MX357798B - Aparato y método para la criogranulación de una composición farmacéutica. - Google Patents

Aparato y método para la criogranulación de una composición farmacéutica.

Info

Publication number
MX357798B
MX357798B MX2014014383A MX2014014383A MX357798B MX 357798 B MX357798 B MX 357798B MX 2014014383 A MX2014014383 A MX 2014014383A MX 2014014383 A MX2014014383 A MX 2014014383A MX 357798 B MX357798 B MX 357798B
Authority
MX
Mexico
Prior art keywords
pharmaceutical
cryogranulating
fluid medium
substances
dispenser assembly
Prior art date
Application number
MX2014014383A
Other languages
English (en)
Inventor
Michael A White
Edwin Amoro
Karel Vanackere
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX357798B publication Critical patent/MX357798B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La presente invención se refiere a una composición farmacéutica que comprende una pluralidad de gránulos congelados homogéneos que comprenden micropartículas de dicetopiperazina, en donde dicha composición se forma al despachar una solución o una suspensión de la composición farmacéutica por medio de un ensamble despachador dentro de un flujo de un agente de enfriamiento para formar los gránulos congelados, el ensamble despachador que incluye primera y segunda filas de orificios despachadores, las filas de los orificios despachadores están dispuestas perpendicularmente con respecto al flujo del agente de enfriamiento, separar los gránulos congelados del agente de enfriamiento por medio de un ensamble de transporte, y transportar los gránulos congelados a un receptáculo de gránulos, dicha composición farmacéutica caracterizad porque los gránulos congelados homogéneos varían en el diámetro de 3 a 6 mm, en donde el 41% o más de lo gránulos tienen diámetros mayores a 4.75 mm y en donde el 22% o menos de los gránulos tienen diámetros menores que 3.35 mm.
MX2014014383A 2009-11-02 2010-11-02 Aparato y método para la criogranulación de una composición farmacéutica. MX357798B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25738509P 2009-11-02 2009-11-02
PCT/US2010/055085 WO2011053959A1 (en) 2009-11-02 2010-11-02 Apparatus and method for cryogranulating a pharmaceutical composition

Publications (1)

Publication Number Publication Date
MX357798B true MX357798B (es) 2018-07-25

Family

ID=43922628

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014014383A MX357798B (es) 2009-11-02 2010-11-02 Aparato y método para la criogranulación de una composición farmacéutica.
MX2012005090A MX2012005090A (es) 2009-11-02 2010-11-02 Aparato y metodo para la criogranulacion de una composicion farmaceutica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012005090A MX2012005090A (es) 2009-11-02 2010-11-02 Aparato y metodo para la criogranulacion de una composicion farmaceutica.

Country Status (14)

Country Link
US (7) US8590320B2 (es)
EP (2) EP3533517A1 (es)
JP (2) JP5960599B2 (es)
KR (2) KR101931069B1 (es)
CN (2) CN104027312B (es)
AU (1) AU2010313173B2 (es)
BR (1) BR112012011603B8 (es)
CA (3) CA2779613C (es)
HK (2) HK1173647A1 (es)
IL (2) IL219303A0 (es)
MX (2) MX357798B (es)
RU (2) RU2638794C2 (es)
SG (1) SG10201406835XA (es)
WO (1) WO2011053959A1 (es)

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CN110090594A (zh) * 2018-01-30 2019-08-06 徐州市禾协肥业有限公司 一种用于斜面冷却造粒的冷却设备和造粒装置
CN110090598A (zh) * 2018-01-30 2019-08-06 徐州市禾协肥业有限公司 一种肥料料浆液滴固化成型的板式设备
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KR102090895B1 (ko) * 2019-03-02 2020-04-24 조형권 엑스제의 구형과립 제조방법 및 이를 제조하기 위한 엑스제의 구형과립 제조장치
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Also Published As

Publication number Publication date
CA3107195C (en) 2023-02-14
US11077063B2 (en) 2021-08-03
HK1173647A1 (en) 2013-05-24
KR20180011336A (ko) 2018-01-31
EP3533517A1 (en) 2019-09-04
US20240074976A1 (en) 2024-03-07
US10500159B2 (en) 2019-12-10
CN102596238B (zh) 2014-06-18
US20180338920A1 (en) 2018-11-29
US20140044790A1 (en) 2014-02-13
KR20120120154A (ko) 2012-11-01
KR101931069B1 (ko) 2018-12-19
KR101822208B1 (ko) 2018-01-25
CA2976705C (en) 2021-03-16
CA2779613A1 (en) 2011-05-05
CA3107195A1 (en) 2011-05-05
IL238630A (en) 2017-02-28
JP5960599B2 (ja) 2016-08-02
SG10201406835XA (en) 2014-11-27
US20210322320A1 (en) 2021-10-21
JP6228175B2 (ja) 2017-11-08
CN104027312B (zh) 2018-11-02
US20110100028A1 (en) 2011-05-05
US10052285B2 (en) 2018-08-21
JP2016128400A (ja) 2016-07-14
EP2496253B1 (en) 2019-01-09
RU2014145428A (ru) 2015-06-20
JP2013509276A (ja) 2013-03-14
RU2638794C2 (ru) 2017-12-15
US11839688B2 (en) 2023-12-12
US20200069590A1 (en) 2020-03-05
HK1201748A1 (en) 2015-09-11
AU2010313173B2 (en) 2015-02-12
CA2976705A1 (en) 2011-05-05
RU2012118253A (ru) 2013-12-10
CN104027312A (zh) 2014-09-10
IL238630A0 (en) 2015-06-30
CA2779613C (en) 2017-10-10
BR112012011603B1 (pt) 2021-03-30
BR112012011603B8 (pt) 2021-07-27
BR112012011603A2 (pt) 2018-04-17
WO2011053959A1 (en) 2011-05-05
US9566243B2 (en) 2017-02-14
US20170119673A1 (en) 2017-05-04
CN102596238A (zh) 2012-07-18
AU2010313173A1 (en) 2012-05-17
EP2496253A4 (en) 2013-04-03
EP2496253A1 (en) 2012-09-12
IL219303A0 (en) 2012-06-28
US8590320B2 (en) 2013-11-26
MX2012005090A (es) 2012-06-19
RU2563122C2 (ru) 2015-09-20

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