MX346424B - Formulacion de polvo seco que comprende un inhibidor de fosfodiesterasa. - Google Patents
Formulacion de polvo seco que comprende un inhibidor de fosfodiesterasa.Info
- Publication number
- MX346424B MX346424B MX2013001172A MX2013001172A MX346424B MX 346424 B MX346424 B MX 346424B MX 2013001172 A MX2013001172 A MX 2013001172A MX 2013001172 A MX2013001172 A MX 2013001172A MX 346424 B MX346424 B MX 346424B
- Authority
- MX
- Mexico
- Prior art keywords
- dry powder
- powder formulation
- phosphodiesterase inhibitor
- relates
- phosphodiesterase
- Prior art date
Links
- 239000000843 powder Substances 0.000 title abstract 2
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se relaciona con una formulación farmacéutica en la forma de un polvo seco inhalable que comprende partículas de un inhibidor de fosfodiesterasa-4 como ingrediente activo. La invención también se relaciona con el proceso para preparar la formulación y con su uso en la prevención y/o el tratamiento de una enfermedad respiratoria tal como asma y EPOC.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10171748 | 2010-08-03 | ||
| PCT/EP2011/062872 WO2012016889A2 (en) | 2010-08-03 | 2011-07-27 | Dry powder formulation comprising a phosphodiesterase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013001172A MX2013001172A (es) | 2013-03-07 |
| MX346424B true MX346424B (es) | 2017-03-21 |
Family
ID=43262631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013001172A MX346424B (es) | 2010-08-03 | 2011-07-27 | Formulacion de polvo seco que comprende un inhibidor de fosfodiesterasa. |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US9132121B2 (es) |
| EP (2) | EP3246016B1 (es) |
| JP (1) | JP6004233B2 (es) |
| KR (1) | KR101805958B1 (es) |
| CN (2) | CN103052379A (es) |
| AR (1) | AR082443A1 (es) |
| AU (1) | AU2011287711B2 (es) |
| BR (1) | BR112013002506A2 (es) |
| CA (1) | CA2807256C (es) |
| CL (1) | CL2013000293A1 (es) |
| CO (1) | CO6690744A2 (es) |
| CY (1) | CY1120605T1 (es) |
| DK (2) | DK2600830T3 (es) |
| EA (2) | EA024922B1 (es) |
| ES (2) | ES3033142T3 (es) |
| FI (1) | FI3246016T3 (es) |
| GE (1) | GEP20156343B (es) |
| HR (2) | HRP20180717T1 (es) |
| HU (2) | HUE071256T2 (es) |
| IL (1) | IL224517B (es) |
| LT (2) | LT3246016T (es) |
| MA (1) | MA34449B1 (es) |
| ME (1) | ME03022B (es) |
| MX (1) | MX346424B (es) |
| MY (1) | MY179703A (es) |
| NO (1) | NO2600830T3 (es) |
| NZ (1) | NZ606548A (es) |
| PE (2) | PE20171256A1 (es) |
| PH (1) | PH12013500235A1 (es) |
| PL (2) | PL2600830T3 (es) |
| PT (2) | PT2600830T (es) |
| RS (2) | RS57061B1 (es) |
| SG (1) | SG187258A1 (es) |
| SI (2) | SI3246016T1 (es) |
| SM (1) | SMT202500256T1 (es) |
| TR (1) | TR201807012T4 (es) |
| UA (1) | UA112296C2 (es) |
| WO (1) | WO2012016889A2 (es) |
| ZA (1) | ZA201300870B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
| US8293489B2 (en) | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
| EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| KR101803121B1 (ko) | 2010-08-03 | 2017-11-29 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제를 포함하는 약학적 제제 |
| WO2012168226A1 (en) | 2011-06-06 | 2012-12-13 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| US9737521B2 (en) | 2012-11-08 | 2017-08-22 | Rhizen Pharmaceuticals Sa | Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor |
| EP2968204B1 (en) * | 2013-03-15 | 2019-05-15 | Robert I. Henkin | Phosphodiesterase inhibitors for treating taste and smell disorders |
| US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
| RS61558B1 (sr) | 2013-10-22 | 2021-04-29 | Chiesi Farm Spa | Kristalni oblik pde4 inhibitora |
| GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| CN104800192A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入粉雾剂及制备方法 |
| CN106233141B (zh) | 2014-02-18 | 2018-08-21 | 罗伯特·I·汉金 | 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物 |
| US20180021256A1 (en) | 2014-07-09 | 2018-01-25 | Arven Ilac Sanayi Ve Ticaret A.S. | Process for the preparation of formulations for inhalation |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| US10583085B2 (en) * | 2017-05-17 | 2020-03-10 | Chiesi Farmaceutici S.P.A. | Carrier particles for dry powder formulations for inhalation |
| US12569493B2 (en) | 2020-03-24 | 2026-03-10 | Cyrano Therapeutics Inc. | Treatment of chemosensory dysfunction from a coronavirus infection |
| CN118475343A (zh) | 2021-12-21 | 2024-08-09 | 凯西制药公司 | 填充在具有改善的耐湿性的吸入器中的干粉制剂 |
| WO2023208982A1 (en) | 2022-04-27 | 2023-11-02 | Chiesi Farmaceutici S.P.A. | Crystal form of a pde4 inhibitor |
| WO2024027901A1 (en) | 2022-08-02 | 2024-02-08 | Chiesi Farmaceutici S.P.A. | Predictive biomarker of clinical response to a pde4 inhibitor |
| CA3268243A1 (en) | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | CAPSULE INHALATOR FOR THE ADMINISTRATION OF A PHOSPHODIESTERASE-4 INHIBITOR |
| CA3268102A1 (en) | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | CAPSULE INHALATOR FOR THE ADMINISTRATION OF A PHOSPHODIESTERASE-4 INHIBITOR |
| KR20250069949A (ko) | 2022-09-22 | 2025-05-20 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포다이에스테라제-4 억제제의 투여를 위한 캡슐 흡입기 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19841248A1 (de) | 1997-09-12 | 1999-04-29 | Fraunhofer Ges Forschung | Demonstrationseinrichtung in Form eines Lebewesens |
| DE59801018D1 (de) | 1997-09-16 | 2001-08-16 | Trench Switzerland Ag Basel | Spannungsteiler |
| PL196951B1 (pl) | 1999-03-05 | 2008-02-29 | Chiesi Farma Spa | Proszek do stosowania w inhalatorze suchego proszku, cząsteczki nośnika i sposób wytwarzania nośnika |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| IL153705A0 (en) | 2000-06-27 | 2003-07-06 | Vectura Ltd | Method of making particles for use in a pharmaceutical composition |
| US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| PT1386630E (pt) | 2002-07-31 | 2006-09-29 | Chiesi Farma Spa | Inalador em po |
| DE10255387A1 (de) * | 2002-11-28 | 2004-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Tiotropium-haltige Pulverformulierung für die Inhalation |
| GB0326632D0 (en) * | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| CA2608837C (en) * | 2005-06-06 | 2011-08-02 | F. Hoffmann-La Roche Ag | Sulfonamide derivatives useful as liver carnitine palmitoyl transferase (l-cpt1) inhibitors |
| GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| EP2022783A1 (en) * | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| EP2070913A1 (en) * | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
| EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| KR101803121B1 (ko) | 2010-08-03 | 2017-11-29 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제를 포함하는 약학적 제제 |
| WO2012168226A1 (en) | 2011-06-06 | 2012-12-13 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| RS61558B1 (sr) | 2013-10-22 | 2021-04-29 | Chiesi Farm Spa | Kristalni oblik pde4 inhibitora |
-
2011
- 2011-07-27 NO NO11741172A patent/NO2600830T3/no unknown
- 2011-07-27 SG SG2013008107A patent/SG187258A1/en unknown
- 2011-07-27 NZ NZ606548A patent/NZ606548A/en unknown
- 2011-07-27 ES ES17176635T patent/ES3033142T3/es active Active
- 2011-07-27 PT PT117411728T patent/PT2600830T/pt unknown
- 2011-07-27 HR HRP20180717TT patent/HRP20180717T1/hr unknown
- 2011-07-27 CN CN2011800382903A patent/CN103052379A/zh active Pending
- 2011-07-27 HU HUE17176635A patent/HUE071256T2/hu unknown
- 2011-07-27 KR KR1020137002872A patent/KR101805958B1/ko active Active
- 2011-07-27 MY MYPI2013000339A patent/MY179703A/en unknown
- 2011-07-27 DK DK11741172.8T patent/DK2600830T3/en active
- 2011-07-27 LT LTEP17176635.5T patent/LT3246016T/lt unknown
- 2011-07-27 BR BR112013002506A patent/BR112013002506A2/pt not_active Application Discontinuation
- 2011-07-27 GE GEAP201112988A patent/GEP20156343B/en unknown
- 2011-07-27 PL PL11741172T patent/PL2600830T3/pl unknown
- 2011-07-27 EA EA201390049A patent/EA024922B1/ru unknown
- 2011-07-27 CA CA2807256A patent/CA2807256C/en active Active
- 2011-07-27 ME MEP-2018-101A patent/ME03022B/me unknown
- 2011-07-27 JP JP2013522202A patent/JP6004233B2/ja active Active
- 2011-07-27 MX MX2013001172A patent/MX346424B/es active IP Right Grant
- 2011-07-27 UA UAA201302607A patent/UA112296C2/uk unknown
- 2011-07-27 SI SI201132132T patent/SI3246016T1/sl unknown
- 2011-07-27 TR TR2018/07012T patent/TR201807012T4/tr unknown
- 2011-07-27 PT PT171766355T patent/PT3246016T/pt unknown
- 2011-07-27 PE PE2017001245A patent/PE20171256A1/es unknown
- 2011-07-27 PE PE2013000155A patent/PE20130601A1/es active IP Right Grant
- 2011-07-27 SI SI201131448T patent/SI2600830T1/en unknown
- 2011-07-27 EP EP17176635.5A patent/EP3246016B1/en active Active
- 2011-07-27 PH PH1/2013/500235A patent/PH12013500235A1/en unknown
- 2011-07-27 RS RS20180394A patent/RS57061B1/sr unknown
- 2011-07-27 RS RS20250479A patent/RS66876B1/sr unknown
- 2011-07-27 WO PCT/EP2011/062872 patent/WO2012016889A2/en not_active Ceased
- 2011-07-27 CN CN201710259305.8A patent/CN106890165A/zh active Pending
- 2011-07-27 SM SM20250256T patent/SMT202500256T1/it unknown
- 2011-07-27 AU AU2011287711A patent/AU2011287711B2/en active Active
- 2011-07-27 PL PL17176635.5T patent/PL3246016T3/pl unknown
- 2011-07-27 EA EA201690541A patent/EA027692B1/ru unknown
- 2011-07-27 DK DK17176635.5T patent/DK3246016T3/da active
- 2011-07-27 HU HUE11741172A patent/HUE037620T2/hu unknown
- 2011-07-27 HR HRP20250711TT patent/HRP20250711T1/hr unknown
- 2011-07-27 LT LTEP11741172.8T patent/LT2600830T/lt unknown
- 2011-07-27 EP EP11741172.8A patent/EP2600830B1/en active Active
- 2011-07-27 ES ES11741172.8T patent/ES2664175T3/es active Active
- 2011-07-27 FI FIEP17176635.5T patent/FI3246016T3/fi active
- 2011-07-27 MA MA35635A patent/MA34449B1/fr unknown
- 2011-08-02 US US13/195,885 patent/US9132121B2/en active Active
- 2011-08-02 AR ARP110102782 patent/AR082443A1/es not_active Application Discontinuation
-
2013
- 2013-01-30 CL CL2013000293A patent/CL2013000293A1/es unknown
- 2013-01-31 IL IL224517A patent/IL224517B/en active IP Right Grant
- 2013-02-01 ZA ZA2013/00870A patent/ZA201300870B/en unknown
- 2013-02-01 CO CO13019325A patent/CO6690744A2/es unknown
-
2015
- 2015-08-07 US US14/820,939 patent/US9308200B2/en active Active
-
2018
- 2018-03-09 CY CY181100288T patent/CY1120605T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |