MX350258B - Emulsiones cationicas de aceite en agua. - Google Patents

Emulsiones cationicas de aceite en agua.

Info

Publication number
MX350258B
MX350258B MX2014000040A MX2014000040A MX350258B MX 350258 B MX350258 B MX 350258B MX 2014000040 A MX2014000040 A MX 2014000040A MX 2014000040 A MX2014000040 A MX 2014000040A MX 350258 B MX350258 B MX 350258B
Authority
MX
Mexico
Prior art keywords
cationic
water emulsions
cationic oil
nucleic acid
negatively charged
Prior art date
Application number
MX2014000040A
Other languages
English (en)
Spanish (es)
Other versions
MX2014000040A (es
Inventor
Brito Luis
Chan Michelle
Geall Andrew
O'hagan Derek
Singh Manmohan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014000040A publication Critical patent/MX2014000040A/es
Publication of MX350258B publication Critical patent/MX350258B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K47/02—Inorganic compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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MX2014000040A 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua. MX350258B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161505109P 2011-07-06 2011-07-06
US201161545936P 2011-10-11 2011-10-11
US201261585641P 2012-01-11 2012-01-11
PCT/US2012/045845 WO2013006837A1 (en) 2011-07-06 2012-07-06 Cationic oil-in-water emulsions

Publications (2)

Publication Number Publication Date
MX2014000040A MX2014000040A (es) 2014-02-27
MX350258B true MX350258B (es) 2017-08-31

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MX2014000040A MX350258B (es) 2011-07-06 2012-07-06 Emulsiones cationicas de aceite en agua.

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US (3) US9636410B2 (enExample)
EP (2) EP3456316A1 (enExample)
JP (2) JP6120839B2 (enExample)
CN (1) CN103796639B (enExample)
AU (2) AU2012280904B2 (enExample)
BR (1) BR112014000235A8 (enExample)
CA (1) CA2840965C (enExample)
ES (1) ES2702318T3 (enExample)
MX (1) MX350258B (enExample)
RU (1) RU2649133C2 (enExample)
SG (1) SG10201605500TA (enExample)
WO (1) WO2013006837A1 (enExample)

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BR112013000244A2 (pt) 2010-07-06 2016-05-17 Novartis Ag lipossomas com lipídeos apresentando pka vantajoso para administração de rna
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RS63315B1 (sr) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa Pegilovani lipozomi za isporuku rnk koja kodira imunogen
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US20140206753A1 (en) 2011-06-08 2014-07-24 Shire Human Genetic Therapies, Inc. Lipid nanoparticle compositions and methods for mrna delivery
US9655845B2 (en) 2011-07-06 2017-05-23 Glaxosmithkline Biologicals, S.A. Oil-in-water emulsions that contain nucleic acids
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CN103796639B (zh) 2017-05-31
BR112014000235A2 (pt) 2017-02-14
CA2840965A1 (en) 2013-01-10
RU2014104094A (ru) 2015-08-20
US20170202960A1 (en) 2017-07-20
JP6120839B2 (ja) 2017-04-26
MX2014000040A (es) 2014-02-27
SG10201605500TA (en) 2016-08-30
EP2729124B1 (en) 2018-10-24
US10183074B2 (en) 2019-01-22
US9636410B2 (en) 2017-05-02
EP2729124A1 (en) 2014-05-14
BR112014000235A8 (pt) 2018-03-06
RU2649133C2 (ru) 2018-03-29
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CN103796639A (zh) 2014-05-14
US20190091329A1 (en) 2019-03-28
US11167028B2 (en) 2021-11-09
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