MX350087B - Metodos para vigilar la capacidad de respuesta a la terapia anti-smad7. - Google Patents
Metodos para vigilar la capacidad de respuesta a la terapia anti-smad7.Info
- Publication number
- MX350087B MX350087B MX2014003295A MX2014003295A MX350087B MX 350087 B MX350087 B MX 350087B MX 2014003295 A MX2014003295 A MX 2014003295A MX 2014003295 A MX2014003295 A MX 2014003295A MX 350087 B MX350087 B MX 350087B
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- methods
- smad7 therapy
- ccr9
- monitoring responsiveness
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 230000004043 responsiveness Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 7
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 abstract 3
- 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 abstract 3
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 abstract 3
- 102100027581 Forkhead box protein P3 Human genes 0.000 abstract 2
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 abstract 2
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 abstract 2
- 102100037850 Interferon gamma Human genes 0.000 abstract 2
- 108010074328 Interferon-gamma Proteins 0.000 abstract 2
- 102100033461 Interleukin-17A Human genes 0.000 abstract 2
- 238000002965 ELISA Methods 0.000 abstract 1
- 238000000684 flow cytometry Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Virology (AREA)
- Ecology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11425234 | 2011-09-15 | ||
| US201161576556P | 2011-12-16 | 2011-12-16 | |
| PCT/EP2012/068146 WO2013037970A1 (en) | 2011-09-15 | 2012-09-14 | Methods for monitoring responsiveness to anti-smad7 therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003295A MX2014003295A (es) | 2014-05-28 |
| MX350087B true MX350087B (es) | 2017-08-24 |
Family
ID=47882658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003295A MX350087B (es) | 2011-09-15 | 2012-09-14 | Metodos para vigilar la capacidad de respuesta a la terapia anti-smad7. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9791442B2 (https=) |
| EP (2) | EP3165929A3 (https=) |
| JP (1) | JP6389122B2 (https=) |
| KR (1) | KR102099990B1 (https=) |
| CN (1) | CN104040349B (https=) |
| AU (1) | AU2012307336B2 (https=) |
| CA (1) | CA2848595A1 (https=) |
| ES (1) | ES2617200T3 (https=) |
| MX (1) | MX350087B (https=) |
| RU (1) | RU2678450C2 (https=) |
| WO (1) | WO2013037970A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RU2593939C2 (ru) | 2008-11-13 | 2016-08-10 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| CN107252492A (zh) | 2012-04-18 | 2017-10-17 | 诺格尔制药有限公司 | 治疗糖尿病和/或促进胰岛移植后存活的方法 |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| AU2014229985B2 (en) * | 2013-03-15 | 2018-12-13 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| US20160139123A1 (en) * | 2013-07-12 | 2016-05-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Shear Wave Imaging Method and Installation for Collecting Information on a Soft Solid |
| AU2015257589A1 (en) * | 2014-05-09 | 2016-11-24 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| EP3213070A2 (en) * | 2014-10-17 | 2017-09-06 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| MA41271A (fr) * | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| EP3329276A2 (en) * | 2015-07-27 | 2018-06-06 | H. Hoffnabb-La Roche Ag | Methods for diagnosing and treating inflammatory bowel disease |
| CA3000569A1 (en) * | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| WO2017059225A1 (en) * | 2015-09-30 | 2017-04-06 | Celgene Corporation | Tlr modulators and methods of use |
| EP3420082A4 (en) | 2016-02-23 | 2019-10-16 | Celgene Alpine Investment Company II, LLC | METHOD FOR THE TREATMENT OF DARM FIBROSIS USING SMAD7 INHIBITION |
| US10517889B2 (en) | 2017-09-08 | 2019-12-31 | Ionis Pharmaceuticals, Inc. | Modulators of SMAD7 expression |
| US11619832B2 (en) | 2018-03-08 | 2023-04-04 | Coopervision International Limited | Identification of contact lens wearers predisposed to contact lens discomfort |
| CN110082538B (zh) * | 2019-04-19 | 2021-12-03 | 中山大学附属第六医院 | CCR9+IL-17+Treg细胞在制备用于检测NEC的试剂盒中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159697A (en) * | 2000-01-19 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad7 expression |
| RU2185627C2 (ru) * | 2000-09-11 | 2002-07-20 | Новосибирская государственная медицинская академия | Способ определения чувствительности (восприимчивости) к внутривенной лазеротерапии больных ишемической болезнью сердца |
| EP1456380B1 (en) | 2001-11-02 | 2012-04-18 | Giuliani International Limited | Smad7 inhibitors for the treatment of cns diseases |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| US20090275496A1 (en) | 2004-05-07 | 2009-11-05 | Peptimmune, Inc. | Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods |
| EP1913387B1 (en) * | 2005-08-02 | 2016-01-20 | Centenary Institute of Cancer Medicine & Cell Biology | Method for identifying regulatory t cells |
| EP2122018A4 (en) * | 2006-03-10 | 2010-04-07 | Mount Sinai Hospital Corp | DIAGNOSTIC COMPOSITIONS AND TREATMENT METHODS FOR SUFFERING WITH TROPHOBLAST CELL DEOD, DIFFERENTIATION, INVASION, AND / OR CELL FUSION AND TURNOVER |
| EP2167647A2 (en) * | 2007-06-13 | 2010-03-31 | La Jolla Institute For Allergy And Immunology | Regulatory t cells and methods of making and using same |
| CN101960021A (zh) * | 2008-02-28 | 2011-01-26 | 希森美康株式会社 | 产生il-17的辅助t细胞检测用标记及产生il-17的辅助t细胞的检测方法 |
| JP2010051307A (ja) | 2008-07-28 | 2010-03-11 | Eisai R & D Management Co Ltd | Ｔｈ１７細胞およびＴｒｅｇ細胞の分化誘導を調節する物質のスクリーニング方法 |
| RU2593939C2 (ru) | 2008-11-13 | 2016-08-10 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| CN102483405B (zh) | 2009-07-10 | 2015-12-02 | 特朗斯吉有限公司 | 用于选择患者的生物标志物及相关方法 |
| US8766034B2 (en) | 2010-09-22 | 2014-07-01 | Cedars-Sinai Medical Center | TL1A model of inflammation fibrosis and autoimmunity |
| CN107252492A (zh) | 2012-04-18 | 2017-10-17 | 诺格尔制药有限公司 | 治疗糖尿病和/或促进胰岛移植后存活的方法 |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| AU2014229985B2 (en) | 2013-03-15 | 2018-12-13 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| AU2015257589A1 (en) | 2014-05-09 | 2016-11-24 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| EP3213070A2 (en) | 2014-10-17 | 2017-09-06 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| CA3000569A1 (en) | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
-
2012
- 2012-09-14 JP JP2014530245A patent/JP6389122B2/ja not_active Expired - Fee Related
- 2012-09-14 WO PCT/EP2012/068146 patent/WO2013037970A1/en not_active Ceased
- 2012-09-14 ES ES12759150.1T patent/ES2617200T3/es active Active
- 2012-09-14 MX MX2014003295A patent/MX350087B/es active IP Right Grant
- 2012-09-14 AU AU2012307336A patent/AU2012307336B2/en not_active Ceased
- 2012-09-14 US US14/344,969 patent/US9791442B2/en not_active Expired - Fee Related
- 2012-09-14 EP EP16184629.0A patent/EP3165929A3/en not_active Ceased
- 2012-09-14 EP EP12759150.1A patent/EP2748611B1/en not_active Not-in-force
- 2012-09-14 RU RU2014114838A patent/RU2678450C2/ru not_active IP Right Cessation
- 2012-09-14 CA CA2848595A patent/CA2848595A1/en not_active Abandoned
- 2012-09-14 KR KR1020147009572A patent/KR102099990B1/ko not_active Expired - Fee Related
- 2012-09-14 CN CN201280056296.8A patent/CN104040349B/zh not_active Expired - Fee Related
-
2017
- 2017-09-15 US US15/705,715 patent/US20180128829A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ719884A (en) | 2020-02-28 |
| EP2748611B1 (en) | 2016-11-23 |
| NZ622067A (en) | 2016-05-27 |
| JP2014531584A (ja) | 2014-11-27 |
| US9791442B2 (en) | 2017-10-17 |
| CA2848595A1 (en) | 2013-03-21 |
| EP3165929A2 (en) | 2017-05-10 |
| EP2748611A1 (en) | 2014-07-02 |
| WO2013037970A1 (en) | 2013-03-21 |
| CN104040349A (zh) | 2014-09-10 |
| US20150148245A1 (en) | 2015-05-28 |
| MX2014003295A (es) | 2014-05-28 |
| AU2012307336B2 (en) | 2017-08-24 |
| EP3165929A3 (en) | 2017-06-21 |
| AU2012307336A1 (en) | 2014-03-27 |
| HK1199095A1 (en) | 2015-06-19 |
| RU2014114838A (ru) | 2015-10-20 |
| KR20140059859A (ko) | 2014-05-16 |
| KR102099990B1 (ko) | 2020-04-13 |
| CN104040349B (zh) | 2017-07-04 |
| ES2617200T3 (es) | 2017-06-15 |
| US20180128829A1 (en) | 2018-05-10 |
| JP6389122B2 (ja) | 2018-09-12 |
| RU2678450C2 (ru) | 2019-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FG | Grant or registration |