MX340424B - Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso. - Google Patents

Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso.

Info

Publication number
MX340424B
MX340424B MX2011010765A MX2011010765A MX340424B MX 340424 B MX340424 B MX 340424B MX 2011010765 A MX2011010765 A MX 2011010765A MX 2011010765 A MX2011010765 A MX 2011010765A MX 340424 B MX340424 B MX 340424B
Authority
MX
Mexico
Prior art keywords
manufacturing
turn mimetics
reverse
same
novel compounds
Prior art date
Application number
MX2011010765A
Other languages
English (en)
Other versions
MX2011010765A (es
Inventor
Uk Chung Jae
Lee Yong-Sil
Jung Hee-Kyung
Jung Kyung-Yun
La Hyun-Ju
Wook Jeong Min-
Ma Sang-Ho
Original Assignee
Jw Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jw Pharmaceutical Corp filed Critical Jw Pharmaceutical Corp
Publication of MX2011010765A publication Critical patent/MX2011010765A/es
Publication of MX340424B publication Critical patent/MX340424B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Abstract

Se describen miméticos novedosos de giro inverso, basados en el marco de pirazino-triazinona y su uso en el tratamiento de cánceres, en particular de leucemia mieloide aguda. También se provee un método para fabricar los miméticos de giro inverso, a escala masiva.
MX2011010765A 2009-04-15 2010-04-14 Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso. MX340424B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090032937 2009-04-15
PCT/KR2010/002306 WO2010120112A2 (en) 2009-04-15 2010-04-14 Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof

Publications (2)

Publication Number Publication Date
MX2011010765A MX2011010765A (es) 2012-02-08
MX340424B true MX340424B (es) 2016-07-08

Family

ID=42981437

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011010765A MX340424B (es) 2009-04-15 2010-04-14 Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso.

Country Status (14)

Country Link
US (1) US20100267672A1 (es)
EP (1) EP2419430A4 (es)
JP (1) JP5657642B2 (es)
KR (1) KR101692921B1 (es)
CN (1) CN102459271B (es)
AU (1) AU2010237633B2 (es)
BR (1) BRPI1014574A2 (es)
CA (1) CA2758904C (es)
IL (1) IL215732A (es)
MX (1) MX340424B (es)
RU (1) RU2515983C2 (es)
SG (1) SG175045A1 (es)
WO (1) WO2010120112A2 (es)
ZA (1) ZA201107357B (es)

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EP2533048A4 (en) 2010-02-03 2013-08-21 Prism Biolab Co Ltd CONNECTION TO THE BINDING OF NATURALLY OBTAINING DENATURED PROTEINS AND METHOD FOR SCREENING AFTER THIS CONNECTION
JP5809279B2 (ja) * 2010-10-14 2015-11-10 ジェイダブリュ ファーマセウティカル コーポレーション リバースターン類似体の新規な化合物およびその製造方法と用途
EP2678341A1 (en) * 2011-02-25 2014-01-01 PRISM Pharma Co., Ltd. Alpha helix mimetics and methods relating thereto
PL2754441T3 (pl) * 2011-08-09 2016-11-30 Kompozycja do profilaktyki i leczenia niedrobnokomórkowego raka płuc, zawierająca pochodne pirazyno-triazynowe
US9353119B2 (en) 2011-08-09 2016-05-31 Jw Pharmaceutical Corporation Composition for preventing and treating non-small cell lung cancer, containing pyrazino-triazine derivatives
KR20140053952A (ko) * 2011-08-26 2014-05-08 제이더블유중외제약 주식회사 피라지노-트리아진 유도체를 포함하는 조성물
JPWO2015037587A1 (ja) * 2013-09-11 2017-03-02 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ ピラジノ［２，１−ｃ］［１，２，４］トリアジン化合物の製造方法
CN106029076B (zh) * 2013-11-18 2019-06-07 福马疗法公司 作为bet溴域抑制剂的苯并哌嗪组合物
CN105934246B (zh) 2013-11-18 2019-10-22 福马疗法公司 作为bet溴域抑制剂的四氢喹啉组成物
US9174998B2 (en) * 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
RU2729936C2 (ru) 2015-06-16 2020-08-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противораковое средство
SG11201709593VA (en) 2015-06-23 2017-12-28 Eisai R&D Man Co Ltd CRYSTAL OF (6S,9aS)-N-BENZYL-6-[(4-HYDROXYPHENYL)METHYL]- 4,7-DIOXO-8-({6-[3-(PIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN- 2-YL}METHYL)-2-(PROP-2-EN-1-YL)-OCTAHYDRO-1H-PYRAZINO[2,1-c][1,2,4]TRIAZINE-1-CARBOXAMIDE COMPOUND
WO2019055869A1 (en) 2017-09-15 2019-03-21 Forma Therapeutics, Inc. TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300
US10870648B2 (en) 2018-06-29 2020-12-22 Forma Therapeutics, Inc. Inhibiting CREB binding protein (CBP)
KR20210153908A (ko) 2020-06-11 2021-12-20 제이더블유중외제약 주식회사 코로나바이러스감염증-19(covid-19) 치료용 조성물
KR20220000460A (ko) 2020-06-26 2022-01-04 제이더블유중외제약 주식회사 폐섬유화증 치료용 조성물
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers

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US559184A (en) * 1896-04-28 Eli marshall
CA2103577A1 (en) 1991-02-07 1992-08-08 Michael Kahn Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US5475085A (en) * 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
WO1994003494A1 (en) 1992-08-06 1994-02-17 The Board Of Trustees Of The University Of Illinois Conformationally restricted mimetics of reverse turns and peptides containing the same
US5446128A (en) * 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
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US6872825B2 (en) * 1999-12-21 2005-03-29 The Procter & Gamble Company Peptide β-turn mimetic compounds and processes for making them
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US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
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US7576084B2 (en) * 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
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US8080657B2 (en) * 2001-10-12 2011-12-20 Choongwae Pharma Corporation Compounds of reverse turn mimetics and the use thereof
US7671054B1 (en) * 2001-10-12 2010-03-02 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US6762185B1 (en) * 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
JP2007503816A (ja) * 2003-08-28 2007-03-01 チョンウェ ファーマ コーポレーション β−カテニン／ＴＣＦ活性化転写の調節
US7563825B1 (en) * 2005-03-18 2009-07-21 Choongwae Pharma Corporation Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation
EP1957516B1 (en) * 2005-11-08 2016-03-09 Choongwae Pharma Corporation Alfa-helix mimetics and method relating to the treatment of cancer stem cells
US20090215783A1 (en) * 2006-05-30 2009-08-27 Choongwae Pharma Corporation Composition for induction or inhibition of stem cell differentiation

Also Published As

Publication number Publication date
ZA201107357B (en) 2012-07-25
KR20120028877A (ko) 2012-03-23
JP2012524061A (ja) 2012-10-11
EP2419430A4 (en) 2012-10-31
SG175045A1 (en) 2011-11-28
CA2758904C (en) 2017-04-04
WO2010120112A3 (en) 2011-03-31
BRPI1014574A2 (pt) 2015-08-25
RU2515983C2 (ru) 2014-05-20
MX2011010765A (es) 2012-02-08
JP5657642B2 (ja) 2015-01-21
EP2419430A2 (en) 2012-02-22
CN102459271A (zh) 2012-05-16
CN102459271B (zh) 2014-07-02
WO2010120112A2 (en) 2010-10-21
US20100267672A1 (en) 2010-10-21
IL215732A (en) 2014-08-31
AU2010237633B2 (en) 2015-09-17
KR101692921B1 (ko) 2017-01-05
IL215732A0 (en) 2012-01-31
RU2011146146A (ru) 2013-05-20
CA2758904A1 (en) 2010-10-21
AU2010237633A1 (en) 2011-10-27

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