BR112013002030B1 - hidroxiapatita intrinsecamente magnética - Google Patents

hidroxiapatita intrinsecamente magnética Download PDF

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Publication number
BR112013002030B1
BR112013002030B1 BR112013002030A BR112013002030A BR112013002030B1 BR 112013002030 B1 BR112013002030 B1 BR 112013002030B1 BR 112013002030 A BR112013002030 A BR 112013002030A BR 112013002030 A BR112013002030 A BR 112013002030A BR 112013002030 B1 BR112013002030 B1 BR 112013002030B1
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Brazil
Prior art keywords
hydroxyapatite
magnetic
ions
intrinsically
drugs
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BR112013002030A
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BR112013002030A2 (pt
Inventor
Tampieri Anna
Pressato Daniele
Landi Elena
Rivas Rey Jose
Banobre Lopez Manuel
Marcacci Maurilio
Sandri Monica
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Consiglio Nazionale Ricerche
Fin Ceram Faensa S P A
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Publication of BR112013002030A2 publication Critical patent/BR112013002030A2/pt
Publication of BR112013002030B1 publication Critical patent/BR112013002030B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00Phosphorus; Compounds thereof
    • C01B25/16Oxyacids of phosphorus; Salts thereof
    • C01B25/26Phosphates
    • C01B25/32Phosphates of magnesium, calcium, strontium, or barium
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00Phosphorus; Compounds thereof
    • C01B25/16Oxyacids of phosphorus; Salts thereof
    • C01B25/26Phosphates
    • C01B25/32Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/322Preparation by neutralisation of orthophosphoric acid
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00Phosphorus; Compounds thereof
    • C01B25/16Oxyacids of phosphorus; Salts thereof
    • C01B25/26Phosphates
    • C01B25/45Phosphates containing plural metal, or metal and ammonium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/12Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/62Submicrometer sized, i.e. from 0.1-1 micrometer
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    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00Physical properties of inorganic compounds
    • C01P2006/60Optical properties, e.g. expressed in CIELAB-values
    • C01P2006/62L* (lightness axis)
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00Physical properties of inorganic compounds
    • C01P2006/60Optical properties, e.g. expressed in CIELAB-values
    • C01P2006/64Optical properties, e.g. expressed in CIELAB-values b* (yellow-blue axis)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Compositions Of Oxide Ceramics (AREA)

Abstract

hidroxiapatita intrisecamente magnética. a presente invenção refere-se à hidroxiapatita dopada com íons fe2+e íons fe3+ que substituem parcialmente os íons de cálcio na treliça de cristal. a hidroxiapatita é caracterizada por um magnetismo intríseco de 0,05 8emu/g, medido aplicando-se um campo magnético de 34 oe, devido à presença de nanodomínios magnéticos na treliça de cristal de ha, dada a quantidade limitada de fases magnéticas secundárias presentes, menor do que aproximadamente 3% em volume. a hidroxiapatita intrinsecamente magnética pode ser carregada com substâncias biológicas selecioanadas no grupo que consiste de proteínas, genes, células-tronco, fatores de crescimento, fatores de vascularização, substâncias ativas e fármacos, sob o controle de um campo magnético externo, como um carregador e agente de liberação para substâncias biológicas ou fármacos, como um agente de contraste em diagnóstico ou para regeneração óssea ou de osteocartilagem.
BR112013002030A 2010-07-29 2011-07-28 hidroxiapatita intrinsecamente magnética BR112013002030B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2010A001420A IT1401487B1 (it) 2010-07-29 2010-07-29 Idrossiapatite intrinsecamente magnetica
PCT/IB2011/053362 WO2012014172A1 (en) 2010-07-29 2011-07-28 Intrinsically magnetic hydroxyapatite

Publications (2)

Publication Number Publication Date
BR112013002030A2 BR112013002030A2 (pt) 2017-09-19
BR112013002030B1 true BR112013002030B1 (pt) 2020-04-28

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BR112013002030A BR112013002030B1 (pt) 2010-07-29 2011-07-28 hidroxiapatita intrinsecamente magnética

Country Status (17)

Country Link
US (1) US9327027B2 (pt)
EP (1) EP2598437B1 (pt)
JP (1) JP5822927B2 (pt)
KR (1) KR101854380B1 (pt)
CN (1) CN103038161B (pt)
AU (1) AU2011284364B2 (pt)
BR (1) BR112013002030B1 (pt)
CA (1) CA2806680C (pt)
DK (1) DK2598437T3 (pt)
ES (1) ES2630169T3 (pt)
IL (1) IL224432A (pt)
IT (1) IT1401487B1 (pt)
MX (1) MX349464B (pt)
NZ (1) NZ607003A (pt)
SG (1) SG188186A1 (pt)
WO (1) WO2012014172A1 (pt)
ZA (1) ZA201301272B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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DE102011056815A1 (de) * 2011-12-21 2013-08-01 Chemische Fabrik Budenheim Kg Nährstoffzusammensetzung für biologische Systeme
US9353137B2 (en) * 2014-02-07 2016-05-31 Ghassem Amoabediny Method for separation and purification of phosphatidylcholine employing magnetic nanoparticles and compositions so produced
WO2015193836A1 (en) 2014-06-19 2015-12-23 Consiglio Nazionale Delle Ricerche (Cnr) Injectable apatitic cement ionically multi-substituted for regenerative vertebroplasty and kyphoplasty
EP3164106B1 (en) * 2014-07-02 2020-11-11 Universidade Católica Portuguesa Uv-filters, method of producing the same and their use in compositions, in particular sunscreens
US10960192B2 (en) * 2014-07-08 2021-03-30 University Of Maryland, Baltimore Compositions and delivery methods for treating dental infections, inflammation, sensitivity, and for use in dental restorations
RU2607743C1 (ru) * 2015-09-22 2017-01-10 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения катионзамещенного трикальцийфосфата
WO2017096342A1 (en) * 2015-12-03 2017-06-08 Amrita Vishwa Vidyapeetham Radio-wave responsive doped nanoparticles for image-guided therapeutics
ITUA20161416A1 (it) * 2016-03-07 2017-09-07 Consiglio Nazionale Ricerche Filtro solare fisico costituito da idrossiapatite sostituita in una matrice organica
KR101818852B1 (ko) 2016-05-03 2018-01-16 성균관대학교산학협력단 자성의 베타 삼인산칼슘 구형 입자의 제조 방법 및 이에 의해 제작된 자성의 베타 삼인산칼슘 구형 입자
CN105923617B (zh) * 2016-05-11 2018-01-09 中国科学院上海硅酸盐研究所 一种柱状磁性羟基磷灰石纳米材料及其制备方法
CN106430137B (zh) * 2016-09-27 2018-07-13 哈尔滨理工大学 一种球形纳米羟基磷灰石颗粒的制备方法
KR101927196B1 (ko) 2016-10-26 2018-12-11 전남대학교 산학협력단 자기구동 관절연골 재생 시스템
CN106853264A (zh) * 2016-11-10 2017-06-16 南京市口腔医院 超顺磁性纳米纤维膜支架材料、制备方法和应用
IT201700022625A1 (it) * 2017-02-28 2018-08-28 Consiglio Nazionale Ricerche Filtro per lo scambio di calore e umidità per applicazione in campo medicale e procedimento per la sua produzione
WO2019135216A1 (en) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
CN111330089B (zh) * 2020-03-04 2021-08-03 西南交通大学 一种用作骨修复的全降解磁修复水凝胶的制备方法
KR20230114474A (ko) 2022-01-25 2023-08-01 부산대학교 산학협력단 철 이온과 스트론튬 이온이 동시 도핑된 베타-제삼인산칼슘의 제조방법

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US7485282B2 (en) * 2004-03-26 2009-02-03 Board Of Trustees Of Michigan State University Method for the preparation of metal oxides in nanometric particle form
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TWI375567B (en) * 2007-09-19 2012-11-01 Univ Nat Taiwan One kind of nanometer-scaled magnetic hydroxyapatite particle and its manufacturing method
CN101759170B (zh) 2009-12-23 2011-07-06 天津大学 磁性纳米片状羟基磷灰石及其制备方法和应用

Also Published As

Publication number Publication date
RU2013109226A (ru) 2014-09-10
ITMI20101420A1 (it) 2012-01-30
KR101854380B1 (ko) 2018-05-28
IT1401487B1 (it) 2013-07-26
KR20140009968A (ko) 2014-01-23
EP2598437B1 (en) 2017-04-05
MX2013001169A (es) 2013-06-28
DK2598437T3 (en) 2017-07-17
US20130129634A1 (en) 2013-05-23
AU2011284364B2 (en) 2014-01-23
NZ607003A (en) 2014-09-26
CN103038161B (zh) 2016-08-10
AU2011284364A1 (en) 2013-03-07
CA2806680C (en) 2018-09-04
JP5822927B2 (ja) 2015-11-25
BR112013002030A2 (pt) 2017-09-19
JP2013538775A (ja) 2013-10-17
EP2598437A1 (en) 2013-06-05
CN103038161A (zh) 2013-04-10
US9327027B2 (en) 2016-05-03
CA2806680A1 (en) 2012-02-02
SG188186A1 (en) 2013-04-30
ES2630169T3 (es) 2017-08-18
ZA201301272B (en) 2014-04-30
IL224432A (en) 2016-03-31
WO2012014172A1 (en) 2012-02-02
MX349464B (es) 2017-07-31

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