MX338373B - Composicion antipsicotica inyectable de liberacion controlada. - Google Patents

Composicion antipsicotica inyectable de liberacion controlada.

Info

Publication number
MX338373B
MX338373B MX2012013937A MX2012013937A MX338373B MX 338373 B MX338373 B MX 338373B MX 2012013937 A MX2012013937 A MX 2012013937A MX 2012013937 A MX2012013937 A MX 2012013937A MX 338373 B MX338373 B MX 338373B
Authority
MX
Mexico
Prior art keywords
drug
composition
day
plasma levels
antipsychotic
Prior art date
Application number
MX2012013937A
Other languages
English (en)
Other versions
MX2012013937A (es
Inventor
Aduriz Ibon Gutierro
Ochoa María Teresa Gómez
Original Assignee
Rovi Lab Farmaceut Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43301889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX338373(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rovi Lab Farmaceut Sa filed Critical Rovi Lab Farmaceut Sa
Publication of MX2012013937A publication Critical patent/MX2012013937A/es
Publication of MX338373B publication Critical patent/MX338373B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La presente invención se refiere a una composición que puede utilizarse para administrar un fármaco antipsicótico tal como risperidona en forma de un implante inyectable biodegradable que se forma in-situ para liberación prolongada, proporcionando niveles plasmáticos terapéuticos desde el primer día. La composición está en forma de suspensión de fármaco en una solución de copolímero o copolímeros biodegradables y biocompatibles utilizando disolventes miscibles en agua, que se administra en forma líquida. Una vez que la composición se pone en contacto con los fluidos corporales, la matriz polimérica se endurece reteniendo el fármaco, formando un implante sólido o semisólido que libera el fármaco de forma continuada. Pueden lograrse niveles terapéuticos del fármaco en plasma desde el primer día hasta al menos 14 días o más.
MX2012013937A 2010-05-31 2011-05-31 Composicion antipsicotica inyectable de liberacion controlada. MX338373B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10382154.2A EP2394664B1 (en) 2010-05-31 2010-05-31 Antipsychotic injectable depot composition
PCT/EP2011/059000 WO2011151355A1 (en) 2010-05-31 2011-05-31 Antipsychotic injectable depot composition

Publications (2)

Publication Number Publication Date
MX2012013937A MX2012013937A (es) 2013-02-11
MX338373B true MX338373B (es) 2016-04-13

Family

ID=43301889

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013937A MX338373B (es) 2010-05-31 2011-05-31 Composicion antipsicotica inyectable de liberacion controlada.

Country Status (32)

Country Link
US (2) US10085936B2 (es)
EP (2) EP2394664B1 (es)
JP (1) JP5882993B2 (es)
KR (1) KR101784330B1 (es)
CN (1) CN103002917B (es)
AP (1) AP3524A (es)
AU (1) AU2011260318B2 (es)
BR (1) BR112012030686B1 (es)
CA (1) CA2800111C (es)
CL (1) CL2012003350A1 (es)
CY (2) CY1117969T1 (es)
DK (2) DK2394664T3 (es)
EA (1) EA024155B1 (es)
ES (2) ES2589106T3 (es)
HR (2) HRP20161049T1 (es)
HU (2) HUE029895T2 (es)
IL (1) IL223129A (es)
LT (2) LT2394664T (es)
MA (1) MA34296B1 (es)
ME (1) ME02501B (es)
MX (1) MX338373B (es)
MY (1) MY161930A (es)
NZ (1) NZ604342A (es)
PL (2) PL2394664T3 (es)
PT (2) PT2394664T (es)
RS (1) RS55190B1 (es)
SG (1) SG185775A1 (es)
SI (2) SI2394664T1 (es)
SM (2) SMT201600320B (es)
UA (1) UA108885C2 (es)
WO (1) WO2011151355A1 (es)
ZA (1) ZA201209346B (es)

Families Citing this family (18)

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US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
HUE029895T2 (en) 2010-05-31 2017-04-28 Farm Rovi Lab Sa Antipsychotic injectable depot preparation
HUE057236T2 (hu) 2010-05-31 2022-04-28 Farm Rovi Lab Sa Készítmények befecskendezhetõ in-situ biológiailag lebontható implantátumokhoz
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
DK2529756T3 (da) 2011-05-31 2021-08-02 Farm Rovi Lab Sa Risperidon- og/eller paliperidon-implantatformulering
ES2456917T3 (es) * 2011-05-31 2014-04-24 Laboratorios Farmacéuticos Rovi, S.A. Formulación de implante de paliperidona
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
EP2986278A1 (en) 2013-03-11 2016-02-24 DURECT Corporation Injectable controlled release composition comprising high viscosity liquid carrier
WO2016199170A2 (en) * 2015-06-10 2016-12-15 Cipla Limited Paliperidone palmitate particles and compositions thereof
AU2018238136A1 (en) 2017-03-20 2019-11-07 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulations
CN109589304A (zh) * 2017-10-01 2019-04-09 万特制药(海南)有限公司 利培酮口服溶液及其制备方法
CN110420212A (zh) * 2019-08-19 2019-11-08 韩自勤 一种用于治疗精神分裂症组合物及其制备方法
TW202313047A (zh) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 抗精神病可注射儲積型組合物

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BE758156R (fr) 1970-05-13 1971-04-28 Ethicon Inc Element de suture absorbable et sa
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US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
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US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
DK0729357T3 (da) 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
ES2158611T3 (es) 1996-12-20 2001-09-01 Alza Corp Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion.
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
EP1248596B1 (de) * 2000-01-11 2007-03-07 Roland Bodmeier Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel
US6604561B2 (en) * 2000-02-11 2003-08-12 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
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JP2008518881A (ja) * 2003-07-18 2008-06-05 オークウッド ラボラトリーズ，エル．エル．シー． 高分子組成物中の高分子の分子量低下、不純物形成およびゲル化の防止
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US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
HUE057236T2 (hu) 2010-05-31 2022-04-28 Farm Rovi Lab Sa Készítmények befecskendezhetõ in-situ biológiailag lebontható implantátumokhoz
HUE029895T2 (en) 2010-05-31 2017-04-28 Farm Rovi Lab Sa Antipsychotic injectable depot preparation
ES2456917T3 (es) 2011-05-31 2014-04-24 Laboratorios Farmacéuticos Rovi, S.A. Formulación de implante de paliperidona
DK2529756T3 (da) 2011-05-31 2021-08-02 Farm Rovi Lab Sa Risperidon- og/eller paliperidon-implantatformulering

Also Published As

Publication number Publication date
SMT201600320B (it) 2016-11-10
UA108885C2 (uk) 2015-06-25
RS55190B1 (sr) 2017-01-31
ME02501B (me) 2017-02-20
CY1117964T1 (el) 2017-05-17
SI2575890T1 (sl) 2016-10-28
ES2589106T3 (es) 2016-11-10
EP2575890A1 (en) 2013-04-10
US10182982B2 (en) 2019-01-22
BR112012030686B1 (pt) 2022-11-01
EP2575890B1 (en) 2016-06-01
JP2013528612A (ja) 2013-07-11
JP5882993B2 (ja) 2016-03-09
AU2011260318B2 (en) 2014-11-27
PL2394664T3 (pl) 2016-12-30
SI2394664T1 (sl) 2016-10-28
AP2012006626A0 (en) 2012-12-31
SMT201600321B (it) 2016-11-10
IL223129A0 (en) 2013-02-03
EP2394664B1 (en) 2016-06-01
CL2012003350A1 (es) 2013-10-18
HRP20161049T1 (hr) 2016-12-30
CY1117969T1 (el) 2017-05-17
KR101784330B1 (ko) 2017-10-11
SG185775A1 (en) 2013-01-30
AP3524A (en) 2016-01-11
US10085936B2 (en) 2018-10-02
PT2394664T (pt) 2016-09-06
LT2394664T (lt) 2016-09-26
WO2011151355A1 (en) 2011-12-08
KR20130118742A (ko) 2013-10-30
ES2592527T3 (es) 2016-11-30
DK2575890T3 (en) 2016-09-12
CN103002917A (zh) 2013-03-27
NZ604342A (en) 2014-11-28
EP2394664A1 (en) 2011-12-14
EA201201569A1 (ru) 2013-04-30
LT2575890T (lt) 2016-09-26
PL2575890T3 (pl) 2016-12-30
CA2800111A1 (en) 2011-12-08
DK2394664T3 (en) 2016-09-12
IL223129A (en) 2016-02-29
HUE029895T2 (en) 2017-04-28
PT2575890T (pt) 2016-09-06
MX2012013937A (es) 2013-02-11
EA024155B1 (ru) 2016-08-31
HRP20161100T1 (hr) 2016-11-04
AU2011260318A1 (en) 2013-01-10
HUE029056T2 (en) 2017-02-28
BR112012030686A2 (pt) 2020-08-25
MY161930A (en) 2017-05-15
MA34296B1 (fr) 2013-06-01
US20180221272A1 (en) 2018-08-09
US20130171202A1 (en) 2013-07-04
CN103002917B (zh) 2016-04-27
ZA201209346B (en) 2013-08-28
CA2800111C (en) 2018-05-22

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