MX2023004326A - Células madre pluripotentes inducidas (ipsc) multiplexadas modificadas y células efectoras inmunitarias dirigidas a tumores sólidos. - Google Patents

Células madre pluripotentes inducidas (ipsc) multiplexadas modificadas y células efectoras inmunitarias dirigidas a tumores sólidos.

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Publication number
MX2023004326A
MX2023004326A MX2023004326A MX2023004326A MX2023004326A MX 2023004326 A MX2023004326 A MX 2023004326A MX 2023004326 A MX2023004326 A MX 2023004326A MX 2023004326 A MX2023004326 A MX 2023004326A MX 2023004326 A MX2023004326 A MX 2023004326A
Authority
MX
Mexico
Prior art keywords
ipsc
effector cells
pluripotentive
induced
solid tumors
Prior art date
Application number
MX2023004326A
Other languages
English (en)
Spanish (es)
Inventor
Bahram Valamehr
Mochtar Pribadi
Chia-Wei Chang
Tom T Lee
Bi-Huei Yang
Original Assignee
Fate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of MX2023004326A publication Critical patent/MX2023004326A/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/0634—Cells from the blood or the immune system
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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MX2023004326A 2020-11-04 2021-11-04 Células madre pluripotentes inducidas (ipsc) multiplexadas modificadas y células efectoras inmunitarias dirigidas a tumores sólidos. MX2023004326A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063109842P 2020-11-04 2020-11-04
US202163228490P 2021-08-02 2021-08-02
PCT/US2021/072255 WO2022099297A1 (en) 2020-11-04 2021-11-04 Multiplexed engineered ipsc and immune effector cells targeting solid tumors

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MX2023004326A true MX2023004326A (es) 2023-07-04

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MX2023004326A MX2023004326A (es) 2020-11-04 2021-11-04 Células madre pluripotentes inducidas (ipsc) multiplexadas modificadas y células efectoras inmunitarias dirigidas a tumores sólidos.

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US (1) US20230381235A1 (https=)
EP (1) EP4240834A4 (https=)
JP (1) JP2023549098A (https=)
KR (1) KR20230096110A (https=)
AU (1) AU2021376382A1 (https=)
CA (1) CA3196555A1 (https=)
IL (1) IL302481A (https=)
MX (1) MX2023004326A (https=)
WO (1) WO2022099297A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
US20230288405A1 (en) * 2022-01-20 2023-09-14 3T Biosciences, Inc. T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
AU2023273018A1 (en) * 2022-05-18 2024-11-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Production and/or delivery of multispecific binding agents
GB202208545D0 (en) * 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
WO2025064828A1 (en) * 2023-09-20 2025-03-27 Kure.Ai, Inc. Methods and reagents to improve cell therapy with the creation of novel car-targeting mr1 protein
GB202318950D0 (en) * 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201717578D0 (en) * 2017-10-26 2017-12-13 Univ College Cardiff Consultants Ltd Novel T-cell receptor
CA3177757A1 (en) * 2018-02-16 2019-08-22 Kite Pharma, Inc. Modified pluripotent stem cells and methods of making and use
WO2019204683A1 (en) * 2018-04-19 2019-10-24 Board Of Regents, The University Of Texas System T cell receptors with mage-b2 specificity and uses thereof
EP3632460A1 (en) * 2018-10-05 2020-04-08 St. Anna Kinderkrebsforschung A group of chimeric antigen receptors (cars)
KR20210139472A (ko) * 2019-04-11 2021-11-22 페이트 세러퓨틱스, 인코포레이티드 조작된 iPSC 및 면역 효과기 세포에서의 CD3 재구성
US20220213198A1 (en) * 2019-05-22 2022-07-07 The Council Of The Queensland Institute Of Medical Research Method of treatment

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WO2022099297A1 (en) 2022-05-12
CA3196555A1 (en) 2022-05-12
US20230381235A1 (en) 2023-11-30
EP4240834A1 (en) 2023-09-13
AU2021376382A1 (en) 2023-06-15
IL302481A (en) 2023-06-01
EP4240834A4 (en) 2025-04-02
KR20230096110A (ko) 2023-06-29
JP2023549098A (ja) 2023-11-22

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