MX351107B - Acidos nucleicos que se enlazan con mcp-1. - Google Patents

Acidos nucleicos que se enlazan con mcp-1.

Info

Publication number
MX351107B
MX351107B MX2016003546A MX2016003546A MX351107B MX 351107 B MX351107 B MX 351107B MX 2016003546 A MX2016003546 A MX 2016003546A MX 2016003546 A MX2016003546 A MX 2016003546A MX 351107 B MX351107 B MX 351107B
Authority
MX
Mexico
Prior art keywords
nucleic acids
mcp
binding nucleic
type
nucleic
Prior art date
Application number
MX2016003546A
Other languages
English (en)
Inventor
Buchner Klaus
Maasch Christian
Klussmann Sven
Purschke Werner
Jarosch Florian
Eulberg Dirk
Original Assignee
Noxxon Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of MX351107B publication Critical patent/MX351107B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/16—Aptamers
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Abstract

La presente invención se refiere a un ácido nucleico L capaz de enlazarse a MCP-1, en donde el ácido nucleico comprende en dirección 5´->3´una primera extensión Cuadro B1A, una segunda extensión Cuadro B2, y una tercera extensión Cuadro B1B, en la cual la primera extensión Cuadro B1A, comprende una secuencia de nucleótidos seleccionada a partir del grupo que comprende ACGCA, CGCA y GCA, la segunda extensión Cuadro B2 comprende una secuencia de nucleótidos de CSUCCCUCACCGGUGCAAGUGAAGCCGYGGCUC, y la tercera extensión cuadro B1B comprende una secuencia de nucleótidos seleccionada a partir del grupo que comprende UGCGU, UGCG y UGC.
MX2016003546A 2006-02-14 2007-02-14 Acidos nucleicos que se enlazan con mcp-1. MX351107B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06002935 2006-02-14
EP06024202 2006-11-22
PCT/EP2007/001294 WO2007093409A2 (en) 2006-02-14 2007-02-14 Mcp-i binding nucleic acids

Publications (1)

Publication Number Publication Date
MX351107B true MX351107B (es) 2017-10-02

Family

ID=38198593

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011010706A MX337801B (es) 2006-02-14 2007-02-14 Acidos nucleicos que se enlazan on mcp-1.
MX2016003546A MX351107B (es) 2006-02-14 2007-02-14 Acidos nucleicos que se enlazan con mcp-1.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011010706A MX337801B (es) 2006-02-14 2007-02-14 Acidos nucleicos que se enlazan on mcp-1.

Country Status (17)

Country Link
US (4) US8193159B2 (es)
EP (3) EP2135949B1 (es)
JP (1) JP5537812B2 (es)
KR (2) KR101572893B1 (es)
CN (2) CN103275984A (es)
AT (1) ATE510014T1 (es)
AU (1) AU2007214668B2 (es)
BR (1) BRPI0707842B8 (es)
CA (1) CA2638847C (es)
DK (1) DK2135949T3 (es)
ES (1) ES2397803T3 (es)
HK (1) HK1129127A1 (es)
MX (2) MX337801B (es)
PL (1) PL2135949T3 (es)
PT (1) PT2135949E (es)
RU (1) RU2518330C2 (es)
WO (1) WO2007093409A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103275984A (zh) 2006-02-14 2013-09-04 诺松制药股份公司 结合mcp-1的核酸
US8367629B2 (en) 2006-02-14 2013-02-05 Noxxon Pharma Ag MCP-1 binding nucleic acids and use thereof
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
AU2008329070B2 (en) * 2007-11-30 2014-11-20 Noxxon Pharma Ag MCP-I binding nucleic acids and use thereof
WO2009149921A2 (en) * 2008-06-11 2009-12-17 Bionucleon S.R.L. Inhibition of hrp-3 using modified oligonucleotides
WO2010070394A1 (en) * 2008-12-17 2010-06-24 Universite Pierre Et Marie Curie-Paris Vi Modulators of the cx3cr1 receptor and therapeutic uses thereof
WO2012025251A1 (en) * 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
US8465413B2 (en) 2010-11-25 2013-06-18 Coloplast A/S Method of treating Peyronie's disease
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
US20170233737A1 (en) 2013-11-04 2017-08-17 Noxxon Pharma Ag Means and Methods for the Treatment of Nephropathy
WO2021178923A1 (en) 2020-03-06 2021-09-10 Drinksavvy, Inc. Devices and methods for detecting a target analyte of interest
WO2023154452A1 (en) 2022-02-11 2023-08-17 Waypoint Bio, Inc. Cellular staining probes for analyte detection

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6670321B1 (en) * 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
EP1306382A1 (de) 2001-10-26 2003-05-02 Noxxon Pharma AG Modifizierte L-Nukleinsäure
ES2346640T4 (es) * 2001-10-26 2011-04-26 Noxxon Pharma Ag Ácido l-nucleico modificado.
EP1386972A1 (en) * 2002-08-01 2004-02-04 Noxxon Pharma AG Method and apparatus for designing a nucleic acid having a desired property
US7750140B2 (en) * 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
EP1713509A2 (de) 2004-02-09 2006-10-25 Noxxon Pharma AG Verfahren zur herstellung von konjugaten aus polysacchariden und polynukleotiden
US20060030535A1 (en) * 2004-03-05 2006-02-09 Healy Judith M Controlled modulation of the pharmacokinetics and biodistribution of aptamer therapeutics
WO2005108431A1 (en) * 2004-05-04 2005-11-17 University Of Kentucky Research Foundation Methods and compositions for the treatment of ocular neovascularization
CN103275984A (zh) 2006-02-14 2013-09-04 诺松制药股份公司 结合mcp-1的核酸
US8367629B2 (en) * 2006-02-14 2013-02-05 Noxxon Pharma Ag MCP-1 binding nucleic acids and use thereof
US8772257B2 (en) * 2007-08-06 2014-07-08 Noxxon Pharma Ag SDF-1 binding nucleic acids and the use thereof
AU2008329070B2 (en) 2007-11-30 2014-11-20 Noxxon Pharma Ag MCP-I binding nucleic acids and use thereof

Also Published As

Publication number Publication date
CN101415825A (zh) 2009-04-22
CN101415825B (zh) 2013-05-08
KR101572893B1 (ko) 2015-12-02
EP1984501A2 (en) 2008-10-29
JP5537812B2 (ja) 2014-07-02
US8193159B2 (en) 2012-06-05
BRPI0707842B1 (pt) 2021-09-21
CA2638847A1 (en) 2007-08-23
BRPI0707842B8 (pt) 2023-04-18
US10273480B2 (en) 2019-04-30
US20160208262A1 (en) 2016-07-21
CN103275984A (zh) 2013-09-04
RU2518330C2 (ru) 2014-06-10
EP2365080A1 (en) 2011-09-14
AU2007214668B2 (en) 2012-05-24
DK2135949T3 (da) 2013-02-04
ATE510014T1 (de) 2011-06-15
JP2009526532A (ja) 2009-07-23
WO2007093409A8 (en) 2011-01-20
PL2135949T3 (pl) 2013-03-29
WO2007093409A3 (en) 2007-12-13
EP2135949A1 (en) 2009-12-23
BRPI0707842A2 (pt) 2011-05-10
US9670491B2 (en) 2017-06-06
RU2008136907A (ru) 2010-03-20
HK1129127A1 (en) 2009-11-20
US20100284961A1 (en) 2010-11-11
EP1984501B1 (en) 2011-05-18
EP2135949B1 (en) 2012-10-17
KR101475865B1 (ko) 2015-01-02
KR20080105078A (ko) 2008-12-03
ES2397803T3 (es) 2013-03-11
EP2365080B1 (en) 2016-04-13
PT2135949E (pt) 2013-01-07
WO2007093409A2 (en) 2007-08-23
AU2007214668A1 (en) 2007-08-23
KR20130100213A (ko) 2013-09-09
MX337801B (es) 2016-03-18
US20180066265A1 (en) 2018-03-08
CA2638847C (en) 2016-08-09
US20130035376A1 (en) 2013-02-07
US8691784B2 (en) 2014-04-08

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