MX2011010765A - Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso. - Google Patents

Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso.

Info

Publication number
MX2011010765A
MX2011010765A MX2011010765A MX2011010765A MX2011010765A MX 2011010765 A MX2011010765 A MX 2011010765A MX 2011010765 A MX2011010765 A MX 2011010765A MX 2011010765 A MX2011010765 A MX 2011010765A MX 2011010765 A MX2011010765 A MX 2011010765A
Authority
MX
Mexico
Prior art keywords
manufacturing
turn mimetics
reverse
same
novel compounds
Prior art date
Application number
MX2011010765A
Other languages
English (en)
Other versions
MX340424B (es
Inventor
Jae Uk Chung
Yong-Sil Lee
Hee-Kyung Jung
Kyung-Yun Jung
Hyun-Ju La
Min-Wook Jeong
Sang-Ho Ma
Original Assignee
Jw Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jw Pharmaceutical Corp filed Critical Jw Pharmaceutical Corp
Publication of MX2011010765A publication Critical patent/MX2011010765A/es
Publication of MX340424B publication Critical patent/MX340424B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen miméticos novedosos de giro inverso, basados en el marco de pirazino-triazinona y su uso en el tratamiento de cánceres, en particular de leucemia mieloide aguda. También se provee un método para fabricar los miméticos de giro inverso, a escala masiva.
MX2011010765A 2009-04-15 2010-04-14 Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso. MX340424B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090032937 2009-04-15
PCT/KR2010/002306 WO2010120112A2 (en) 2009-04-15 2010-04-14 Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof

Publications (2)

Publication Number Publication Date
MX2011010765A true MX2011010765A (es) 2012-02-08
MX340424B MX340424B (es) 2016-07-08

Family

ID=42981437

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011010765A MX340424B (es) 2009-04-15 2010-04-14 Compuestos novedosos de mimeticos de cambio inverso; metodo para fabricarlos y su uso.

Country Status (14)

Country Link
US (1) US20100267672A1 (es)
EP (1) EP2419430A4 (es)
JP (1) JP5657642B2 (es)
KR (1) KR101692921B1 (es)
CN (1) CN102459271B (es)
AU (1) AU2010237633B2 (es)
BR (1) BRPI1014574A2 (es)
CA (1) CA2758904C (es)
IL (1) IL215732A (es)
MX (1) MX340424B (es)
RU (1) RU2515983C2 (es)
SG (1) SG175045A1 (es)
WO (1) WO2010120112A2 (es)
ZA (1) ZA201107357B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102906566A (zh) 2010-02-03 2013-01-30 株式会社棱镜生物实验室 与天然变性蛋白质结合的化合物及其筛选方法
WO2012050393A2 (ko) * 2010-10-14 2012-04-19 제이더블유중외제약 주식회사 리버스-턴 유사체의 신규한 화합물 및 그 제조방법과 용도
JP2014509298A (ja) * 2011-02-25 2014-04-17 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ アルファへリックスミメティック及びその関連の方法
PL2754441T3 (pl) * 2011-08-09 2016-11-30 Kompozycja do profilaktyki i leczenia niedrobnokomórkowego raka płuc, zawierająca pochodne pirazyno-triazynowe
US9353119B2 (en) 2011-08-09 2016-05-31 Jw Pharmaceutical Corporation Composition for preventing and treating non-small cell lung cancer, containing pyrazino-triazine derivatives
WO2013032184A2 (ko) * 2011-08-26 2013-03-07 제이더블유중외제약 주식회사 피라지노-트리아진 유도체를 포함하는 조성물
AU2014319460A1 (en) * 2013-09-11 2016-04-14 Prism Pharma Co., Ltd. Method of producing pyrazino[2,1-c][1,2,4]triazine compound
MX370535B (es) 2013-11-18 2019-12-17 Forma Therapeutics Inc Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
EP3071205B1 (en) * 2013-11-18 2020-02-05 Forma Therapeutics, Inc. Benzopiperazine compositions as bet bromodomain inhibitors
US9174998B2 (en) * 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
WO2016204193A1 (ja) 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
MX2017015257A (es) 2015-06-23 2018-02-19 Eisai R&D Man Co Ltd Cristal de (6s, 9as)-n-bencil-8-({6-[3-(4-etilpiperazin-1-il)azeti din-1-il]piridin-2-il}metil)-6-(2-(fluoruro-4-hidroxibencil)-4,7- dioxo-2-prop-2-en-1-il)hexahidro-2h-pirazino[2,1-c] [1,2,4]triazon-1-(6h)-carboxamida.
AU2018334272B2 (en) 2017-09-15 2023-06-15 Forma Therapeutics, Inc. Tetrahydro-imidazo quinoline compositions as CBP/p300 inhibitors
MX2020014303A (es) 2018-06-29 2021-03-25 Forma Therapeutics Inc Inhibición de la proteína de union a creb (cbp).
KR20210153908A (ko) 2020-06-11 2021-12-20 제이더블유중외제약 주식회사 코로나바이러스감염증-19(covid-19) 치료용 조성물
KR20220000460A (ko) 2020-06-26 2022-01-04 제이더블유중외제약 주식회사 폐섬유화증 치료용 조성물
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)

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US6872825B2 (en) * 1999-12-21 2005-03-29 The Procter & Gamble Company Peptide β-turn mimetic compounds and processes for making them
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7566711B2 (en) * 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
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US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
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US6762185B1 (en) * 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
WO2005021025A2 (en) * 2003-08-28 2005-03-10 Choongwae Pharma Corporation MODULATION OF β-CATENIN/TCF ACTIVATED TRANSCRIPTION
US7563825B1 (en) * 2005-03-18 2009-07-21 Choongwae Pharma Corporation Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation
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KR20090026302A (ko) * 2006-05-30 2009-03-12 주식회사 중외제약 줄기세포 분화의 유도 또는 억제를 위한 조성물

Also Published As

Publication number Publication date
CN102459271B (zh) 2014-07-02
US20100267672A1 (en) 2010-10-21
WO2010120112A3 (en) 2011-03-31
KR101692921B1 (ko) 2017-01-05
JP2012524061A (ja) 2012-10-11
SG175045A1 (en) 2011-11-28
EP2419430A2 (en) 2012-02-22
MX340424B (es) 2016-07-08
IL215732A0 (en) 2012-01-31
ZA201107357B (en) 2012-07-25
RU2011146146A (ru) 2013-05-20
IL215732A (en) 2014-08-31
BRPI1014574A2 (pt) 2015-08-25
RU2515983C2 (ru) 2014-05-20
CA2758904C (en) 2017-04-04
JP5657642B2 (ja) 2015-01-21
AU2010237633A1 (en) 2011-10-27
AU2010237633B2 (en) 2015-09-17
KR20120028877A (ko) 2012-03-23
CN102459271A (zh) 2012-05-16
CA2758904A1 (en) 2010-10-21
WO2010120112A2 (en) 2010-10-21
EP2419430A4 (en) 2012-10-31

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