JP5822927B2 - 本質的に磁性を有するハイドロキシアパタイト - Google Patents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2430/00—Materials or treatment for tissue regeneration
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Description
a)Fe(II)およびFe(III)イオンを有する溶液を、Ca(II)イオンを有する懸濁液/溶液に添加する工程。
b)工程a)の懸濁液を15〜80℃に加熱する工程。
c)工程a)の懸濁液/溶液にリン酸イオンの溶液を添加する工程。
d)母液から沈殿物を分離させる工程。
の骨結合性のスピードに影響を与え得る。前記影響は、治療過程で困難が見つかった場所で、必要とするだけ、個々の患者に応じて、成長および血管新生因子を増量させることにより、与えられる。外部磁場を作用させることにより、前記因子を増量することが可能で、それにより本発明の粒子を、骨または軟骨の再生が極めて困難であるという部位にガイドし得る。
前述した一般的な合成方法を維持しながら、1つの合成方法では、Fe3+イオン源としてFeCl3を単独で添加し、それらをFe2+イオンに部分的に還元し、Fe3+/Fe2+の比率が約3となるようにする。
前述した一般的な合成方法を維持しながら、他の合成方法では、Fe2+イオン源としてFeCl2を単独で添加した。後者は、反応条件下でFe3+イオンに自然酸化された。
Fe3+:Fe2+=1:1の比率となるように、水酸化カルシウムの懸濁液にFeCl2およびFeCl3を同時に加えた。
物理化学性および磁性の特徴
インビトロテスト
ハイドロキシアパタイトであり、バルク段階で表面に構築され、HA自身に磁性を生じさせるよう調整する。
Claims (22)
- 結晶格子内にカルシウムイオンおよびリン酸イオンを有するハイドロキシアパタイトであって、
Fe2+イオンおよびFe3+イオンがドープされ、Fe3+/Fe2+のモル比1〜4で、前記結晶格子内の前記カルシウムイオンが部分的に置換され、
前記ハイドロキシアパタイトの格子内における磁性ナノドメインの存在に起因する磁場34 Oeを作用し測定される磁化は0.05〜8emu/gで、
3vol%未満の2次磁気位相を有することを特徴とする、ハイドロキシアパタイト。 - 請求項1に記載のハイドロキシアパタイトであって、
磁場34 Oeを作用して表示される前記磁化が0.1〜5emu/gであることを特徴とする、ハイドロキシアパタイト。 - 請求項1または2に記載のハイドロキシアパタイトであって、
前記Fe3+/Fe2+のモル比が2〜3.5であることを特徴とする、ハイドロキシアパタイト。 - 請求項1〜3の何れかに記載のハイドロキシアパタイトであって、
2次磁気位相の量が2vol%以下であるハイドロキシアパタイト。 - 請求項1〜4の何れかに記載のハイドロキシアパタイトであって、
(Fe+Ca)/Pのモル比が1.5〜1.9であるハイドロキシアパタイト。 - 請求項1〜5の何れかに記載のハイドロキシアパタイトであって、
幅5〜30nm、長さ最大80〜150nmのナノ粒子の形状、または、前記ナノ粒子の塊/顆粒の形状を有する、ハイドロキシアパタイト。 - 請求項6に記載のハイドロキシアパタイトであって、
前記ナノ粒子が2〜5nmの球形ボイドを有することを特徴とする、ハイドロキシアパタイト。 - 請求項1〜7の何れかに記載のハイドロキシアパタイトであって、
蛋白質、遺伝子、幹細胞、成長因子、血管新生因子からなる群から選択する生物学的物質を搭載する、または、抗癌剤、抗生物質または医薬品を搭載するハイドロキシアパタイト。 - 請求項1〜8の何れかに記載のハイドロキシアパタイトを有する、生体模倣用骨または骨軟骨代替品。
- 請求項1〜8の何れかに記載のハイドロキシアパタイト、または、請求項9に記載の生体模倣用骨または骨軟骨代替品であって、
医療用または診断に用いるハイドロキシアパタイト、または、生体模倣用骨または骨軟骨代替品。 - 請求項10に記載のハイドロキシアパタイトであって、
生物学的物質または医薬品を運搬し、放出するハイドロキシアパタイト。 - 請求項10に記載のハイドロキシアパタイトであって、
診断用の造影剤として使用するハイドロキシアパタイト。 - 骨または骨軟骨を再生する、請求項10に記載の生体模倣用骨または骨軟骨代替品。
- 請求項1〜7の何れかに記載のハイドロキシアパタイトを準備する方法であって、
a)Fe(II)イオンおよびFe(III)イオンを有する溶液を、Ca(II)イオンを有する懸濁液/溶液に添加する工程と、
b)工程a)の懸濁液/溶液にリン酸イオンの溶液を添加する工程と、
c)工程b)の懸濁液/溶液を15〜80℃に加熱する工程と、
d)母液から沈殿物を分離させる工程と、を有する方法。 - 請求項14に記載の方法であって、
前記工程c)において、前記工程b)の懸濁液/溶液を25〜60℃に加熱することを特徴とする方法。 - 請求項14または請求項15に記載の方法であって、
前記リン酸イオンの溶液を、Ca(II)イオンおよび鉄イオンを有する懸濁液/溶液に、1〜3時間添加することを特徴とする方法。 - 請求項16に記載の方法であって、
前記懸濁液/溶液を加熱し、撹拌しながら前記リン酸イオンの溶液を添加することを特徴とする方法。 - 請求項14〜17の何れかに記載の方法であって、
前記リン酸イオンを添加した後、鉄イオンの溶液を更に添加し、カルシウムイオンに対する鉄イオンの量を調製し、Fe/Caのモル比を5〜30mol%とすることを特徴とする方法。 - 請求項18に記載の方法であって、
前記Fe/Caのモル比を10〜20mol%とすることを特徴とする方法。 - 請求項14〜19の何れかに記載の方法であって、
前記Fe(II)イオンおよび前記Fe(III)イオンが、各々、FeCl2およびFeCl3由来であることを特徴とする方法。 - 請求項14〜20の何れかに記載の方法であって、
前記Ca(II)イオンが、水酸化カルシウム、硝酸カルシウム、酢酸カルシウム、炭酸カルシウム、および/または、他のカルシウム塩由来であることを特徴とする方法。 - 請求項14〜21の何れかに記載の方法であって、
前記リン酸イオンがリン酸および/またはその可溶性塩由来であることを特徴とする方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A001420A IT1401487B1 (it) | 2010-07-29 | 2010-07-29 | Idrossiapatite intrinsecamente magnetica |
ITMI2010A001420 | 2010-07-29 | ||
PCT/IB2011/053362 WO2012014172A1 (en) | 2010-07-29 | 2011-07-28 | Intrinsically magnetic hydroxyapatite |
Publications (2)
Publication Number | Publication Date |
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JP2013538775A JP2013538775A (ja) | 2013-10-17 |
JP5822927B2 true JP5822927B2 (ja) | 2015-11-25 |
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JP2013521278A Active JP5822927B2 (ja) | 2010-07-29 | 2011-07-28 | 本質的に磁性を有するハイドロキシアパタイト |
Country Status (17)
Country | Link |
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US (1) | US9327027B2 (ja) |
EP (1) | EP2598437B1 (ja) |
JP (1) | JP5822927B2 (ja) |
KR (1) | KR101854380B1 (ja) |
CN (1) | CN103038161B (ja) |
AU (1) | AU2011284364B2 (ja) |
BR (1) | BR112013002030B1 (ja) |
CA (1) | CA2806680C (ja) |
DK (1) | DK2598437T3 (ja) |
ES (1) | ES2630169T3 (ja) |
IL (1) | IL224432A (ja) |
IT (1) | IT1401487B1 (ja) |
MX (1) | MX349464B (ja) |
NZ (1) | NZ607003A (ja) |
SG (1) | SG188186A1 (ja) |
WO (1) | WO2012014172A1 (ja) |
ZA (1) | ZA201301272B (ja) |
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DE102011056815A1 (de) * | 2011-12-21 | 2013-08-01 | Chemische Fabrik Budenheim Kg | Nährstoffzusammensetzung für biologische Systeme |
US9353137B2 (en) * | 2014-02-07 | 2016-05-31 | Ghassem Amoabediny | Method for separation and purification of phosphatidylcholine employing magnetic nanoparticles and compositions so produced |
WO2015193836A1 (en) | 2014-06-19 | 2015-12-23 | Consiglio Nazionale Delle Ricerche (Cnr) | Injectable apatitic cement ionically multi-substituted for regenerative vertebroplasty and kyphoplasty |
WO2016001871A1 (en) * | 2014-07-02 | 2016-01-07 | Universidade Católica Portuguesa | Uv-filters, method of producing the same and their use in compositions, in particular sunscreens |
RU2607743C1 (ru) * | 2015-09-22 | 2017-01-10 | Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) | Способ получения катионзамещенного трикальцийфосфата |
EP3383264A4 (en) * | 2015-12-03 | 2019-08-14 | Amrita Vishwa Vidyapeetham | RADIO WAVE SENSITIVE NANOPARTICLES FOR IMAGE GUIDED THERAPY |
ITUA20161416A1 (it) * | 2016-03-07 | 2017-09-07 | Consiglio Nazionale Ricerche | Filtro solare fisico costituito da idrossiapatite sostituita in una matrice organica |
KR101818852B1 (ko) | 2016-05-03 | 2018-01-16 | 성균관대학교산학협력단 | 자성의 베타 삼인산칼슘 구형 입자의 제조 방법 및 이에 의해 제작된 자성의 베타 삼인산칼슘 구형 입자 |
CN105923617B (zh) * | 2016-05-11 | 2018-01-09 | 中国科学院上海硅酸盐研究所 | 一种柱状磁性羟基磷灰石纳米材料及其制备方法 |
CN106430137B (zh) * | 2016-09-27 | 2018-07-13 | 哈尔滨理工大学 | 一种球形纳米羟基磷灰石颗粒的制备方法 |
KR101927196B1 (ko) * | 2016-10-26 | 2018-12-11 | 전남대학교 산학협력단 | 자기구동 관절연골 재생 시스템 |
CN106853264A (zh) * | 2016-11-10 | 2017-06-16 | 南京市口腔医院 | 超顺磁性纳米纤维膜支架材料、制备方法和应用 |
IT201700022625A1 (it) * | 2017-02-28 | 2018-08-28 | Consiglio Nazionale Ricerche | Filtro per lo scambio di calore e umidità per applicazione in campo medicale e procedimento per la sua produzione |
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CN111330089B (zh) * | 2020-03-04 | 2021-08-03 | 西南交通大学 | 一种用作骨修复的全降解磁修复水凝胶的制备方法 |
KR20230114474A (ko) | 2022-01-25 | 2023-08-01 | 부산대학교 산학협력단 | 철 이온과 스트론튬 이온이 동시 도핑된 베타-제삼인산칼슘의 제조방법 |
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WO2007124511A2 (en) * | 2006-04-25 | 2007-11-01 | Washington State University | Resorbable ceramics with controlled strength loss rates |
TWI375567B (en) * | 2007-09-19 | 2012-11-01 | Univ Nat Taiwan | One kind of nanometer-scaled magnetic hydroxyapatite particle and its manufacturing method |
CN101759170B (zh) * | 2009-12-23 | 2011-07-06 | 天津大学 | 磁性纳米片状羟基磷灰石及其制备方法和应用 |
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ITMI20101420A1 (it) | 2012-01-30 |
US9327027B2 (en) | 2016-05-03 |
IL224432A (en) | 2016-03-31 |
CA2806680C (en) | 2018-09-04 |
BR112013002030B1 (pt) | 2020-04-28 |
EP2598437B1 (en) | 2017-04-05 |
CN103038161B (zh) | 2016-08-10 |
BR112013002030A2 (pt) | 2017-09-19 |
AU2011284364B2 (en) | 2014-01-23 |
KR101854380B1 (ko) | 2018-05-28 |
CN103038161A (zh) | 2013-04-10 |
JP2013538775A (ja) | 2013-10-17 |
ZA201301272B (en) | 2014-04-30 |
ES2630169T3 (es) | 2017-08-18 |
DK2598437T3 (en) | 2017-07-17 |
US20130129634A1 (en) | 2013-05-23 |
AU2011284364A1 (en) | 2013-03-07 |
SG188186A1 (en) | 2013-04-30 |
RU2013109226A (ru) | 2014-09-10 |
MX349464B (es) | 2017-07-31 |
KR20140009968A (ko) | 2014-01-23 |
IT1401487B1 (it) | 2013-07-26 |
WO2012014172A1 (en) | 2012-02-02 |
CA2806680A1 (en) | 2012-02-02 |
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