MX350258B - Emulsiones cationicas de aceite en agua. - Google Patents

Emulsiones cationicas de aceite en agua.

Info

Publication number
MX350258B
MX350258B MX2014000040A MX2014000040A MX350258B MX 350258 B MX350258 B MX 350258B MX 2014000040 A MX2014000040 A MX 2014000040A MX 2014000040 A MX2014000040 A MX 2014000040A MX 350258 B MX350258 B MX 350258B
Authority
MX
Mexico
Prior art keywords
cationic
water emulsions
cationic oil
nucleic acid
negatively charged
Prior art date
Application number
MX2014000040A
Other languages
English (en)
Spanish (es)
Other versions
MX2014000040A (es
Inventor
Brito Luis
Chan Michelle
Geall Andrew
O'hagan Derek
Singh Manmohan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014000040A publication Critical patent/MX2014000040A/es
Publication of MX350258B publication Critical patent/MX350258B/es

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    • A—HUMAN NECESSITIES
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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MX2014000040A 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua. MX350258B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161505109P 2011-07-06 2011-07-06
US201161545936P 2011-10-11 2011-10-11
US201261585641P 2012-01-11 2012-01-11
PCT/US2012/045845 WO2013006837A1 (en) 2011-07-06 2012-07-06 Cationic oil-in-water emulsions

Publications (2)

Publication Number Publication Date
MX2014000040A MX2014000040A (es) 2014-02-27
MX350258B true MX350258B (es) 2017-08-31

Family

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MX2014000040A MX350258B (es) 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua.

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US (3) US9636410B2 (enExample)
EP (2) EP2729124B1 (enExample)
JP (2) JP6120839B2 (enExample)
CN (1) CN103796639B (enExample)
AU (2) AU2012280904B2 (enExample)
BR (1) BR112014000235A8 (enExample)
CA (1) CA2840965C (enExample)
ES (1) ES2702318T3 (enExample)
MX (1) MX350258B (enExample)
RU (1) RU2649133C2 (enExample)
SG (1) SG10201605500TA (enExample)
WO (1) WO2013006837A1 (enExample)

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PT3243526T (pt) 2010-07-06 2020-03-04 Glaxosmithkline Biologicals Sa Distribuição de arn para despoletar múltiplas vias imunitárias
US10487332B2 (en) 2010-07-06 2019-11-26 Glaxosmithkline Biologicals Sa Immunisation of large mammals with low doses of RNA
CN103153284B (zh) 2010-07-06 2015-11-25 诺华股份有限公司 含有其pKa值有利于RNA递送的脂质的脂质体
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP5911870B2 (ja) 2010-08-31 2016-04-27 ノバルティス アーゲー 免疫原をコードするｒｎａの送達のためのｐｅｇ化リポソーム
EP2857499A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
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US9636410B2 (en) 2017-05-02
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RU2014104094A (ru) 2015-08-20
US20170202960A1 (en) 2017-07-20
ES2702318T3 (es) 2019-02-28
EP2729124B1 (en) 2018-10-24
JP2016210792A (ja) 2016-12-15
US11167028B2 (en) 2021-11-09
US10183074B2 (en) 2019-01-22
RU2649133C2 (ru) 2018-03-29
BR112014000235A2 (pt) 2017-02-14
EP2729124A1 (en) 2014-05-14
EP3456316A1 (en) 2019-03-20
US20140220083A1 (en) 2014-08-07
AU2017203342A1 (en) 2017-06-08
AU2012280904B2 (en) 2017-02-23
CA2840965A1 (en) 2013-01-10
MX2014000040A (es) 2014-02-27
CN103796639B (zh) 2017-05-31
CN103796639A (zh) 2014-05-14
JP6120839B2 (ja) 2017-04-26
US20190091329A1 (en) 2019-03-28
JP2014522841A (ja) 2014-09-08
WO2013006837A1 (en) 2013-01-10
BR112014000235A8 (pt) 2018-03-06

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