MX349697B - Nuevo derivado de fenilpiridina y farmaco que contiene el mismo. - Google Patents

Nuevo derivado de fenilpiridina y farmaco que contiene el mismo.

Info

Publication number
MX349697B
MX349697B MX2013010553A MX2013010553A MX349697B MX 349697 B MX349697 B MX 349697B MX 2013010553 A MX2013010553 A MX 2013010553A MX 2013010553 A MX2013010553 A MX 2013010553A MX 349697 B MX349697 B MX 349697B
Authority
MX
Mexico
Prior art keywords
ring
alkyl group
general formula
phenylpiridine
pharmaco
Prior art date
Application number
MX2013010553A
Other languages
English (en)
Other versions
MX2013010553A (es
Inventor
Ohgiya Tadaaki
Miura Toru
Sato Seiichi
Yamada Hajime
Tagashira Junya
Watanabe Toshiaki
Sekimoto Ryohei
Ishida Rie
Aoki Hitomi
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of MX2013010553A publication Critical patent/MX2013010553A/es
Publication of MX349697B publication Critical patent/MX349697B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona: un compuesto representado por la siguiente fórmula general (1), que tiene el antagonista de receptor de la angiotensina II y un efecto de activación de PPAR? y que es útil como un agente preventivo y/o terapéutico para la presión arterial alta, enfermedades cardíacas, arteriosclerosis, diabetes tipo 2, y similares; y una composición de fármaco que contiene el compuesto. La fórmula general (I) (en la fórmula: el anillo A representa un anillo de piridina; el anillo B representa un anillo de tetrazol o un anillo de oxadiazol-5(4H)-ona; X representa C-R5 o un átomo de nitrógeno; R1 representa un grupo alquilo; R2 representa un grupo alquilo o un grupo cicloalquilo; y R3, R4, y R5 cada uno independientemente representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo, un grupo alcoxi o similares (Ver Formulas).
MX2013010553A 2011-03-14 2012-03-13 Nuevo derivado de fenilpiridina y farmaco que contiene el mismo. MX349697B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011055691 2011-03-14
PCT/JP2012/001709 WO2012124311A1 (ja) 2011-03-14 2012-03-13 新規なフェニルピリジン誘導体及びこれを含有する医薬

Publications (2)

Publication Number Publication Date
MX2013010553A MX2013010553A (es) 2013-10-28
MX349697B true MX349697B (es) 2017-08-09

Family

ID=46830402

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010553A MX349697B (es) 2011-03-14 2012-03-13 Nuevo derivado de fenilpiridina y farmaco que contiene el mismo.

Country Status (22)

Country Link
US (1) US9315493B2 (es)
EP (1) EP2687523B1 (es)
JP (1) JP5583841B2 (es)
KR (1) KR101559307B1 (es)
CN (1) CN103459380B (es)
AU (1) AU2012227763B2 (es)
BR (1) BR112013023038B1 (es)
CA (1) CA2830043C (es)
CY (1) CY1117348T1 (es)
DK (1) DK2687523T3 (es)
EA (1) EA026694B1 (es)
ES (1) ES2562994T3 (es)
HU (1) HUE028252T2 (es)
MX (1) MX349697B (es)
PH (1) PH12013501857A1 (es)
PL (1) PL2687523T3 (es)
PT (1) PT2687523E (es)
RS (1) RS54666B1 (es)
SG (1) SG193477A1 (es)
TW (1) TWI525088B (es)
WO (1) WO2012124311A1 (es)
ZA (1) ZA201307333B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103690955B (zh) * 2013-12-27 2016-04-20 福州乾正药业有限公司 含有替格瑞洛的药物组合物及其制备方法和药物应用
WO2019117291A1 (ja) * 2017-12-14 2019-06-20 興和株式会社 医薬組成物
CN115138481B (zh) * 2022-07-06 2024-01-26 中南大学 一种将方铅矿、闪锌矿中的至少一种矿物与辉钼矿浮选分离的药剂和方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331165A (en) * 1976-09-03 1978-03-24 Iseki Kaihatsu Koki Continuous specific gravity meter
JPS5779456A (en) * 1980-11-06 1982-05-18 Fujitsu Ltd Voltage readout system by electron beam
JPS6211845A (ja) * 1985-07-10 1987-01-20 Sharp Corp 複写装置
US5472967A (en) 1991-02-20 1995-12-05 Synthelabo 4-pyrimidinone derivatives their preparation and their application in therapy
CN1079223A (zh) * 1991-05-16 1993-12-08 格拉克索公司 苯并呋喃衍生物
JPH06211845A (ja) 1991-05-16 1994-08-02 Glaxo Group Ltd ベンゾフラン誘導体
IL102183A (en) 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
US5212177A (en) 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
JPH07179456A (ja) 1993-12-21 1995-07-18 Nkk Corp アルキルベンゾフラン誘導体及びアンジオテンシンｉｉ拮抗剤
IT1273790B (it) 1994-02-18 1997-07-10 Guidotti & C Spa Labor Derivati eterociclici diazotati aventi attivita' aii antagonista
JP2010510962A (ja) 2006-11-24 2010-04-08 武田薬品工業株式会社 複素単環化合物およびその用途
CN101589037A (zh) * 2006-11-24 2009-11-25 武田药品工业株式会社 杂单环化合物及其用途
US20100029710A1 (en) 2006-12-21 2010-02-04 Pfizer Products Inc. COMPOUNDS HAVING BOTH ANGIOTENSIN II RECEPTOR ANTAGONISM AND PPARy ACTIVATING ACTIVITIES
KR101126383B1 (ko) 2007-02-07 2012-04-12 교와 핫꼬 기린 가부시키가이샤 3환계 화합물
WO2008096820A1 (ja) 2007-02-07 2008-08-14 Kyowa Hakko Kirin Co., Ltd. ビフェニル誘導体
EP2151440A4 (en) 2007-05-21 2010-10-20 Takeda Pharmaceutical Heterocyclic compound and use thereof
EP2399917A1 (en) 2009-02-23 2011-12-28 Kowa Company, Ltd. Novel compounds comprising a 3-(5-alkoxypyrimidin-2-yl) pyrimidin-4(3h)-one structure and drugs that comprise same
JPWO2010119700A1 (ja) 2009-04-17 2012-10-22 興和株式会社 新規な３−ヘテロアリールピリミジン−４−（３ｈ）−オン構造を有する化合物及びこれを含有する医薬
TWI500611B (zh) 2009-09-29 2015-09-21 Kowa Co 新穎苯基吡啶衍生物及含有該衍生物之醫藥

Also Published As

Publication number Publication date
SG193477A1 (en) 2013-10-30
CN103459380A (zh) 2013-12-18
CN103459380B (zh) 2015-07-15
EA201391314A1 (ru) 2014-02-28
JP5583841B2 (ja) 2014-09-03
EA026694B1 (ru) 2017-05-31
PH12013501857A1 (en) 2013-10-14
HUE028252T2 (en) 2016-12-28
TW201245180A (en) 2012-11-16
EP2687523A1 (en) 2014-01-22
TWI525088B (zh) 2016-03-11
WO2012124311A8 (ja) 2013-05-10
EP2687523A4 (en) 2014-11-12
AU2012227763A2 (en) 2013-11-14
ES2562994T3 (es) 2016-03-09
CA2830043C (en) 2018-06-05
RS54666B1 (sr) 2016-08-31
DK2687523T3 (en) 2016-03-14
MX2013010553A (es) 2013-10-28
BR112013023038A2 (pt) 2016-12-13
CY1117348T1 (el) 2017-04-26
JPWO2012124311A1 (ja) 2014-07-17
KR20140008431A (ko) 2014-01-21
EP2687523B1 (en) 2016-01-06
NZ616158A (en) 2015-07-31
PL2687523T3 (pl) 2016-06-30
AU2012227763A8 (en) 2013-11-21
ZA201307333B (en) 2015-01-28
BR112013023038B1 (pt) 2019-09-03
US20140011823A1 (en) 2014-01-09
HK1189232A1 (en) 2014-05-30
WO2012124311A1 (ja) 2012-09-20
PT2687523E (pt) 2016-03-31
CA2830043A1 (en) 2012-09-20
AU2012227763B2 (en) 2016-01-14
AU2012227763A1 (en) 2013-10-24
KR101559307B1 (ko) 2015-10-12
US9315493B2 (en) 2016-04-19

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