MX359638B - Vacunas basadas en el virus de la parainfluenza 5. - Google Patents

Vacunas basadas en el virus de la parainfluenza 5.

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Publication number
MX359638B
MX359638B MX2014008557A MX2014008557A MX359638B MX 359638 B MX359638 B MX 359638B MX 2014008557 A MX2014008557 A MX 2014008557A MX 2014008557 A MX2014008557 A MX 2014008557A MX 359638 B MX359638 B MX 359638B
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MX
Mexico
Prior art keywords
gene
nucleotide sequence
genome
parainfluenza virus
heterologous nucleotide
Prior art date
Application number
MX2014008557A
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English (en)
Other versions
MX2014008557A (es
Inventor
He Biao
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Univ Georgia
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Publication date
Application filed by Univ Georgia filed Critical Univ Georgia
Publication of MX2014008557A publication Critical patent/MX2014008557A/es
Publication of MX359638B publication Critical patent/MX359638B/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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Abstract

La presente invención se refiere a vacunas seguras, estables, eficaces y económicas basadas en los vectores de expresión viral que incluyen un genoma del virus de la parainfluenza 5 (PIV5) que incluyen una secuencia nucleotídica heteróloga que expresa un polipéptido heterólogo. En algunas modalidades, la secuencia nucleotídica heteróloga se inserta más cerca del líder que entre el gen hemaglutinina-neuraminidasa (HN) y el gen de la proteína (L) ARN polimerasa grande del genoma PIVS. En algunas modalidades, la secuencia nucleotídica heteróloga se inserta entre el gen de la proteína hidrófoba pequeña (SH) y el gen hemaglutinina-neuraminidasa (HN) del genoma PIV5.
MX2014008557A 2012-01-24 2013-01-24 Vacunas basadas en el virus de la parainfluenza 5. MX359638B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261590070P 2012-01-24 2012-01-24
US201261590056P 2012-01-24 2012-01-24
US201261683810P 2012-08-16 2012-08-16
PCT/US2013/022962 WO2013112720A1 (en) 2012-01-24 2013-01-24 Parainfluenza virus 5 based vaccines

Publications (2)

Publication Number Publication Date
MX2014008557A MX2014008557A (es) 2014-10-24
MX359638B true MX359638B (es) 2018-10-04

Family

ID=48873896

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008557A MX359638B (es) 2012-01-24 2013-01-24 Vacunas basadas en el virus de la parainfluenza 5.

Country Status (13)

Country Link
US (6) US9505807B2 (es)
EP (2) EP3536341A1 (es)
JP (3) JP6228136B2 (es)
CN (2) CN108130345A (es)
AU (1) AU2013212097B2 (es)
BR (1) BR112014018179B1 (es)
CA (2) CA2860388C (es)
ES (1) ES2728248T3 (es)
MX (1) MX359638B (es)
MY (1) MY173638A (es)
PH (1) PH12014501255A1 (es)
PT (1) PT2806891T (es)
WO (2) WO2013112720A1 (es)

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CL2018003869A1 (es) * 2018-12-28 2021-01-15 Univ Pontificia Catolica Chile Anticuerpos monoclonales específicos para la proteína quimérica l del virus de la parainfluenza humana (piv), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por piv
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WO2022099185A1 (en) * 2020-11-09 2022-05-12 Thrive Bioscience, Inc. Plaque counting assay method
CN113005149A (zh) * 2021-03-26 2021-06-22 中国农业大学 一种表达冠状病毒受体结合域串联二聚体的重组副流感病毒5型载体
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CN108130345A (zh) 2012-01-24 2018-06-08 乔治亚大学研究基金公司 基于副流感病毒5的疫苗

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