MX352672B - Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. - Google Patents
Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.Info
- Publication number
- MX352672B MX352672B MX2014003642A MX2014003642A MX352672B MX 352672 B MX352672 B MX 352672B MX 2014003642 A MX2014003642 A MX 2014003642A MX 2014003642 A MX2014003642 A MX 2014003642A MX 352672 B MX352672 B MX 352672B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- cancer
- heterocyclic compounds
- mdm2 inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539715P | 2011-09-27 | 2011-09-27 | |
| US201161566449P | 2011-12-02 | 2011-12-02 | |
| PCT/US2012/057389 WO2013049250A1 (fr) | 2011-09-27 | 2012-09-26 | Heterocycles utilises comme inhibiteurs de mdm2 dans le traitement du cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003642A MX2014003642A (es) | 2014-08-26 |
| MX352672B true MX352672B (es) | 2017-12-04 |
Family
ID=47071456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003642A MX352672B (es) | 2011-09-27 | 2012-09-26 | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9376425B2 (fr) |
| EP (1) | EP2760845B1 (fr) |
| JP (1) | JP6093770B2 (fr) |
| AU (1) | AU2012316055B2 (fr) |
| CA (1) | CA2850166C (fr) |
| MX (1) | MX352672B (fr) |
| WO (1) | WO2013049250A1 (fr) |
Families Citing this family (47)
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| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
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| EP2408773A2 (fr) | 2009-03-20 | 2012-01-25 | Amgen, Inc | Inhibiteurs de pi3 kinase |
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| MA39094B1 (fr) | 2013-11-11 | 2020-06-30 | Amgen Inc | Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers |
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2012
- 2012-09-26 MX MX2014003642A patent/MX352672B/es active IP Right Grant
- 2012-09-26 EP EP12775888.6A patent/EP2760845B1/fr active Active
- 2012-09-26 US US14/347,628 patent/US9376425B2/en active Active
- 2012-09-26 JP JP2014533695A patent/JP6093770B2/ja active Active
- 2012-09-26 AU AU2012316055A patent/AU2012316055B2/en active Active
- 2012-09-26 CA CA2850166A patent/CA2850166C/fr active Active
- 2012-09-26 WO PCT/US2012/057389 patent/WO2013049250A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2760845B1 (fr) | 2016-11-16 |
| WO2013049250A1 (fr) | 2013-04-04 |
| AU2012316055A1 (en) | 2014-04-17 |
| US9376425B2 (en) | 2016-06-28 |
| JP2014528002A (ja) | 2014-10-23 |
| CA2850166C (fr) | 2019-12-03 |
| EP2760845A1 (fr) | 2014-08-06 |
| JP6093770B2 (ja) | 2017-03-08 |
| CA2850166A1 (fr) | 2013-04-04 |
| MX2014003642A (es) | 2014-08-26 |
| US20140235629A1 (en) | 2014-08-21 |
| AU2012316055B2 (en) | 2016-05-12 |
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