MX338373B - Composicion antipsicotica inyectable de liberacion controlada. - Google Patents
Composicion antipsicotica inyectable de liberacion controlada.Info
- Publication number
- MX338373B MX338373B MX2012013937A MX2012013937A MX338373B MX 338373 B MX338373 B MX 338373B MX 2012013937 A MX2012013937 A MX 2012013937A MX 2012013937 A MX2012013937 A MX 2012013937A MX 338373 B MX338373 B MX 338373B
- Authority
- MX
- Mexico
- Prior art keywords
- drug
- composition
- day
- plasma levels
- antipsychotic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Abstract
La presente invención se refiere a una composición que puede utilizarse para administrar un fármaco antipsicótico tal como risperidona en forma de un implante inyectable biodegradable que se forma in-situ para liberación prolongada, proporcionando niveles plasmáticos terapéuticos desde el primer día. La composición está en forma de suspensión de fármaco en una solución de copolímero o copolímeros biodegradables y biocompatibles utilizando disolventes miscibles en agua, que se administra en forma líquida. Una vez que la composición se pone en contacto con los fluidos corporales, la matriz polimérica se endurece reteniendo el fármaco, formando un implante sólido o semisólido que libera el fármaco de forma continuada. Pueden lograrse niveles terapéuticos del fármaco en plasma desde el primer día hasta al menos 14 días o más.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382154.2A EP2394664B1 (en) | 2010-05-31 | 2010-05-31 | Antipsychotic injectable depot composition |
PCT/EP2011/059000 WO2011151355A1 (en) | 2010-05-31 | 2011-05-31 | Antipsychotic injectable depot composition |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012013937A MX2012013937A (es) | 2013-02-11 |
MX338373B true MX338373B (es) | 2016-04-13 |
Family
ID=43301889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013937A MX338373B (es) | 2010-05-31 | 2011-05-31 | Composicion antipsicotica inyectable de liberacion controlada. |
Country Status (32)
Country | Link |
---|---|
US (2) | US10085936B2 (es) |
EP (2) | EP2394664B1 (es) |
JP (1) | JP5882993B2 (es) |
KR (1) | KR101784330B1 (es) |
CN (1) | CN103002917B (es) |
AP (1) | AP3524A (es) |
AU (1) | AU2011260318B2 (es) |
BR (1) | BR112012030686B1 (es) |
CA (1) | CA2800111C (es) |
CL (1) | CL2012003350A1 (es) |
CY (2) | CY1117969T1 (es) |
DK (2) | DK2394664T3 (es) |
EA (1) | EA024155B1 (es) |
ES (2) | ES2589106T3 (es) |
HR (2) | HRP20161049T1 (es) |
HU (2) | HUE029895T2 (es) |
IL (1) | IL223129A (es) |
LT (2) | LT2394664T (es) |
MA (1) | MA34296B1 (es) |
ME (1) | ME02501B (es) |
MX (1) | MX338373B (es) |
MY (1) | MY161930A (es) |
NZ (1) | NZ604342A (es) |
PL (2) | PL2394664T3 (es) |
PT (2) | PT2394664T (es) |
RS (1) | RS55190B1 (es) |
SG (1) | SG185775A1 (es) |
SI (2) | SI2394664T1 (es) |
SM (2) | SMT201600320B (es) |
UA (1) | UA108885C2 (es) |
WO (1) | WO2011151355A1 (es) |
ZA (1) | ZA201209346B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
NZ597621A (en) | 2007-05-25 | 2013-06-28 | Tolmar Therapeutics Inc | Sustained delivery formulations of risperidone compounds |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
PL2394663T3 (pl) | 2010-05-31 | 2022-02-21 | Laboratorios Farmaceuticos Rovi, S.A. | Kompozycje do wstrzykiwania implantów biodegradowalnych in-situ |
ES2589106T3 (es) | 2010-05-31 | 2016-11-10 | Laboratorios Farmaceuticos Rovi, S.A. | Composición inyectable antipsicótica de liberación controlada |
SI2529757T1 (sl) * | 2011-05-31 | 2014-05-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija paliperidon implantata |
ES2878112T3 (es) * | 2011-05-31 | 2021-11-18 | Farm Rovi Lab Sa | Formulación de implante de risperidona y/o paliperidona |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
EP2986278A1 (en) | 2013-03-11 | 2016-02-24 | DURECT Corporation | Injectable controlled release composition comprising high viscosity liquid carrier |
WO2016199170A2 (en) * | 2015-06-10 | 2016-12-15 | Cipla Limited | Paliperidone palmitate particles and compositions thereof |
EP3600258A1 (en) | 2017-03-20 | 2020-02-05 | Teva Pharmaceuticals International GmbH | Sustained release olanzapine formulaitons |
CN109589304A (zh) * | 2017-10-01 | 2019-04-09 | 万特制药(海南)有限公司 | 利培酮口服溶液及其制备方法 |
CN110420212A (zh) * | 2019-08-19 | 2019-11-08 | 韩自勤 | 一种用于治疗精神分裂症组合物及其制备方法 |
TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
Family Cites Families (36)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
BE758156R (fr) | 1970-05-13 | 1971-04-28 | Ethicon Inc | Element de suture absorbable et sa |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4523591A (en) | 1982-10-22 | 1985-06-18 | Kaplan Donald S | Polymers for injection molding of absorbable surgical devices |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5620700A (en) | 1990-10-30 | 1997-04-15 | Alza Corporation | Injectable drug delivery system and method |
US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
SI0729357T1 (en) | 1993-11-19 | 2005-06-30 | Janssen Pharmaceutica N.V. | Microencapsulated 1,2-benzazoles |
DE69735384T2 (de) | 1996-12-20 | 2006-08-10 | Alza Corp., Mountain View | Gelzusammensetzungen und verfahren |
US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
EP1248596B1 (de) * | 2000-01-11 | 2007-03-07 | Roland Bodmeier | Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel |
US6604561B2 (en) * | 2000-02-11 | 2003-08-12 | Medical Instill Technologies, Inc. | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
KR20050083605A (ko) * | 2002-07-31 | 2005-08-26 | 알자 코포레이션 | 주사 가능한 다원성 중합체 데포트 조성물 및 이의 용도 |
WO2004064752A2 (en) * | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
US20050003007A1 (en) | 2003-07-02 | 2005-01-06 | Michele Boix | Method of sterilization of polymeric microparticles |
CA2819769C (en) * | 2003-07-18 | 2016-06-28 | Oakwood Laboratories, L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
DE102005031868A1 (de) * | 2005-07-04 | 2007-01-18 | Biotronik Vi Patent Ag | Arzneimitteldepot zur parenteralen, insbesondere intravaskulären Arzneimittelfreisetzung |
US8852638B2 (en) * | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US8076448B2 (en) | 2006-10-11 | 2011-12-13 | Tolmar Therapeutics, Inc. | Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction |
FR2908775B1 (fr) * | 2006-11-17 | 2012-08-31 | Biomatlante | Hydrogel et ses applications biomedicales |
LT3660073T (lt) | 2007-02-15 | 2023-10-10 | Tolmar International Limited | Poli(laktidas-ko-glikolidas) su lėtu pradiniu atsipalaidavimu |
CA2686137C (en) * | 2007-05-18 | 2021-01-12 | Durect Corporation | Improved depot formulations |
NZ597621A (en) * | 2007-05-25 | 2013-06-28 | Tolmar Therapeutics Inc | Sustained delivery formulations of risperidone compounds |
WO2009060473A2 (en) * | 2007-11-06 | 2009-05-14 | Panacea Biotec Limited | Injectable compositions, processes and uses thereof |
CA2731316C (en) * | 2008-08-12 | 2017-10-03 | Novartis Ag | Pharmaceutical compositions |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
ES2589106T3 (es) | 2010-05-31 | 2016-11-10 | Laboratorios Farmaceuticos Rovi, S.A. | Composición inyectable antipsicótica de liberación controlada |
PL2394663T3 (pl) | 2010-05-31 | 2022-02-21 | Laboratorios Farmaceuticos Rovi, S.A. | Kompozycje do wstrzykiwania implantów biodegradowalnych in-situ |
SI2529757T1 (sl) | 2011-05-31 | 2014-05-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija paliperidon implantata |
ES2878112T3 (es) | 2011-05-31 | 2021-11-18 | Farm Rovi Lab Sa | Formulación de implante de risperidona y/o paliperidona |
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2010
- 2010-05-31 ES ES10382154.2T patent/ES2589106T3/es active Active
- 2010-05-31 DK DK10382154.2T patent/DK2394664T3/en active
- 2010-05-31 HU HUE10382154A patent/HUE029895T2/en unknown
- 2010-05-31 PT PT103821542T patent/PT2394664T/pt unknown
- 2010-05-31 PL PL10382154.2T patent/PL2394664T3/pl unknown
- 2010-05-31 LT LTEP10382154.2T patent/LT2394664T/lt unknown
- 2010-05-31 SI SI201031270A patent/SI2394664T1/sl unknown
- 2010-05-31 EP EP10382154.2A patent/EP2394664B1/en active Active
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2011
- 2011-05-31 RS RS20160730A patent/RS55190B1/sr unknown
- 2011-05-31 EA EA201201569A patent/EA024155B1/ru unknown
- 2011-05-31 LT LTEP11725383.1T patent/LT2575890T/lt unknown
- 2011-05-31 ME MEP-2016-178A patent/ME02501B/me unknown
- 2011-05-31 BR BR112012030686-3A patent/BR112012030686B1/pt active IP Right Grant
- 2011-05-31 SI SI201130939A patent/SI2575890T1/sl unknown
- 2011-05-31 CA CA2800111A patent/CA2800111C/en active Active
- 2011-05-31 MA MA35428A patent/MA34296B1/fr unknown
- 2011-05-31 WO PCT/EP2011/059000 patent/WO2011151355A1/en active Application Filing
- 2011-05-31 CN CN201180026475.2A patent/CN103002917B/zh active Active
- 2011-05-31 SG SG2012087136A patent/SG185775A1/en unknown
- 2011-05-31 AU AU2011260318A patent/AU2011260318B2/en active Active
- 2011-05-31 AP AP2012006626A patent/AP3524A/xx active
- 2011-05-31 HU HUE11725383A patent/HUE029056T2/en unknown
- 2011-05-31 ES ES11725383.1T patent/ES2592527T3/es active Active
- 2011-05-31 NZ NZ604342A patent/NZ604342A/en unknown
- 2011-05-31 DK DK11725383.1T patent/DK2575890T3/en active
- 2011-05-31 EP EP11725383.1A patent/EP2575890B1/en active Active
- 2011-05-31 JP JP2013512879A patent/JP5882993B2/ja active Active
- 2011-05-31 PL PL11725383.1T patent/PL2575890T3/pl unknown
- 2011-05-31 MY MYPI2012701044A patent/MY161930A/en unknown
- 2011-05-31 UA UAA201214486A patent/UA108885C2/ru unknown
- 2011-05-31 PT PT117253831T patent/PT2575890T/pt unknown
- 2011-05-31 KR KR1020127033021A patent/KR101784330B1/ko active IP Right Grant
- 2011-05-31 MX MX2012013937A patent/MX338373B/es active IP Right Grant
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2012
- 2012-11-19 IL IL223129A patent/IL223129A/en active IP Right Grant
- 2012-11-29 CL CL2012003350A patent/CL2012003350A1/es unknown
- 2012-11-30 US US13/690,647 patent/US10085936B2/en active Active
- 2012-12-10 ZA ZA2012/09346A patent/ZA201209346B/en unknown
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2016
- 2016-08-19 HR HRP20161049TT patent/HRP20161049T1/hr unknown
- 2016-08-29 HR HRP20161100TT patent/HRP20161100T1/hr unknown
- 2016-08-31 CY CY20161100857T patent/CY1117969T1/el unknown
- 2016-08-31 CY CY20161100858T patent/CY1117964T1/el unknown
- 2016-09-15 SM SM201600320T patent/SMT201600320B/it unknown
- 2016-09-15 SM SM201600321T patent/SMT201600321B/it unknown
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2018
- 2018-04-04 US US15/944,894 patent/US10182982B2/en active Active
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Legal Events
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FG | Grant or registration |