MX2024004063A - Estereocomplejos dobles que comprende componentes de grupos hidrofilos, enlazadores de acido polilactico y 2 agentes anticancerigenos diferentes, y el uso de estos para tratar cancer o reducir tumores. - Google Patents
Estereocomplejos dobles que comprende componentes de grupos hidrofilos, enlazadores de acido polilactico y 2 agentes anticancerigenos diferentes, y el uso de estos para tratar cancer o reducir tumores.Info
- Publication number
- MX2024004063A MX2024004063A MX2024004063A MX2024004063A MX2024004063A MX 2024004063 A MX2024004063 A MX 2024004063A MX 2024004063 A MX2024004063 A MX 2024004063A MX 2024004063 A MX2024004063 A MX 2024004063A MX 2024004063 A MX2024004063 A MX 2024004063A
- Authority
- MX
- Mexico
- Prior art keywords
- stereocomplexes
- cancer agents
- delivery
- cancer
- disclosed
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
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- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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Abstract
En el presente documento se describen estereocomplejos para la administración de uno o más agentes anticancerígenos. Los estereocomplejos exhiben baja toxicidad y son biodegradables al mismo tiempo que proporcionan una liberación controlada de uno o más agentes anticancerígenos en los sitios del tumor. Los estereocomplejos pueden diseñarse de manera que los agentes anticancerígenos operen de forma sinérgica y pueden incluir opcionalmente grupos de direccionamiento y funcionalidades adicionales. Los estereocomplejos divulgados en este documento se pueden combinar con vehículos y/o excipientes farmacéuticamente aceptables para formar composiciones farmacéuticas. Variando la cantidad de cada agente anticancerígeno en el estereocomplejo, se pueden tratar tipos específicos de tumores y líneas de células cancerosas. Las ventajas de los materiales, métodos y dispositivos divulgados en este documento se expondrán en parte en la descripción que sigue, o se pueden aprender mediante la práctica de los aspectos descritos a continuación. Las ventajas descritas a continuación se realizarán y alcanzarán mediante los elementos y combinaciones señalados particularmente en las reivindicaciones adjuntas. Debe entenderse que tanto la descripción general anterior como la descripción detallada siguiente son únicamente ilustrativas y explicativas y no son restrictivas.
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MX2021006557A MX2021006557A (es) | 2018-12-04 | 2019-12-03 | Estereocomplejos para la administración de agentes anticancerígenos. |
MX2024004063A MX2024004063A (es) | 2018-12-04 | 2021-06-03 | Estereocomplejos dobles que comprende componentes de grupos hidrofilos, enlazadores de acido polilactico y 2 agentes anticancerigenos diferentes, y el uso de estos para tratar cancer o reducir tumores. |
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MX2021006557A MX2021006557A (es) | 2018-12-04 | 2019-12-03 | Estereocomplejos para la administración de agentes anticancerígenos. |
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US (1) | US12029792B2 (es) |
EP (2) | EP3891207B1 (es) |
JP (2) | JP2022514463A (es) |
KR (1) | KR20210107029A (es) |
CN (2) | CN115671286B (es) |
AU (1) | AU2019394855A1 (es) |
CA (1) | CA3121902A1 (es) |
MX (2) | MX2021006557A (es) |
TW (1) | TWI744730B (es) |
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CN113289062B (zh) * | 2021-05-17 | 2022-08-30 | 辽宁省计划生育科学研究院 | 一种溶剂沉淀型原位凝胶注射植入剂及应用 |
WO2023204581A1 (ko) * | 2022-04-20 | 2023-10-26 | 동국대학교 산학협력단 | 암세포 사멸효과를 가지는 3d 하이드로젤 복합체 및 이의 제조방법 |
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JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
EP1242401B1 (en) | 1999-11-24 | 2006-12-27 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
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US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US6596757B1 (en) | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
EP1765285A2 (en) | 2004-06-16 | 2007-03-28 | University of Massachusetts | Poly (lactid acid) copolymer hydrogels and related methods of drug delivery |
EA200702239A1 (ru) | 2005-04-15 | 2008-10-30 | Иммьюноджен, Инк. | Уничтожение гетерогенной или смешанной клеточной популяции в опухолях |
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TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
HRP20220428T3 (hr) | 2007-02-16 | 2022-05-27 | Rotalec Ip Holdings Llc | Fiksni omjeri lijeka za liječenje hematopoetskih tumora i proliferativnih poremećaja |
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KR101892411B1 (ko) | 2008-04-30 | 2018-08-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
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CN103772686B (zh) * | 2012-10-26 | 2015-01-07 | 苏州雷纳药物研发有限公司 | 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统 |
WO2016145096A1 (en) | 2015-03-09 | 2016-09-15 | The Regents Of The University Of California | Polymer-drug conjugates for combination anticancer therapy |
CN105031672A (zh) | 2015-07-14 | 2015-11-11 | 同济大学 | 一种聚乳酸立构复合物磁性纳米胶束的制备方法 |
CA3017690C (en) * | 2016-03-14 | 2024-02-20 | Wisconsin Alumni Research Foundation | Oligolactic acid conjugates and micelles with enhanced anticancer efficacy |
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CN106581691B (zh) | 2016-12-04 | 2019-09-10 | 苏州大学 | 还原响应的靶向聚乙二醇-聚碳酸酯美登素前药胶束、其制备方法与应用 |
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CN115671286A (zh) | 2023-02-03 |
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AU2019394855A1 (en) | 2021-06-24 |
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TW202042843A (zh) | 2020-12-01 |
CN113260653A (zh) | 2021-08-13 |
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