MX350312B - Uso terapeutico de la proteina de union a neurotrofina del receptor neutrofico p75. - Google Patents
Uso terapeutico de la proteina de union a neurotrofina del receptor neutrofico p75.Info
- Publication number
- MX350312B MX350312B MX2014011029A MX2014011029A MX350312B MX 350312 B MX350312 B MX 350312B MX 2014011029 A MX2014011029 A MX 2014011029A MX 2014011029 A MX2014011029 A MX 2014011029A MX 350312 B MX350312 B MX 350312B
- Authority
- MX
- Mexico
- Prior art keywords
- binding protein
- therapeutic use
- neurotrophin binding
- p75ntr
- p75ntr neurotrophin
- Prior art date
Links
- 102000019507 neurotrophin binding proteins Human genes 0.000 title 1
- 108091016216 neurotrophin binding proteins Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 abstract 2
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 1
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Abstract
La presente invención se refiere a una proteína de unión a la neurotrofina p75NTR, p75NTR(NBP), para usarse el tratamiento de dolor, en donde la p75NTR(NBP),se une a cualquiera de NGF, BDNF, NT3 o NT4/5 con una afinidad de unión (Kd) de entre 0.1 nM a 50 nM como se mide por resonancia de plasmón de superficie a 20°C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261610682P | 2012-03-14 | 2012-03-14 | |
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CN102586313A (zh) * | 2012-03-05 | 2012-07-18 | 中国人民解放军第三军医大学野战外科研究所 | p75NTR-ED-Fc融合蛋白的制备方法及其在损伤中枢神经再生与功能恢复中的应用 |
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GB201316592D0 (en) | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
GB201412748D0 (en) | 2014-07-17 | 2014-09-03 | Levicept Ltd | Therapeutic use of P75NTR neurotrophin binding protein |
GB201504691D0 (en) | 2015-03-19 | 2015-05-06 | Levicept Ltd | Fusion protein |
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