BR112013002030B1 - hidroxiapatita intrinsecamente magnética - Google Patents
hidroxiapatita intrinsecamente magnética Download PDFInfo
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- BR112013002030B1 BR112013002030B1 BR112013002030A BR112013002030A BR112013002030B1 BR 112013002030 B1 BR112013002030 B1 BR 112013002030B1 BR 112013002030 A BR112013002030 A BR 112013002030A BR 112013002030 A BR112013002030 A BR 112013002030A BR 112013002030 B1 BR112013002030 B1 BR 112013002030B1
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- hydroxyapatite
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- ions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/322—Preparation by neutralisation of orthophosphoric acid
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/45—Phosphates containing plural metal, or metal and ammonium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/62—Submicrometer sized, i.e. from 0.1-1 micrometer
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/60—Optical properties, e.g. expressed in CIELAB-values
- C01P2006/62—L* (lightness axis)
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/60—Optical properties, e.g. expressed in CIELAB-values
- C01P2006/64—Optical properties, e.g. expressed in CIELAB-values b* (yellow-blue axis)
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
hidroxiapatita intrisecamente magnética. a presente invenção refere-se à hidroxiapatita dopada com íons fe2+e íons fe3+ que substituem parcialmente os íons de cálcio na treliça de cristal. a hidroxiapatita é caracterizada por um magnetismo intríseco de 0,05 8emu/g, medido aplicando-se um campo magnético de 34 oe, devido à presença de nanodomínios magnéticos na treliça de cristal de ha, dada a quantidade limitada de fases magnéticas secundárias presentes, menor do que aproximadamente 3% em volume. a hidroxiapatita intrinsecamente magnética pode ser carregada com substâncias biológicas selecioanadas no grupo que consiste de proteínas, genes, células-tronco, fatores de crescimento, fatores de vascularização, substâncias ativas e fármacos, sob o controle de um campo magnético externo, como um carregador e agente de liberação para substâncias biológicas ou fármacos, como um agente de contraste em diagnóstico ou para regeneração óssea ou de osteocartilagem.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A001420A IT1401487B1 (it) | 2010-07-29 | 2010-07-29 | Idrossiapatite intrinsecamente magnetica |
PCT/IB2011/053362 WO2012014172A1 (en) | 2010-07-29 | 2011-07-28 | Intrinsically magnetic hydroxyapatite |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013002030A2 BR112013002030A2 (pt) | 2017-09-19 |
BR112013002030B1 true BR112013002030B1 (pt) | 2020-04-28 |
Family
ID=43629403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013002030A BR112013002030B1 (pt) | 2010-07-29 | 2011-07-28 | hidroxiapatita intrinsecamente magnética |
Country Status (17)
Country | Link |
---|---|
US (1) | US9327027B2 (pt) |
EP (1) | EP2598437B1 (pt) |
JP (1) | JP5822927B2 (pt) |
KR (1) | KR101854380B1 (pt) |
CN (1) | CN103038161B (pt) |
AU (1) | AU2011284364B2 (pt) |
BR (1) | BR112013002030B1 (pt) |
CA (1) | CA2806680C (pt) |
DK (1) | DK2598437T3 (pt) |
ES (1) | ES2630169T3 (pt) |
IL (1) | IL224432A (pt) |
IT (1) | IT1401487B1 (pt) |
MX (1) | MX349464B (pt) |
NZ (1) | NZ607003A (pt) |
SG (1) | SG188186A1 (pt) |
WO (1) | WO2012014172A1 (pt) |
ZA (1) | ZA201301272B (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102011056815A1 (de) * | 2011-12-21 | 2013-08-01 | Chemische Fabrik Budenheim Kg | Nährstoffzusammensetzung für biologische Systeme |
US9353137B2 (en) * | 2014-02-07 | 2016-05-31 | Ghassem Amoabediny | Method for separation and purification of phosphatidylcholine employing magnetic nanoparticles and compositions so produced |
WO2015193836A1 (en) | 2014-06-19 | 2015-12-23 | Consiglio Nazionale Delle Ricerche (Cnr) | Injectable apatitic cement ionically multi-substituted for regenerative vertebroplasty and kyphoplasty |
EP3164106B1 (en) * | 2014-07-02 | 2020-11-11 | Universidade Católica Portuguesa | Uv-filters, method of producing the same and their use in compositions, in particular sunscreens |
US10960192B2 (en) * | 2014-07-08 | 2021-03-30 | University Of Maryland, Baltimore | Compositions and delivery methods for treating dental infections, inflammation, sensitivity, and for use in dental restorations |
RU2607743C1 (ru) * | 2015-09-22 | 2017-01-10 | Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) | Способ получения катионзамещенного трикальцийфосфата |
WO2017096342A1 (en) * | 2015-12-03 | 2017-06-08 | Amrita Vishwa Vidyapeetham | Radio-wave responsive doped nanoparticles for image-guided therapeutics |
ITUA20161416A1 (it) * | 2016-03-07 | 2017-09-07 | Consiglio Nazionale Ricerche | Filtro solare fisico costituito da idrossiapatite sostituita in una matrice organica |
KR101818852B1 (ko) | 2016-05-03 | 2018-01-16 | 성균관대학교산학협력단 | 자성의 베타 삼인산칼슘 구형 입자의 제조 방법 및 이에 의해 제작된 자성의 베타 삼인산칼슘 구형 입자 |
CN105923617B (zh) * | 2016-05-11 | 2018-01-09 | 中国科学院上海硅酸盐研究所 | 一种柱状磁性羟基磷灰石纳米材料及其制备方法 |
CN106430137B (zh) * | 2016-09-27 | 2018-07-13 | 哈尔滨理工大学 | 一种球形纳米羟基磷灰石颗粒的制备方法 |
KR101927196B1 (ko) | 2016-10-26 | 2018-12-11 | 전남대학교 산학협력단 | 자기구동 관절연골 재생 시스템 |
CN106853264A (zh) * | 2016-11-10 | 2017-06-16 | 南京市口腔医院 | 超顺磁性纳米纤维膜支架材料、制备方法和应用 |
IT201700022625A1 (it) * | 2017-02-28 | 2018-08-28 | Consiglio Nazionale Ricerche | Filtro per lo scambio di calore e umidità per applicazione in campo medicale e procedimento per la sua produzione |
WO2019135216A1 (en) | 2018-01-02 | 2019-07-11 | Cartiheal (2009) Ltd. | Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth |
CN111330089B (zh) * | 2020-03-04 | 2021-08-03 | 西南交通大学 | 一种用作骨修复的全降解磁修复水凝胶的制备方法 |
KR20230114474A (ko) | 2022-01-25 | 2023-08-01 | 부산대학교 산학협력단 | 철 이온과 스트론튬 이온이 동시 도핑된 베타-제삼인산칼슘의 제조방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL98744A0 (en) * | 1990-07-06 | 1992-07-15 | Gen Hospital Corp | Method of studying biological tissue using monocrystalline particles |
US5344640A (en) | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
US7485282B2 (en) * | 2004-03-26 | 2009-02-03 | Board Of Trustees Of Michigan State University | Method for the preparation of metal oxides in nanometric particle form |
US9028871B2 (en) * | 2006-04-25 | 2015-05-12 | Washington State University | Resorbable ceramics with controlled strength loss rates |
TWI375567B (en) * | 2007-09-19 | 2012-11-01 | Univ Nat Taiwan | One kind of nanometer-scaled magnetic hydroxyapatite particle and its manufacturing method |
CN101759170B (zh) | 2009-12-23 | 2011-07-06 | 天津大学 | 磁性纳米片状羟基磷灰石及其制备方法和应用 |
-
2010
- 2010-07-29 IT ITMI2010A001420A patent/IT1401487B1/it active
-
2011
- 2011-07-28 WO PCT/IB2011/053362 patent/WO2012014172A1/en active Application Filing
- 2011-07-28 DK DK11752344.9T patent/DK2598437T3/en active
- 2011-07-28 BR BR112013002030A patent/BR112013002030B1/pt active IP Right Grant
- 2011-07-28 ES ES11752344.9T patent/ES2630169T3/es active Active
- 2011-07-28 KR KR1020137004737A patent/KR101854380B1/ko active IP Right Grant
- 2011-07-28 EP EP11752344.9A patent/EP2598437B1/en active Active
- 2011-07-28 CN CN201180037098.2A patent/CN103038161B/zh active Active
- 2011-07-28 NZ NZ607003A patent/NZ607003A/en unknown
- 2011-07-28 SG SG2013006812A patent/SG188186A1/en unknown
- 2011-07-28 US US13/812,741 patent/US9327027B2/en active Active
- 2011-07-28 CA CA2806680A patent/CA2806680C/en active Active
- 2011-07-28 JP JP2013521278A patent/JP5822927B2/ja active Active
- 2011-07-28 MX MX2013001169A patent/MX349464B/es active IP Right Grant
- 2011-07-28 AU AU2011284364A patent/AU2011284364B2/en active Active
-
2013
- 2013-01-27 IL IL224432A patent/IL224432A/en active IP Right Grant
- 2013-02-19 ZA ZA2013/01272A patent/ZA201301272B/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2013109226A (ru) | 2014-09-10 |
ITMI20101420A1 (it) | 2012-01-30 |
KR101854380B1 (ko) | 2018-05-28 |
IT1401487B1 (it) | 2013-07-26 |
KR20140009968A (ko) | 2014-01-23 |
EP2598437B1 (en) | 2017-04-05 |
MX2013001169A (es) | 2013-06-28 |
DK2598437T3 (en) | 2017-07-17 |
US20130129634A1 (en) | 2013-05-23 |
AU2011284364B2 (en) | 2014-01-23 |
NZ607003A (en) | 2014-09-26 |
CN103038161B (zh) | 2016-08-10 |
AU2011284364A1 (en) | 2013-03-07 |
CA2806680C (en) | 2018-09-04 |
JP5822927B2 (ja) | 2015-11-25 |
BR112013002030A2 (pt) | 2017-09-19 |
JP2013538775A (ja) | 2013-10-17 |
EP2598437A1 (en) | 2013-06-05 |
CN103038161A (zh) | 2013-04-10 |
US9327027B2 (en) | 2016-05-03 |
CA2806680A1 (en) | 2012-02-02 |
SG188186A1 (en) | 2013-04-30 |
ES2630169T3 (es) | 2017-08-18 |
ZA201301272B (en) | 2014-04-30 |
IL224432A (en) | 2016-03-31 |
WO2012014172A1 (en) | 2012-02-02 |
MX349464B (es) | 2017-07-31 |
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