MX2023006856A - Composiciones de polvo seco con estearato de magnesio. - Google Patents

Composiciones de polvo seco con estearato de magnesio.

Info

Publication number
MX2023006856A
MX2023006856A MX2023006856A MX2023006856A MX2023006856A MX 2023006856 A MX2023006856 A MX 2023006856A MX 2023006856 A MX2023006856 A MX 2023006856A MX 2023006856 A MX2023006856 A MX 2023006856A MX 2023006856 A MX2023006856 A MX 2023006856A
Authority
MX
Mexico
Prior art keywords
dry powder
magnesium stearate
powder compositions
âμm
powder composition
Prior art date
Application number
MX2023006856A
Other languages
English (en)
Inventor
Kambiz Yadidi
Original Assignee
Otitopic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otitopic Inc filed Critical Otitopic Inc
Publication of MX2023006856A publication Critical patent/MX2023006856A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0023—Mouthpieces therefor retractable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición de polvo seco estable para inhalación incluye ácido acetilsalicílico en partículas que tienen un diámetro aerodinámico medio de masa (MMAD) en un intervalo de aproximadamente 1 µm a aproximadamente 5 µm. La composición de polvo seco puede contener un excipiente farmacéuticamente aceptable, tal como un estearato, en una cantidad que varía de aproximadamente 0.04% (p/p) a aproximadamente 0.06% (p/p), o de aproximadamente 0.4% (p/p) a aproximadamente 0.6% (p/p) de la composición.
MX2023006856A 2017-09-22 2020-03-12 Composiciones de polvo seco con estearato de magnesio. MX2023006856A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762562295P 2017-09-22 2017-09-22

Publications (1)

Publication Number Publication Date
MX2023006856A true MX2023006856A (es) 2023-06-22

Family

ID=65200304

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020002769A MX2020002769A (es) 2017-09-22 2017-09-26 Composiciones de polvo seco con estearato de magnesio.
MX2023006856A MX2023006856A (es) 2017-09-22 2020-03-12 Composiciones de polvo seco con estearato de magnesio.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020002769A MX2020002769A (es) 2017-09-22 2017-09-26 Composiciones de polvo seco con estearato de magnesio.

Country Status (9)

Country Link
US (3) US10195147B1 (es)
EP (1) EP3684338A4 (es)
JP (1) JP2022137070A (es)
KR (2) KR102507987B1 (es)
CN (2) CN115919780A (es)
AU (1) AU2017432640B2 (es)
CA (1) CA3076353A1 (es)
MX (2) MX2020002769A (es)
WO (1) WO2019059953A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013388034B2 (en) * 2013-04-30 2019-08-15 Vectura Inc. Dry powder formulations and methods of use
PT3393517T (pt) * 2015-12-22 2021-10-19 Aspiair Gmbh Ácido acetilsalicílico para utilização no tratamento de influenza moderada a grave
EP3463378A4 (en) * 2016-06-03 2020-01-08 Otitopic Inc. DRY POWDER FORMULAS FOR INHALATION
CN117379443A (zh) 2017-05-30 2024-01-12 罗山制药股份有限公司 稳定、无菌和结晶的邻乙酰水杨酸(阿司匹林)的小瓶内沉积物
WO2023205388A1 (en) * 2022-04-22 2023-10-26 Board Of Regents, The University Of Texas System Inhaled antibacterial formulations for treating lung infections

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
FR2580634B1 (fr) 1985-04-19 1988-08-05 Rhone Poulenc Sante Nouveau derive de l'acide acetylsalicylique, sa preparation et les compositions pharmaceutiques qui le contiennent
DE3814856A1 (de) 1988-05-02 1989-11-16 Verla Pharm Mittel zur prophylaxe des herzinfarkts und zur verhuetung des reinfarkts
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US5327883A (en) 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US20070117862A1 (en) 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US5533502A (en) 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
CN100358494C (zh) 1998-11-12 2008-01-02 弗兰克G·皮尔基威克兹 一种吸入给药系统
US20030176421A1 (en) 1999-12-30 2003-09-18 Watson John W. Prokinetic agents for treating gastric hypomotility and related disorders
MXPA02008403A (es) 2000-02-28 2004-09-27 Vectura Ltd Mejoras en o relacionadas con el suministro de farmacos por via oral.
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0010709D0 (en) 2000-05-03 2000-06-28 Vectura Ltd Powders for use a in dry powder inhaler
EP1177805A1 (en) 2000-07-31 2002-02-06 Maryland Financial Inc. Powder inhaler
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
BR0115524A (pt) 2000-12-22 2003-09-16 Aspen Aerogels Inc Pó seco dispersìvel para transferência pulmonar e método de tratamento de um estado de doença responsivo ao tratamento por meio de um agente terapêutico
DE60101451T2 (de) 2001-03-05 2004-10-21 Pera Ivo E Inhaliergerät zur Verteilung von in einer Kapsel enthaltenen Medikamenten in Pulverform durch die Atemwege
US20060293217A1 (en) 2001-03-19 2006-12-28 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained release
US20040049022A1 (en) 2001-04-24 2004-03-11 Nyce Jonathan W. Composition & methods for treatment and screening
GB0129270D0 (en) 2001-12-06 2002-01-23 Pfizer Ltd Pharmaceutical combination
GB0129397D0 (en) 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
AU2003215334A1 (en) 2002-02-22 2003-09-09 Advanced Inhalation Research, Inc. Inhalable formulations for sustained release
US7405207B2 (en) 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
US20040092470A1 (en) 2002-06-18 2004-05-13 Leonard Sherry A. Dry powder oligonucleotide formualtion, preparation and its uses
KR20050056222A (ko) 2002-09-30 2005-06-14 아쿠스피어 인코포레이티드 흡입용 지속 방출형 다공성 미세입자
GB0226105D0 (en) 2002-11-08 2002-12-18 St Georges S Entpr Ltd Pain relief agents
US7516741B2 (en) 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
SE0203687D0 (sv) 2002-12-13 2002-12-13 Ian Harwigsson Med Adagit Fa Pharmaceutical Porous Particles
JP4943838B2 (ja) 2003-04-09 2012-05-30 ネクター セラピューティクス 空気入口シールドを備えたエアゾール化装置
MXPA05010763A (es) 2003-04-09 2005-12-12 Wyeth Corp Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo.
GB0312419D0 (en) 2003-05-30 2003-07-02 Boots Healthcare Int Ltd Use of a compound in the treatment of sleep disorders and the like, in providing refreshedness on waking and a method for the treatment of grogginess
SE527069C2 (sv) 2003-06-19 2005-12-13 Mederio Ag Förfarande och anordning för administrering av läkemedelspulver
US7041286B2 (en) 2003-07-23 2006-05-09 Nerenberg Arnold P Composition for mitigating a pernicious thrombotic event
US20060257987A1 (en) 2003-08-20 2006-11-16 Gonzalez Valcarcel Isabel Cris Ppar modulators
CN1838958A (zh) 2003-08-22 2006-09-27 贝林格尔·英格海姆药物公司 治疗慢性阻塞性肺病和肺动脉高血压的方法
WO2005039489A2 (en) 2003-09-24 2005-05-06 Polymerix Corporation Compositions and methods for the inhibition of bone growth and resorption
JP2011168615A (ja) * 2003-10-16 2011-09-01 Daiichi Sankyo Healthcare Co Ltd サリチル酸類含有経口組成物
WO2005040163A1 (en) 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
WO2005041886A2 (en) 2003-10-31 2005-05-12 Metaphore Pharmaceuticals, Inc. Methods for generating or increasing revenues related to pain inhibitor commerce
EP1722799A4 (en) 2004-02-05 2011-02-09 Etienne-Emile Baulieu TREATMENT OF PULMONARY ARTERIAL HYPERTENSION BY DHEA, ITS ANALOGUES OR DERIVATIVES
JP2007523197A (ja) 2004-02-23 2007-08-16 プロレキシーズ ファーマシューティカルズ インコーポレイテッド ｐＨＳＰ２０様活性を有する非ペプチジル剤、およびその使用
BRPI0510666A (pt) 2004-05-04 2007-12-04 Pfizer compostos de amida de arila ou heteroarila de metila substituìda, composições farmacêuticas compreendendo os mesmos, uso e combinação
US7189750B2 (en) 2004-05-05 2007-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
RU2006143544A (ru) 2004-05-10 2008-06-20 Нэстек Фармасьютикал Кампани Инк. (Us) Композиции и способ для облегченной чресслизистой доставки паратиреоидного гормона
WO2006017354A1 (en) 2004-07-13 2006-02-16 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing disease or pain
CA2575932A1 (en) 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
AU2005310247A1 (en) 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methods for inhibition of NKT cells
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0426301D0 (en) * 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations
EA200800041A1 (ru) * 2005-06-13 2008-04-28 Элан Фарма Интернэшнл Лтд. Составы с наночастицами клопидогреля, содержащие комбинацию клопидогреля и аспирина
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
JP2009502967A (ja) 2005-07-27 2009-01-29 ナステック ファーマスーティカル カンパニー インク． 粘膜送達を向上させるためのタイトジャンクション調節ペプチド化合物
US20070036831A1 (en) 2005-08-09 2007-02-15 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
WO2007070851A2 (en) 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
JP2009519975A (ja) 2005-12-16 2009-05-21 ユニバーシティ・オブ・カンザス 治療薬を送達するナノクラスター
WO2007072503A2 (en) 2005-12-21 2007-06-28 Panacea Biotec Ltd. Combinations for managing inflammation and associated disorders
RU2464973C2 (ru) 2006-01-24 2012-10-27 НексБио, Инк. Технология изготовления макромолекулярных микросфер
GB0605723D0 (en) 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
CA3177366A1 (en) 2006-08-10 2008-02-21 Roy C. Levitt Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
GB0617171D0 (en) 2006-08-31 2006-10-11 Generics Uk Ltd Novel compositions and methods
US20080066739A1 (en) 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
GB0621957D0 (en) 2006-11-03 2006-12-13 Vectura Group Plc Inhaler devices and bespoke pharmaceutical compositions
GB0700839D0 (en) 2007-01-17 2007-02-21 Braithwaite Philip Device
EP1964564A1 (en) 2007-04-19 2008-09-03 LAB International SRL Breakthrough Pain Management
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
CA2687720A1 (en) 2007-06-13 2008-12-24 Amgen Inc. Il-17 heteromeric receptor complex
JP2010533181A (ja) 2007-07-13 2010-10-21 アボツト・バイオテクノロジー・リミテツド ＴＮＦα阻害剤の肺投与のための方法及び組成物
AU2008279129A1 (en) 2007-07-24 2009-01-29 Nexbio, Inc. Technology for the preparation of microparticles
WO2009019598A2 (en) * 2007-08-03 2009-02-12 Dr. Reddy's Laboratories Ltd. Inhalation therapy for respiratory disorders
WO2009026434A1 (en) 2007-08-21 2009-02-26 Alkermes, Inc. Pulmonary pharmaceutical formulations
US9358242B2 (en) 2007-08-30 2016-06-07 Prelief Inc. Calcium glycerophosphate for treating and preventing respiratory diseases or conditions
US20110142914A1 (en) 2007-12-06 2011-06-16 Cytotech Labs, Llc Inhalable compositions having enhanced bioavailability
CA2710349A1 (en) 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
DE102008004386A1 (de) 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen
KR20160017105A (ko) 2008-01-15 2016-02-15 유니베르시떼 드 스트라스부르 치료제로서 유용한 레조르실산 락톤의 합성
KR101240904B1 (ko) 2008-02-21 2013-03-11 키린-암젠 인코포레이티드 Ｉｌ-１７ｒａ-ｉｌ-１７ｒｂ 길항제 및 그의 용도
JP2011512406A (ja) 2008-02-22 2011-04-21 ハナル バイオファーマ カンパニー リミテッド 複合製剤
GB0803369D0 (en) 2008-02-25 2008-04-02 Helperby Therapeutics Ltd Biological materials and uses thereof
BRPI0910691A2 (pt) 2008-04-04 2018-03-27 Irm Llc compostos e composições como inibidores de itpkb
JP2011518155A (ja) 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化ｌｆａ−１アンタゴニスト
EP2300469B1 (en) 2008-05-13 2015-06-24 Novartis AG Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
US20110112134A1 (en) 2008-05-16 2011-05-12 Amira Pharmaceuticals, Inc. Tricyclic Antagonists of Prostaglandin D2 Receptors
CA2730590A1 (en) 2008-07-15 2010-01-21 Schering Corporation Intranasal compositions comprising a decongestant and a corticosteroid
ES2611031T3 (es) 2008-07-18 2017-05-04 Prosonix Limited Proceso de mejora de la cristalinidad
WO2010011329A2 (en) 2008-07-23 2010-01-28 Map Pharmaceuticals, Inc. The delivery of powdered drug via inhalation
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
EP2334285A1 (en) 2008-09-12 2011-06-22 Critical Pharmaceuticals Limited Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
EP2405747A4 (en) 2009-03-13 2013-01-16 Nucitec Sa De Cv COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES
WO2010117951A1 (en) 2009-04-06 2010-10-14 The Regents Of The University Of California Inhibitors of soluble epoxide hydrolase to inhibit or prevent niacin-induced flushing
ES2552805T3 (es) 2009-04-20 2015-12-02 Auspex Pharmaceuticals, Llc Inhibidores piperidínicos de la cinasa Janus 3
EP2429495A4 (en) 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS
US9125999B2 (en) 2009-05-18 2015-09-08 Adamis Pharmaceuticals Corporation Dry powder inhaler dose counters
CA2762216C (en) 2009-05-18 2017-07-11 3M Innovative Properties Company Dry powder inhalers
EP2437741A1 (en) 2009-06-01 2012-04-11 Biocopea Limited The use of amlexanox in the therapy of neutrophil-driven diseases
GB201111485D0 (en) 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
GB0917054D0 (en) 2009-09-29 2009-11-11 Cytoguide As Agents, uses and methods
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
GB0918431D0 (en) 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
JP2013523153A (ja) 2010-04-07 2013-06-17 アッヴィ・インコーポレイテッド ＴＮＦ−α結合タンパク質
CN105640925B (zh) 2010-08-30 2019-08-16 普马特里克斯营业公司 干燥粉末配方及用于治疗肺部疾病的方法
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
ES2646748T3 (es) 2010-12-07 2017-12-15 Respira Therapeutics, Inc. Inhalador de polvo seco
CN102058886A (zh) 2010-12-20 2011-05-18 云南白药集团无锡药业有限公司 医用粉雾剂及其应用
WO2012107364A1 (en) 2011-02-07 2012-08-16 Scipharm Sàrl Novel composition for the treatment of cystic fibrosis
GB201102237D0 (en) 2011-02-09 2011-03-23 Kuecept Ltd Particle formulation
SG10201604560TA (en) 2011-04-12 2016-07-28 Moerae Matrix Inc Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
US20120306613A1 (en) 2011-06-02 2012-12-06 Nokia Siemens Networks Oy Sensor allocation
MX351781B (es) 2011-06-17 2017-10-30 Berg Llc Composiciones farmaceuticas inhalables.
WO2013016220A1 (en) 2011-07-22 2013-01-31 Amgen Inc. Il-17 receptor a is required for il-17c biology
KR20140069091A (ko) 2011-09-06 2014-06-09 베로나 파마 피엘씨 기침 및 기침으로 인한 발작 치료
CN104159633B (zh) 2011-12-16 2018-10-12 因多西斯有限公司 单位剂量药剂盒以及输送装置
US20130196906A1 (en) 2012-01-31 2013-08-01 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
JP6231022B2 (ja) * 2012-02-28 2017-11-15 アイシューティカ ホールディングス インク．Ｉｃｅｕｔｉｃａ Ｈｏｌｄｉｎｇｓ Ｉｎｃ． 吸入可能な医薬組成物
AU2013225982B2 (en) 2012-02-29 2017-11-30 Pulmatrix, Inc. Inhalable dry powders
EP2831072B1 (en) 2012-03-26 2017-04-19 Arroyo BioSciences L.L.C. Novel sphingosine 1-phosphate receptor antagonists
GB201205632D0 (en) 2012-03-30 2012-05-16 Vectura Ltd Method and apparatus
CA2871748C (en) 2012-05-03 2021-07-06 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
SG11201407676VA (en) 2012-05-21 2015-03-30 Agency Science Tech & Res A dry powder formulation
KR102177557B1 (ko) 2012-06-20 2020-11-11 유니버시티 오브 워터루 점막접착성 나노입자의 전달 시스템
EP2900665B1 (en) 2012-09-28 2018-01-03 Merck Sharp & Dohme Corp. Triazolyl derivatives as syk inhibitors
JP2015531384A (ja) 2012-10-03 2015-11-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル インバリアントｎｋｔ細胞アゴニストを用いたインフルエンザ後の細菌重複感染の予防的処置のための方法及び薬学的組成物
EP2916836A4 (en) 2012-11-07 2016-08-03 Merck Sharp & Dohme AMINOPYRIDE-CONTAINING MILK TYROSINE KINASE (SYK) INHIBITOR
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
CA2897464C (en) 2013-01-28 2021-05-18 Incozen Therapeutics Pvt. Ltd. Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
GB201305813D0 (en) 2013-03-28 2013-05-15 Vectura Ltd Compositions and methods
AU2013388034B2 (en) 2013-04-30 2019-08-15 Vectura Inc. Dry powder formulations and methods of use
MX2015016102A (es) 2013-05-23 2016-08-08 Aztherapies Inc Metodos para la liberacion de cromolina.
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
CA2926793C (en) 2013-10-11 2022-11-22 Lawrence S. ZISMAN Spray-dry formulations for treating pulmonary arterial hypertension
EP3087980B1 (en) 2013-12-23 2018-12-05 Wen, Xiaoguang Double-layer tablet and preparation method thereof
CA2939626C (en) 2014-02-20 2023-01-17 Allergan, Inc. Complement component c5 antibodies
EP4119131A1 (en) * 2014-02-20 2023-01-18 Otitopic Inc. Dry powder formulations for inhalation
US9796776B2 (en) 2014-02-27 2017-10-24 Allergan, Inc. Complement factor Bb antibodies
US10344037B2 (en) 2014-03-26 2019-07-09 Canget BioTek Pharma LLC Use of the FL-one hundred eighteen core chemical structure platform to generate FL-one hundred eighteen derivatives for treatment of human disease
WO2015153838A1 (en) 2014-04-02 2015-10-08 Rogne Bioscience Inc. Methods and compositions for treating inflammatory disorders
US20170027963A1 (en) 2014-04-10 2017-02-02 Patrick Crowley Delivery of non-steroidal agents to the brain via the nasal tract to treat neurological disorders
KR102603897B1 (ko) 2014-07-31 2023-11-20 벡추라 인코포레이티드 흡입용 건조 분말 제형
CN105833399B (zh) * 2015-03-21 2018-11-09 深圳百美酶生物医药科技有限公司 手动干粉吸入器
CN106619549B (zh) * 2017-01-03 2019-12-06 江苏吴中医药集团有限公司苏州制药厂 一种替格瑞洛与阿司匹林复合片剂及其制备方法

Also Published As

Publication number Publication date
WO2019059953A3 (en) 2019-09-26
US20190336448A1 (en) 2019-11-07
KR20200090755A (ko) 2020-07-29
JP2021502954A (ja) 2021-02-04
US20220016030A1 (en) 2022-01-20
US11077058B2 (en) 2021-08-03
EP3684338A4 (en) 2021-06-23
AU2017432640A1 (en) 2020-03-19
KR20230040375A (ko) 2023-03-22
MX2020002769A (es) 2020-07-20
CN115919780A (zh) 2023-04-07
KR102507987B1 (ko) 2023-03-21
US10195147B1 (en) 2019-02-05
CN111315363A (zh) 2020-06-19
EP3684338A2 (en) 2020-07-29
WO2019059953A2 (en) 2019-03-28
JP2022137070A (ja) 2022-09-21
AU2017432640B2 (en) 2023-11-30
CA3076353A1 (en) 2019-03-28
CN111315363B (zh) 2022-10-11

Similar Documents

Publication Publication Date Title
MX2023006856A (es) Composiciones de polvo seco con estearato de magnesio.
MX2020011166A (es) Agentes crioprotectores para formulaciones en forma de particulas.
PH12017502326B1 (en) Orodispersible dosage unit containing an estetrol component
NZ723838A (en) Cannabinoid compositions and uses
WO2015160843A8 (en) Ion channel activators and methods of use
PH12017502325A1 (en) Orodispersible dosage unit containing an estetrol component
BR112013026363A2 (pt) nanossuspensões de fármaco criodessecadas
EA202190331A1 (ru) Композиции терапевтически активных частиц с модифицированной поверхностью, полученные путем ультрабыстрой заморозки
MY175781A (en) Composition comprising at least two dry powders obtained by spray drying to increase the stability of the formulation
MX2016001422A (es) Composicion farmaceutica de fingolimod.
MY191712A (en) Composition comprising at least one dry powder obtained by spray drying to increase the stability of the formulation
IN2013MU01177A (es)
MX2018014790A (es) Formulacion combinada de tres compuestos antivirales.
WO2020127819A3 (en) Pharmaceutical composition comprising apixaban
WO2017064652A3 (en) Low dose oral dipyridamole compositions and uses thereof
WO2016197042A8 (en) Modified or targeted release formulations of linaclotide
MX2019013493A (es) Composicion para mejorar la absorcion de suplementos.
WO2020055357A3 (en) Inhalation compositions comprising phosphodiesterase-4 inhibitor
WO2019104062A8 (en) Polymorphs and uses thereof
WO2020013793A3 (en) Inhalation compositions comprising dopamine agonists
MX2020010928A (es) Una composicion farmaceutica en polvo seco para inhalacion que comprende una hormona tiroidea.
MX2022002681A (es) Composicion farmaceutica.
MX2019011701A (es) Composiciones de canabinoide y usos.
PH12019500473A1 (en) Solid composition for quick ingestion with facilitated swallowing, in the form of solid, non-agglomerated particles, comprising two different types of particles
MX2018013274A (es) Uso de alcoholes de azucar en composiciones de tibolona.