MX342807B - Cocristales farmacéuticamente aceptables de n- [2-(7-metoxi-1-naftil) etil] acetamida y métodos para su preparación. - Google Patents
Cocristales farmacéuticamente aceptables de n- [2-(7-metoxi-1-naftil) etil] acetamida y métodos para su preparación.Info
- Publication number
- MX342807B MX342807B MX2013012103A MX2013012103A MX342807B MX 342807 B MX342807 B MX 342807B MX 2013012103 A MX2013012103 A MX 2013012103A MX 2013012103 A MX2013012103 A MX 2013012103A MX 342807 B MX342807 B MX 342807B
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutically acceptable
- methods
- napht
- acetamide
- methoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title 1
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 abstract 1
- 229960002629 agomelatine Drugs 0.000 abstract 1
- 238000011170 pharmaceutical development Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11075073.4A EP2517700B1 (en) | 2011-04-28 | 2011-04-28 | Pharmaceutically acceptable cocrystals of N-[2-(7-methoxy-1-naphthyl]acetamide and methods of their preparation |
| PCT/EP2012/001761 WO2012146371A1 (en) | 2011-04-28 | 2012-04-25 | Pharmaceutically acceptable cocrystals of n-[2-(7-methoxy-1-naphtyl)ethyl]acetamide and methods of their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013012103A MX2013012103A (es) | 2014-01-24 |
| MX342807B true MX342807B (es) | 2016-10-13 |
Family
ID=44519907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013012103A MX342807B (es) | 2011-04-28 | 2012-04-25 | Cocristales farmacéuticamente aceptables de n- [2-(7-metoxi-1-naftil) etil] acetamida y métodos para su preparación. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8927771B2 (OSRAM) |
| EP (1) | EP2517700B1 (OSRAM) |
| JP (1) | JP5770928B2 (OSRAM) |
| KR (1) | KR20140008370A (OSRAM) |
| CN (1) | CN103501777B (OSRAM) |
| BR (1) | BR112013023471A2 (OSRAM) |
| EA (1) | EA024422B1 (OSRAM) |
| ES (1) | ES2429348T3 (OSRAM) |
| IL (1) | IL228916A (OSRAM) |
| MX (1) | MX342807B (OSRAM) |
| PL (1) | PL2517700T3 (OSRAM) |
| PT (1) | PT2517700E (OSRAM) |
| RS (1) | RS52982B (OSRAM) |
| UA (1) | UA111844C2 (OSRAM) |
| WO (1) | WO2012146371A1 (OSRAM) |
| ZA (1) | ZA201307688B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12012000132A1 (en) | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
| EP2551257A1 (en) * | 2011-07-28 | 2013-01-30 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of agomelatine with co-crystal-formers |
| JP2015521179A (ja) * | 2012-05-14 | 2015-07-27 | 上海右手医葯科技▲開▼発有限公司 | アゴメラチン酸基複合体およびその製造方法と用途 |
| US10098859B2 (en) | 2012-09-05 | 2018-10-16 | Amri Ssci, Llc | Cocrystals of p-coumaric acid |
| EP2743255B1 (en) | 2012-12-17 | 2016-06-22 | Dr. Reddy's Laboratories Ltd. | Cocrystal of agomelatine with phosphoric acid |
| EP2810647A1 (en) * | 2013-06-06 | 2014-12-10 | Zentiva, a.s. | Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid |
| PL2810656T3 (pl) | 2013-06-06 | 2018-01-31 | Zentiva Ks | Preparaty agomelatyny zawierające agomelatynę w postaci kokryształów |
| FR3012142B1 (fr) * | 2013-10-17 | 2016-07-15 | Servier Lab | Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2014298304B2 (en) * | 2013-07-29 | 2018-07-26 | Les Laboratoires Servier | Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them |
| WO2015013865A1 (en) * | 2013-07-29 | 2015-02-05 | Les Laboratoires Servier | Agomelatine sulfonic acids complexes and preparation thereof |
| CN105473551B (zh) * | 2013-07-31 | 2019-01-11 | 法国施维雅药厂 | 阿戈美拉汀和对甲苯磺酸的共晶的新形式、其制备方法和包含其的药物组合物 |
| WO2015013903A1 (en) * | 2013-07-31 | 2015-02-05 | Les Laboratoires Servier | NEW AGOMELATINE p-TOLUENESULFONIC ACID CO-CRYSTAL FORMS AND PREPARATION THEREOF |
| RS58778B1 (sr) * | 2013-07-31 | 2019-06-28 | Servier Lab | Ko-kristali agomelatina i p-toluensulfonske kiseline, postupak za njihovu proizvodnju i farmaceutske kompozicije koje ih sadrže |
| KR101404836B1 (ko) | 2014-03-21 | 2014-06-09 | 순천향대학교 산학협력단 | 아고멜라틴의 공결정 및 그의 제조방법 |
| KR101470794B1 (ko) | 2014-06-30 | 2014-12-08 | 순천향대학교 산학협력단 | 아고멜라틴 공결정의 제조 방법 및 이를 포함하는 조성물 |
| PL3075724T3 (pl) | 2015-03-31 | 2023-12-27 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Stała postać agomelatyny |
| WO2017115284A1 (en) * | 2015-12-28 | 2017-07-06 | Leiutis Pharmaceuticals Pvt, Ltd. | Novel co-crystal forms of agomelatine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078163A2 (en) * | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AR047553A1 (es) * | 2003-07-04 | 2006-01-25 | Lundbeck & Co As H | La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina |
| WO2008035177A2 (en) * | 2006-09-18 | 2008-03-27 | Copharm | Combination of mt1 and mt2 melatonin receptor agonists and a norepinephrine/dopamine reuptake inhibitor |
| CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
| CN102106806B (zh) * | 2009-12-29 | 2013-04-17 | 上海中西制药有限公司 | 一种固体制剂的制备方法及所得固体制剂 |
| WO2012046253A2 (en) | 2010-10-08 | 2012-04-12 | Msn Laboratories Limited | Process for the preparation of n-[2- (7-methoxy-l-naphthyl) ethyl] acetamide and its novel crystalline forms |
| PH12012000132A1 (en) * | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
-
2011
- 2011-04-28 PL PL11075073T patent/PL2517700T3/pl unknown
- 2011-04-28 PT PT110750734T patent/PT2517700E/pt unknown
- 2011-04-28 EP EP11075073.4A patent/EP2517700B1/en not_active Not-in-force
- 2011-04-28 ES ES11075073T patent/ES2429348T3/es active Active
- 2011-04-28 RS RS20130436A patent/RS52982B/sr unknown
-
2012
- 2012-04-25 KR KR1020137024023A patent/KR20140008370A/ko not_active Ceased
- 2012-04-25 EA EA201391574A patent/EA024422B1/ru not_active IP Right Cessation
- 2012-04-25 CN CN201280020790.9A patent/CN103501777B/zh not_active Expired - Fee Related
- 2012-04-25 JP JP2014506792A patent/JP5770928B2/ja not_active Expired - Fee Related
- 2012-04-25 WO PCT/EP2012/001761 patent/WO2012146371A1/en not_active Ceased
- 2012-04-25 US US14/114,211 patent/US8927771B2/en not_active Expired - Fee Related
- 2012-04-25 MX MX2013012103A patent/MX342807B/es active IP Right Grant
- 2012-04-25 BR BR112013023471A patent/BR112013023471A2/pt not_active Application Discontinuation
- 2012-04-25 UA UAA201313793A patent/UA111844C2/uk unknown
-
2013
- 2013-10-16 ZA ZA2013/07688A patent/ZA201307688B/en unknown
- 2013-10-16 IL IL228916A patent/IL228916A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT2517700E (pt) | 2013-10-14 |
| US8927771B2 (en) | 2015-01-06 |
| UA111844C2 (uk) | 2016-06-24 |
| JP2014522388A (ja) | 2014-09-04 |
| WO2012146371A1 (en) | 2012-11-01 |
| IL228916A (en) | 2016-05-31 |
| BR112013023471A2 (pt) | 2016-12-13 |
| CN103501777B (zh) | 2015-08-19 |
| ZA201307688B (en) | 2015-04-29 |
| IL228916A0 (en) | 2013-12-31 |
| CN103501777A (zh) | 2014-01-08 |
| EP2517700A1 (en) | 2012-10-31 |
| US20140051887A1 (en) | 2014-02-20 |
| ES2429348T3 (es) | 2013-11-14 |
| RS52982B (sr) | 2014-02-28 |
| PL2517700T3 (pl) | 2013-12-31 |
| EA201391574A1 (ru) | 2014-04-30 |
| KR20140008370A (ko) | 2014-01-21 |
| JP5770928B2 (ja) | 2015-08-26 |
| EA024422B1 (ru) | 2016-09-30 |
| EP2517700B1 (en) | 2013-07-17 |
| MX2013012103A (es) | 2014-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |