MX342824B - Nuevos compuestos de triazol iii. - Google Patents

Nuevos compuestos de triazol iii.

Info

Publication number
MX342824B
MX342824B MX2013005965A MX2013005965A MX342824B MX 342824 B MX342824 B MX 342824B MX 2013005965 A MX2013005965 A MX 2013005965A MX 2013005965 A MX2013005965 A MX 2013005965A MX 342824 B MX342824 B MX 342824B
Authority
MX
Mexico
Prior art keywords
triazole compounds
compounds iii
novel triazole
present
novel
Prior art date
Application number
MX2013005965A
Other languages
English (en)
Other versions
MX2013005965A (es
Inventor
Thomas Andrew
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013005965A publication Critical patent/MX2013005965A/es
Publication of MX342824B publication Critical patent/MX342824B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de 1,2,3-triazol-imidazol de fórmula (I) en donde X, R1, R2, y R3 son como se describen en la presente, así como también sales y ésteres de los mismos farmacéuticamente aceptables. Los compuestos activos de la presente invención tienen afinidad y selectividad para el receptor GABA A a5. Además la presente invención está relacionada con la manufactura de los compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y su uso como medicamentos.
MX2013005965A 2010-12-10 2011-12-07 Nuevos compuestos de triazol iii. MX342824B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10194496 2010-12-10
PCT/EP2011/072041 WO2012076590A1 (en) 2010-12-10 2011-12-07 Novel triazole compounds iii

Publications (2)

Publication Number Publication Date
MX2013005965A MX2013005965A (es) 2013-07-15
MX342824B true MX342824B (es) 2016-10-12

Family

ID=45099109

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005965A MX342824B (es) 2010-12-10 2011-12-07 Nuevos compuestos de triazol iii.

Country Status (9)

Country Link
US (1) US8466181B2 (es)
EP (1) EP2649064B1 (es)
JP (1) JP6138049B2 (es)
KR (1) KR20130130773A (es)
CN (1) CN103249728B (es)
BR (1) BR112013014362A2 (es)
CA (1) CA2819277A1 (es)
MX (1) MX342824B (es)
WO (1) WO2012076590A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168259B2 (en) * 2010-10-20 2015-10-27 Grünenthal GmbH Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
AU2013283488A1 (en) 2012-06-26 2015-01-15 Saniona Aps A phenyl triazole derivative and its use for modulating the GABAA receptor complex
US9206160B2 (en) 2012-06-26 2015-12-08 Saniona Aps Phenyl triazole derivative and its use for modulating the GABAA receptor complex
US9969724B2 (en) 2014-04-16 2018-05-15 Merck Sharp & Dohme Corp. Factor IXa inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3824658A1 (de) * 1988-07-15 1990-01-18 Schering Ag N-hetaryl-imidazolderivate
IT1237793B (it) 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
JP3873746B2 (ja) * 2000-05-19 2007-01-24 アステラス製薬株式会社 トリアゾール誘導体
US6727364B2 (en) * 2001-04-30 2004-04-27 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
EA011634B1 (ru) * 2004-03-09 2009-04-28 Бёрингер Ингельхайм Фармасьютиклз, Инк. 3-[4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды в качестве ингибиторов продуцирования цитокинов, предназначенные для лечения хронических воспалительных заболеваний
WO2007074078A2 (en) * 2005-12-27 2007-07-05 F. Hoffmann-La Roche Ag Aryl-isoxazol-4-yl-imidazole derivatives
ES2369805T3 (es) * 2007-06-22 2011-12-07 F. Hoffmann-La Roche Ag Derivados de isoxazol-imidazol.
MX2010005753A (es) * 2007-12-04 2010-06-15 Hoffmann La Roche Derivados de isoxazolo-pirazina.

Also Published As

Publication number Publication date
KR20130130773A (ko) 2013-12-02
CA2819277A1 (en) 2012-06-14
EP2649064B1 (en) 2019-10-02
JP6138049B2 (ja) 2017-05-31
JP2014502279A (ja) 2014-01-30
CN103249728A (zh) 2013-08-14
US8466181B2 (en) 2013-06-18
CN103249728B (zh) 2015-01-21
BR112013014362A2 (pt) 2016-09-27
WO2012076590A1 (en) 2012-06-14
EP2649064A1 (en) 2013-10-16
US20120149675A1 (en) 2012-06-14
RU2013130213A (ru) 2015-01-20
MX2013005965A (es) 2013-07-15
HK1186177A1 (en) 2014-03-07

Similar Documents

Publication Publication Date Title
MX2013004588A (es) Derivados de triazol y su uso para trastornos neurologicos.
MX2011011484A (es) Derivados de isoxazol-piridina como moduladores del acido gamma-aminobutirico.
MX2011007772A (es) Derivados de isoxazol/o-piridina con enlazador etilo y etenilo.
MX2011007737A (es) Derivados de hidroximetil isoxazol como moduladores de acido gamma-aminobutirico a.
TN2012000125A1 (en) Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors
MY183312A (en) Pharmaceutical formulation
MX2011011303A (es) Derivados de isoxazol.
MY158974A (en) Prodrugs comprising an exendin linker conjugate
MX2012009186A (es) Pirrolidina-2-carboxamidas sustituidas.
AU2012259422A8 (en) Solid forms of a pharmaceutically active substance
MY187718A (en) Pharmaceutical formulations
GEP20146146B (en) Pyrrolopyrimidine compounds as inhibitors of cdk4/6
MX2013005533A (es) Derivados de acido amino-bisfenil-pentanoico sustituidos como inhibidores de nep.
MX2010004232A (es) Compuesto de indolina de pirimidilo.
TN2009000287A1 (en) Cyclized derivatives as eg-5inhibitors
MX2013000474A (es) Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.
TN2013000257A1 (en) Immunosuppressant formulations
MX345544B (es) Derivados de triazol como ligandos para receptores de acido gamma-aminobutirico (gaba).
WO2010129057A8 (en) Tetracycline compounds
IN2012DN02502A (es)
WO2011123536A8 (en) Polycyclic tetracycline compounds
TN2012000105A1 (en) Spirolactam derivatives and uses of same
PH12013501462A1 (en) Novel benzodioxole piperazine compounds
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
MY161749A (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

Legal Events

Date Code Title Description
FG Grant or registration