MX347570B - Compuestos triciclicos, composiciones que los comprenden y usos de los mismos. - Google Patents
Compuestos triciclicos, composiciones que los comprenden y usos de los mismos.Info
- Publication number
- MX347570B MX347570B MX2014005765A MX2014005765A MX347570B MX 347570 B MX347570 B MX 347570B MX 2014005765 A MX2014005765 A MX 2014005765A MX 2014005765 A MX2014005765 A MX 2014005765A MX 347570 B MX347570 B MX 347570B
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- same
- compounds
- tricycle
- tricycle compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033307 Overweight Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559964P | 2011-11-15 | 2011-11-15 | |
| US201261603508P | 2012-02-27 | 2012-02-27 | |
| PCT/IL2012/050461 WO2013072915A1 (en) | 2011-11-15 | 2012-11-15 | Tricyclic compounds, compositions comprising them and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014005765A MX2014005765A (es) | 2015-09-23 |
| MX347570B true MX347570B (es) | 2017-05-02 |
Family
ID=48429067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014005765A MX347570B (es) | 2011-11-15 | 2012-11-15 | Compuestos triciclicos, composiciones que los comprenden y usos de los mismos. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9447040B2 (enExample) |
| EP (1) | EP2802320B1 (enExample) |
| JP (1) | JP6087367B2 (enExample) |
| KR (1) | KR101986272B1 (enExample) |
| CN (1) | CN104010636B (enExample) |
| AU (1) | AU2012338362B2 (enExample) |
| BR (1) | BR112014011641B1 (enExample) |
| CA (1) | CA2855759C (enExample) |
| CL (1) | CL2014001278A1 (enExample) |
| CO (1) | CO7020909A2 (enExample) |
| DK (1) | DK2802320T3 (enExample) |
| ES (1) | ES2729713T3 (enExample) |
| HR (1) | HRP20190927T1 (enExample) |
| HU (1) | HUE043827T2 (enExample) |
| IN (1) | IN2014CN03610A (enExample) |
| MX (1) | MX347570B (enExample) |
| PE (1) | PE20141940A1 (enExample) |
| PH (1) | PH12014501061B1 (enExample) |
| PL (1) | PL2802320T3 (enExample) |
| PT (1) | PT2802320T (enExample) |
| RU (1) | RU2624446C9 (enExample) |
| SG (1) | SG11201402258UA (enExample) |
| SI (1) | SI2802320T1 (enExample) |
| WO (1) | WO2013072915A1 (enExample) |
| ZA (1) | ZA201404065B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016020919A1 (en) | 2014-08-07 | 2016-02-11 | Raziel Therapeutics Ltd. | Compositions comprising tricyclic compounds, and uses thereof |
| WO2016203468A1 (en) * | 2015-06-15 | 2016-12-22 | Raziel Therapeutics Ltd. | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
| JP2023503769A (ja) * | 2019-09-15 | 2023-02-01 | ラジエル セラピューティクス エルティーディー． | 固形腫瘍の処置のための組成物 |
| EP4096653A4 (en) * | 2020-01-28 | 2024-02-28 | Raziel Therapeutics Ltd. | Compositions for the treatment of angiolipoma |
| WO2022058792A1 (en) * | 2020-09-16 | 2022-03-24 | Raziel Therapeutics Ltd. | Compositions for the treatment of fat related conditions and disorders |
| AU2021344871A1 (en) * | 2020-09-16 | 2023-05-25 | Raziel Therapeutics Ltd. | Compositions and methods for the treatment of lipid-related disorders |
| WO2022234337A2 (en) * | 2021-05-06 | 2022-11-10 | Raziel Therapeutics Ltd. | Crystalline carbazole derivative |
| CN117956990A (zh) * | 2021-07-28 | 2024-04-30 | 拉结尔治疗有限公司 | 用于治疗脂肪瘤疼痛的组合物和方法 |
| CN115073374B (zh) * | 2022-06-14 | 2023-10-27 | 五邑大学 | 一种α-葡萄糖苷酶抑制剂及其制备方法和应用 |
| KR20250152557A (ko) * | 2022-11-07 | 2025-10-23 | 라지엘 테라퓨틱스 리미티드 | 결정질 카바졸 유도체 및 이의 제조 방법 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2590125A (en) * | 1952-03-25 | Quaternary-ammonium alkyl | ||
| US2676966A (en) | 1951-04-04 | 1954-04-27 | Searle & Co | Quaternary salts of 9-carbazolealkylamines and 10-acridanalkylamines and methods forpreparing same |
| US2676971A (en) * | 1951-04-21 | 1954-04-27 | Searle & Co | Quaternary ammonium derivatives of aminoalkylxanthenes and aminoalkylthiaxanthenes |
| GB832568A (en) * | 1956-08-03 | 1960-04-13 | Clin Byla Ets | Heterocyclic compounds and production thereof |
| FR1186832A (fr) * | 1956-08-03 | 1959-09-02 | Etablissements Clin-Byla | Composés hétérocycliques dérivés du pyrrol et des benzopyrrols et leur fabrication |
| US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
| GB866418A (en) * | 1958-01-25 | 1961-04-26 | Bayer Ag | Phenoxazine derivatives |
| US3836587A (en) * | 1969-11-17 | 1974-09-17 | American Cyanamid Co | Organo phosphonium salts |
| AR205331A1 (es) * | 1972-07-24 | 1976-04-30 | Hoffmann La Roche | Procedimiento para la preparacion de carbazoles |
| FR2691459B1 (fr) * | 1992-05-25 | 1995-06-09 | Adir | Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH11504905A (ja) | 1995-05-05 | 1999-05-11 | ノボ ノルディスク アクティーゼルスカブ | 新規複素環の化学 |
| US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| EP1094063A1 (en) | 1999-10-18 | 2001-04-25 | Applied Research Systems ARS Holding N.V. | 9-(Piperazinylalkyl)carbazoles as Bax-modulators |
| GB9925880D0 (en) | 1999-11-01 | 1999-12-29 | British Tech Group Int | B-Carboline derivatives |
| DE60218155D1 (de) * | 2001-03-28 | 2007-03-29 | Lilly Co Eli | Substituierte carbazole als inhibitoren von spla2 |
| WO2003027084A1 (en) * | 2001-09-25 | 2003-04-03 | Dr. Reddy's Laboratories Ltd. | Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents |
| US7428091B2 (en) * | 2004-11-15 | 2008-09-23 | Gentex Corporation | Electrochromic compounds and associated media and devices |
| WO2007079239A2 (en) | 2005-12-30 | 2007-07-12 | Acadia Pharmaceuticals Inc. | Bicyclic nitrogen compounds as modulators of ghrelin receptor and uses thereof |
| US20090317372A1 (en) * | 2008-06-20 | 2009-12-24 | Zoltan Kiss | Small molecules for the reduction of high blood glucose level |
| UA107652C2 (en) * | 2008-10-06 | 2015-02-10 | Incuron Llc | Carbazole compounds and therapeutic uses of the compounds |
| US8362277B2 (en) * | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8604074B2 (en) | 2009-01-09 | 2013-12-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2012006419A2 (en) * | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
-
2012
- 2012-11-15 ES ES12850186T patent/ES2729713T3/es active Active
- 2012-11-15 PE PE2014000685A patent/PE20141940A1/es active IP Right Grant
- 2012-11-15 IN IN3610CHN2014 patent/IN2014CN03610A/en unknown
- 2012-11-15 CA CA2855759A patent/CA2855759C/en active Active
- 2012-11-15 PH PH1/2014/501061A patent/PH12014501061B1/en unknown
- 2012-11-15 WO PCT/IL2012/050461 patent/WO2013072915A1/en not_active Ceased
- 2012-11-15 CN CN201280060159.1A patent/CN104010636B/zh active Active
- 2012-11-15 SG SG11201402258UA patent/SG11201402258UA/en unknown
- 2012-11-15 EP EP12850186.3A patent/EP2802320B1/en active Active
- 2012-11-15 JP JP2014540635A patent/JP6087367B2/ja active Active
- 2012-11-15 HR HRP20190927TT patent/HRP20190927T1/hr unknown
- 2012-11-15 PT PT12850186T patent/PT2802320T/pt unknown
- 2012-11-15 RU RU2014119711A patent/RU2624446C9/ru active
- 2012-11-15 KR KR1020147016247A patent/KR101986272B1/ko active Active
- 2012-11-15 MX MX2014005765A patent/MX347570B/es active IP Right Grant
- 2012-11-15 BR BR112014011641-5A patent/BR112014011641B1/pt active IP Right Grant
- 2012-11-15 HU HUE12850186A patent/HUE043827T2/hu unknown
- 2012-11-15 DK DK12850186.3T patent/DK2802320T3/da active
- 2012-11-15 SI SI201231605T patent/SI2802320T1/sl unknown
- 2012-11-15 AU AU2012338362A patent/AU2012338362B2/en active Active
- 2012-11-15 PL PL12850186T patent/PL2802320T3/pl unknown
- 2012-11-15 US US14/358,431 patent/US9447040B2/en active Active
-
2014
- 2014-05-14 CL CL2014001278A patent/CL2014001278A1/es unknown
- 2014-05-19 CO CO14107499A patent/CO7020909A2/es unknown
- 2014-06-04 ZA ZA2014/04065A patent/ZA201404065B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |