
US9913860B2 (en) | 2018-03-13 |
ZA201502186B (en) | 2016-01-27 |
PH12015500849B1 (en) | 2015-06-22 |
US20140113002A1 (en) | 2014-04-24 |
JP2016505510A (ja) | 2016-02-25 |
US8877255B2 (en) | 2014-11-04 |
BR112015008962A2 (pt) | 2017-07-04 |
US20150250821A1 (en) | 2015-09-10 |
EP2882444A4 (en) | 2016-03-02 |
AR093106A1 (es) | 2015-05-20 |
AU2013334776A1 (en) | 2015-05-07 |
WO2014066407A1 (en) | 2014-05-01 |
IL237905A (en) | 2017-12-31 |
CA2891053A1 (en) | 2014-05-01 |
PH12015500849A1 (en) | 2015-06-22 |
BR112015008962B1 (pt) | 2021-09-21 |
HK1211494A1 (en) | 2016-05-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2016204124A1 (en) | Microporous zirconium silicate for the treatment of hyperkalemia | |
PH12015500849B1 (en) | Microporous zirconium silicate for treating hyperkalemia | |
PH12016500861A1 (en) | Microporous zirconium silicate for the treatment of hyperkalemia | |
PH12015500071A1 (en) | Microporous zirconium silicate for the treatment of hyperkalemia in hypercalcemic patients and improved calcium-containing compositions for the treatment of hyperkalemia | |
PH12015500274A1 (en) | Alkylpyrimidine derivatives for the treatment of viral infections and further diseases | |
NZ708928A (en) | Mannose derivatives for treating bacterial infections | |
MX2015012866A (es) | Compuestos de piridazinona y metodos para el tratamiento de la fibrosis quistica. | |
UA109991C2 (xx) | Карбаматні сполуки, їх отримання і застосування | |
EA026385B9 (ru) | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов | |
NZ719185A (en) | Crystalline forms of therapeutic compounds and uses thereof | |
EA028156B9 (ru) | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов | |
MX2013004329A (es) | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3. | |
MX2011011083A (es) | Compuestos heterociclicos como inhibidores de mek. | |
PH12016500864A1 (en) | Microporous zirconium silicate for the treatment of hyperkalemia | |
MX2013002118A (es) | 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. | |
MX342459B (es) | 2-oxo- y 2-tioxo-dihidroquinolin-3-carboxamidas sustituidas, como moduladores de kcnq2/3. | |
PH12016501119A1 (en) | Zirconium silicate for treating hyperkalemia without co-administering lithium | |
UA109359C2 (xx) | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
MX2012000680A (es) | Sal de citrato de 9e-15-(2-pirrolidin-1-il-etoxi)-7,12,25-trioxa-1 9,21,24-triaza-tetraciclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2 ,4,9,14,16,18(26),20,22-nonaeno. | |
WO2011085288A3 (en) | Method of administration and treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GD | Licence granted | ||
FG | Grant or registration |