MX2025007819A - Composiciones para usarse en el tratamiento de un sujeto que tiene hemofilia - Google Patents

Composiciones para usarse en el tratamiento de un sujeto que tiene hemofilia

Info

Publication number
MX2025007819A
MX2025007819A MX2025007819A MX2025007819A MX2025007819A MX 2025007819 A MX2025007819 A MX 2025007819A MX 2025007819 A MX2025007819 A MX 2025007819A MX 2025007819 A MX2025007819 A MX 2025007819A MX 2025007819 A MX2025007819 A MX 2025007819A
Authority
MX
Mexico
Prior art keywords
compositions
hemophilia
subject
methods
treating
Prior art date
Application number
MX2025007819A
Other languages
English (en)
Spanish (es)
Inventor
Akin Akinc
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2025007819A publication Critical patent/MX2025007819A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MX2025007819A 2017-07-10 2020-01-10 Composiciones para usarse en el tratamiento de un sujeto que tiene hemofilia MX2025007819A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762530518P 2017-07-10 2017-07-10
US201762599223P 2017-12-15 2017-12-15
US201862614111P 2018-01-05 2018-01-05
US201862673424P 2018-05-18 2018-05-18
PCT/US2018/041400 WO2019014187A1 (en) 2017-07-10 2018-07-10 METHODS AND COMPOSITIONS FOR TREATING A BLEEDING EVENT IN A SUBJECT WITH HEMOPHILIA

Publications (1)

Publication Number Publication Date
MX2025007819A true MX2025007819A (es) 2025-08-01

Family

ID=63036452

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2025007819A MX2025007819A (es) 2017-07-10 2020-01-10 Composiciones para usarse en el tratamiento de un sujeto que tiene hemofilia

Country Status (17)

Country Link
US (2) US20200163987A1 (https=)
EP (3) EP4588512A3 (https=)
JP (3) JP2020530442A (https=)
KR (2) KR20250159269A (https=)
CN (1) CN111093771A (https=)
AU (2) AU2018301801A1 (https=)
BR (1) BR112020000400A2 (https=)
CA (1) CA3069150A1 (https=)
CO (1) CO2020001354A2 (https=)
IL (1) IL271646A (https=)
MX (1) MX2025007819A (https=)
NZ (1) NZ761103A (https=)
PY (1) PY1855437A (https=)
SG (1) SG11201912243PA (https=)
TW (2) TW202434265A (https=)
UY (1) UY37803A (https=)
WO (1) WO2019014187A1 (https=)

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AU2021296786A1 (en) 2020-06-22 2023-02-23 Genzyme Corporation Methods and compositions for treating hemophilia
WO2022076835A1 (en) * 2020-10-09 2022-04-14 Dyax Corp. Methods and apparatuses for modeling adamts13 and von willebrand factor interactions
IL303452A (en) * 2020-12-06 2023-08-01 Genzyme Corp Treatment of hemophilia with fitusiran
WO2022120291A1 (en) * 2020-12-06 2022-06-09 Genzyme Corporation Treatment of hemophilia with fitusiran
KR102755621B1 (ko) 2021-08-19 2025-01-21 (주) 바텍에스이씨 폭발 위험도 산출 장치 및 방법
KR102826316B1 (ko) 2021-08-19 2025-06-27 (주) 바텍에스이씨 액체 누설에 의한 폭발 위험도 산출 장치 및 방법
TW202342065A (zh) 2021-12-22 2023-11-01 美商健臻公司 治療血友病的方法和組成物
IL317440A (en) 2022-06-08 2025-02-01 Genzyme Corp FITUSIRAN for the treatment of hemophilia A and B
WO2023240193A2 (en) 2022-06-08 2023-12-14 Genzyme Corporation Treatment of hemophilia with fitusiran in pediatric patients
EP4611847A1 (en) 2022-10-31 2025-09-10 Sanofi Container holder and drug delivery device comprising the container holder
WO2024094705A1 (en) 2022-10-31 2024-05-10 Sanofi Drug delivery device having a two-part user indicator
EP4611853A1 (en) 2022-10-31 2025-09-10 Sanofi Assembly for a drug delivery device
EP4611851A1 (en) 2022-10-31 2025-09-10 Sanofi Drug delivery device with feedback element and method for providing a user of a drug delivery device feedback regarding a dose dispensing process
WO2024094700A1 (en) 2022-10-31 2024-05-10 Sanofi Method for assembling an assembly for a drug delivery device and drug delivery device.
CN120129547A (zh) 2022-10-31 2025-06-10 赛诺菲 用于药物递送装置的装置本体、用于药物递送装置的组件以及药物递送装置
EP4611846A1 (en) 2022-10-31 2025-09-10 Sanofi Plunger for expelling a drug, drug delivery device, rear sub-assembly and corresponding methods
CN120476001A (zh) 2022-10-31 2025-08-12 赛诺菲 用于药物递送装置的前子组件
WO2024094704A1 (en) 2022-10-31 2024-05-10 Sanofi Arrangement for a drug delivery device, drug delivery device and method for assembly
WO2024094706A1 (en) 2022-10-31 2024-05-10 Sanofi Audible indicator, indicator holder and method of assembling an audible indicator
EP4612687A1 (en) 2022-11-02 2025-09-10 Genzyme Corporation Systems and methods for modeling thrombin-antithrombin
CN121285406A (zh) 2023-06-05 2026-01-06 赛诺菲 药物递送装置
EP4719537A1 (en) 2023-06-05 2026-04-08 Sanofi Drug delivery device
EP4719527A1 (en) 2023-06-05 2026-04-08 Sanofi Drug delivery device
WO2024251797A1 (en) 2023-06-05 2024-12-12 Sanofi Drug delivery device
CN121240902A (zh) 2023-06-05 2025-12-30 赛诺菲 自驱动药剂容器和药剂递送装置
CN121240901A (zh) 2023-06-05 2025-12-30 赛诺菲 具有侧向柔性针头套筒的药物递送装置
WO2024251796A1 (en) 2023-06-05 2024-12-12 Sanofi Drug delivery device having two drug delivery arrangements
EP4719538A1 (en) 2023-06-05 2026-04-08 Sanofi Drug delivery device
EP4719531A1 (en) 2023-06-05 2026-04-08 Sanofi Drug delivery device and method for decoupling a drug administration element and at least one part of a drug delivery device
WO2024251792A1 (en) 2023-06-05 2024-12-12 Sanofi Drug delivery device
CN121263160A (zh) 2023-06-05 2026-01-02 赛诺菲 刺孔封闭辅助构件、药物递送装置和方法
CN121816187A (zh) 2023-09-15 2026-04-07 建新公司 用非妥西兰治疗血友病a
WO2025162927A1 (en) 2024-01-29 2025-08-07 Sanofi Purifying device, system and method for purifying a needle for delivering a medicament
WO2025162926A1 (en) 2024-01-29 2025-08-07 Sanofi Needle arrangement, drug delivery device comprising the needle arrangement and method for operating the drug delivery device
WO2025162928A1 (en) 2024-01-29 2025-08-07 Sanofi Needle shroud unlock device for a medicament delivery device
WO2025171279A1 (en) 2024-02-09 2025-08-14 Genzyme Corporation Treatment of hemophilia with fitusiran
WO2025212516A1 (en) 2024-04-01 2025-10-09 Genzyme Corporation Treatment of factor x deficiency with fitusiran
CN118557756B (zh) * 2024-05-24 2025-04-29 华中科技大学同济医学院附属协和医院 一种基于aav的遗传性抗凝血酶缺乏的基因疗法
WO2026012399A1 (zh) * 2024-07-10 2026-01-15 正大天晴药业集团股份有限公司 靶向serpinc1的双链核糖核酸

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