MX359516B - Composiciones y metodos para prevenir o tratar enfermedades, afecciones, o procesos caracterizados por la proliferacion abrellante de fibro blasto y deposicion de matriz extracelular. - Google Patents
Composiciones y metodos para prevenir o tratar enfermedades, afecciones, o procesos caracterizados por la proliferacion abrellante de fibro blasto y deposicion de matriz extracelular.Info
- Publication number
- MX359516B MX359516B MX2013011771A MX2013011771A MX359516B MX 359516 B MX359516 B MX 359516B MX 2013011771 A MX2013011771 A MX 2013011771A MX 2013011771 A MX2013011771 A MX 2013011771A MX 359516 B MX359516 B MX 359516B
- Authority
- MX
- Mexico
- Prior art keywords
- preventing
- methods
- extracellular matrix
- fibroblast proliferation
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a composiciones y métodos para prevenir o tratara una enfermedad, afección o proceso patológico caracterizado por la aberrante proliferación de fibroblasto y la deposición de matriz extracelular en un tejido de un sujeto. El método incluye administrar una cantidad terapéutica de una composición farmacéutica que comprende un polipéptido que tiene la secuencia de aminoácido YAPAAARQARAKALARQLGVAA (SEQ ID NO: 1) o uno de sus equivalentes funcionales, y un portador farmacéuticamente aceptable.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474370P | 2011-04-12 | 2011-04-12 | |
| PCT/US2012/033368 WO2012142320A2 (en) | 2011-04-12 | 2012-04-12 | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013011771A MX2013011771A (es) | 2014-07-30 |
| MX359516B true MX359516B (es) | 2018-10-01 |
Family
ID=47006527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011771A MX359516B (es) | 2011-04-12 | 2012-04-12 | Composiciones y metodos para prevenir o tratar enfermedades, afecciones, o procesos caracterizados por la proliferacion abrellante de fibro blasto y deposicion de matriz extracelular. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9642888B2 (es) |
| EP (1) | EP2696888B1 (es) |
| JP (1) | JP6031510B2 (es) |
| KR (1) | KR101862291B1 (es) |
| CN (3) | CN104302310A (es) |
| AU (1) | AU2012242768B2 (es) |
| BR (1) | BR112013026313A8 (es) |
| CA (2) | CA2832910C (es) |
| DK (1) | DK2696888T3 (es) |
| ES (1) | ES2711670T3 (es) |
| HK (1) | HK1255005A1 (es) |
| MX (1) | MX359516B (es) |
| RU (1) | RU2620066C2 (es) |
| SG (2) | SG194135A1 (es) |
| WO (1) | WO2012142320A2 (es) |
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| PL1976828T3 (pl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4 |
| US8741849B2 (en) | 2007-01-10 | 2014-06-03 | Purdue Research Foundation | Kinase inhibitors and uses thereof |
| EP2155228B1 (en) | 2007-01-10 | 2014-04-02 | Purdue Research Foundation | Polypeptide inhibitors of hsp27 kinase and uses therefor |
| EP2378875B1 (en) * | 2008-12-10 | 2018-05-30 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
| WO2011017132A2 (en) * | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| EP2575855A4 (en) * | 2010-05-24 | 2014-03-12 | Moerae Matrix Inc | METHOD FOR TREATING OR PREVENTING VASCULAR GRAFT BREAKAGE |
| US9890200B2 (en) * | 2011-04-12 | 2018-02-13 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
| EP2696888B1 (en) | 2011-04-12 | 2018-12-05 | Moerae Matrix, Inc., | Compositions and methods for preventing or treating pulmonary fibrosis |
| FR2976587B1 (fr) * | 2011-06-20 | 2015-04-03 | Basf Beauty Care Solutions F | Methode de dosage in vitro par technique immunologique |
| WO2013134636A1 (en) | 2012-03-09 | 2013-09-12 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| CA2884802A1 (en) * | 2012-10-31 | 2014-05-08 | Galecto Biotech Ab | Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis |
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| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| JP6527851B2 (ja) | 2013-03-12 | 2019-06-05 | セルタクシス,インコーポレイテッド | ロイコトリエンa4加水分解酵素を阻害する方法 |
| EP2968264A4 (en) | 2013-03-14 | 2016-11-02 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
| CA2910766C (en) | 2013-04-30 | 2020-12-15 | Otitopic Inc. | Dry powder formulations and methods of use |
| WO2015138784A2 (en) * | 2014-03-14 | 2015-09-17 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating chronic lung allograft dysfunction (clad) and idiopathic pulmonary fibrosis (ipf) |
| US10336788B2 (en) * | 2014-04-17 | 2019-07-02 | Moerae Matrix, Inc. | Inhibition of cardiac fibrosis in myocardial infarction |
| KR20170083063A (ko) * | 2014-11-17 | 2017-07-17 | 모레 매트릭스 인코포레이티드 | 이상 섬유모세포 증식 및 세포외 기질 침착을 특징으로 하는 질병, 질환, 또는 과정의 예방 또는 치료용 조성물 및 방법 |
| BR112017014737A2 (pt) | 2015-01-08 | 2018-01-16 | Moerae Matrix Inc | formulação de peptídeos inibidores de mk2 |
| CN107921082A (zh) * | 2015-03-12 | 2018-04-17 | 莫伊莱麦屈克斯公司 | 含有mk2抑制剂肽的组合物用于治疗非小细胞肺癌的用途 |
| CA3076353A1 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | Dry powder compositions with magnesium stearate |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| CN107987128B (zh) * | 2017-11-17 | 2019-06-11 | 广东医科大学 | 一种功能多肽及其在制备防治肺纤维化药物中的应用 |
| JP7471660B2 (ja) | 2018-05-17 | 2024-04-22 | アクチュエイト セラピューティクス インク. | グリコーゲンシンターゼキナーゼ3型β阻害剤による特発性肺線維症の治療 |
| CA3102077A1 (en) | 2018-05-31 | 2019-12-05 | Sanjeev AHUJA | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN110108883A (zh) * | 2018-10-27 | 2019-08-09 | 广州呼吸健康研究院 | 用于筛选与靶治疗ards患者的msc精准医学的标志物组合 |
| CN109406795A (zh) * | 2018-11-20 | 2019-03-01 | 昆明医科大学 | 一种轻型脑外伤的血清分子诊断标记物及应用 |
| WO2021040673A1 (en) * | 2019-08-26 | 2021-03-04 | Alain Martin | Methods for the treatment of chronic hypoxemia and inhibiting lung fibrosis in patients with pulmonary fibrosis with and without copd |
| USD958124S1 (en) | 2019-12-16 | 2022-07-19 | Samsung Electronics Co., Ltd. | Television receiver |
| USD978094S1 (en) | 2019-12-27 | 2023-02-14 | Samsung Electronics Co., Ltd. | Television receiver |
| WO2021146662A1 (en) * | 2020-01-17 | 2021-07-22 | Muhammed Majeed | Therapeutic compositions and methods for pulmonary fibrosis |
| CN112386682B (zh) * | 2020-02-12 | 2022-12-06 | 王斌 | 纤连蛋白在制备治疗新型冠状病毒肺炎药物中的应用 |
| US20230127499A1 (en) * | 2020-03-30 | 2023-04-27 | Figene, Llc | Peptides and adjuvants for augmentation of fibroblast therapy for coronavirus |
| EP4142751A4 (en) * | 2020-04-01 | 2025-01-08 | Figene, LLC | Fibroblast mediated expansion and augmentation of immune regulatory cells for treatment of acute respiratory distress syndrome (ards) |
| US11505584B2 (en) * | 2020-04-21 | 2022-11-22 | Remodeless Cv Ltd | Therapy for reducing brain damage |
| USD989726S1 (en) | 2020-12-03 | 2023-06-20 | Samsung Electronics Co., Ltd. | Television receiver |
| AU2021390125A1 (en) * | 2020-12-03 | 2023-06-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising anti-connective tissue growth factor antibody |
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-
2012
- 2012-04-12 EP EP12771584.5A patent/EP2696888B1/en not_active Not-in-force
- 2012-04-12 CN CN201280027012.2A patent/CN104302310A/zh active Pending
- 2012-04-12 WO PCT/US2012/033368 patent/WO2012142320A2/en not_active Ceased
- 2012-04-12 JP JP2014505291A patent/JP6031510B2/ja not_active Expired - Fee Related
- 2012-04-12 SG SG2013075031A patent/SG194135A1/en unknown
- 2012-04-12 CA CA2832910A patent/CA2832910C/en not_active Expired - Fee Related
- 2012-04-12 US US13/445,759 patent/US9642888B2/en not_active Expired - Fee Related
- 2012-04-12 BR BR112013026313A patent/BR112013026313A8/pt not_active Application Discontinuation
- 2012-04-12 DK DK12771584.5T patent/DK2696888T3/en active
- 2012-04-12 CA CA3042808A patent/CA3042808A1/en not_active Abandoned
- 2012-04-12 CN CN201711403446.9A patent/CN108014340A/zh active Pending
- 2012-04-12 SG SG10201604560TA patent/SG10201604560TA/en unknown
- 2012-04-12 CN CN201910892185.4A patent/CN111110850A/zh active Pending
- 2012-04-12 AU AU2012242768A patent/AU2012242768B2/en not_active Ceased
- 2012-04-12 ES ES12771584T patent/ES2711670T3/es active Active
- 2012-04-12 KR KR1020137029996A patent/KR101862291B1/ko not_active Expired - Fee Related
- 2012-04-12 MX MX2013011771A patent/MX359516B/es active IP Right Grant
- 2012-04-12 RU RU2013150249A patent/RU2620066C2/ru not_active IP Right Cessation
-
2017
- 2017-04-04 US US15/478,950 patent/US20190022169A1/en not_active Abandoned
-
2018
- 2018-11-06 HK HK18114121.3A patent/HK1255005A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111110850A (zh) | 2020-05-08 |
| DK2696888T3 (en) | 2019-03-25 |
| US9642888B2 (en) | 2017-05-09 |
| CN108014340A (zh) | 2018-05-11 |
| BR112013026313A2 (pt) | 2016-12-27 |
| CA3042808A1 (en) | 2012-10-18 |
| KR101862291B1 (ko) | 2018-05-29 |
| WO2012142320A2 (en) | 2012-10-18 |
| CN104302310A (zh) | 2015-01-21 |
| WO2012142320A3 (en) | 2015-06-11 |
| SG194135A1 (en) | 2013-11-29 |
| CA2832910A1 (en) | 2012-10-18 |
| AU2012242768A1 (en) | 2013-10-24 |
| ES2711670T3 (es) | 2019-05-06 |
| CA2832910C (en) | 2019-07-02 |
| RU2013150249A (ru) | 2015-05-20 |
| EP2696888A4 (en) | 2016-04-20 |
| KR20140063517A (ko) | 2014-05-27 |
| US20190022169A1 (en) | 2019-01-24 |
| WO2012142320A8 (en) | 2014-02-20 |
| AU2012242768B2 (en) | 2017-10-12 |
| JP2014533235A (ja) | 2014-12-11 |
| EP2696888A2 (en) | 2014-02-19 |
| SG10201604560TA (en) | 2016-07-28 |
| JP6031510B2 (ja) | 2016-11-24 |
| MX2013011771A (es) | 2014-07-30 |
| NZ616672A (en) | 2016-04-29 |
| BR112013026313A8 (pt) | 2018-01-30 |
| EP2696888B1 (en) | 2018-12-05 |
| HK1255005A1 (zh) | 2019-08-02 |
| US20120263680A1 (en) | 2012-10-18 |
| RU2620066C2 (ru) | 2017-05-22 |
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