MX2008013416A - Medios para inhibir la expresion de cd31. - Google Patents

Medios para inhibir la expresion de cd31.

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Publication number
MX2008013416A
MX2008013416A MX2008013416A MX2008013416A MX2008013416A MX 2008013416 A MX2008013416 A MX 2008013416A MX 2008013416 A MX2008013416 A MX 2008013416A MX 2008013416 A MX2008013416 A MX 2008013416A MX 2008013416 A MX2008013416 A MX 2008013416A
Authority
MX
Mexico
Prior art keywords
stretch
nucleotide
seq
nucleic acid
strand
Prior art date
Application number
MX2008013416A
Other languages
English (en)
Inventor
Joerg Kaufmann
Oliver Keil
Ansgar Santel
Original Assignee
Silence Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silence Therapeutics Ag filed Critical Silence Therapeutics Ag
Publication of MX2008013416A publication Critical patent/MX2008013416A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
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Abstract

La presente invención se refiere a una molécula de ácido nucleico que comprende una estructura de hebra doble, caracterizada por que la estructura de hebra doble comprende una primera hebra y una segunda hebra, en donde la primera hebra comprende una primera extensión de nucleótidos contiguos y la primera extensión es al menos parcialmente complementaria con un ácido nucleico objetivo, y en donde la segunda hebra comprende una segunda extensión de nucleótidos contiguos y la segundo extensión es al menos parcialmente complementaria a la primera extensión, en donde la primera extensión comprende una secuencia de ácido nucleico la cual es al menos parcialmente complementaria a una secuencia de centro de nucleótido de la secuencia de ácido nucleico de acuerdo con SEQ. ID. No. 1, en donde la secuencia de centro de nucleótido comprende la secuencia de nucleótidos de las posiciones de nucleótidos 1277 a 1295 de SEQ. ID No. 1; de las posiciones de nucleótidos 2140 a 2158 de SEQ. ID No. 1; de las posiciones de nucleótidos de 2391 a 2409 de SEQ. ID No. 1; y en donde la primera extensión es además al menos parcialmente complementaria a una región que procede del extremo 5' de la secuencia de centro de nucleótido y/o a una región después del extremo 3' de la secuencia de centro de nucleótido.
MX2008013416A 2006-04-20 2007-04-20 Medios para inhibir la expresion de cd31. MX2008013416A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06008208 2006-04-20
PCT/EP2007/003495 WO2007121946A2 (en) 2006-04-20 2007-04-20 Means for inhibiting the expression of cd31

Publications (1)

Publication Number Publication Date
MX2008013416A true MX2008013416A (es) 2008-11-12

Family

ID=38229748

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013416A MX2008013416A (es) 2006-04-20 2007-04-20 Medios para inhibir la expresion de cd31.

Country Status (11)

Country Link
US (1) US20090252783A1 (es)
EP (1) EP2007890A2 (es)
JP (1) JP2009535018A (es)
KR (1) KR20090004984A (es)
CN (1) CN101426915A (es)
AU (1) AU2007241369A1 (es)
BR (1) BRPI0711626A2 (es)
CA (1) CA2649020A1 (es)
MX (1) MX2008013416A (es)
RU (1) RU2008145782A (es)
WO (1) WO2007121946A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
WO2010110314A1 (ja) * 2009-03-27 2010-09-30 協和発酵キリン株式会社 核酸を含有する肺高血圧症治療剤
CA3043768A1 (en) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes for delivery of therapeutic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2474631B1 (en) * 2002-12-20 2014-02-12 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
WO2005105152A2 (en) * 2004-05-05 2005-11-10 Atugen Ag Lipids, lipid complexes and use thereof
KR20070085232A (ko) * 2004-08-20 2007-08-27 더 존스 홉킨스 유니버시티 혈관신생 치료방법

Also Published As

Publication number Publication date
WO2007121946A3 (en) 2008-01-10
EP2007890A2 (en) 2008-12-31
WO2007121946A2 (en) 2007-11-01
JP2009535018A (ja) 2009-10-01
BRPI0711626A2 (pt) 2011-12-06
AU2007241369A1 (en) 2007-11-01
US20090252783A1 (en) 2009-10-08
KR20090004984A (ko) 2009-01-12
CA2649020A1 (en) 2007-11-01
RU2008145782A (ru) 2010-05-27
CN101426915A (zh) 2009-05-06

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