MX349464B - Hidroxiapatita intrinsecamente magnetica. - Google Patents

Hidroxiapatita intrinsecamente magnetica.

Info

Publication number
MX349464B
MX349464B MX2013001169A MX2013001169A MX349464B MX 349464 B MX349464 B MX 349464B MX 2013001169 A MX2013001169 A MX 2013001169A MX 2013001169 A MX2013001169 A MX 2013001169A MX 349464 B MX349464 B MX 349464B
Authority
MX
Mexico
Prior art keywords
hydroxyapatite
magnetic
ions
drugs
crystal lattice
Prior art date
Application number
MX2013001169A
Other languages
English (en)
Other versions
MX2013001169A (es
Inventor
Pressato Daniele
Tampieri Anna
Landi Elena
Sandri Monica
Rivas Rey José
Banobre López Manuel
Marcacci Maurilio
Original Assignee
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche
Publication of MX2013001169A publication Critical patent/MX2013001169A/es
Publication of MX349464B publication Critical patent/MX349464B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/322—Preparation by neutralisation of orthophosphoric acid
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/45—Phosphates containing plural metal, or metal and ammonium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/62—Submicrometer sized, i.e. from 0.1-1 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/60—Optical properties, e.g. expressed in CIELAB-values
    • C01P2006/62—L* (lightness axis)
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/60—Optical properties, e.g. expressed in CIELAB-values
    • C01P2006/64—Optical properties, e.g. expressed in CIELAB-values b* (yellow-blue axis)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Dental Preparations (AREA)

Abstract

La presente invención se refiere a hidroxiapatita contaminada con iones Fe2+ y iones Fe3+ que sustituyen parcialmente los iones calcio en la red cristalina. La hidroxiapatita se caracteriza por un magnetismo intrínseco de 0.05 a 8 emu/g, medido por la aplicación de un campo magnético de 34 Oe, debido a la presencia de nano-dominios magnéticos en la red cristalina de HA, dada la cantidad limitada de fases secundarias magnéticas presentes, menor a aproximadamente 3% en volumen. La hidroxiapatita intrínsecamente magnética puede cargarse con sustancias biológicas seleccionadas del grupo que consiste de proteínas, genes, células madre, factores de crecimiento, factores de vascularización, sustancias activas y fármacos, bajo el control de un campo magnético externo, como un portador y agente de liberación para sustancias biológicas o fármacos, como un agente de contraste en el diagnóstico o para regeneración de huesos u osteocartílagos.
MX2013001169A 2010-07-29 2011-07-28 Hidroxiapatita intrinsecamente magnetica. MX349464B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2010A001420A IT1401487B1 (it) 2010-07-29 2010-07-29 Idrossiapatite intrinsecamente magnetica
PCT/IB2011/053362 WO2012014172A1 (en) 2010-07-29 2011-07-28 Intrinsically magnetic hydroxyapatite

Publications (2)

Publication Number Publication Date
MX2013001169A MX2013001169A (es) 2013-06-28
MX349464B true MX349464B (es) 2017-07-31

Family

ID=43629403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001169A MX349464B (es) 2010-07-29 2011-07-28 Hidroxiapatita intrinsecamente magnetica.

Country Status (17)

Country Link
US (1) US9327027B2 (es)
EP (1) EP2598437B1 (es)
JP (1) JP5822927B2 (es)
KR (1) KR101854380B1 (es)
CN (1) CN103038161B (es)
AU (1) AU2011284364B2 (es)
BR (1) BR112013002030B1 (es)
CA (1) CA2806680C (es)
DK (1) DK2598437T3 (es)
ES (1) ES2630169T3 (es)
IL (1) IL224432A (es)
IT (1) IT1401487B1 (es)
MX (1) MX349464B (es)
NZ (1) NZ607003A (es)
SG (1) SG188186A1 (es)
WO (1) WO2012014172A1 (es)
ZA (1) ZA201301272B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011056815A1 (de) * 2011-12-21 2013-08-01 Chemische Fabrik Budenheim Kg Nährstoffzusammensetzung für biologische Systeme
US9353137B2 (en) * 2014-02-07 2016-05-31 Ghassem Amoabediny Method for separation and purification of phosphatidylcholine employing magnetic nanoparticles and compositions so produced
EP3157590B1 (en) 2014-06-19 2020-04-15 Consiglio Nazionale Delle Ricerche (C.N.R.) Injectable apatitic cement ionically multi-substituted for regenerative vertebroplasty and kyphoplasty
US10314772B2 (en) * 2014-07-02 2019-06-11 Universidade Catolica Portuguesa UV-filters, method of producing the same and their use in compositions, in particular sunscreens
EP3166648A4 (en) * 2014-07-08 2018-05-30 University of Maryland, Baltimore Compositions and delivery methods for treating dental infections, inflammation, sensitivity, and for use in dental restorations
RU2607743C1 (ru) * 2015-09-22 2017-01-10 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения катионзамещенного трикальцийфосфата
WO2017096342A1 (en) * 2015-12-03 2017-06-08 Amrita Vishwa Vidyapeetham Radio-wave responsive doped nanoparticles for image-guided therapeutics
ITUA20161416A1 (it) * 2016-03-07 2017-09-07 Consiglio Nazionale Ricerche Filtro solare fisico costituito da idrossiapatite sostituita in una matrice organica
KR101818852B1 (ko) 2016-05-03 2018-01-16 성균관대학교산학협력단 자성의 베타 삼인산칼슘 구형 입자의 제조 방법 및 이에 의해 제작된 자성의 베타 삼인산칼슘 구형 입자
CN105923617B (zh) * 2016-05-11 2018-01-09 中国科学院上海硅酸盐研究所 一种柱状磁性羟基磷灰石纳米材料及其制备方法
CN106430137B (zh) * 2016-09-27 2018-07-13 哈尔滨理工大学 一种球形纳米羟基磷灰石颗粒的制备方法
KR101927196B1 (ko) * 2016-10-26 2018-12-11 전남대학교 산학협력단 자기구동 관절연골 재생 시스템
CN106853264A (zh) * 2016-11-10 2017-06-16 南京市口腔医院 超顺磁性纳米纤维膜支架材料、制备方法和应用
IT201700022625A1 (it) * 2017-02-28 2018-08-28 Consiglio Nazionale Ricerche Filtro per lo scambio di calore e umidità per applicazione in campo medicale e procedimento per la sua produzione
AU2018399962A1 (en) 2018-01-02 2020-07-30 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
CN111330089B (zh) * 2020-03-04 2021-08-03 西南交通大学 一种用作骨修复的全降解磁修复水凝胶的制备方法
KR20230114474A (ko) 2022-01-25 2023-08-01 부산대학교 산학협력단 철 이온과 스트론튬 이온이 동시 도핑된 베타-제삼인산칼슘의 제조방법

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IL98744A0 (en) * 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
US5344640A (en) 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
US7485282B2 (en) * 2004-03-26 2009-02-03 Board Of Trustees Of Michigan State University Method for the preparation of metal oxides in nanometric particle form
WO2007124511A2 (en) * 2006-04-25 2007-11-01 Washington State University Resorbable ceramics with controlled strength loss rates
TWI375567B (en) * 2007-09-19 2012-11-01 Univ Nat Taiwan One kind of nanometer-scaled magnetic hydroxyapatite particle and its manufacturing method
CN101759170B (zh) 2009-12-23 2011-07-06 天津大学 磁性纳米片状羟基磷灰石及其制备方法和应用

Also Published As

Publication number Publication date
BR112013002030A2 (pt) 2017-09-19
AU2011284364B2 (en) 2014-01-23
CA2806680A1 (en) 2012-02-02
US9327027B2 (en) 2016-05-03
SG188186A1 (en) 2013-04-30
MX2013001169A (es) 2013-06-28
CN103038161B (zh) 2016-08-10
RU2013109226A (ru) 2014-09-10
ZA201301272B (en) 2014-04-30
NZ607003A (en) 2014-09-26
US20130129634A1 (en) 2013-05-23
KR20140009968A (ko) 2014-01-23
IL224432A (en) 2016-03-31
ITMI20101420A1 (it) 2012-01-30
IT1401487B1 (it) 2013-07-26
CA2806680C (en) 2018-09-04
KR101854380B1 (ko) 2018-05-28
BR112013002030B1 (pt) 2020-04-28
ES2630169T3 (es) 2017-08-18
JP5822927B2 (ja) 2015-11-25
JP2013538775A (ja) 2013-10-17
CN103038161A (zh) 2013-04-10
EP2598437B1 (en) 2017-04-05
AU2011284364A1 (en) 2013-03-07
WO2012014172A1 (en) 2012-02-02
EP2598437A1 (en) 2013-06-05
DK2598437T3 (en) 2017-07-17

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