MX348464B - Agente inductor de inmunidad. - Google Patents
Agente inductor de inmunidad.Info
- Publication number
- MX348464B MX348464B MX2015000895A MX2015000895A MX348464B MX 348464 B MX348464 B MX 348464B MX 2015000895 A MX2015000895 A MX 2015000895A MX 2015000895 A MX2015000895 A MX 2015000895A MX 348464 B MX348464 B MX 348464B
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- agent
- immunity
- seq
- immunity inducing
- Prior art date
Links
- 230000036039 immunity Effects 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 9
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000001939 inductive effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008202065 | 2008-08-05 | ||
| PCT/JP2009/063881 WO2010016525A1 (ja) | 2008-08-05 | 2009-08-05 | 免疫誘導剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX348464B true MX348464B (es) | 2017-06-14 |
Family
ID=41663742
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011001113A MX339277B (es) | 2008-08-05 | 2009-08-05 | Agente inductor de inmunidad. |
| MX2015000895A MX348464B (es) | 2008-08-05 | 2009-08-05 | Agente inductor de inmunidad. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011001113A MX339277B (es) | 2008-08-05 | 2009-08-05 | Agente inductor de inmunidad. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8454968B2 (OSRAM) |
| EP (2) | EP2837383B1 (OSRAM) |
| JP (2) | JP5691171B2 (OSRAM) |
| KR (3) | KR102009241B1 (OSRAM) |
| CN (2) | CN103751771B (OSRAM) |
| AU (2) | AU2009278385B2 (OSRAM) |
| BR (2) | BRPI0912462B1 (OSRAM) |
| CA (1) | CA2732283C (OSRAM) |
| DK (2) | DK2837383T3 (OSRAM) |
| ES (2) | ES2539603T3 (OSRAM) |
| HU (1) | HUE031343T2 (OSRAM) |
| MX (2) | MX339277B (OSRAM) |
| PL (2) | PL2324842T3 (OSRAM) |
| PT (2) | PT2324842E (OSRAM) |
| RU (2) | RU2511039C2 (OSRAM) |
| WO (1) | WO2010016525A1 (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101667319B1 (ko) | 2008-08-05 | 2016-10-18 | 도레이 카부시키가이샤 | 암의 치료 및 예방용 의약 조성물 |
| ES2570731T3 (es) * | 2008-08-05 | 2016-05-20 | Toray Industries | Método de detección de cáncer |
| CA2788720C (en) * | 2010-02-04 | 2019-08-20 | Takayoshi Ido | Medicament for treating and/or preventing cancer |
| WO2011096533A1 (ja) * | 2010-02-04 | 2011-08-11 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| KR101758117B1 (ko) | 2010-02-04 | 2017-07-14 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| CN102821788B (zh) | 2010-02-04 | 2016-11-16 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| KR101805520B1 (ko) | 2010-02-04 | 2017-12-07 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| WO2011096517A1 (ja) * | 2010-02-04 | 2011-08-11 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
| EP2711017B1 (en) * | 2011-05-19 | 2016-08-03 | Toray Industries, Inc. | Immunity inducing agent |
| DK2740794T3 (en) | 2011-08-04 | 2018-06-14 | Toray Industries | PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR CANCER PREVENTION |
| EP2740798B1 (en) * | 2011-08-04 | 2016-12-07 | Toray Industries, Inc. | Cancer treatment and/or prevention drug composition |
| HUE035689T2 (en) * | 2011-08-04 | 2018-05-28 | Toray Industries | A pharmaceutical composition for the treatment and / or prevention of cancer |
| ES2634249T3 (es) | 2011-08-04 | 2017-09-27 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y/o la profilaxis del cáncer |
| PT2740795T (pt) | 2011-08-04 | 2017-01-09 | Toray Industries | Composição de fármaco para o tratamento e/ou a prevenção de cancro |
| CA2844037C (en) | 2011-08-04 | 2020-07-14 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of pancreatic cancer |
| HUE033628T2 (en) * | 2011-08-04 | 2017-12-28 | Toray Industries | Method for detecting pancreatic cancer |
| PL2818483T3 (pl) | 2012-02-21 | 2018-01-31 | Toray Industries | Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi |
| RU2633505C2 (ru) | 2012-02-21 | 2017-10-12 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
| KR102009238B1 (ko) | 2012-02-21 | 2019-08-09 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| RU2639522C2 (ru) | 2012-02-21 | 2017-12-21 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
| DK2832366T3 (en) * | 2012-03-30 | 2018-01-22 | Toray Industries | PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR PREVENTION OF Gallbladder cancer |
| CN104220095B (zh) * | 2012-03-30 | 2016-09-07 | 东丽株式会社 | 肝癌的治疗和/或预防用药物组合物 |
| CN104471403B (zh) | 2012-07-19 | 2017-03-01 | 东丽株式会社 | 癌的检测方法 |
| PT2876447T (pt) | 2012-07-19 | 2020-02-03 | Toray Industries | Método para deteção de cancro |
| ES2704909T3 (es) | 2013-08-09 | 2019-03-20 | Toray Industries | Composición farmacéutica para el tratamiento y/o la prevención del cáncer |
| CN107530411B (zh) * | 2015-04-30 | 2021-08-13 | 东丽株式会社 | 免疫诱导剂 |
| US12274745B2 (en) * | 2016-10-28 | 2025-04-15 | Toray Industries, Inc. | Conjugate of CAPRIN-1 antibody linked to immune activator for cancer treatment |
| CA3095719A1 (en) * | 2018-03-30 | 2019-10-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| CN109206502B (zh) * | 2018-09-26 | 2022-03-04 | 东北农业大学 | 一种猫干扰素ω及其制备方法和在抗病毒中的应用 |
| CN109206501B (zh) * | 2018-09-26 | 2022-03-04 | 东北农业大学 | 猫干扰素ω、其编码基因及其在抗病毒方面的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| KR20010083111A (ko) * | 1998-07-14 | 2001-08-31 | 길리스 스티브 | 전립선암의 치료 및 진단을 위한 조성물 및 방법 |
| WO2002083070A2 (en) * | 2001-04-10 | 2002-10-24 | Corixa Corporation | Compounds for immunotherapy and diagnosis of colon cancer and methods for their use |
| US20030190640A1 (en) * | 2001-05-31 | 2003-10-09 | Mary Faris | Genes expressed in prostate cancer |
| RU2319503C2 (ru) * | 2001-11-07 | 2008-03-20 | Цитос Байотекнолоджи Аг | Композиция для иммунизации (варианты), способ ее получения и применение для лечения аллергических эозинофильных заболеваний |
| US20050003390A1 (en) * | 2002-05-17 | 2005-01-06 | Axenovich Sergey A. | Targets for controlling cellular growth and for diagnostic methods |
| US20060121029A1 (en) | 2002-08-30 | 2006-06-08 | Hiroshi Shiku | Method and composition for regulating the activity of regulatory t cells |
| WO2005100998A2 (en) | 2004-04-16 | 2005-10-27 | Europroteome Ag | Membrane markers for use in cancer diagnosis and therapy |
| DE102004026135A1 (de) | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US8211634B2 (en) | 2006-02-14 | 2012-07-03 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| US20080107668A1 (en) * | 2006-08-30 | 2008-05-08 | Immunotope, Inc. | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| KR20080075722A (ko) | 2007-02-13 | 2008-08-19 | 엘지이노텍 주식회사 | 튜너 |
| JP4826496B2 (ja) | 2007-02-16 | 2011-11-30 | 三菱マテリアル株式会社 | 電解メッキ用アノード電極取付構造 |
| WO2013143026A1 (en) * | 2012-03-31 | 2013-10-03 | Abmart (Shanghai) Co., Ltd | Peptide and antibody libraries and uses thereof |
| WO2014197471A1 (en) * | 2013-06-03 | 2014-12-11 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase ( hdac) biomarkers in multiple myeloma |
-
2009
- 2009-08-05 PT PT98050081T patent/PT2324842E/pt unknown
- 2009-08-05 JP JP2009546597A patent/JP5691171B2/ja active Active
- 2009-08-05 US US13/056,122 patent/US8454968B2/en active Active
- 2009-08-05 ES ES09805008.1T patent/ES2539603T3/es active Active
- 2009-08-05 EP EP14185710.2A patent/EP2837383B1/en active Active
- 2009-08-05 KR KR1020177032975A patent/KR102009241B1/ko active Active
- 2009-08-05 WO PCT/JP2009/063881 patent/WO2010016525A1/ja not_active Ceased
- 2009-08-05 CN CN201410047289.2A patent/CN103751771B/zh active Active
- 2009-08-05 BR BRPI0912462-4A patent/BRPI0912462B1/pt active IP Right Grant
- 2009-08-05 DK DK14185710.2T patent/DK2837383T3/en active
- 2009-08-05 HU HUE14185710A patent/HUE031343T2/hu unknown
- 2009-08-05 ES ES14185710.2T patent/ES2619322T3/es active Active
- 2009-08-05 KR KR1020117001808A patent/KR101669827B1/ko active Active
- 2009-08-05 DK DK09805008.1T patent/DK2324842T3/da active
- 2009-08-05 CA CA2732283A patent/CA2732283C/en active Active
- 2009-08-05 KR KR1020167029224A patent/KR20160127146A/ko not_active Ceased
- 2009-08-05 CN CN200980130313.6A patent/CN102112146B/zh active Active
- 2009-08-05 MX MX2011001113A patent/MX339277B/es active IP Right Grant
- 2009-08-05 EP EP09805008.1A patent/EP2324842B1/en active Active
- 2009-08-05 PL PL09805008T patent/PL2324842T3/pl unknown
- 2009-08-05 RU RU2011108315/10A patent/RU2511039C2/ru active
- 2009-08-05 AU AU2009278385A patent/AU2009278385B2/en active Active
- 2009-08-05 PL PL14185710T patent/PL2837383T3/pl unknown
- 2009-08-05 BR BR122020027042-0A patent/BR122020027042B1/pt active IP Right Grant
- 2009-08-05 PT PT141857102T patent/PT2837383T/pt unknown
- 2009-08-05 MX MX2015000895A patent/MX348464B/es unknown
-
2013
- 2013-05-06 US US13/888,137 patent/US9592281B2/en active Active
- 2013-12-19 RU RU2013156620A patent/RU2639518C2/ru active
-
2014
- 2014-11-05 JP JP2014225626A patent/JP5962739B2/ja active Active
-
2015
- 2015-08-07 AU AU2015210461A patent/AU2015210461B2/en active Active
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