MX2023011576A - Compuestos para la inhibicion de proteinas que contienen el dominio de pirina de la familia nlr 3 (nlrp3) y usos de estos. - Google Patents

Compuestos para la inhibicion de proteinas que contienen el dominio de pirina de la familia nlr 3 (nlrp3) y usos de estos.

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Publication number
MX2023011576A
MX2023011576A MX2023011576A MX2023011576A MX2023011576A MX 2023011576 A MX2023011576 A MX 2023011576A MX 2023011576 A MX2023011576 A MX 2023011576A MX 2023011576 A MX2023011576 A MX 2023011576A MX 2023011576 A MX2023011576 A MX 2023011576A
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MX
Mexico
Prior art keywords
pyridazine compounds
inhibiting nlrp3
nlrp3
inhibiting
pyridazine
Prior art date
Application number
MX2023011576A
Other languages
English (en)
Inventor
Jason Burch
Ramsay Beveridge
Alexandre Côté
Stéphane Dorich
Miguel St-Onge
Amandine Chefson
Stéphane Ciblat
Original Assignee
Ventus Therapeutics U S Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventus Therapeutics U S Inc filed Critical Ventus Therapeutics U S Inc
Publication of MX2023011576A publication Critical patent/MX2023011576A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente descripción está relacionada con inhibidores de NLRP3 útiles en el tratamiento de enfermedades y trastornos inhibidos por la proteína y con la Fórmula (I): (ver Fórmula).
MX2023011576A 2021-04-07 2022-04-07 Compuestos para la inhibicion de proteinas que contienen el dominio de pirina de la familia nlr 3 (nlrp3) y usos de estos. MX2023011576A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163171932P 2021-04-07 2021-04-07
US17/528,928 US11319319B1 (en) 2021-04-07 2021-11-17 Compounds for inhibiting NLRP3 and uses thereof
PCT/US2022/023893 WO2022216971A1 (en) 2021-04-07 2022-04-07 Pyridazine compounds for inhibiting nlrp3

Publications (1)

Publication Number Publication Date
MX2023011576A true MX2023011576A (es) 2023-11-09

Family

ID=81385286

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023011576A MX2023011576A (es) 2021-04-07 2022-04-07 Compuestos para la inhibicion de proteinas que contienen el dominio de pirina de la familia nlr 3 (nlrp3) y usos de estos.

Country Status (15)

Country Link
US (6) US11319319B1 (es)
EP (2) EP4320102A1 (es)
JP (2) JP2024514837A (es)
KR (1) KR20230167394A (es)
CN (2) CN117510495A (es)
AU (2) AU2022256052A1 (es)
BR (1) BR112023020483A2 (es)
CA (1) CA3214676A1 (es)
CL (1) CL2023002973A1 (es)
CO (1) CO2023013356A2 (es)
IL (2) IL307303A (es)
MX (1) MX2023011576A (es)
PE (1) PE20240765A1 (es)
TW (2) TW202304905A (es)
WO (1) WO2022216971A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11319319B1 (en) * 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CN115433163A (zh) * 2021-06-05 2022-12-06 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
EP4363406A1 (en) * 2021-07-02 2024-05-08 Astrazeneca AB Nlrp3 inflammasome inhibitors
JPWO2023003002A1 (es) 2021-07-21 2023-01-26
CA3229539A1 (en) * 2021-08-25 2023-03-02 Xiaoyan Zhang Inhibitors of nlrp3
CA3233482A1 (en) * 2021-09-30 2023-04-06 Origiant Pharmaceutical Co., Ltd Pharmaceutical use and preparation method for substituted heteroaryl phthalazine derivative
WO2023066377A1 (zh) * 2021-10-22 2023-04-27 索智生物科技（浙江）有限公司 一种含氮化合物、其制备方法及应用
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
TW202345836A (zh) * 2022-03-25 2023-12-01 美商凡特斯治療美國公司 可用作ＮＬＲＰ３衍生物之吡啶并－〔３，４－ｄ〕噠嗪胺衍生物
WO2023186020A1 (en) * 2022-03-31 2023-10-05 Hangzhou Highlightll Pharmaceutical Co., Ltd Nlrp3 inflammasome inhibitors
US20240034735A1 (en) * 2022-07-14 2024-02-01 Ac Immune Sa Novel compounds
WO2024064245A1 (en) 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2024090469A1 (ja) * 2022-10-26 2024-05-02 アステラス製薬株式会社 縮環ピリダジン誘導体
WO2024097629A1 (en) * 2022-10-31 2024-05-10 Ventus Therapeutics U.S., Inc. Bridged bicyclic heterocycloalkyl pyrido-[3,4-d]pyridazine amine derivatives useful as nlrp3 inhibitors
CN117986258A (zh) * 2022-11-04 2024-05-07 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
WO2024109922A1 (zh) * 2022-11-25 2024-05-30 成都赜灵生物医药科技有限公司 桥环并哒嗪类化合物及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303061A (es) * 1969-05-03 1973-01-17
GB2063249A (en) * 1979-10-09 1981-06-03 Mitsubishi Yuka Pharma 4-Phenylphthalazine derivatives
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPH03284669A (ja) * 1990-03-30 1991-12-16 Mitsubishi Kasei Corp ４―フェニルフタラジン誘導体
DE69533057T2 (de) * 1994-08-09 2005-06-16 Eisai Co., Ltd. Kondensierte pyridazinverbindungen
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
AU2005260102A1 (en) * 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
US10947241B2 (en) * 2016-10-28 2021-03-16 Seoul National University Hospital Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
AR119731A1 (es) * 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
US11319319B1 (en) * 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof

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AU2022256052A1 (en) 2023-11-16
CN117510495A (zh) 2024-02-06
PE20240765A1 (es) 2024-04-17
EP4320102A1 (en) 2024-02-14
IL308378A (en) 2024-01-01
KR20230167394A (ko) 2023-12-08
CN117500792A (zh) 2024-02-02
WO2022216971A9 (en) 2022-12-08
EP4331668A3 (en) 2024-06-05
AU2023263450A1 (en) 2023-11-23
EP4331668A2 (en) 2024-03-06
US20220340567A1 (en) 2022-10-27
JP2024050527A (ja) 2024-04-10
CL2023002973A1 (es) 2024-03-08
CA3214676A1 (en) 2022-10-13
US11319319B1 (en) 2022-05-03
WO2022216971A1 (en) 2022-10-13
BR112023020483A2 (pt) 2023-11-21
TW202330522A (zh) 2023-08-01
CO2023013356A2 (es) 2023-10-30
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US20240158396A1 (en) 2024-05-16
IL307303A (en) 2023-11-01
US20230159526A1 (en) 2023-05-25
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