MX2023015125A - Composiciones y metodos para reducir la carga biologica en cromatografia. - Google Patents

Composiciones y metodos para reducir la carga biologica en cromatografia.

Info

Publication number
MX2023015125A
MX2023015125A MX2023015125A MX2023015125A MX2023015125A MX 2023015125 A MX2023015125 A MX 2023015125A MX 2023015125 A MX2023015125 A MX 2023015125A MX 2023015125 A MX2023015125 A MX 2023015125A MX 2023015125 A MX2023015125 A MX 2023015125A
Authority
MX
Mexico
Prior art keywords
chromatography
reducing bioburden
bioburden reduction
bioburden
reducing
Prior art date
Application number
MX2023015125A
Other languages
English (en)
Inventor
Bernhard Schilling
Scott Carver
Nathan L Mao
Wenbin Qi
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2023015125A publication Critical patent/MX2023015125A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/10—Terrestrial scenes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/40—Scenes; Scene-specific elements in video content
    • G06V20/46—Extracting features or characteristics from the video content, e.g. video fingerprints, representative shots or key frames
    • G—PHYSICS
    • G08—SIGNALLING
    • G08G—TRAFFIC CONTROL SYSTEMS
    • G08G1/00—Traffic control systems for road vehicles
    • G08G1/01—Detecting movement of traffic to be counted or controlled
    • G08G1/017—Detecting movement of traffic to be counted or controlled identifying vehicles
    • G08G1/0175—Detecting movement of traffic to be counted or controlled identifying vehicles by photographing vehicles, e.g. when violating traffic rules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/62—Text, e.g. of license plates, overlay texts or captions on TV images
    • G06V20/625—License plates
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/08—Detecting or categorising vehicles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La invención proporciona métodos para reducir la carga biológica microbiana de varias matrices cromatográficas, incluyendo la reducción de la carga biológica en el contexto de las columnas de cromatografía de afinidad basadas en proteína A a gran escala.
MX2023015125A 2017-01-30 2019-07-29 Composiciones y metodos para reducir la carga biologica en cromatografia. MX2023015125A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762452140P 2017-01-30 2017-01-30

Publications (1)

Publication Number Publication Date
MX2023015125A true MX2023015125A (es) 2024-01-22

Family

ID=61249704

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019008996A MX2019008996A (es) 2017-01-30 2018-01-29 Composiciones y metodos para reducir la carga biologica en cromatografia.
MX2023015125A MX2023015125A (es) 2017-01-30 2019-07-29 Composiciones y metodos para reducir la carga biologica en cromatografia.
MX2023008870A MX2023008870A (es) 2017-01-30 2019-07-29 Composiciones y metodos para reducir la carga biologica en cromatografia.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019008996A MX2019008996A (es) 2017-01-30 2018-01-29 Composiciones y metodos para reducir la carga biologica en cromatografia.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023008870A MX2023008870A (es) 2017-01-30 2019-07-29 Composiciones y metodos para reducir la carga biologica en cromatografia.

Country Status (11)

Country Link
US (4) US10925986B2 (es)
EP (2) EP4403193A2 (es)
JP (5) JP7479151B2 (es)
KR (2) KR102586771B1 (es)
CN (2) CN114470872A (es)
AU (2) AU2018212974B2 (es)
CA (2) CA3233933A1 (es)
IL (4) IL287543B1 (es)
MX (3) MX2019008996A (es)
SG (2) SG11201905510XA (es)
WO (1) WO2018140887A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
AU2018212974B2 (en) * 2017-01-30 2023-08-24 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography
CA3110666A1 (en) * 2018-08-31 2020-03-05 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
KR20210148349A (ko) * 2019-04-17 2021-12-07 브리스톨-마이어스 스큅 컴퍼니 크로마토그래피 수지의 재생 방법
WO2022236085A1 (en) * 2021-05-07 2022-11-10 Genzyme Corporation Composition and methods for sanitization

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202246A (en) * 1989-08-16 1993-04-13 Armour Pharmaceutical Company Treatment of immobilized matrices for preparation of pharmaceutical and biological products with anti-microbial agents to remove pyrogen-producing organisms and pyrogens
AT408191B (de) * 1991-08-19 2001-09-25 Haemosan Erzeugung Pharmazeuti Verfahren zur inaktivierung von prionen
DE4321904B4 (de) * 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
US5643755A (en) * 1994-10-07 1997-07-01 Regeneron Pharmaceuticals Inc. Nucleic acid encoding tie-2 ligand
AU685954B2 (en) * 1994-05-31 1998-01-29 Biosepra Inc. Sterilization of liquid chromatography resins
US5814464A (en) * 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
US5650496A (en) * 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
US6022694A (en) * 1997-04-04 2000-02-08 Regeneron Pharmaceuticals, Inc. Assay for ligands to tyrosine kinase receptors
WO2000048639A1 (en) * 1999-02-17 2000-08-24 Resolution Pharmaceuticals Inc. Immobilized labeling compounds and methods
CA2385179A1 (en) * 1999-10-08 2001-04-19 David J. Hammond Isoagglutinin-depleted blood compositions and methods of making same
EP1358202A2 (en) * 2000-02-08 2003-11-05 The Regents Of The University Of Michigan Protein separation and display
WO2002032537A2 (en) * 2000-10-13 2002-04-25 Eli Lilly And Company Improved method of expanded bed chromatography
SE0004929D0 (sv) * 2000-12-29 2000-12-29 Apbiotech Ab A method for producing liquid chromatography matrices
DE10155984A1 (de) * 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
US6913695B2 (en) 2003-07-08 2005-07-05 Bayer Healthcare Llc Sanitization of chromatographic media
CA2577822C (en) * 2004-09-22 2012-11-20 Ge Healthcare Bio-Sciences Ab Method of preparing a chromatography matrix
KR101243425B1 (ko) * 2004-10-21 2013-03-13 지이 헬스케어 바이오-사이언시스 에이비 항체의 정제 방법
WO2007109163A2 (en) * 2006-03-16 2007-09-27 Amgen Inc Wash buffer and method of using
WO2007139463A1 (en) * 2006-05-29 2007-12-06 Ge Healthcare Bio-Sciences Ab Preparation of monolithic articles
ES2764222T3 (es) * 2006-09-08 2020-06-02 Wyeth Llc Lavado con arginina en la purificación de proteínas mediante el uso de cromatografía de afinidad
ES2384659T3 (es) 2007-02-01 2012-07-10 Avantor Performance Materials, Inc. Disoluciones para el almacenamiento de medios cromatográficos y equipo cromatográfico y uso de las mismas
DE102008030142A1 (de) * 2008-06-27 2009-12-31 Qiagen Gmbh Verfahren zur Proteinaufreinigung unter denaturierenden Bedingungen
ES2391931T3 (es) 2008-09-15 2012-12-03 Emd Millipore Corporation Procedimientos para cuantificar la filtración de proteína desde resinas de cromatografía de afinidad basada en proteína
US20120282654A1 (en) * 2009-04-29 2012-11-08 Schering Corporation Antibody purification
ES2743156T3 (es) * 2010-04-23 2020-02-18 Serum Institute Of India Pvt Ltd Método simple para eliminación simultánea de múltiples impurezas a partir de sobrenadantes de cultivo a niveles ultrabajos
US20120264920A1 (en) * 2010-10-11 2012-10-18 Abbott Laboratories Processes for purification of proteins
US9102709B1 (en) * 2011-07-08 2015-08-11 Biogen Ma Inc. Regeneration of chromatography material
CA2862820A1 (en) * 2012-02-29 2013-09-06 F. Hoffmann-La Roche Ag On-column enzymatic cleavage
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US20140154270A1 (en) * 2012-05-21 2014-06-05 Chen Wang Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
JP5782533B2 (ja) * 2013-03-28 2015-09-24 富士フイルム株式会社 クロマトグラフ方法及びクロマトグラフキット
EP3041857B1 (en) 2013-09-04 2019-05-08 EMD Millipore Corporation Protein a chromatography
WO2015035180A1 (en) 2013-09-05 2015-03-12 Genentech, Inc. Method for chromatography reuse
JP5910696B1 (ja) * 2014-10-06 2016-04-27 栗田工業株式会社 逆浸透膜の洗浄剤、洗浄液、および洗浄方法
GB201503578D0 (en) 2015-03-03 2015-04-15 Ge Healthcare Bio Sciences Ab Sanitization method for affinity chromatography matrices
EP3268100A1 (en) 2015-03-13 2018-01-17 Bristol-Myers Squibb Company Use of alkaline washes during chromatography to remove impurities
US20170066839A1 (en) * 2015-09-08 2017-03-09 Merck Patent Gmbh Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies
CN107064286B (zh) * 2017-01-16 2018-07-20 常州市疾病预防控制中心 革兰氏阳性及阴性菌质谱检测试剂盒及快速鉴定的方法
AU2018212974B2 (en) * 2017-01-30 2023-08-24 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography

Also Published As

Publication number Publication date
EP4403193A2 (en) 2024-07-24
JP2022137067A (ja) 2022-09-21
CA3047790A1 (en) 2018-08-02
KR20230041082A (ko) 2023-03-23
US20220331468A1 (en) 2022-10-20
CN114470872A (zh) 2022-05-13
IL268029A (en) 2019-09-26
KR20190109493A (ko) 2019-09-25
CN110267721B (zh) 2022-03-01
CN110267721A (zh) 2019-09-20
EP3573734A1 (en) 2019-12-04
JP2022028013A (ja) 2022-02-14
US20230343086A1 (en) 2023-10-26
AU2018212974A1 (en) 2019-08-08
US10925986B2 (en) 2021-02-23
US20180214587A1 (en) 2018-08-02
SG10202102298YA (en) 2021-04-29
IL268029B (en) 2021-12-01
CA3233933A1 (en) 2018-08-02
KR102716846B1 (ko) 2024-10-15
KR102586771B1 (ko) 2023-10-11
JP2020507371A (ja) 2020-03-12
AU2023270342A1 (en) 2023-12-14
IL287543A (en) 2021-12-01
US11717586B2 (en) 2023-08-08
AU2018212974B2 (en) 2023-08-24
IL299270A (en) 2023-02-01
WO2018140887A1 (en) 2018-08-02
IL299270B2 (en) 2024-10-01
JP7361754B2 (ja) 2023-10-16
IL287543B1 (en) 2024-10-01
JP7479151B2 (ja) 2024-05-08
IL312404A (en) 2024-06-01
US20210138098A1 (en) 2021-05-13
MX2023008870A (es) 2023-08-15
JP2023174943A (ja) 2023-12-08
JP2024119801A (ja) 2024-09-03
IL299270B1 (en) 2024-06-01
WO2018140887A8 (en) 2019-08-01
SG11201905510XA (en) 2019-08-27
MX2019008996A (es) 2019-09-11
US11369707B2 (en) 2022-06-28

Similar Documents

Publication Publication Date Title
MX2023015125A (es) Composiciones y metodos para reducir la carga biologica en cromatografia.
IN2013MU02145A (es)
AU2019268074A1 (en) Methods for treating hepcidin-mediated disorders
EP3200072A4 (en) Method for updating terminal system, terminal and system
MX2017016169A (es) Anticuerpos anti-her2 y metodos de uso.
BR112016016916A2 (pt) método de tratamento de angiodema hereditário (hae)
EP3677320A4 (en) TRAINING ASSISTANCE PROGRAM, TRAINING ASSISTANCE PROCESS AND TRAINING ASSISTANCE SYSTEM
EP3330160A4 (en) Steer-by-wire system, and control method for steer-by-wire system
MX2024006922A (es) Metodo de cromatografia para cuantificar un tensioactivo no ionico en una composicion que comprende el tensioactivo no ionico y un polipeptido.
EP3382576A4 (en) Anonymous search system, anonymous search method, and anonymous search program
PL3337812T3 (pl) Sposób zmniejszenia zawartości białek komórki gospodarza w chromatografii powinowactwa
WO2019083318A3 (ko) 개선된 면역글로불린의 정제방법
EP3255058A4 (en) Protein having affinity to immunoglobulin, and affinity separation medium and column for liquid chromatography using same
MX2016013416A (es) Nuevo proceso de purificacion de gonadotropina.
EP3572507A4 (en) EXPRESSION METHOD FOR RECOMBINANT HAEMOCOAGULASE ACUTUS PROTEIN
EP3260862A4 (en) Method for suppressing protein adsorption
MX2017010883A (es) Composicion para el tratamiento de la infertilidad.
EP3336191A4 (en) Escherichia sp. microorganism having l-tryptophan productivity and method for preparing l-tryptophan by using same
EP3816313A4 (en) ELECTRIC RESISTANCE WELDED STEEL PIPE TO PRODUCE A HOLLOW STABILIZER, HOLLOW STABILIZER AND ITS PRODUCTION PROCESS
EP3367093A4 (en) Affinity chromatography carrier and biological substance purification method
EP3321327A4 (en) Liquid composition, method for producing same and method for producing membrane electrode assembly
EP3679147C0 (en) 2-O-SULFATION ENZYME MUTANT AND 3-O-SULFATION ENZYME MUTANT AND METHODS OF USE THEREOF
EP3536805A3 (en) Analytical methods and arrays for use in the same
EP3673989A4 (en) CHROMATOGRAPHY CARRIER, LIGAND-IMMOBILIZING CARRIER, CHROMATOGRAPHY COLUMN, TARGET SUBSTANCE CLEANING PROCESS AND CHROMATOGRAPHY CARRIER MANUFACTURING PROCESS
HK1251583A1 (zh) 在親和層析中減少宿主細胞蛋白的方法